PubRank

Toshikazu Ushijima

Author PubWeight™ 124.18‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 2002 5.69
2 High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res 2006 2.69
3 Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci 2006 2.00
4 Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation. Gastroenterology 2012 1.91
5 Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res 2010 1.80
6 A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory. EMBO J 2006 1.71
7 DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect. Int J Cancer 2009 1.66
8 RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD. Mol Cell Biol 2005 1.64
9 CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas. Cancer Res 2005 1.57
10 Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas. Cancer Res 2006 1.55
11 Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis. Int J Cancer 2012 1.53
12 Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers. Oncogene 2003 1.38
13 The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. Cancer 2009 1.38
14 Identification of silencing of nine genes in human gastric cancers. Cancer Res 2002 1.37
15 Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. Cancer Res 2004 1.35
16 The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands. Genome Res 2009 1.32
17 Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers. Cancer Epidemiol Biomarkers Prev 2006 1.28
18 Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers. Oncogene 2004 1.27
19 Identification of 20 genes aberrantly methylated in human breast cancers. Int J Cancer 2005 1.27
20 Methylation-associated silencing of the Wnt antagonist SFRP1 gene in human ovarian cancers. Cancer Sci 2004 1.23
21 Silencing of tissue factor pathway inhibitor-2 gene in malignant melanomas. Int J Cancer 2007 1.21
22 Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment. Hippocampus 2011 1.20
23 Reduced expression of GNA11 and silencing of MCT1 in human breast cancers. Oncology 2003 1.20
24 Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development 2013 1.19
25 Identification of genes targeted by CpG island methylator phenotype in neuroblastomas, and their possible integrative involvement in poor prognosis. Oncology 2008 1.19
26 Diagnostic and therapeutic applications of epigenetics. Jpn J Clin Oncol 2005 1.17
27 Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia. J Cancer Res Clin Oncol 2003 1.16
28 The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae. Int J Cancer 2009 1.16
29 Silencing of the UCHL1 gene in human colorectal and ovarian cancers. Int J Cancer 2006 1.15
30 Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation. Cancer Sci 2004 1.14
31 Promoter methylation profiling of 30 genes in human malignant melanoma. Cancer Sci 2004 1.13
32 Overexpression of PIK3CA is associated with lymph node metastasis in esophageal squamous cell carcinoma. Int J Oncol 2009 1.13
33 Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer. Int J Cancer 2013 1.11
34 Enhanced IL-1beta production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice. Synapse 2010 1.07
35 Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation. Carcinogenesis 2010 1.05
36 Methylation and expression analysis of 15 genes and three normally-methylated genes in 13 Ovarian cancer cell lines. Cancer Lett 2005 1.01
37 Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain. Brain 2013 1.01
38 Persistence of a component of DNA methylation in gastric mucosae after Helicobacter pylori eradication. J Gastroenterol 2009 1.01
39 Adenomatous polyposis coli 1A is likely to be methylated as a passenger in human gastric carcinogenesis. Cancer Lett 2009 1.00
40 Expression quantitative trait loci analysis of 13 genes in the rat prostate. Genetics 2005 1.00
41 Induction of epigenetic alterations by chronic inflammation and its significance on carcinogenesis. Adv Genet 2010 0.99
42 Alu and Satα hypomethylation in Helicobacter pylori-infected gastric mucosae. Int J Cancer 2011 0.99
43 Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis. Cancer Lett 2013 0.99
44 Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers. Prostate 2003 0.97
45 Decreased expression of the seven ARP2/3 complex genes in human gastric cancers. Cancer Lett 2004 0.96
46 Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer. Gastric Cancer 2014 0.95
47 Identification of gastric cancer risk markers that are informative in individuals with past H. pylori infection. Gastric Cancer 2012 0.95
48 Identification of PRTFDC1 silencing and aberrant promoter methylation of GPR150, ITGA8 and HOXD11 in ovarian cancers. Life Sci 2007 0.94
49 Estimation of the fraction of cancer cells in a tumor DNA sample using DNA methylation. PLoS One 2013 0.94
50 Methylation-sensitive representational difference analysis and its application to cancer research. Ann N Y Acad Sci 2003 0.94
