Published in J Cell Sci on September 01, 2001
Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol (2007) 5.60
Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers. J Cell Biol (2006) 3.37
Keratocyte phenotype mediates proteoglycan structure: a role for fibroblasts in corneal fibrosis. J Biol Chem (2003) 2.14
Modulation of fibroblast morphology and adhesion during collagen matrix remodeling. Mol Biol Cell (2002) 1.92
Cancer associated fibroblasts (CAFs) in tumor microenvironment. Front Biosci (Landmark Ed) (2010) 1.87
Fibroblasts and myofibroblasts in renal fibrosis. Int J Exp Pathol (2011) 1.76
Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts. Mol Biol Cell (2003) 1.70
Myofibroblast development is characterized by specific cell-cell adherens junctions. Mol Biol Cell (2004) 1.56
Whole animal knockout of smooth muscle alpha-actin does not alter excisional wound healing or the fibroblast-to-myofibroblast transition. Wound Repair Regen (2012) 1.47
Tenascin-C regulates recruitment of myofibroblasts during tissue repair after myocardial injury. Am J Pathol (2005) 1.46
Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis. Am J Physiol Lung Cell Mol Physiol (2014) 1.29
Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β. Am J Physiol Lung Cell Mol Physiol (2011) 1.26
Heading off with the herd: how cancer cells might maneuver supernumerary centrosomes for directional migration. Cancer Metastasis Rev (2013) 1.26
Matrix stiffness reverses the effect of actomyosin tension on cell proliferation. J Cell Sci (2012) 1.23
Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-β responsiveness. Am J Physiol Lung Cell Mol Physiol (2012) 1.22
Fibroblasts and myofibroblasts in wound healing. Clin Cosmet Investig Dermatol (2014) 1.22
Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells. Am J Physiol Lung Cell Mol Physiol (2010) 1.20
FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype. Mol Biol Cell (2007) 1.19
Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2. EMBO J (2009) 1.16
Myocardin-related transcription factors A and B are key regulators of TGF-β1-induced fibroblast to myofibroblast differentiation. J Invest Dermatol (2011) 1.16
Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic Intervention. Adv Wound Care (New Rochelle) (2013) 1.10
Stretch-activated force shedding, force recovery, and cytoskeletal remodeling in contractile fibroblasts. J Biomech (2008) 1.09
Rac1 expression by fibroblasts is required for tissue repair in vivo. Am J Pathol (2009) 1.03
Nanoscale topography-induced modulation of fundamental cell behaviors of rabbit corneal keratocytes, fibroblasts, and myofibroblasts. Invest Ophthalmol Vis Sci (2009) 1.02
Cancer cell invasion is enhanced by applied mechanical stimulation. PLoS One (2011) 0.99
The wound healing, chronic fibrosis, and cancer progression triad. Physiol Genomics (2014) 0.99
TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals. J Mol Cell Cardiol (2012) 0.98
Actin cytoskeleton in myofibroblast differentiation: ultrastructure defining form and driving function. Transl Res (2011) 0.96
Cells lacking β-actin are genetically reprogrammed and maintain conditional migratory capacity. Mol Cell Proteomics (2012) 0.95
Rac inhibition reverses the phenotype of fibrotic fibroblasts. PLoS One (2009) 0.94
Fibronectin extra domain-A promotes hepatic stellate cell motility but not differentiation into myofibroblasts. Gastroenterology (2011) 0.93
Peptide-mediated inhibition of mitogen-activated protein kinase-activated protein kinase-2 ameliorates bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol (2013) 0.92
PDGF-Ralpha gene expression predicts proliferation, but PDGF-A suppresses transdifferentiation of neonatal mouse lung myofibroblasts. Respir Res (2009) 0.91
The involvement of integrin β1 signaling in the migration and myofibroblastic differentiation of skin fibroblasts on anisotropic collagen-containing nanofibers. Biomaterials (2011) 0.89
Cellular fibronectin expression in human trabecular meshwork and induction by transforming growth factor-β2. Invest Ophthalmol Vis Sci (2013) 0.88
Focal Adhesion Kinase: A Key Mediator of Transforming Growth Factor Beta Signaling in Fibroblasts. Adv Wound Care (New Rochelle) (2013) 0.88
Tyrosine phosphatase PTPalpha regulates focal adhesion remodeling through Rac1 activation. Am J Physiol Cell Physiol (2008) 0.87
