Published in J Biol Chem on October 10, 1978
Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria. Proc Natl Acad Sci U S A (1990) 3.98
Crystallographic and molecular-orbital studies on the geometry of antifolate drugs. Biochem J (1980) 3.11
The nucleotide sequence of the trimethoprim-resistant dihydrofolate reductase gene harbored by Tn7. Nucleic Acids Res (1983) 2.28
Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase. Proc Natl Acad Sci U S A (1989) 2.20
Isolation and expression of the Pneumocystis carinii dihydrofolate reductase gene. Proc Natl Acad Sci U S A (1989) 1.74
Computer simulation of the dynamics of hydrated protein crystals and its comparison with x-ray data. Proc Natl Acad Sci U S A (1983) 1.69
Mutations in the dihydrofolate reductase gene of trimethoprim-resistant isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother (1997) 1.66
Polyvalent dendrimer-methotrexate as a folate receptor-targeted cancer therapeutic. Mol Pharm (2012) 0.92
19F-n.m.r. studies of 3',5'-difluoromethotrexate binding to Lactobacillus casei dihydrofolate reductase. Molecular motion and coenzyme-induced conformational changes. Biochem J (1984) 0.86
The kinetic mechanism of the major form of ox kidney aldehyde reductase with D-glucuronic acid. Biochem J (1982) 0.82
Design and in vitro validation of multivalent dendrimer methotrexates as a folate-targeting anticancer therapeutic. Curr Pharm Des (2013) 0.80
A 1H n.m.r. study of the role of the glutamate moiety in the binding of methotrexate to Lactobacillus casei dihydrofolate reductase. Br J Pharmacol (1984) 0.80
The effects of modification with N-bromosuccinimide on the binding of ligands to dihydrofolate reductase. Biochem J (1980) 0.75
Selectivity analysis of 5-(arylthio)-2,4-diaminoquinazolines as inhibitors of Candida albicans dihydrofolate reductase by molecular dynamics simulations. J Comput Aided Mol Des (2000) 0.75
Three-dimensional structure of poliovirus at 2.9 A resolution. Science (1985) 11.47
Prediction of the occurrence of the ADP-binding beta alpha beta-fold in proteins, using an amino acid sequence fingerprint. J Mol Biol (1986) 9.13
Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP. Nature (1985) 8.46
Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP. Science (1994) 5.57
Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry (1997) 5.46
Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase. Science (1991) 5.42
Serine proteases: structure and mechanism of catalysis. Annu Rev Biochem (1977) 5.37
Crystal structure of a complex between electron transfer partners, cytochrome c peroxidase and cytochrome c. Science (1992) 4.82
The alpha-helix dipole and the properties of proteins. Nature (1978) 4.59
Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Biochemistry (1997) 4.55
Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science (1998) 4.51
Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli. Nature (1991) 4.11
Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism. Science (1994) 4.11
A model for the mechanism of human topoisomerase I. Science (1998) 4.10
Structure of subtilisin BPN' at 2.5 angström resolution. Nature (1969) 3.98
Predicted nucleotide-binding properties of p21 protein and its cancer-associated variant. Nature (1983) 3.94
Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. Biochemistry (1993) 3.88
Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate. J Biol Chem (1982) 3.84
The role of the alpha-helix dipole in protein function and structure. Prog Biophys Mol Biol (1985) 3.42
Crystal structure of cholera toxin B-pentamer bound to receptor GM1 pentasaccharide. Protein Sci (1994) 3.19
The crystal structure of Dps, a ferritin homolog that binds and protects DNA. Nat Struct Biol (1998) 3.02
The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450. J Biol Chem (1985) 2.95
Dihydrofolate reductase: x-ray structure of the binary complex with methotrexate. Science (1977) 2.88
Novel subunit-subunit interactions in the structure of glutamine synthetase. Nature (1986) 2.87
The mental health of patients with a chief complaint of chronic fatigue. A prospective evaluation and follow-up. Arch Intern Med (1988) 2.85
Molecular tectonic model of virus structural transitions: the putative cell entry states of poliovirus. J Virol (2000) 2.74
Crystal structure of the biphenyl-cleaving extradiol dioxygenase from a PCB-degrading pseudomonad. Science (1995) 2.68
Three-dimensional structure of poliovirus serotype 1 neutralizing determinants. J Virol (1988) 2.67
Three-dimensional structure of poliovirus receptor bound to poliovirus. Proc Natl Acad Sci U S A (2000) 2.64
Crystal structure of yeast cytochrome c peroxidase refined at 1.7-A resolution. J Biol Chem (1984) 2.56
Dipoles of the alpha-helix and beta-sheet: their role in protein folding. Nature (1981) 2.56
Low-resolution electron-density and anomalous-scattering-density maps of Chromatium high-potential iron protein. J Mol Biol (1968) 2.46
