Published in J Mol Biol on March 19, 2010
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Characterization of the Type III sulfide:quinone oxidoreductase from Caldivirga maquilingensis and its membrane binding. Biochim Biophys Acta (2012) 0.79
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Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide. Sci Rep (2017) 0.78
Quaternary structure of WzzB and WzzE polysaccharide copolymerases. Protein Sci (2014) 0.77
Construction and characterization of tetH overexpression and knockout strains of Acidithiobacillus ferrooxidans. J Bacteriol (2014) 0.77
Structural and Functional insights into the catalytic mechanism of the Type II NADH:quinone oxidoreductase family. Sci Rep (2017) 0.75
H2S oxidation by nanodisc-embedded human sulfide quinone oxidoreductase. J Biol Chem (2017) 0.75
Insights into the respiratory electron transfer pathway from the structure of nitrate reductase A. Nat Struct Biol (2003) 2.31
Structure of shiga toxin type 2 (Stx2) from Escherichia coli O157:H7. J Biol Chem (2004) 2.14
Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase. J Biol Chem (2001) 2.00
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J Biol Chem (2005) 1.87
Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease. J Mol Biol (2003) 1.79
The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes. PLoS One (2008) 1.70
Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition. J Biol Chem (2002) 1.63
The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis. Proc Natl Acad Sci U S A (2007) 1.62
Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis. J Mol Biol (2006) 1.59
The prokaryotic complex iron-sulfur molybdoenzyme family. Biochim Biophys Acta (2007) 1.53
Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol Cell Proteomics (2005) 1.31
Structural and biochemical identification of a novel bacterial oxidoreductase. J Biol Chem (2004) 1.30
The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature (2013) 1.27
Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state. J Biol Chem (2002) 1.26
Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors. J Org Chem (2002) 1.25
The crystal and molecular structures of a cathepsin K:chondroitin sulfate complex. J Mol Biol (2008) 1.14
Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target. Proc Natl Acad Sci U S A (2006) 1.14
Genome-wide analysis of lipoprotein expression in Escherichia coli MG1655. J Bacteriol (2004) 1.11
Characterization of an Escherichia coli sulfite oxidase homologue reveals the role of a conserved active site cysteine in assembly and function. Biochemistry (2005) 1.11
The Escherichia coli ynfEFGHI operon encodes polypeptides which are paralogues of dimethyl sulfoxide reductase (DmsABC). Arch Biochem Biophys (2003) 1.09
The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold. J Biol Chem (2003) 1.09
VSTM1-v2, a novel soluble glycoprotein, promotes the differentiation and activation of Th17 cells. Cell Immunol (2012) 1.09
Pyranopterin conformation defines the function of molybdenum and tungsten enzymes. Proc Natl Acad Sci U S A (2012) 1.08
Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole. J Biol Chem (2002) 1.07
The molecular structure and catalytic mechanism of a novel carboxyl peptidase from Scytalidium lignicolum. Proc Natl Acad Sci U S A (2004) 1.07
Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Proteomics (2007) 1.07
Crystal structures of the main peptidase from the SARS coronavirus inhibited by a substrate-like aza-peptide epoxide. J Mol Biol (2005) 1.05
Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia. J Mol Biol (2007) 1.05
Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition. J Mol Biol (2006) 1.05
The quinone binding site in Escherichia coli succinate dehydrogenase is required for electron transfer to the heme b. J Biol Chem (2006) 1.04
The TB Structural Genomics Consortium: a decade of progress. Tuberculosis (Edinb) (2011) 1.03
Lentivirus-mediated silencing of Tiam1 gene influences multiple functions of a human colorectal cancer cell line. Neoplasia (2006) 1.01
Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro. J Med Chem (2004) 1.01