Functional and phenotypical comparison of myofibroblasts derived from biopsies and bronchoalveolar lavage in mild asthma and scleroderma. Respir Res (2006) 0.85
Role of IGF-1 pathway in lung fibroblast activation. Respir Res (2013) 0.85
Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGFβ Type 1 Receptor Modulation by Antisense Oligonucleotides. Mol Ther Nucleic Acids (2014) 0.84
The myofibroblast in wound healing and fibrosis: answered and unanswered questions. F1000Res (2016) 0.83
Stromal dynamic reciprocity in cancer: intricacies of fibroblastic-ECM interactions. Curr Opin Cell Biol (2016) 0.83
The role of osteopontin and osteopontin aptamer (OPN-R3) in fibroblast activity. J Surg Res (2011) 0.82
Targeting Inflammatory Cytokines and Extracellular Matrix Composition to Promote Wound Regeneration. Adv Wound Care (New Rochelle) (2014) 0.81
Human osteoblast cell spreading and vinculin expression upon biomaterial surfaces. J Mol Histol (2007) 0.80
Protease-activated receptor 1 inhibition by SCH79797 attenuates left ventricular remodeling and profibrotic activities of cardiac fibroblasts. J Cardiovasc Pharmacol Ther (2013) 0.80
S-nitrosoglutathione accelerates recovery from 5-fluorouracil-induced oral mucositis. PLoS One (2014) 0.79
Matrix-driven Myosin II Mediates the Pro-fibrotic Fibroblast Phenotype. J Biol Chem (2016) 0.78
PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis. Nat Commun (2016) 0.78
Transient expression of myofibroblast-like cells in rat rib fracture callus. Acta Orthop (2012) 0.78
β2-adrenoceptor activation modulates skin wound healing processes to reduce scarring. J Invest Dermatol (2014) 0.77
A Chemomechanical Model of Matrix and Nuclear Rigidity Regulation of Focal Adhesion Size. Biophys J (2015) 0.76
Adhesion and proliferation of human periodontal ligament cells on poly(2-methoxyethyl acrylate). Biomed Res Int (2014) 0.76
Matrix-regulated integrin αvβ5 maintains α5β1-dependent desmoplastic traits prognostic of neoplastic recurrence. Elife (2017) 0.75
Collective epithelial cell sheet adhesion and migration on polyelectrolyte multilayers with uniform and gradients of compliance. Exp Cell Res (2016) 0.75
SPOCK1 Is a Novel Transforming Growth Factor-β-Induced Myoepithelial Marker That Enhances Invasion and Correlates with Poor Prognosis in Breast Cancer. PLoS One (2016) 0.75
Dermal Fibroblasts from the Red Duroc Pig Have an Inherently Fibrogenic Phenotype: An In Vitro Model of Fibroproliferative Scarring. Plast Reconstr Surg (2015) 0.75
Conditional knockout of N-WASP in mouse fibroblast caused keratinocyte hyper proliferation and enhanced wound closure. Sci Rep (2016) 0.75
Model of Vascular Desmoplastic Multispecies Tumor Growth. J Theor Biol (2017) 0.75
Vascular disease-causing mutation, smooth muscle α-actin R258C, dominantly suppresses functions of α-actin in human patient fibroblasts. Proc Natl Acad Sci U S A (2017) 0.75
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol (1993) 8.36
A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol (1986) 6.83
Nonmuscle actin-binding proteins. Annu Rev Cell Biol (1985) 5.46
Granulation tissue as a contractile organ. A study of structure and function. J Exp Med (1972) 5.42
Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia (1971) 5.14
Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab Invest (1990) 4.67
Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell (2001) 4.25
Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol (1995) 4.00
Mechanisms of myofibroblast activity and phenotypic modulation. Exp Cell Res (1999) 3.78
The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J Cell Biol (1998) 3.65
Human smooth muscle autoantibody. Its identification as antiactin antibody and a study of its binding to "nonmuscular" cells. Am J Pathol (1973) 3.36
Contraction of granulation tissue in vitro: similarity to smooth muscle. Science (1971) 3.29
Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations. Lab Invest (1990) 3.15
Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation. Am J Pathol (2001) 3.07
Immunochemical identification of intermediate-sized filaments in human neoplastic cells. A diagnostic aid for the surgical pathologist. Am J Pathol (1981) 2.94
Vascular smooth muscle cells differ from other smooth muscle cells: predominance of vimentin filaments and a specific alpha-type actin. Proc Natl Acad Sci U S A (1981) 2.94
Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture. J Submicrosc Cytol Pathol (1992) 2.72
Morphological and immunochemical differences between keloid and hypertrophic scar. Am J Pathol (1994) 2.44
Dupuytren's contracture: fibroblast contraction? An ultrastructural study. Am J Pathol (1972) 2.31
Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins. Lab Invest (1989) 2.30
Alpha-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes. J Histochem Cytochem (1989) 2.23
Interactions of gelsolin and gelsolin-actin complexes with actin. Effects of calcium on actin nucleation, filament severing, and end blocking. Biochemistry (1985) 2.16
Expression of class II transplantation antigen on vascular smooth muscle cells in human atherosclerosis. J Clin Invest (1985) 2.16
Cytoskeleton of rat aortic smooth muscle cells. Normal conditions and experimental intimal thickening. Lab Invest (1984) 2.15
"Contractile interstitial cells" in pulmonary alveolar septa: a possible regulator of ventilation-perfusion ratio? Ultrastructural, immunofluorescence, and in vitro studies. J Cell Biol (1974) 2.11
Actin and tubulin co-cap with surface immunoglobulins in mouse B lymphocytes. Nature (1977) 2.10
Smooth-muscle differentiation in stromal cells of malignant and non-malignant breast tissues. Int J Cancer (1988) 2.01
Reversible binding of actin to gelsolin and profilin in human platelet extracts. J Cell Biol (1987) 1.97
Actin expression in smooth muscle cells of rat aortic intimal thickening, human atheromatous plaque, and cultured rat aortic media. J Clin Invest (1984) 1.95
The actin filament-severing domain of plasma gelsolin. J Cell Biol (1986) 1.93
The role of cytoskeletal and cytocontractile elements in pathologic processes. Am J Pathol (1983) 1.91
The myofibroblast: a quarter century after its discovery. Am J Surg Pathol (1998) 1.82
Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity. Virchows Arch (1994) 1.79
Phalloidin-induced hyperplasia of actin filaments in rat hepatocytes. Lab Invest (1975) 1.78
Interferon gamma inhibits both proliferation and expression of differentiation-specific alpha-smooth muscle actin in arterial smooth muscle cells. J Exp Med (1989) 1.70
Myofibroblasts in human granulation tissue. Hum Pathol (1974) 1.68
Cytoskeletal protein modulation in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis. Possible role of transforming growth factor beta and tumor necrosis factor alpha. Am J Respir Crit Care Med (1995) 1.67
Proliferation and phenotypic modulation of portal fibroblasts in the early stages of cholestatic fibrosis in the rat. Lab Invest (1996) 1.65
Cellular events and intracellular survival of Campylobacter jejuni during infection of HEp-2 cells. Infect Immun (1989) 1.65
Alpha-smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblasts and is modulated by gamma-interferon. Exp Cell Res (1992) 1.64
Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding. J Cell Biol (1999) 1.64
Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers. Am J Pathol (1991) 1.62
Malignant soft tissue tumors of probable histiocytic origin (malignant fibrous histiocytomas): general considerations and electron microscopic and tissue culture studies. Cancer (1975) 1.62
Effect of gamma-interferon on the clinical and biologic evolution of hypertrophic scars and Dupuytren's disease: an open pilot study. Plast Reconstr Surg (1994) 1.58
Localization of T lymphocytes and macrophages in fibrous and complicated human atherosclerotic plaques. Atherosclerosis (1988) 1.57
Myofibroblast development is characterized by specific cell-cell adherens junctions. Mol Biol Cell (2004) 1.56
Distribution of vimentin and desmin filaments in smooth muscle tissue of mammalian and avian aorta. Exp Cell Res (1982) 1.52
Cytoplasmic filaments and gap junctions in epithelial cells and myofibroblasts during wound healing. J Cell Biol (1978) 1.52
Alpha-smooth muscle actin in parenchymal cells of bleomycin-injured rat lung. Lab Invest (1989) 1.50
The contractile fibroblast. Its relevance in plastic surgery. Plast Reconstr Surg (1973) 1.46
Intranuclear injection of anti-actin antibodies into Xenopus oocytes blocks chromosome condensation. Nature (1979) 1.45
Rat alveolar myofibroblasts acquire alpha-smooth muscle actin expression during bleomycin-induced pulmonary fibrosis. Am J Pathol (1993) 1.44
