Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers.

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Published in Am J Pathol on May 01, 1991

Authors

A Schmitt-Gräff1, S Krüger, F Bochard, G Gabbiani, H Denk

Author Affiliations

1: Department of Pathology, University of Geneva, Switzerland.

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Blood pressure-independent cardiac hypertrophy induced by locally activated renin-angiotensin system. Hypertension (1998) 1.25

Hepatocellular hyalin in cholestasis and cirrhosis: its diagnostic significance. Gastroenterology (1973) 1.23

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A 10-year experience with Japanese-type radical lymph node dissection for gastric cancer outside of Japan. Cancer (1995) 1.22