Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli.

PubWeight™: 4.11‹?› | Rank: Top 1%

🔗 View Article (PMID 2034287)

Published in Nature on May 30, 1991

Authors

T K Sixma1, S E Pronk, K H Kalk, E S Wartna, B A van Zanten, B Witholt, W G Hol

Author Affiliations

1: BIOSON Research Institute, Groningen, The Netherlands.

Articles citing this

(truncated to the top 100)

The complete general secretory pathway in gram-negative bacteria. Microbiol Rev (1993) 16.84

Cholera. Clin Microbiol Rev (1995) 12.33

OB(oligonucleotide/oligosaccharide binding)-fold: common structural and functional solution for non-homologous sequences. EMBO J (1993) 5.61

Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin. Microbiol Rev (1992) 5.15

Crystal structure of cholera toxin B-pentamer bound to receptor GM1 pentasaccharide. Protein Sci (1994) 3.19

An operational RNA code for amino acids and possible relationship to genetic code. Proc Natl Acad Sci U S A (1993) 2.87

Type II secretion and pathogenesis. Infect Immun (2001) 2.75

General secretion pathway (eps) genes required for toxin secretion and outer membrane biogenesis in Vibrio cholerae. J Bacteriol (1997) 2.69

Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins. Microbiol Mol Biol Rev (2004) 2.60

Expression of the native cholera toxin B subunit gene and assembly as functional oligomers in transgenic tobacco chloroplasts. J Mol Biol (2001) 2.44

Interaction between the autokinase EpsE and EpsL in the cytoplasmic membrane is required for extracellular secretion in Vibrio cholerae. EMBO J (1995) 2.24

Interaction of polyomavirus internal protein VP2 with the major capsid protein VP1 and implications for participation of VP2 in viral entry. EMBO J (1998) 2.06

Mechanism of cholera toxin action on a polarized human intestinal epithelial cell line: role of vesicular traffic. J Cell Biol (1992) 2.00

Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity. J Exp Med (1998) 1.98

Ganglioside structure dictates signal transduction by cholera toxin and association with caveolae-like membrane domains in polarized epithelia. J Cell Biol (1998) 1.90

Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody. Structure (2009) 1.89

Refined structure of dimeric diphtheria toxin at 2.0 A resolution. Protein Sci (1994) 1.88

Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL. J Cell Biol (1995) 1.86

Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting. J Exp Med (1996) 1.75

The family of bacterial ADP-ribosylating exotoxins. Clin Microbiol Rev (1995) 1.73

Entry of cholera toxin into polarized human intestinal epithelial cells. Identification of an early brefeldin A sensitive event required for A1-peptide generation. J Clin Invest (1993) 1.69

A genetically detoxified derivative of heat-labile Escherichia coli enterotoxin induces neutralizing antibodies against the A subunit. J Exp Med (1994) 1.68

Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity. J Exp Med (1997) 1.61

Interactions among the major and minor coat proteins of polyomavirus. J Virol (1994) 1.58

Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin. Infect Immun (1997) 1.54

Identification of host cell factors required for intoxication through use of modified cholera toxin. J Cell Biol (2011) 1.47

Transcytosis of cholera toxin subunits across model human intestinal epithelia. Proc Natl Acad Sci U S A (1995) 1.46

Structure of the cholera toxin secretion channel in its closed state. Nat Struct Mol Biol (2010) 1.44

The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development. Biochem J (1997) 1.35

Receptor-mediated oral delivery of a bioencapsulated green fluorescent protein expressed in transgenic chloroplasts into the mouse circulatory system. FASEB J (2006) 1.35

Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum. Toxins (Basel) (2010) 1.34

Peptide models for membrane channels. Biochem J (1996) 1.31

Biochemical relationships between the 53-kilodalton (Exo53) and 49-kilodalton (ExoS) forms of exoenzyme S of Pseudomonas aeruginosa. J Bacteriol (1997) 1.30

Delineation and comparison of ganglioside-binding epitopes for the toxins of Vibrio cholerae, Escherichia coli, and Clostridium tetani: evidence for overlapping epitopes. Proc Natl Acad Sci U S A (1994) 1.25

Construction of nontoxic derivatives of cholera toxin and characterization of the immunological response against the A subunit. Infect Immun (1995) 1.20

