Published in Curr Biol on March 25, 2010
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Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation. EMBO J (2012) 1.34
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A palmitoylation switch mechanism regulates Rac1 function and membrane organization. EMBO J (2011) 1.31
Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1. EMBO J (2011) 1.22
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A gene trap knockout of the Tiam-1 protein results in malformation of the early embryonic brain. Mol Cells (2012) 0.82
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The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. Neuron (2005) 2.91
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature (2002) 2.79
Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science (2003) 2.46
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Kif15 cooperates with eg5 to promote bipolar spindle assembly. Curr Biol (2009) 2.10
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Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly. J Cell Biol (2009) 1.65
SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1. Mol Cell (2009) 1.30
Spindle assembly: asters part their separate ways. Nat Cell Biol (2005) 1.21
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The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J (2012) 3.70
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell (2010) 3.65
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Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci U S A (2009) 3.08
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Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol Cell Biol (2006) 2.83
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science (2002) 2.73
Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol Cell (2011) 2.40
ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell (2013) 2.32
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature (2009) 2.22
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nat Commun (2011) 2.18
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nat Cell Biol (2002) 2.12
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat Cell Biol (2011) 2.07
TIGAR is required for efficient intestinal regeneration and tumorigenesis. Dev Cell (2013) 2.03
SUMOylation of the GTPase Rac1 is required for optimal cell migration. Nat Cell Biol (2010) 1.95
Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Dev Cell (2011) 1.87
Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2010) 1.81
p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma. J Pathol (2010) 1.79
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell (2010) 1.79
Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. J Clin Invest (2012) 1.73
Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. Development (2012) 1.71
WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. J Clin Invest (2015) 1.68
Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib. Mol Cancer Ther (2006) 1.66
MicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma. Clin Cancer Res (2011) 1.57
Gene therapy: X-SCID transgene leukaemogenicity. Nature (2006) 1.57
Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nat Genet (2008) 1.50
LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest. Gastroenterology (2010) 1.47
N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. J Cell Biol (2012) 1.45
Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res (2011) 1.44
The diverse roles of Rac signaling in tumorigenesis. Cell Cycle (2011) 1.38
Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis. J Clin Invest (2014) 1.33
SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1. Mol Cell (2009) 1.30
Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Proc Natl Acad Sci U S A (2003) 1.29
Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Dev Cell (2011) 1.29
Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism. Gastroenterology (2009) 1.25
PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine. Oncogene (2004) 1.24
Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. Cancer Res (2010) 1.21
Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling. Proc Natl Acad Sci U S A (2013) 1.20
Inducible progenitor-derived Wingless regulates adult midgut regeneration in Drosophila. EMBO J (2012) 1.18
Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. PLoS One (2009) 1.18
Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discov (2013) 1.17
Targeting of de novo DNA methylation throughout the Oct-4 gene regulatory region in differentiating embryonic stem cells. PLoS One (2010) 1.17
Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis (2006) 1.16
Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet (2010) 1.16
The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly. EMBO Rep (2010) 1.14
C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine. Cancer Res (2008) 1.13
Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas. Cancer Res (2007) 1.12
RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53. Oncogene (2004) 1.12
Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma. Cancer Res (2002) 1.10
UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer. Cancer (2010) 1.09
K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder. Dis Model Mech (2011) 1.08
Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy. Cancer Res (2005) 1.08
Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. Oncogene (2002) 1.08
Runx2 disruption promotes immortalization and confers resistance to oncogene-induced senescence in primary murine fibroblasts. Cancer Res (2007) 1.07
p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Res (2010) 1.06
B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proc Natl Acad Sci U S A (2008) 1.06
Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo. Cell Rep (2012) 1.05
Enforced expression of Runx2 perturbs T cell development at a stage coincident with beta-selection. J Immunol (2002) 1.03
Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi. Proc Natl Acad Sci U S A (2009) 1.03
Advances in mouse models of prostate cancer. Expert Rev Mol Med (2008) 1.01
Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer. Cancer Res (2013) 0.99
Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. J Clin Invest (2013) 0.99
A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer (2008) 0.97
Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism. J Invest Dermatol (2012) 0.97
β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity. Nat Cell Biol (2012) 0.97
Deficiency of Mbd2 attenuates Wnt signaling. Mol Cell Biol (2008) 0.97
Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis. Exp Cell Res (2007) 0.97
Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation. Development (2013) 0.96
A modified tandem affinity purification technique identifies that 14-3-3 proteins interact with Tiam1, an interaction which controls Tiam1 stability. J Proteome Res (2009) 0.95
Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes. Nat Commun (2013) 0.95
The Runx genes as dominant oncogenes. Blood Cells Mol Dis (2003) 0.94
A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model. Carcinogenesis (2008) 0.94
A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity. Mol Ther (2009) 0.93
Wnt/Myc interactions in intestinal cancer: partners in crime. Exp Cell Res (2011) 0.93
HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer. Proc Natl Acad Sci U S A (2011) 0.92
p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. EMBO Mol Med (2010) 0.91
Downregulated AP-1 activity is associated with inhibition of Protein-Kinase-C-dependent CD44 and ezrin localisation and upregulation of PKC theta in A431 cells. J Cell Sci (2002) 0.91
Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma. Cancer Res (2013) 0.90
RUNX2 in mammary gland development and breast cancer. J Cell Physiol (2013) 0.90
Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells. Oncogene (2005) 0.89
Exploring molecular genetics of bladder cancer: lessons learned from mouse models. Dis Model Mech (2012) 0.88
MYC-y mice: from tumour initiation to therapeutic targeting of endogenous MYC. Mol Oncol (2013) 0.88
Nuclear expression of Rac1 in cervical premalignant lesions and cervical cancer cells. BMC Cancer (2012) 0.87
High expression of TNF alpha is associated with -308 and -238 TNF alpha polymorphisms in knee osteoarthritis. Clin Exp Med (2012) 0.87
RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland. Dis Model Mech (2014) 0.87
Focal adhesion kinase is required for β-catenin-induced mobilization of epidermal stem cells. Carcinogenesis (2012) 0.87
Dasatinib inhibits mammary tumour development in a genetically engineered mouse model. J Pathol (2013) 0.86
Wnt signaling potentiates nevogenesis. Proc Natl Acad Sci U S A (2013) 0.86