Published in J Biol Chem on August 08, 2002
Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease. J Mol Biol (2003) 1.79
Substrate specificity of bacterial oligosaccharyltransferase suggests a common transfer mechanism for the bacterial and eukaryotic systems. Proc Natl Acad Sci U S A (2006) 1.69
Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis. J Mol Biol (2006) 1.59
Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis. EMBO J (2006) 1.57
Bifidobacterium bifidum lacto-N-biosidase, a critical enzyme for the degradation of human milk oligosaccharides with a type 1 structure. Appl Environ Microbiol (2008) 1.52
Chemoenzymatic synthesis of glycopeptides and glycoproteins through endoglycosidase-catalyzed transglycosylation. Carbohydr Res (2008) 1.23
Streptococcus pneumoniae endohexosaminidase D, structural and mechanistic insight into substrate-assisted catalysis in family 85 glycoside hydrolases. J Biol Chem (2009) 1.12
Efficient glycosynthase mutant derived from Mucor hiemalis endo-beta-N-acetylglucosaminidase capable of transferring oligosaccharide from both sugar oxazoline and natural N-glycan. J Biol Chem (2009) 1.04
Muropeptide rescue in Bacillus subtilis involves sequential hydrolysis by beta-N-acetylglucosaminidase and N-acetylmuramyl-L-alanine amidase. J Bacteriol (2010) 1.04
Structural determinants of an insect beta-N-Acetyl-D-hexosaminidase specialized as a chitinolytic enzyme. J Biol Chem (2010) 0.98
Molecular cloning and catalytic mechanism of a novel glycosphingolipid-degrading beta-N-acetylgalactosaminidase from Paenibacillus sp. TS12. J Biol Chem (2011) 0.97
Phylogenetic analyses suggest multiple changes of substrate specificity within the glycosyl hydrolase 20 family. BMC Evol Biol (2008) 0.97
Structural basis for the substrate specificity of a novel β-N-acetylhexosaminidase StrH protein from Streptococcus pneumoniae R6. J Biol Chem (2011) 0.96
Mechanism, Structure, and Inhibition of O-GlcNAc Processing Enzymes. Curr Signal Transduct Ther (2010) 0.94
Novel β-N-acetylglucosaminidases from Vibrio harveyi 650: cloning, expression, enzymatic properties, and subsite identification. BMC Biochem (2010) 0.90
The Amazing Transglycosylation Activity of Endo-β-N-acetylglucosaminidases. (2011) 0.90
Structure of the dimeric N-glycosylated form of fungal beta-N-acetylhexosaminidase revealed by computer modeling, vibrational spectroscopy, and biochemical studies. BMC Struct Biol (2007) 0.82
Crystal structures of a glycoside hydrolase family 20 lacto-N-biosidase from Bifidobacterium bifidum. J Biol Chem (2013) 0.82
High resolution crystal structure of the endo-N-Acetyl-β-D-glucosaminidase responsible for the deglycosylation of Hypocrea jecorina cellulases. PLoS One (2012) 0.81
Mammalian cells contain a second nucleocytoplasmic hexosaminidase. Biochem J (2009) 0.81
Probing the Catalytic Mechanism of Vibrio harveyi GH20 β-N-Acetylglucosaminidase by Chemical Rescue. PLoS One (2016) 0.77
Azide anions inhibit GH-18 endochitinase and GH-20 Exo β-N-acetylglucosaminidase from the marine bacterium Vibrio harveyi. J Biochem (2015) 0.77
Structural-Functional Analysis Reveals a Specific Domain Organization in Family GH20 Hexosaminidases. PLoS One (2015) 0.76
Characterization of β-N-acetylhexosaminidase (LeHex20A), a member of glycoside hydrolase family 20, from Lentinula edodes (shiitake mushroom). AMB Express (2012) 0.76
A Second β-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans. J Biol Chem (2015) 0.76
Fungal chitinases: function, regulation, and potential roles in plant/pathogen interactions. Curr Genet (2015) 0.76
Expression, purification, crystallization and preliminary crystallographic analysis of a GH20 β-N-acetylglucosaminidase from the marine bacterium Vibrio harveyi. Acta Crystallogr F Struct Biol Commun (2015) 0.75
Mutagenesis and mechanistic study of a glycoside hydrolase family 54 alpha-L-arabinofuranosidase from Trichoderma koningii. Biochem J (2007) 0.75
Mechanism of Human Nucleocytoplasmic Hexosaminidase D. Biochemistry (2016) 0.75
Molecular phylogeny and predicted 3D structure of plant beta-D-N-acetylhexosaminidase. ScientificWorldJournal (2014) 0.75
Computational study of β-N-acetylhexosaminidase from Talaromyces flavus, a glycosidase with high substrate flexibility. BMC Bioinformatics (2015) 0.75
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol (2008) 3.46
Breakdown of oligosaccharides by the process of elimination. Curr Opin Chem Biol (2006) 2.38
O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors. J Biol Chem (2005) 2.22
Structure of shiga toxin type 2 (Stx2) from Escherichia coli O157:H7. J Biol Chem (2004) 2.14
Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc). Proc Natl Acad Sci U S A (2009) 2.12
Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase. J Biol Chem (2001) 2.00
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nat Chem Biol (2012) 1.89
Pharmacological enhancement of beta-hexosaminidase activity in fibroblasts from adult Tay-Sachs and Sandhoff Patients. J Biol Chem (2004) 1.88
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J Biol Chem (2005) 1.87
High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones. Chem Biol (2007) 1.85
High-throughput screening methodology for the directed evolution of glycosyltransferases. Nat Methods (2006) 1.81
Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease. J Mol Biol (2003) 1.79
Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome. Am J Hum Genet (2009) 1.78
Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells. Nat Chem Biol (2011) 1.75
The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes. PLoS One (2008) 1.70
Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation. Nat Struct Mol Biol (2008) 1.66
Using substrate engineering to harness enzymatic promiscuity and expand biological catalysis. Nat Chem Biol (2006) 1.63
Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition. J Biol Chem (2002) 1.63
The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis. Proc Natl Acad Sci U S A (2007) 1.62
Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity. Science (2013) 1.61
Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis. J Mol Biol (2006) 1.59
Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis. Structure (2011) 1.53
Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity. Nat Struct Mol Biol (2006) 1.52
Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog. Nat Struct Mol Biol (2004) 1.50
Engineering of glycosidases and glycosyltransferases. Curr Opin Chem Biol (2006) 1.49
Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise. J Am Chem Soc (2007) 1.46
The conformation and function of a multimodular glycogen-degrading pneumococcal virulence factor. Structure (2011) 1.45
The donor subsite of trehalose-6-phosphate synthase: binary complexes with UDP-glucose and UDP-2-deoxy-2-fluoro-glucose at 2 A resolution. J Biol Chem (2003) 1.43
Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase. Structure (2004) 1.42
In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation. J Biol Chem (2008) 1.39
Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase. Biochim Biophys Acta (2009) 1.32
Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells. J Biol Chem (2013) 1.31
Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance. J Biol Chem (2008) 1.28
The search for novel human pancreatic alpha-amylase inhibitors: high-throughput screening of terrestrial and marine natural product extracts. Chembiochem (2008) 1.27
The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature (2013) 1.27
Emerging methods for the production of homogeneous human glycoproteins. Nat Chem Biol (2009) 1.26
Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors. J Org Chem (2002) 1.25
Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease. Proc Natl Acad Sci U S A (2011) 1.24
HCF-1 is cleaved in the active site of O-GlcNAc transferase. Science (2013) 1.21
Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates. J Biol Chem (2003) 1.21
Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology. Nat Chem Biol (2012) 1.21
Crystal structure of Thermotoga maritima alpha-L-fucosidase. Insights into the catalytic mechanism and the molecular basis for fucosidosis. J Biol Chem (2004) 1.20
Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nat Chem Biol (2012) 1.20
The structure of Clostridium perfringens NanI sialidase and its catalytic intermediates. J Biol Chem (2008) 1.19
Recent advances in GFP folding reporter and split-GFP solubility reporter technologies. Application to improving the folding and solubility of recalcitrant proteins from Mycobacterium tuberculosis. J Struct Funct Genomics (2005) 1.18
Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue. J Biol Chem (2004) 1.16
Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants. Biochemistry (2006) 1.15
Substrate distortion by a beta-mannanase: snapshots of the Michaelis and covalent-intermediate complexes suggest a B(2,5) conformation for the transition state. Angew Chem Int Ed Engl (2002) 1.14
The crystal and molecular structures of a cathepsin K:chondroitin sulfate complex. J Mol Biol (2008) 1.14
Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target. Proc Natl Acad Sci U S A (2006) 1.14