Comparative analysis of the mucosal adjuvanticity of the type II heat-labile enterotoxins LT-IIa and LT-IIb. Infect Immun (2000) 1.19

Cholera toxin, LT-I, LT-IIa and LT-IIb: the critical role of ganglioside binding in immunomodulation by type I and type II heat-labile enterotoxins. Expert Rev Vaccines (2007) 1.17

Protease susceptibility and toxicity of heat-labile enterotoxins with a mutation in the active site or in the protease-sensitive loop. Infect Immun (1997) 1.16

Fusion proteins containing the A2 domain of cholera toxin assemble with B polypeptides of cholera toxin to form immunoreactive and functional holotoxin-like chimeras. Infect Immun (1992) 1.16

Molecular genetic analysis of ganglioside GD1b-binding activity of Escherichia coli type IIa heat-labile enterotoxin by use of random and site-directed mutagenesis. Infect Immun (1992) 1.16

Role of receptor binding in toxicity, immunogenicity, and adjuvanticity of Escherichia coli heat-labile enterotoxin. Infect Immun (1997) 1.13

Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation. Proc Natl Acad Sci U S A (1996) 1.13

Biological and biochemical characterization of variant A subunits of cholera toxin constructed by site-directed mutagenesis. J Bacteriol (2001) 1.10

Molecular characterization of NAD:arginine ADP-ribosyltransferase from rabbit skeletal muscle. Proc Natl Acad Sci U S A (1992) 1.07

The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation. Proc Natl Acad Sci U S A (2006) 1.06

The crystal structure of Pseudomonas aeruginosa exotoxin domain III with nicotinamide and AMP: conformational differences with the intact exotoxin. Proc Natl Acad Sci U S A (1995) 1.05

Identification of motifs in cholera toxin A1 polypeptide that are required for its interaction with human ADP-ribosylation factor 6 in a bacterial two-hybrid system. Proc Natl Acad Sci U S A (2000) 1.04

Mutations in the A subunit affect yield, stability, and protease sensitivity of nontoxic derivatives of heat-labile enterotoxin. Infect Immun (1996) 1.02

Site-specific mutagenesis of the catalytic subunit of cholera toxin: substituting lysine for arginine 7 causes loss of activity. Infect Immun (1991) 1.01

Reduction in oral immunogenicity of cholera toxin B subunit by N-terminal peptide addition. Infect Immun (1993) 1.01

The VP1 subunit of JC polyomavirus recapitulates early events in viral trafficking and is a novel tool to study polyomavirus entry. Virology (2012) 1.00

Immunogenicity of the B monomer of Escherichia coli heat-labile toxin expressed on the surface of Streptococcus gordonii. Infect Immun (2000) 1.00

Identification of functional domains of Bordetella dermonecrotizing toxin. Infect Immun (1999) 0.98

Intermolecular interactions between the A and B subunits of heat-labile enterotoxin from Escherichia coli promote holotoxin assembly and stability in vivo. Proc Natl Acad Sci U S A (1992) 0.95

Characterization of hybrid toxins produced in Escherichia coli by assembly of A and B polypeptides from type I and type II heat-labile enterotoxins. Infect Immun (1992) 0.95

Synthesis of hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits: potential for use in a broad-spectrum vaccine. Infect Immun (1996) 0.95

Cyclic AMP receptor protein-dependent repression of heat-labile enterotoxin. Infect Immun (2008) 0.95

Protein crystallography and infectious diseases. Protein Sci (1994) 0.95

Diversity and impact of prokaryotic toxins on aquatic environments: a review. Toxins (Basel) (2010) 0.94

Immunogenicity and efficacy of recombinant RSV-F vaccine in a mouse model. Vaccine (2007) 0.92

Heat-labile enterotoxin: beyond G(m1) binding. Toxins (Basel) (2010) 0.92

Roles of Glu 349 and Asp 352 in membrane insertion and translocation by diphtheria toxin. Protein Sci (1996) 0.91

Proteolytic cleavage of pertussis toxin S1 subunit is not essential for its activity in mammalian cells. BMC Microbiol (2005) 0.91

The three-dimensional structure of the cytoplasmic domains of EpsF from the type 2 secretion system of Vibrio cholerae. J Struct Biol (2009) 0.91

