Published in Cancer Res on June 07, 2013
Imaging hallmarks of cancer in living mice. Nat Rev Cancer (2014) 1.32
Fluorescent Proteins as Genetically Encoded FRET Biosensors in Life Sciences. Sensors (Basel) (2015) 0.93
High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium. Breast Cancer Res (2015) 0.93
Screening out irrelevant cell-based models of disease. Nat Rev Drug Discov (2016) 0.83
Molecular probes for fluorescence lifetime imaging. Bioconjug Chem (2015) 0.80
Pancreatic cancer organotypics: High throughput, preclinical models for pharmacological agent evaluation. World J Gastroenterol (2014) 0.80
FLIM-FRET for Cancer Applications. Curr Mol Imaging (2015) 0.79
Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging. Cell Adh Migr (2014) 0.78
Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue. Cell Rep (2015) 0.77
Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration. Nat Commun (2016) 0.77
Visualizing S1P-directed cellular egress by intravital imaging. Biochim Biophys Acta (2013) 0.76
The cross-talk of LDL-cholesterol with cell motility: Insights from the Niemann Pick Type C1 mutation and altered integrin trafficking. Cell Adh Migr (2015) 0.76
The lymphatic system and pancreatic cancer. Cancer Lett (2015) 0.76
In vivo imaging of the tumor and its associated microenvironment using combined CARS / 2-photon microscopy. Intravital (2015) 0.75
Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior. Adv Drug Deliv Rev (2016) 0.75
Accurate Morphology Preserving Segmentation of Overlapping Cells based on Active Contours. Sci Rep (2016) 0.75
Assessment of Gate Width Size on Lifetime-Based Förster Resonance Energy Transfer Parameter Estimation. Photonics (2015) 0.75
Temporal Data Set Reduction Based on D-Optimality for Quantitative FLIM-FRET Imaging. PLoS One (2015) 0.75
Novel Bioluminescent Activatable Reporter for Src Tyrosine Kinase Activity in Living Mice. Theranostics (2016) 0.75
Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression. F1000Res (2016) 0.75
Intravital FRET imaging reveals osteopontin-mediated polymorphonuclear leukocyte activation by tumor cell emboli. Cancer Sci (2016) 0.75
Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor. Oncogene (2017) 0.75
SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer. Oncogene (2017) 0.75
Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol (2009) 8.63
The role of focal-adhesion kinase in cancer - a new therapeutic opportunity. Nat Rev Cancer (2005) 5.57
Mutant p53 drives invasion by promoting integrin recycling. Cell (2009) 4.75
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell (2012) 4.58
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med (2012) 3.96
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev Cell (2007) 3.84
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J (2012) 3.70
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell (2010) 3.65
Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology (2004) 3.39
Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway. Dev Cell (2005) 3.26
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci U S A (2009) 3.08
Rapid signal transduction in living cells is a unique feature of mechanotransduction. Proc Natl Acad Sci U S A (2008) 3.04
A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol (2013) 2.98
Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol Cell Biol (2006) 2.83
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science (2002) 2.73
Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. Proc Natl Acad Sci U S A (2007) 2.64
Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. Nat Cell Biol (2002) 2.50
Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. Genes Dev (2004) 2.49
Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion. Trends Cell Biol (2004) 2.46
Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol Cell (2011) 2.40
v-Src's hold over actin and cell adhesions. Nat Rev Mol Cell Biol (2002) 2.40
ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell (2013) 2.32
Polyene-lipids: a new tool to image lipids. Nat Methods (2004) 2.30
E-cadherin-integrin crosstalk in cancer invasion and metastasis. J Cell Sci (2013) 2.23
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature (2009) 2.22
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nat Commun (2011) 2.18
Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex. Nat Cell Biol (2007) 2.18
Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. PLoS Biol (2009) 2.16
RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Dev Cell (2004) 2.13
Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival. Blood (2011) 2.11
The calpain system and cancer. Nat Rev Cancer (2011) 2.10
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat Cell Biol (2011) 2.07
TIGAR is required for efficient intestinal regeneration and tumorigenesis. Dev Cell (2013) 2.03
The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. Proc Natl Acad Sci U S A (2002) 2.01
Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors. Proc Natl Acad Sci U S A (2008) 1.97
N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits. J Cell Sci (2005) 1.89
A phase 1 pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors. Clin Cancer Res (2008) 1.89
Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Dev Cell (2011) 1.87
Design of the silent cerebral infarct transfusion (SIT) trial. Pediatr Hematol Oncol (2010) 1.87
Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition. Curr Opin Cell Biol (2005) 1.85
A role for the actin cytoskeleton in cell death and aging in yeast. J Cell Biol (2004) 1.81
Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2010) 1.81
LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. J Cell Biol (2010) 1.79
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell (2010) 1.79
p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma. J Pathol (2010) 1.79
Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. J Clin Invest (2012) 1.73
Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. Development (2012) 1.71
Nanometer targeting of microtubules to focal adhesions. J Cell Biol (2003) 1.69
Src and focal adhesion kinase as therapeutic targets in cancer. Curr Opin Pharmacol (2008) 1.69
p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB. EMBO J (2003) 1.68
WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. J Clin Invest (2015) 1.68
A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src. Curr Biol (2003) 1.67
Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib. Mol Cancer Ther (2006) 1.66
Phase I dose-escalation and pharmacokinetic study of dasatinib in patients with advanced solid tumors. Clin Cancer Res (2009) 1.63
Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4. EMBO J (2007) 1.59
The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements. J Cell Sci (2007) 1.57