Published in Trends Biochem Sci on March 26, 2010
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell (2012) 4.29
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Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways. Nat Rev Immunol (2011) 2.40
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Necrotic Cells Actively Attract Phagocytes through the Collaborative Action of Two Distinct PS-Exposure Mechanisms. PLoS Genet (2015) 1.47
Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice. Hepatology (2013) 1.41
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci U S A (2014) 1.40
Going up in flames: necrotic cell injury and inflammatory diseases. Cell Mol Life Sci (2010) 1.35
Detection of necrosis by release of lactate dehydrogenase activity. Methods Mol Biol (2013) 1.34
RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. PLoS One (2011) 1.33
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Viral modulation of programmed necrosis. Curr Opin Virol (2013) 1.20
Genetic control of necrosis - another type of programmed cell death. Curr Opin Cell Biol (2010) 1.16
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Programmed necrosis and autophagy in immune function. Immunol Rev (2012) 1.05
Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection. J Virol (2010) 1.04
Intracellular events and cell fate in filovirus infection. Viruses (2011) 1.01
The RIP1-kinase inhibitor necrostatin-1 prevents osmotic nephrosis and contrast-induced AKI in mice. J Am Soc Nephrol (2013) 1.00
Pancreatic β-cell death in response to pro-inflammatory cytokines is distinct from genuine apoptosis. PLoS One (2011) 0.99
True grit: programmed necrosis in antiviral host defense, inflammation, and immunogenicity. J Immunol (2014) 0.99
Protein kinase d regulates cell death pathways in experimental pancreatitis. Front Physiol (2012) 0.98
Structural basis of signal transduction in the TNF receptor superfamily. Adv Immunol (2013) 0.97
Suppression of RIP3-dependent necroptosis by human cytomegalovirus. J Biol Chem (2015) 0.93
The mitochondrial permeability transition pore and the cardiac necrotic program. Pediatr Cardiol (2011) 0.93
Membrane TNF-alpha-activated programmed necrosis is mediated by Ceramide-induced reactive oxygen species. J Mol Signal (2013) 0.92
Commensal microbiota are required for systemic inflammation triggered by necrotic dendritic cells. Cell Rep (2013) 0.91
Role of the mitochondrion in programmed necrosis. Front Physiol (2010) 0.90
Manipulation of apoptosis and necroptosis signaling by herpesviruses. Med Microbiol Immunol (2015) 0.88
Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection. J Immunol (2011) 0.85
Necrostatin-1 reduces intestinal inflammation and colitis-associated tumorigenesis in mice. Am J Cancer Res (2015) 0.85
Genetic inhibition of protein kinase Cε attenuates necrosis in experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol (2014) 0.85
Structural study of the RIPoptosome core reveals a helical assembly for kinase recruitment. Biochemistry (2014) 0.81
Novel Ser/Thr protein phosphatases in cell death regulation. Physiology (Bethesda) (2012) 0.79
Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells. Evid Based Complement Alternat Med (2012) 0.79
Monitoring the clearance of apoptotic and necrotic cells in the nematode Caenorhabditis elegans. Methods Mol Biol (2013) 0.79
Vitamin B2 as a virulence factor in Pseudogymnoascus destructans skin infection. Sci Rep (2016) 0.78
Necroptotic cell death in failing heart: relevance and proposed mechanisms. Heart Fail Rev (2016) 0.78
Ischemia/Reperfusion. Compr Physiol (2016) 0.78
Induction of apoptosis and non-apoptosis in human breast cancer cell line (MCF-7) by cisplatin and caffeine. Iran Biomed J (2011) 0.77
Fundamental research progress of mild hypothermia in cerebral protection. Springerplus (2013) 0.77
TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma. J Clin Cell Immunol (2012) 0.77
Humanin Derivatives Inhibit Necrotic Cell Death in Neurons. Mol Med (2015) 0.77
Necroptosis: STAT3 kills? JAKSTAT (2012) 0.77
Deletion Of XIAP reduces the severity of acute pancreatitis via regulation of cell death and nuclear factor-κB activity. Cell Death Dis (2017) 0.77
Pyroptosis and adaptive immunity mechanisms are promptly engendered in mesenteric lymph-nodes during pig infections with Salmonella enterica serovar Typhimurium. Vet Res (2013) 0.75
Simultaneous induction of apoptosis and necroptosis by Tanshinone IIA in human hepatocellular carcinoma HepG2 cells. Cell Death Discov (2016) 0.75
How are necrotic cells recognized by their predators? Worm (2015) 0.75
Structural insights of homotypic interaction domains in the ligand-receptor signal transduction of tumor necrosis factor (TNF). BMB Rep (2016) 0.75
PKD signaling and pancreatitis. J Gastroenterol (2016) 0.75
An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci U S A (1975) 23.42
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol (2005) 11.63
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell (2009) 11.36
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell (2009) 11.26
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell (2003) 11.07
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science (2009) 9.29
Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol (2008) 9.24
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol (2000) 8.49
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell (2007) 8.48
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell (2007) 7.74
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell (2008) 7.61
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell (2006) 7.32
TNF-alpha induces two distinct caspase-8 activation pathways. Cell (2008) 6.81
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]. Nat Cell Biol (2006) 6.11
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol (2004) 5.74
TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol Cell (2007) 4.53
Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev (1999) 4.39
Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. J Biol Chem (1992) 3.76
A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. J Biol Chem (2003) 3.70
Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J Biol Chem (2003) 3.35
Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochim Biophys Acta (2006) 3.12
To kill or be killed: viral evasion of apoptosis. Nat Immunol (2002) 3.04
RIP1, a kinase on the crossroads of a cell's decision to live or die. Cell Death Differ (2007) 2.96
Reactive oxygen species regulate activation-induced T cell apoptosis. Immunity (1999) 2.84
A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta. Mol Cell (2009) 2.81
Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis. Dev Cell (2001) 2.68
RIPK1 is not essential for TNFR1-induced activation of NF-kappaB. Cell Death Differ (2009) 2.59
Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. J Immunol (2005) 2.57
The RIP kinases: crucial integrators of cellular stress. Trends Biochem Sci (2005) 2.56
FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc Natl Acad Sci U S A (2008) 2.52
Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. J Biol Chem (2001) 2.45
Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation. J Biol Chem (2005) 2.41
The CD95 type I/type II model. Semin Immunol (2003) 2.34
Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation. J Biol Chem (2006) 2.32
Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. Cell Signal (2007) 2.30
Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A (2008) 2.20
Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling. Curr Biol (2007) 2.15
PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan. Nat Immunol (2006) 2.12
Potentiation of neuroblastoma metastasis by loss of caspase-8. Nature (2006) 2.12
The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death. Curr Med Chem (2003) 2.07
Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD. Dev Cell (2007) 2.05
Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis. Mol Cell Biol (2006) 2.03
Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment. J Cell Biol (2009) 2.02
A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes. Eur J Immunol (2000) 1.89
Caspase-independent cell killing by Fas-associated protein with death domain. J Cell Biol (1998) 1.87
Linking JNK signaling to NF-kappaB: a key to survival. J Cell Sci (2004) 1.84
Inhibition of proinflammatory and innate immune signaling pathways by a cytomegalovirus RIP1-interacting protein. Proc Natl Acad Sci U S A (2008) 1.82
The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria. FEBS Lett (2000) 1.80
Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1. J Biol Chem (2008) 1.78
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep (2009) 1.72
Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1. Mol Cell Biol (2006) 1.72
Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors. J Immunol (2008) 1.66
Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature (2009) 1.62
Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA. Cell Death Differ (2002) 1.59
Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells. J Biol Chem (2005) 1.50
Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Proc Natl Acad Sci U S A (2006) 1.40
Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD. J Biol Chem (2003) 1.28
NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling. Cell Death Differ (2009) 1.27
The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage. Proc Natl Acad Sci U S A (2009) 1.27
Cylindromatosis and the CYLD gene: new lessons on the molecular principles of epithelial growth control. Bioessays (2007) 1.11
Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function. J Virol (2002) 1.09
TNF-alpha activates at least two apoptotic signaling cascades. Oncogene (1998) 1.01
Membrane-bound Fas ligand requires RIP1 for efficient activation of caspase-8 within the death-inducing signaling complex. J Immunol (2009) 1.01
Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory. J Immunol (2004) 0.94
The TRAF3-binding site of human molluscipox virus FLIP molecule MC159 is critical for its capacity to inhibit Fas-induced apoptosis. Cell Death Differ (2006) 0.89
Receptor-interacting protein shuttles between cell death and survival signaling pathways. Mol Biol Cell (2009) 0.85
Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity. J Immunol (2006) 0.81
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell (2009) 11.26
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell (2012) 4.29
Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature (2011) 3.86
RIP3: a molecular switch for necrosis and inflammation. Genes Dev (2013) 1.94
Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Proc Natl Acad Sci U S A (2005) 1.69
Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. Nat Med (2005) 1.56
CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis. PLoS One (2013) 1.48
Going up in flames: necrotic cell injury and inflammatory diseases. Cell Mol Life Sci (2010) 1.35
RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. PLoS One (2011) 1.33
TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. Cell Mol Life Sci (2013) 1.20
Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis. Biochem J (2013) 1.07
Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection. J Virol (2010) 1.04
Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity. J Immunol (2006) 0.81
Tumor Necrosis Factor Family Ligands and Receptors in the Immune System: Targets for Future Pharmaceuticals. Drug News Perspect (2002) 0.79
Physiological consequences of programmed necrosis, an alternative form of cell demise. Mol Cells (2010) 0.79
A RNA interference screen identifies RIP3 as an essential inducer of TNF-induced programmed necrosis. Adv Exp Med Biol (2011) 0.79
Cell biology. RIPK3 takes another deadly turn. Science (2014) 0.76