51 Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression. Hepatology 2012 0.92
52 Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation. Cancer Lett 2012 0.91
53 Prevention of Helicobacter pylori-induced gastric cancers in gerbils by a DNA demethylating agent. Cancer Prev Res (Phila) 2013 0.91
54 Reduced expression of the insulin-induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers. Int J Cancer 2002 0.91
55 Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers. Cancer Lett 2012 0.91
56 Development of a novel output value for quantitative assessment in methylated DNA immunoprecipitation-CpG island microarray analysis. DNA Res 2009 0.91
57 Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas. Cancer Lett 2006 0.91
58 Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged. Cancer Res 2005 0.91
59 Association between frequent CpG island methylation and HER2 amplification in human breast cancers. Carcinogenesis 2009 0.90
60 DNA methylation: a marker for carcinogen exposure and cancer risk. Environ Health Prev Med 2007 0.89
61 beta-Catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas. Cancer Sci 2003 0.89
62 Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression. J Clin Invest 2013 0.87
63 Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori-related gastritis. Gastric Cancer 2013 0.87
64 Global expression analysis of N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas using oligonucleotide microarrays. Carcinogenesis 2003 0.86
65 Revisit of field cancerization in squamous cell carcinoma of upper aerodigestive tract: better risk assessment with epigenetic markers. Cancer Prev Res (Phila) 2011 0.85
66 DNA methylation of microRNA-124a is a potential risk marker of colitis-associated cancer in patients with ulcerative colitis. Dig Dis Sci 2014 0.85
67 Induction of aberrant trimethylation of histone H3 lysine 27 by inflammation in mouse colonic epithelial cells. Carcinogenesis 2012 0.85
68 Etiology-specific gene expression profiles in rat mammary carcinomas. Cancer Res 2002 0.85
69 Exclusive KRAS mutation in microsatellite-unstable human colorectal carcinomas with sequence alterations in the DNA mismatch repair gene, MLH1. Gene 2008 0.84
70 Methylation silencing of transforming growth factor-beta receptor type II in rat prostate cancers. Cancer Res 2008 0.84
71 Studies on mammary carcinogenesis induced by a heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in mice and rats. Environ Mol Mutagen 2002 0.84
72 Promoter hypermethylation and post-transcriptional mechanisms for reduced BRCA1 immunoreactivity in sporadic human breast cancers. Jpn J Clin Oncol 2002 0.84
73 Hippocampal epigenetic modification at the doublecortin gene is involved in the impairment of neurogenesis with aging. Synapse 2010 0.83
74 Expression of the intestine-specific transcription factors, Cdx1 and Cdx2, correlates shift to an intestinal phenotype in gastric cancer cells. J Cancer Res Clin Oncol 2003 0.83
75 Methylation of multiple genes in gastric glands with intestinal metaplasia: A disorder with polyclonal origins. Am J Pathol 2006 0.83
76 Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. Cancer Sci 2011 0.82
77 Differential expression of genes related to levels of mucosal cell proliferation among multiple rat strains by using oligonucleotide microarrays. Mamm Genome 2003 0.82
78 EGFR L2 domain mutation is not correlated with resistance to cetuximab in metastatic colorectal cancer patients. J Cancer Res Clin Oncol 2013 0.82
79 Identification and validation of DNA methylation markers to predict lymph node metastasis of esophageal squamous cell carcinomas. Ann Surg Oncol 2010 0.82
80 Hereditary diffuse gastric cancer in a Japanese family with a large deletion involving CDH1. Gastric Cancer 2013 0.82
81 Down-regulation of human X-box binding protein 1 (hXBP-1) expression correlates with tumor progression in human prostate cancers. Prostate 2002 0.81
82 Lack of association between CpG island methylator phenotype in human gastric cancers and methylation in their background non-cancerous gastric mucosae. Cancer Sci 2007 0.81
83 The myelin vacuolation (mv) rat with a null mutation in the attractin gene. Lab Invest 2002 0.81
84 Suppressive effect of global DNA hypomethylation on gastric carcinogenesis. Carcinogenesis 2010 0.81
85 Silencing of the thrombomodulin gene in human malignant melanoma. Melanoma Res 2005 0.81
86 Persistence of gene expression changes in stomach mucosae induced by short-term N-methyl-N'-nitro-N-nitrosoguanidine treatment and their presence in stomach cancers. Mutat Res 2004 0.81
87 Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells: a novel character of tumor educated fibroblasts. Int J Oncol 2010 0.81
88 Cloning of the 5' upstream region of the rat p16 gene and its role in silencing. Jpn J Cancer Res 2002 0.80
89 Framework analysis for the carcinogenic mode of action of nitrobenzene. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2007 0.80