Analysis of Shiga toxin subunit association by using hybrid A polypeptides and site-specific mutagenesis. J Bacteriol (1995) 0.91

Clostridium and bacillus binary enterotoxins: bad for the bowels, and eukaryotic being. Toxins (Basel) (2014) 0.91

Aerolysin and pertussis toxin share a common receptor-binding domain. EMBO J (1997) 0.90

Escherichia coli heat-labile toxin subunit B fusions with Streptococcus sobrinus antigens expressed by Salmonella typhimurium oral vaccine strains: importance of the linker for antigenicity and biological activities of the hybrid proteins. Infect Immun (1993) 0.90

Evidence that the A2 fragment of Shiga-like toxin type I is required for holotoxin integrity. Infect Immun (1994) 0.89

A combined vaccine approach against Vibrio cholerae and ETEC based on outer membrane vesicles. Front Microbiol (2015) 0.89

AB toxins: a paradigm switch from deadly to desirable. Toxins (Basel) (2010) 0.88

Functional diversity of heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli: differential enzymatic and immunological activities of LT1 (hLT) AND LT4 (pLT). J Biol Chem (2010) 0.87

Mutational analysis of ganglioside GM(1)-binding ability, pentamer formation, and epitopes of cholera toxin B (CTB) subunits and CTB/heat-labile enterotoxin B subunit chimeras. Infect Immun (2002) 0.87

Assignment of functional domains involved in ADP-ribosylation and B-oligomer binding within the carboxyl terminus of the S1 subunit of pertussis toxin. Infect Immun (1994) 0.87

Salmonella enterica serovar enteritidis ghosts carrying the Escherichia coli heat-labile enterotoxin B subunit are capable of inducing enhanced protective immune responses. Clin Vaccine Immunol (2014) 0.87

Identification of the Shiga toxin A-subunit residues required for holotoxin assembly. J Bacteriol (1993) 0.87

Residues of heat-labile enterotoxin involved in bacterial cell surface binding. J Bacteriol (2009) 0.87

Fucosylation and protein glycosylation create functional receptors for cholera toxin. Elife (2015) 0.86

Type II heat-labile enterotoxins: structure, function, and immunomodulatory properties. Vet Immunol Immunopathol (2012) 0.86

Concomitant enterotoxigenic Escherichia coli infection induces increased immune responses to Vibrio cholerae O1 antigens in patients with cholera in Bangladesh. Infect Immun (2010) 0.86

Specific inhibition of herpes virus replication by receptor-mediated entry of an antiviral peptide linked to Escherichia coli enterotoxin B subunit. Proc Natl Acad Sci U S A (1994) 0.86

Ingestion of transgenic carrots expressing the Escherichia coli heat-labile enterotoxin B subunit protects mice against cholera toxin challenge. Plant Cell Rep (2007) 0.85

Effects of site-directed mutagenesis of Escherichia coli heat-labile enterotoxin on ADP-ribosyltransferase activity and interaction with ADP-ribosylation factors. Infect Immun (1999) 0.85

Crystal structure of a non-toxic mutant of heat-labile enterotoxin, which is a potent mucosal adjuvant. Protein Sci (1997) 0.85

Toxin mediated diarrhea in the 21 century: the pathophysiology of intestinal ion transport in the course of ETEC, V. cholerae and rotavirus infection. Toxins (Basel) (2010) 0.85

Dynamic modulation of the glycosphingolipid content in supported lipid bilayers by glycolipid transfer protein. Biophys J (2010) 0.85

Crystal structure of heat-labile enterotoxin from Escherichia coli with increased thermostability introduced by an engineered disulfide bond in the A subunit. Protein Sci (1997) 0.84

Cholera toxin: a paradigm of a multifunctional protein. Indian J Med Res (2011) 0.83

The extracellular transport signal of the Vibrio cholerae endochitinase (ChiA) is a structural motif located between amino acids 75 and 555. J Bacteriol (2002) 0.82

Proteomics: a biotechnology tool for crop improvement. Front Plant Sci (2013) 0.82

Importance of ADP-ribosylation in the morphological changes of PC12 cells induced by cholera toxin. Infect Immun (1994) 0.82

Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins. J Biol Chem (2017) 0.81

Structural diversity in a conserved cholera toxin epitope involved in ganglioside binding. Protein Sci (1995) 0.81