Extracellular accumulation of recombinant proteins fused to the carrier protein YebF in Escherichia coli. Nat Biotechnol (2005) 1.00
Structural and biochemical characterization of a quinol binding site of Escherichia coli nitrate reductase A. J Biol Chem (2004) 1.00
Evolutionary persistence of the molybdopyranopterin-containing sulfite oxidase protein fold. Microbiol Mol Biol Rev (2008) 0.99
Escherichia coli succinate dehydrogenase variant lacking the heme b. Proc Natl Acad Sci U S A (2007) 0.97
Differences in protonation of ubiquinone and menaquinone in fumarate reductase from Escherichia coli. J Biol Chem (2006) 0.97
The iron-sulfur clusters in Escherichia coli succinate dehydrogenase direct electron flow. J Biol Chem (2006) 0.97
The catalytic subunit of Escherichia coli nitrate reductase A contains a novel [4Fe-4S] cluster with a high-spin ground state. Biochemistry (2004) 0.96
Structural basis of inhibition revealed by a 1:2 complex of the two-headed tomato inhibitor-II and subtilisin Carlsberg. J Biol Chem (2003) 0.96
X-ray crystal structure of Mycobacterium tuberculosis haloalkane dehalogenase Rv2579. Biochim Biophys Acta (2007) 0.96
Structures of Mycobacterium tuberculosispyridoxine 5'-phosphate oxidase and its complexes with flavin mononucleotide and pyridoxal 5'-phosphate. Acta Crystallogr D Biol Crystallogr (2005) 0.95
Voltammetric studies of the catalytic mechanism of the respiratory nitrate reductase from Escherichia coli: how nitrate reduction and inhibition depend on the oxidation state of the active site. Biochemistry (2004) 0.94
Chromosomal system for studying AmpC-mediated beta-lactam resistance mutation in Escherichia coli. Antimicrob Agents Chemother (2002) 0.93
Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins. J Mol Biol (2005) 0.92
Defining the Q-site of Escherichia coli fumarate reductase by site-directed mutagenesis, fluorescence quench titrations and EPR spectroscopy. FEBS J (2005) 0.92
Fumarate reductase and succinate oxidase activity of Escherichia coli complex II homologs are perturbed differently by mutation of the flavin binding domain. J Biol Chem (2006) 0.91
Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site. J Mol Biol (2005) 0.91
Alternative sites for proton entry from the cytoplasm to the quinone binding site in Escherichia coli succinate dehydrogenase. Biochemistry (2008) 0.90
The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor. J Mol Biol (2008) 0.90
Mechanism of substrate recognition and PLP-induced conformational changes in LL-diaminopimelate aminotransferase from Arabidopsis thaliana. J Mol Biol (2008) 0.89
Molybdenum site structure of Escherichia coli YedY, a novel bacterial oxidoreductase. Inorg Chem (2010) 0.89
Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters. J Med Chem (2007) 0.89
Structure-activity analysis of cathepsin K/chondroitin 4-sulfate interactions. J Biol Chem (2010) 0.89
Crystal structure of diaminopimelate epimerase from Arabidopsis thaliana, an amino acid racemase critical for L-lysine biosynthesis. J Mol Biol (2008) 0.89
Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins. Biochem J (2013) 0.87
Detection and interpretation of redox potential optima in the catalytic activity of enzymes. Biochim Biophys Acta (2002) 0.87
Structural studies on the folded domain of the human prion protein bound to the Fab fragment of the antibody POM1. Acta Crystallogr D Biol Crystallogr (2012) 0.87
Cloning, expression, purification, crystallization and preliminary X-ray studies of epoxide hydrolases A and B from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.87
Protein crystallography reveals a role for the FS0 cluster of Escherichia coli nitrate reductase A (NarGHI) in enzyme maturation. J Biol Chem (2010) 0.86
Binding of adenine to Stx2, the protein toxin from Escherichia coli O157:H7. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.86
Crystal structures reveal an induced-fit binding of a substrate-like Aza-peptide epoxide to SARS coronavirus main peptidase. J Mol Biol (2006) 0.86
Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H(+) cotransporter (NupC) produced in Xenopus laevis oocytes. Mol Membr Biol (2003) 0.85