90 Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells. Nucleic Acids Res 2013 0.80
91 Introduction: epigenetics and cancer. Adv Genet 2010 0.80
92 Larger numbers of silenced genes in cancer cell lines with increased de novo methylation of scattered CpG sites. Cancer Lett 2006 0.79
93 Profiling and selection of genes differentially expressed in the pylorus of rat strains with different proliferative responses and stomach cancer susceptibility. Carcinogenesis 2002 0.79
94 Hypomethylation of Alu repetitive elements in esophageal mucosa, and its potential contribution to the epigenetic field for cancerization. Cancer Causes Control 2012 0.79
95 Mapping of A gene responsible for cataract formation and its modifier in the UPL rat. Invest Ophthalmol Vis Sci 2002 0.79
96 Imagine a world without cancer. BMC Cancer 2014 0.79
97 Comprehensive DNA Methylation and Extensive Mutation Analyses of HER2-Positive Breast Cancer. Oncology 2015 0.79
98 Epigenetic modulation at the CCR2 gene correlates with the maintenance of behavioral sensitization to methamphetamine. Addict Biol 2010 0.79
99 Reduced Brca1 protein expression in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinomas. Mol Carcinog 2002 0.79
100 Effects of genome architecture and epigenetic factors on susceptibility of promoter CpG islands to aberrant DNA methylation induction. Genomics 2011 0.78
101 Establishment of a detection system for demethylating agents using an endogenous promoter CpG island. Mutat Res 2004 0.78
102 Beta-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice. Cancer Lett 2003 0.78
103 A 5'-region polymorphism modulates promoter activity of the tumor suppressor gene MFSD2A. Mol Cancer 2011 0.78
104 Whole-genome analyses of loss of heterozygosity and methylation analysis of four tumor-suppressor genes in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas. Cancer Sci 2005 0.78
105 Gene expression profiling distinguishes between spontaneous and radiation-induced rat mammary carcinomas. J Radiat Res 2008 0.78
106 No-observed effect levels for carcinogenicity and for in vivo mutagenicity of a genotoxic carcinogen. Toxicol Sci 2004 0.78
107 Insertional mutation of the Attractin gene in the black tremor hamster. Mamm Genome 2002 0.77
108 Genome-wide analysis of DNA methylation changes induced by gestational arsenic exposure in liver tumors. Cancer Sci 2013 0.77
109 Clinical application of the CpG island methylator phenotype to prognostic diagnosis in neuroblastomas. J Hum Genet 2013 0.77
110 Identification of a DNA methylation marker that detects the presence of lymph node metastases of gastric cancers. Oncol Lett 2012 0.77
111 Does aberrant DNA methylation occur in human uterine leiomyomas? An attempt of genome-wide screening by MS-RDA. Tokai J Exp Clin Med 2011 0.77
112 Stronger prognostic power of the CpG island methylator phenotype than methylation of individual genes in neuroblastomas. Jpn J Clin Oncol 2013 0.77
113 The absence of Mth1 inactivation and DNA polymerase kappa overexpression in rat mammary carcinomas with frequent A:T to C:G transversions. Jpn J Cancer Res 2002 0.77
114 Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide. J Toxicol Sci 2009 0.77
115 Methylation destiny: Moira takes account of histones and RNA polymerase II. Epigenetics 2010 0.77
116 ZNF695 methylation predicts a response of esophageal squamous cell carcinoma to definitive chemoradiotherapy. J Cancer Res Clin Oncol 2014 0.76
117 Full length and delta lactoferrin display differential cell localization dynamics, but do not act as tumor markers or significantly affect the expression of other genes. Med Chem 2005 0.76
118 Molecular characterization of cancer reveals interactions between ionizing radiation and chemicals on rat mammary carcinogenesis. Int J Cancer 2013 0.76
119 Epigenetics is a fascinating field of modern biology. Preface. Adv Genet 2010 0.76
120 Single nucleotide instability: a wide involvement in human and rat mammary carcinogenesis? Mutat Res 2002 0.75
121 Systemic Administration of Small Interfering RNA Targeting Human Nestin Inhibits Pancreatic Cancer Cell Proliferation and Metastasis. Pancreas 2016 0.75
122 WNT Pathway Gene Mutations Are Associated With the Presence of Dysplasia in Colorectal Sessile Serrated Adenoma/Polyps. Am J Surg Pathol 2017 0.75
123 [Global understanding of pain]. Nihon Shinkei Seishin Yakurigaku Zasshi 2012 0.75
124 Value of KRAS, BRAF, and PIK3CA Mutations and Survival Benefit from Systemic Chemotherapy in Colorectal Peritoneal Carcinomatosis. Asian Pac J Cancer Prev 2016 0.75
125 Cyclin D1 overexpression in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas. Exp Toxicol Pathol 2007 0.75
126 [Genetic alterations and expression changes in breast cancers]. Nihon Rinsho 2007 0.75
127 [DNA methylation and cancer--DNA methylation as a target of cancer chemotherapy]. Gan To Kagaku Ryoho 2003 0.75