Case studies in cholera: lessons in medical history and science. Yale J Biol Med (2001) 0.81

The serine 31 residue of the B subunit of Shiga toxin 2 is essential for secretion in enterohemorrhagic Escherichia coli. Infect Immun (2007) 0.81

Oligosaccharide-derivatized dendrimers: defined multivalent inhibitors of the adherence of the cholera toxin B subunit and the heat labile enterotoxin of E. coli to GM1. Glycoconj J (1997) 0.80

The effect of plant tissue and vaccine formulation on the oral immunogenicity of a model plant-made antigen in sheep. PLoS One (2012) 0.79

Functional pentameric formation via coexpression of the Escherichia coli heat-labile enterotoxin B subunit and its fusion protein subunit with a neutralizing epitope of ApxIIA exotoxin improves the mucosal immunogenicity and protection against challenge by Actinobacillus pleuropneumoniae. Clin Vaccine Immunol (2011) 0.79

Analysis of a cholera toxin B subunit (CTB) and human mucin 1 (MUC1) conjugate protein in a MUC1-tolerant mouse model. Cancer Immunol Immunother (2010) 0.78

Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine. Infect Immun (1996) 0.78

Articles by these authors

Prediction of the occurrence of the ADP-binding beta alpha beta-fold in proteins, using an amino acid sequence fingerprint. J Mol Biol (1986) 9.13

An efficient and reproducible procedure for the formation of spheroplasts from variously grown Escherichia coli. Anal Biochem (1976) 5.79

Industrial biocatalysis today and tomorrow. Nature (2001) 4.99

The alpha-helix dipole and the properties of proteins. Nature (1978) 4.59

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science (1998) 4.51

Degradation of chlorinated aliphatic hydrocarbons by Methylosinus trichosporium OB3b expressing soluble methane monooxygenase. Appl Environ Microbiol (1989) 4.45

A model for the mechanism of human topoisomerase I. Science (1998) 4.10

Predicted nucleotide-binding properties of p21 protein and its cancer-associated variant. Nature (1983) 3.94

Formation of Polyesters by Pseudomonas oleovorans: Effect of Substrates on Formation and Composition of Poly-(R)-3-Hydroxyalkanoates and Poly-(R)-3-Hydroxyalkenoates. Appl Environ Microbiol (1988) 3.46

The role of the alpha-helix dipole in protein function and structure. Prog Biophys Mol Biol (1985) 3.42

Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase. Nature (1993) 3.40

Purification and characterization of hydrolytic haloalkane dehalogenase from Xanthobacter autotrophicus GJ10. J Bacteriol (1985) 3.37

Structure of papain refined at 1.65 A resolution. J Mol Biol (1984) 3.34

Degradation of halogenated aliphatic compounds by Xanthobacter autotrophicus GJ10. Appl Environ Microbiol (1985) 3.26

Crystal structure of cholera toxin B-pentamer bound to receptor GM1 pentasaccharide. Protein Sci (1994) 3.19

Binding of chloromethyl ketone substrate analogues to crystalline papain. Biochemistry (1976) 2.91

Characterization of intracellular inclusions formed by Pseudomonas oleovorans during growth on octane. J Bacteriol (1983) 2.78

Genetics of alkane oxidation by Pseudomonas oleovorans. Biodegradation (1994) 2.66

Cloning of 1,2-dichloroethane degradation genes of Xanthobacter autotrophicus GJ10 and expression and sequencing of the dhlA gene. J Bacteriol (1989) 2.59

X-ray structures along the reaction pathway of cyclodextrin glycosyltransferase elucidate catalysis in the alpha-amylase family. Nat Struct Biol (1999) 2.58

Dipoles of the alpha-helix and beta-sheet: their role in protein folding. Nature (1981) 2.56

Release of outer membrane fragments from normally growing Escherichia coli. Biochim Biophys Acta (1976) 2.51

Metabolism of poly(3-hydroxyalkanoates) (PHAs) by Pseudomonas oleovorans. Identification and sequences of genes and function of the encoded proteins in the synthesis and degradation of PHA. J Biol Chem (1991) 2.43

Synthesis of poly-3-hydroxyalkanoates is a common feature of fluorescent pseudomonads. Appl Environ Microbiol (1989) 2.38