Differentiation of smooth muscle cells in human blood vessels as defined by smoothelin, a novel marker for the contractile phenotype. Arterioscler Thromb Vasc Biol (1997) 1.44
Collagen and myofibroblasts of granulation tissue. A chemical, ultrastructural and immunologic study. Virchows Arch B Cell Pathol (1976) 1.43
Identification of self-renewing myoblasts in the progeny of single human muscle satellite cells. Differentiation (1996) 1.43
Cytoskeletal features of rat aortic cells during development. An electron microscopic, immunohistochemical, and biochemical study. Circ Res (1985) 1.43
Polarized distribution of actin isoforms in gastric parietal cells. Mol Biol Cell (1995) 1.41
Fibroblasts of granulation tissue: immunofluorescent staining with antismooth muscle serum. Proc Soc Exp Biol Med (1971) 1.41
An actin-destabilizing factor is present in human plasma. Experientia (1979) 1.41
Cytoplasmic contractile apparatus in aortic endothelial cells of hypertensive rats. Lab Invest (1975) 1.41
A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. Hepatology (1999) 1.40
Alpha-smooth muscle actin is transiently expressed in embryonic rat cardiac and skeletal muscles. Differentiation (1988) 1.39
Colonic pericryptal fibroblasts. Differentiation pattern in embryogenesis and phenotypic modulation in epithelial proliferative lesions. Virchows Arch A Pathol Anat Histopathol (1989) 1.39
Cytoskeletal features of normal and atheromatous human arterial smooth muscle cells. Hum Pathol (1986) 1.39
Apoptosis participates in cellularity regulation during rat aortic intimal thickening. Am J Pathol (1995) 1.39
Smooth muscle differentiation in scleroderma fibroblastic cells. Am J Pathol (1990) 1.36
Reversibility of gelsolin/actin interaction in macrophages. Evidence of Ca2+-dependent and Ca2+-independent pathways. J Exp Med (1987) 1.35
Vimentin-containing smooth muscle cells in aortic intimal thickening after endothelial injury. Lab Invest (1982) 1.34
Actin isoform synthesis and mRNA levels in quiescent and proliferating rat aortic smooth muscle cells in vivo and in vitro. Lab Invest (1986) 1.33
Apoptosis during wound healing, fibrocontractive diseases and vascular wall injury. Int J Biochem Cell Biol (1997) 1.32
Increase of contractile proteins in human cancer cells. Lancet (1975) 1.32
Cytodifferentiation and expression of alpha-smooth muscle actin mRNA and protein during primary culture of aortic smooth muscle cells. Correlation with cell density and proliferative state. Arteriosclerosis (1989) 1.32
Locally applied GM-CSF induces the accumulation of alpha-smooth muscle actin containing myofibroblasts. Virchows Arch B Cell Pathol Incl Mol Pathol (1991) 1.31
Inhibition of rat hepatic lipocyte activation in culture by interferon-gamma. Hepatology (1992) 1.30
Interferon-gamma inhibits experimental renal fibrosis. Kidney Int (1999) 1.30
Mechanisms of neointima formation and remodeling in the porcine coronary artery. Circulation (2001) 1.28
Rat fibroblasts cultured from various organs exhibit differences in alpha-smooth muscle actin expression, cytoskeletal pattern, and adhesive structure organization. Exp Cell Res (1998) 1.27
Gelsolin-actin interaction and actin polymerization in human neutrophils. J Cell Biol (1990) 1.26
Actin microfilaments, cell shape, and secretory processes in isolated rat hepatocytes. Effect of phalloidin and cytochalasin D. J Cell Biol (1979) 1.25
Phenotypic features of smooth muscle cells during the evolution of experimental carotid artery intimal thickening. Biochemical and morphologic studies. Lab Invest (1991) 1.25
Blood pressure-independent cardiac hypertrophy induced by locally activated renin-angiotensin system. Hypertension (1998) 1.25
The area of attachment of cytotoxic T lymphocytes to their target cells shows high motility and polarization of actin, but not myosin. J Immunol (1982) 1.23
Cultured porcine coronary artery smooth muscle cells. A new model with advanced differentiation. Circ Res (1999) 1.22
Specific demonstration of myoepithelial cells by anti-alpha smooth muscle actin antibody. J Histochem Cytochem (1988) 1.22
Intermediate filament proteins and actin isoforms as markers for soft tissue tumor differentiation and origin. II. Rhabdomyosarcomas. Am J Pathol (1988) 1.22
alpha-Actinin attached to membranes of secretory vesicles. Nature (1977) 1.20
The myofibroblast: a key cell for wound healing and fibrocontractive diseases. Prog Clin Biol Res (1981) 1.20