PTPIP51, a novel 14-3-3 binding protein, regulates cell morphology and motility via Raf-ERK pathway. Cell Signal (2008) 0.85
Structural insights into the activation of P. vivax plasmepsin. J Mol Biol (2003) 0.85
Proteomic analysis of Tiam1-mediated metastasis in colorectal cancer. Cell Biol Int (2007) 0.85
The structure of LL-diaminopimelate aminotransferase from Chlamydia trachomatis: implications for its broad substrate specificity. J Mol Biol (2011) 0.84
Crystal structure of the vitamin B12 biosynthetic cobaltochelatase, CbiXS, from Archaeoglobus fulgidus. J Struct Funct Genomics (2006) 0.84
Insights into mucopolysaccharidosis I from the structure and action of α-L-iduronidase. Nat Chem Biol (2013) 0.84
Catalytic residues and substrate specificity of scytalidoglutamic peptidase, the first member of the eqolisin in family (G1) of peptidases. FEBS Lett (2005) 0.84
Crystallization and preliminary X-ray diffraction analysis of prion protein bound to the Fab fragment of the POM1 antibody. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.84
The molecular structure of Rv2074, a probable pyridoxine 5'-phosphate oxidase from Mycobacterium tuberculosis, at 1.6 angstroms resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.84
Effects of site-directed mutations in Escherichia coli succinate dehydrogenase on the enzyme activity and production of superoxide radicals. Biochem Cell Biol (2006) 0.83
Investigation of the environment surrounding iron-sulfur cluster 4 of Escherichia coli dimethylsulfoxide reductase. Biochemistry (2005) 0.83
Shifting the metallocentric molybdoenzyme paradigm: the importance of pyranopterin coordination. J Biol Inorg Chem (2014) 0.83
Structure-activity characterization of sulfide:quinone oxidoreductase variants. J Struct Biol (2012) 0.83
Perturbation of the quinone-binding site of complex II alters the electronic properties of the proximal [3Fe-4S] iron-sulfur cluster. J Biol Chem (2011) 0.83
A protein export pathway involving Escherichia coli porins. Structure (2012) 0.83
An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors. J Mol Biol (2006) 0.83
Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase. Bioorg Chem (2008) 0.82
Spectroscopic characterization of YedY: the role of sulfur coordination in a Mo(V) sulfite oxidase family enzyme form. J Am Chem Soc (2009) 0.82
Differential effects of a molybdopterin synthase sulfurylase (moeB) mutation on Escherichia coli molybdoenzyme maturation. Biochem Cell Biol (2002) 0.82
Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S. Biol Chem (2007) 0.82
Crystal structure of the arginine repressor protein in complex with the DNA operator from Mycobacterium tuberculosis. J Mol Biol (2008) 0.82
Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase. Biochem Biophys Res Commun (2007) 0.82
Structure of the subtilisin Carlsberg-OMTKY3 complex reveals two different ovomucoid conformations. Acta Crystallogr D Biol Crystallogr (2005) 0.82
The crystal structure of shiga toxin type 2 with bound disaccharide guides the design of a heterobifunctional toxin inhibitor. J Biol Chem (2013) 0.81
Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action. Bioorg Med Chem (2008) 0.81
Crystal structure and mutagenesis of a protein phosphatase-1:calcineurin hybrid elucidate the role of the beta12-beta13 loop in inhibitor binding. J Biol Chem (2004) 0.81
Mutagenesis of SugE, a small multidrug resistance protein. Biochem Biophys Res Commun (2003) 0.81
The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism. J Mol Biol (2007) 0.81
The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase. Org Biomol Chem (2005) 0.81
The structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and Co-repressor, L-arginine. J Mol Biol (2009) 0.81
Crystal structure of β-hexosaminidase B in complex with pyrimethamine, a potential pharmacological chaperone. J Med Chem (2011) 0.81
Characterization and reconstitute of a [Fe4S4] adenosine 5'-phosphosulfate reductase from Acidithiobacillus ferrooxidans. Curr Microbiol (2009) 0.81
Expressional and functional studies of CKLF1 during dendritic cell maturation. Cell Immunol (2010) 0.80