The effect of toluene on the structure and permeability of the outer and cytoplasmic membranes of Escherichia coli. Biochim Biophys Acta (1978) 2.37

Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation. Nature (1997) 2.23

Rubredoxin reductase of Pseudomonas oleovorans. Structural relationship to other flavoprotein oxidoreductases based on one NAD and two FAD fingerprints. J Mol Biol (1990) 2.21

Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxin. J Mol Biol (1993) 2.17

Analysis of Pseudomonas putida alkane-degradation gene clusters and flanking insertion sequences: evolution and regulation of the alk genes. Microbiology (2001) 2.13

Methods for intense aeration, growth, storage, and replication of bacterial strains in microtiter plates. Appl Environ Microbiol (2000) 2.10

Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography. Nature (1992) 2.08

Pseudomonas putida KT2442 cultivated on glucose accumulates poly(3-hydroxyalkanoates) consisting of saturated and unsaturated monomers. Appl Environ Microbiol (1992) 2.07

Structural evidence for dimerization-regulated activation of an integral membrane phospholipase. Nature (1999) 2.07

Structure of the heat shock protein chaperonin-10 of Mycobacterium leprae. Science (1996) 2.03

Difference density quality (DDQ): a method to assess the global and local correctness of macromolecular crystal structures. Acta Crystallogr D Biol Crystallogr (1999) 2.01

The Pseudomonas oleovorans alkane hydroxylase gene. Sequence and expression. J Biol Chem (1989) 1.94

Dihydrofolate reductase from Lactobacillus casei. X-ray structure of the enzyme methotrexate.NADPH complex. J Biol Chem (1978) 1.94

Method for isolating mutants overproducing nicotinamide adenine dinucleotide and its precursors. J Bacteriol (1972) 1.93

The Pseudomonas oleovorans alkBAC operon encodes two structurally related rubredoxins and an aldehyde dehydrogenase. J Biol Chem (1989) 1.83

Stereochemistry of chitin hydrolysis by a plant chitinase/lysozyme and X-ray structure of a complex with allosamidin: evidence for substrate assisted catalysis. Biochemistry (1995) 1.80

Nucleotide sequence and X-ray structure of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 in a maltose-dependent crystal form. J Mol Biol (1994) 1.72

Some characteristics of the outer membrane material released by growing enterotoxigenic Escherichia coli. Infect Immun (1980) 1.70

Preferential release of new outer membrane fragments by exponentially growing Escherichia coli. Biochim Biophys Acta (1978) 1.69

Computer simulation of the dynamics of hydrated protein crystals and its comparison with x-ray data. Proc Natl Acad Sci U S A (1983) 1.69

Structure of bovine liver rhodanese. I. Structure determination at 2.5 A resolution and a comparison of the conformation and sequence of its two domains. J Mol Biol (1978) 1.67

Purification and characterization of a bacterial dehalogenase with activity toward halogenated alkanes, alcohols and ethers. Eur J Biochem (1988) 1.65

Identification of granule-bound starch synthase in potato tubers. Plant Physiol (1986) 1.65

Controlled and functional expression of the Pseudomonas oleovorans alkane utilizing system in Pseudomonas putida and Escherichia coli. J Biol Chem (1987) 1.64

The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions. Nat Struct Biol (1994) 1.63

Crystal structure of hexameric haemocyanin from Panulirus interruptus refined at 3.2 A resolution. J Mol Biol (1989) 1.63

Towards a biocatalyst for (S)-styrene oxide production: characterization of the styrene degradation pathway of Pseudomonas sp. strain VLB120. Appl Environ Microbiol (1998) 1.61

Molecular screening for alkane hydroxylase genes in Gram-negative and Gram-positive strains. Environ Microbiol (1999) 1.61

Crystallographic analysis of oxygenated and deoxygenated states of arthropod hemocyanin shows unusual differences. Proteins (1994) 1.58

Active site and catalytic mechanism of phospholipase A2. Nature (1981) 1.58

Occurrence, synthesis and medical application of bacterial polyhydroxyalkanoate. Adv Drug Deliv Rev (2001) 1.57

Crystal structure of haloalkane dehalogenase: an enzyme to detoxify halogenated alkanes. EMBO J (1991) 1.56

DNA sequence determination and functional characterization of the OCT-plasmid-encoded alkJKL genes of Pseudomonas oleovorans. Mol Microbiol (1992) 1.55

