Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans.

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Published in Biol Blood Marrow Transplant on March 19, 2010

Authors

Michael C Jensen1, Leslie Popplewell, Laurence J Cooper, David DiGiusto, Michael Kalos, Julie R Ostberg, Stephen J Forman

Author Affiliations

1: Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010-3000, USA. mjensen@coh.org

Associated clinical trials:

Phase I Study of CD19-CAR-T2 Cells for Patients With Chemotherapy Resistant or Refractory CD19+ Acute Leukemia | NCT02822326

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