Mechanistic and structural analysis of a family 31 alpha-glycosidase and its glycosyl-enzyme intermediate. J Biol Chem (2004) 1.13
Streptococcus pneumoniae endohexosaminidase D, structural and mechanistic insight into substrate-assisted catalysis in family 85 glycoside hydrolases. J Biol Chem (2009) 1.12
Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother (2009) 1.12
Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB. Proc Natl Acad Sci U S A (2008) 1.12
Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells. Proc Natl Acad Sci U S A (2013) 1.12
Novel catalytic mechanism of glycoside hydrolysis based on the structure of an NAD+/Mn2+ -dependent phospho-alpha-glucosidase from Bacillus subtilis. Structure (2004) 1.11
Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase. J Biol Chem (2005) 1.11
Providing β-lactams a helping hand: targeting the AmpC β-lactamase induction pathway. Future Microbiol (2011) 1.10
Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. J Biol Chem (2007) 1.10
The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold. J Biol Chem (2003) 1.09
Mechanistic analogies amongst carbohydrate modifying enzymes. Chem Commun (Camb) (2004) 1.09
Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates. J Biol Chem (2012) 1.09
Detailed comparative analysis of the catalytic mechanisms of beta-N-acetylglucosaminidases from families 3 and 20 of glycoside hydrolases. Biochemistry (2005) 1.09
Covalent inhibitors of glycosidases and their applications in biochemistry and biology. Glycobiology (2008) 1.08
O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis. J Am Chem Soc (2005) 1.08
The molecular structure and catalytic mechanism of a novel carboxyl peptidase from Scytalidium lignicolum. Proc Natl Acad Sci U S A (2004) 1.07
Molecular basis for G protein control of the prokaryotic ATP sulfurylase. Mol Cell (2006) 1.07
Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole. J Biol Chem (2002) 1.07
NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. Antimicrob Agents Chemother (2010) 1.06
Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile. J Am Chem Soc (2003) 1.06
Ultrahigh-throughput FACS-based screening for directed enzyme evolution. Chembiochem (2009) 1.06
Crystal structures of the main peptidase from the SARS coronavirus inhibited by a substrate-like aza-peptide epoxide. J Mol Biol (2005) 1.05
Designer enzymes for glycosphingolipid synthesis by directed evolution. Nat Chem Biol (2009) 1.05
Structural insight into mammalian sialyltransferases. Nat Struct Mol Biol (2009) 1.05
Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia. J Mol Biol (2007) 1.05
Conformational changes induced by binding UDP-2F-galactose to alpha-1,3 galactosyltransferase- implications for catalysis. J Mol Biol (2007) 1.05
Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition. J Mol Biol (2006) 1.05
Structure and mechanism of chitin deacetylase from the fungal pathogen Colletotrichum lindemuthianum. Biochemistry (2006) 1.05
O-GlcNAc modification and the tauopathies: insights from chemical biology. Curr Alzheimer Res (2009) 1.04
The TB Structural Genomics Consortium: a decade of progress. Tuberculosis (Edinb) (2011) 1.03
Imaging of enzyme replacement therapy using PET. Proc Natl Acad Sci U S A (2010) 1.03
Active site plasticity within the glycoside hydrolase NagZ underlies a dynamic mechanism of substrate distortion. Chem Biol (2012) 1.03
Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis. Chem Biol (2010) 1.03
Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids. Biochemistry (2002) 1.02
Iminoalditol-amino acid hybrids: synthesis and evaluation as glycosidase inhibitors. Carbohydr Res (2007) 1.01
Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro. J Med Chem (2004) 1.01
Kinetic and mechanistic analysis of Trypanosoma cruzi trans-sialidase reveals a classical ping-pong mechanism with acid/base catalysis. Biochemistry (2008) 1.01
An unusual mechanism of glycoside hydrolysis involving redox and elimination steps by a family 4 beta-glycosidase from Thermotoga maritima. J Am Chem Soc (2004) 1.01
Crystal structure of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans: insights into sulfidotrophic respiration and detoxification. J Mol Biol (2010) 1.01
Crystal structure of the AmpR effector binding domain provides insight into the molecular regulation of inducible ampc beta-lactamase. J Mol Biol (2010) 0.99
Crystal structure of beta-D-xylosidase from Thermoanaerobacterium saccharolyticum, a family 39 glycoside hydrolase. J Mol Biol (2004) 0.99
Characterization of a beta-N-acetylhexosaminidase and a beta-N-acetylglucosaminidase/beta-glucosidase from Cellulomonas fimi. FEBS J (2006) 0.99