Crystal structures of hevamine, a plant defence protein with chitinase and lysozyme activity, and its complex with an inhibitor. Structure (1994) 1.54

Crystal structure of p-hydroxybenzoate hydroxylase. J Mol Biol (1979) 1.53

Three-dimensional structure of the diphtheria toxin repressor in complex with divalent cation co-repressors. Structure (1995) 1.53

Refined X-ray structures of haloalkane dehalogenase at pH 6.2 and pH 8.2 and implications for the reaction mechanism. J Mol Biol (1993) 1.51

Refined 1.83 A structure of trypanosomal triosephosphate isomerase crystallized in the presence of 2.4 M-ammonium sulphate. A comparison with the structure of the trypanosomal triosephosphate isomerase-glycerol-3-phosphate complex. J Mol Biol (1991) 1.50

High-resolution structure of the diphtheria toxin repressor complexed with cobalt and manganese reveals an SH3-like third domain and suggests a possible role of phosphate as co-corepressor. Biochemistry (1996) 1.47

Crystal structure of a cobalt-activated diphtheria toxin repressor-DNA complex reveals a metal-binding SH3-like domain. J Mol Biol (1999) 1.46

Isolation of the membranes of an enterotoxigenic strain of Escherichia coli and distribution of enterotoxin activity in different subcellular fractions. Biochim Biophys Acta (1978) 1.46

Glycolysis as a target for the design of new anti-trypanosome drugs. Drug Resist Updat (2001) 1.45

Assembly pathway of newly synthesized LamB protein an outer membrane protein of Escherichia coli K-12. J Mol Biol (1984) 1.45

Doughnut-shaped structure of a bacterial muramidase revealed by X-ray crystallography. Nature (1994) 1.45

Crystal structure of the p-hydroxybenzoate hydroxylase-substrate complex refined at 1.9 A resolution. Analysis of the enzyme-substrate and enzyme-product complexes. J Mol Biol (1989) 1.44

Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex. Science (1992) 1.44

Structure of bovine pancreatic phospholipase A2 at 1.7A resolution. J Mol Biol (1981) 1.44

Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT). Mol Microbiol (1994) 1.43

Alkane utilization in Pseudomonas oleovorans. Structure and function of the regulatory locus alkR. J Biol Chem (1988) 1.43

Crystal structure of a new heat-labile enterotoxin, LT-IIb. Structure (1996) 1.42

The x-ray structure of epoxide hydrolase from Agrobacterium radiobacter AD1. An enzyme to detoxify harmful epoxides. J Biol Chem (1999) 1.41

Crystal structure of deoxygenated Limulus polyphemus subunit II hemocyanin at 2.18 A resolution: clues for a mechanism for allosteric regulation. Protein Sci (1993) 1.41

The covalent and tertiary structure of bovine liver rhodanese. Nature (1978) 1.41

PhaF, a polyhydroxyalkanoate-granule-associated protein of Pseudomonas oleovorans GPo1 involved in the regulatory expression system for pha genes. J Bacteriol (1999) 1.40

Characterization of a low density cytoplasmic membrane subfraction isolated from Escherichia coli. Biochim Biophys Acta (1975) 1.40

Outer-membrane vesicles released by normally growing Escherichia coli contain very little lipoprotein. Eur J Biochem (1981) 1.39

Gene cloning and characterization of multiple alkane hydroxylase systems in Rhodococcus strains Q15 and NRRL B-16531. Appl Environ Microbiol (2002) 1.38

The 2.0 A crystal structure of cephalosporin acylase. Structure (2000) 1.37

Degradation of n-haloalkanes and alpha, omega-dihaloalkanes by wild-type and mutants of Acinetobacter sp. strain GJ70. Appl Environ Microbiol (1987) 1.37

K88-mediated binding of Escherichia coli outer membrane fragments to porcine intestinal epithelial cell brush borders. Infect Immun (1981) 1.35

Crystallographic and fluorescence studies of the interaction of haloalkane dehalogenase with halide ions. Studies with halide compounds reveal a halide binding site in the active site. Biochemistry (1993) 1.34

Molecular dynamics refinement of a thermitase-eglin-c complex at 1.98 A resolution and comparison of two crystal forms that differ in calcium content. J Mol Biol (1989) 1.34