Crystal structure of avian dihydrofolate reductase containing phenyltriazine and NADPH. J Biol Chem (1982) 2.45
The stereochemistry of peroxidase catalysis. J Biol Chem (1980) 2.35
The three-dimensional structure of ricin at 2.8 A. J Biol Chem (1987) 2.34
Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution. Biochemistry (1996) 2.34
Depression and somatization in the chronic fatigue syndrome. Am J Med (1991) 2.33
Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity. Biochemistry (1996) 2.25
Molecular recognition of the inhibitor AG-1343 by HIV-1 protease: conformationally flexible docking by evolutionary programming. Chem Biol (1995) 2.23
Chymotrypsinogen: 2.5-angstrom crystal structure, comparison with alpha-chymotrypsin, and implications for zymogen activation. Biochemistry (1970) 2.23
Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation. Nature (1997) 2.23
Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxin. J Mol Biol (1993) 2.17
Subtilisin; a stereochemical mechanism involving transition-state stabilization. Biochemistry (1972) 2.13
The frequency of the chronic fatigue syndrome in patients with symptoms of persistent fatigue. Ann Intern Med (1988) 2.11
The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase. Mol Cell (2000) 2.09
Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography. Nature (1992) 2.08
Guidelines for the diagnosis and treatment of canine chronic valvular heart disease. J Vet Intern Med (2009) 2.06
Role and mechanism of the maturation cleavage of VP0 in poliovirus assembly: structure of the empty capsid assembly intermediate at 2.9 A resolution. Protein Sci (1994) 2.06
Multiwire area X-ray diffractometers. Methods Enzymol (1985) 2.04
Structure of the heat shock protein chaperonin-10 of Mycobacterium leprae. Science (1996) 2.03
Difference density quality (DDQ): a method to assess the global and local correctness of macromolecular crystal structures. Acta Crystallogr D Biol Crystallogr (1999) 2.01
A comparison of Fe 4 S 4 clusters in high-potential iron protein and in ferredoxin. Proc Natl Acad Sci U S A (1972) 1.93
Crystallographic structure and functional interpretation of the cytoplasmic domain of erythrocyte membrane band 3. Blood (2000) 1.92
Directed mutagenesis of dihydrofolate reductase. Science (1983) 1.88
Evolutionary relationships among extradiol dioxygenases. J Bacteriol (1996) 1.88
Deciphering common failures in molecular docking of ligand-protein complexes. J Comput Aided Mol Des (2000) 1.87
The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. Science (1987) 1.87
Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding. Biochemistry (1991) 1.86
Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta. J Biol Chem (1996) 1.85
Synaptic plasma membranes from rat brain synaptosomes: isolation and partial characterization. Biochim Biophys Acta (1971) 1.84
X-ray crystallographic study of boronic acid adducts with subtilisin BPN' (Novo). A model for the catalytic transition state. J Biol Chem (1975) 1.82
Identification of variable domains of the attachment (G) protein of subgroup A respiratory syncytial viruses. J Gen Virol (1991) 1.79
The structure of oxidized cytochrome c 2 of Rhodospirillum rubrum. J Biol Chem (1973) 1.73
Three-dimensional structure of a mouse-adapted type 2/type 1 poliovirus chimera. EMBO J (1991) 1.72
Analysis of respiratory syncytial virus strain variation in successive epidemics in one city. J Clin Microbiol (1994) 1.72
Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state. Biochemistry (1990) 1.71
Computer simulation of the dynamics of hydrated protein crystals and its comparison with x-ray data. Proc Natl Acad Sci U S A (1983) 1.69
The structure and oligomerization of the yeast arginine methyltransferase, Hmt1. Nat Struct Biol (2000) 1.69
Functional role of aspartic acid-27 in dihydrofolate reductase revealed by mutagenesis. Science (1986) 1.68
Structure of bovine liver rhodanese. I. Structure determination at 2.5 A resolution and a comparison of the conformation and sequence of its two domains. J Mol Biol (1978) 1.67
Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate. Biochemistry (1990) 1.66
What makes the patient-doctor relationship therapeutic? Exploring the connexional dimension of medical care. Ann Intern Med (1988) 1.64
Crystal structure of rat liver dihydropteridine reductase. Proc Natl Acad Sci U S A (1992) 1.63
In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother (1999) 1.63
The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions. Nat Struct Biol (1994) 1.63
Crystal structure of hexameric haemocyanin from Panulirus interruptus refined at 3.2 A resolution. J Mol Biol (1989) 1.63
The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation. EMBO J (1999) 1.63
Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim. J Biol Chem (1985) 1.62