PubRank

Christopher C Goodnow

Author PubWeight™ 130.92‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 2005 6.31
2 Aire regulates negative selection of organ-specific T cells. Nat Immunol 2003 5.85
3 Two levels of protection for the B cell genome during somatic hypermutation. Nature 2008 5.32
4 DNA repair is limiting for haematopoietic stem cells during ageing. Nature 2007 4.71
5 Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med 2008 4.24
6 Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum 2010 3.76
7 Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity 2003 3.36
8 Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature 2007 3.08
9 Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory. Nat Immunol 2002 2.84
10 Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood 2006 2.72
11 Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity. J Exp Med 2004 2.43
12 Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol 2009 2.29
13 Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance. Blood 2011 2.25
14 ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes. Nat Immunol 2011 2.21
15 Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL. Immunity 2008 2.13
16 The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat Immunol 2008 1.97
17 Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Nat Immunol 2009 1.84
18 Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. Immunity 2007 1.83
19 Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors. J Exp Med 2007 1.82
20 DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice. J Exp Med 2011 1.79
21 A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. Proc Natl Acad Sci U S A 2009 1.74
22 Axon growth and guidance genes identify T-dependent germinal centre B cells. Immunol Cell Biol 2007 1.60
23 Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes. J Exp Med 2002 1.58
24 Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim. Immunity 2004 1.57
25 Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. Immunity 2003 1.51
26 CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation. J Exp Med 2011 1.42
27 CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity 2010 1.39
28 ENU-mutagenesis: insight into immune function and pathology. Curr Opin Immunol 2006 1.35
29 Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling. Nat Immunol 2003 1.30
30 Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling. Nat Immunol 2003 1.26
31 Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB. J Exp Med 2013 1.26
32 Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation. Immunity 2013 1.19
33 Fat aussie--a new Alström syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis. Mol Endocrinol 2006 1.18
34 DOCK8 is critical for the survival and function of NKT cells. Blood 2013 1.17
35 Bulk segregation mapping of mutations in closely related strains of mice. Genetics 2010 1.15
36 Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations. PLoS Genet 2013 1.14
37 A mutation in a chromosome condensin II subunit, kleisin beta, specifically disrupts T cell development. Proc Natl Acad Sci U S A 2007 1.11
38 B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A. J Exp Med 2012 1.10
39 Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. Proc Natl Acad Sci U S A 2006 1.09
40 ERK signaling is a molecular switch integrating opposing inputs from B cell receptor and T cell cytokines to control TLR4-driven plasma cell differentiation. J Immunol 2006 1.09
41 The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs. FEBS J 2010 1.06
42 Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism. Blood 2008 1.05
43 Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. Biochem Biophys Res Commun 2006 1.04
44 Analysis of an ethylnitrosourea-generated mouse mutation defines a cell intrinsic role of nuclear factor kappaB2 in regulating circulating B cell numbers. J Exp Med 2002 1.04
45 Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells. Diabetes 2011 1.04
46 Illuminating autoimmune regulators through controlled variation of the mouse genome sequence. Immunity 2004 1.03
47 Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis. Blood 2011 1.02
48 Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kappa B in B cell clonal anergy. J Exp Med 2006 1.01
49 Cell-intrinsic effects of non-MHC NOD genes on dendritic cell generation in vivo. Int Immunol 2002 1.01
50 RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet 2012 1.00
51 A mechanism for Ikaros regulation of human globin gene switching. Br J Haematol 2008 1.00
52 Connecting mammalian genome with phenome by ENU mouse mutagenesis: gene combinations specifying the immune system. Annu Rev Genet 2005 0.99
53 Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling. Genome Biol 2007 0.98
54 Genetic lesions in T-cell tolerance and thresholds for autoimmunity. Immunol Rev 2005 0.98
55 Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance. J Exp Med 2014 0.94
56 Lymphoma and the control of B cell growth and differentiation. Curr Mol Med 2006 0.92
57 Analysis of Lyn/CD22 double-deficient B cells in vivo demonstrates Lyn- and CD22-independent pathways affecting BCR regulation and B cell survival. Eur J Immunol 2005 0.92
58 Genes, pathways and checkpoints in lymphocyte development and homeostasis. Immunol Cell Biol 2005 0.91
59 Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production. J Exp Med 2012 0.91
60 Intrinsic in vitro abnormalities in dendritic cell generation caused by non-MHC non-obese diabetic genes. Immunol Cell Biol 2002 0.91
61 RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility. PLoS Genet 2013 0.90
62 Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies. Elife 2013 0.90
63 Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome. J Clin Invest 2009 0.89
64 T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency. Proc Natl Acad Sci U S A 2010 0.88
65 The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA. Genome Biol 2014 0.87
66 Spontaneous B cell hyperactivity in autoimmune-prone MRL mice. Int Immunol 2006 0.87
67 Tracing the action of IL-2 in tolerance to islet-specific antigen. Immunol Cell Biol 2007 0.87
68 The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity. Immunol Rev 2006 0.87
69 Analysis of B cell memory formation using DNA microarrays. Ann N Y Acad Sci 2002 0.86
70 Immunology: DNA drives autoimmunity. Nature 2002 0.85
71 How host defense is encoded in the mammalian genome. Mamm Genome 2010 0.85
72 Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus T(H)2 effector cells to cause allergy. J Allergy Clin Immunol 2011 0.85
73 Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes. Proc Natl Acad Sci U S A 2014 0.83
74 Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation. J Immunol 2010 0.82
75 Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells. PLoS One 2011 0.81
76 Defective T-cell function leading to reduced antibody production in a kleisin-beta mutant mouse. Immunology 2008 0.81
77 Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells. Proc Natl Acad Sci U S A 2014 0.81
78 Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes. J Immunol 2011 0.80
79 A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction. Immunology 2014 0.80
80 Identification of a pathogenic variant in TREX1 in early-onset cerebral systemic lupus erythematosus by Whole-exome sequencing. Arthritis Rheumatol 2014 0.80
81 Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. J Immunol 2009 0.80
82 Mouse strains with point mutations in TAP1 and TAP2. Immunol Cell Biol 2009 0.80
83 A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J Clin Invest 2016 0.79
84 Novel approaches for identifying genes regulating lymphocyte development and function. Curr Opin Immunol 2002 0.77
85 Lyn/CD22/SHP-1 and their importance in autoimmunity. Curr Dir Autoimmun 2002 0.77
86 Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity. Novartis Found Symp 2005 0.77
87 Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL. Leuk Res 2011 0.76
88 Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 2016 0.75
89 Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson's syndrome. J Pathol 2014 0.75
90 Correction: HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse. PLoS Genet 2015 0.75
91 A missense mutation in the transcription factor ETV5 leads to sterility, increased embryonic and perinatal death, postnatal growth restriction, renal asymmetry and polydactyly in the mouse. PLoS One 2013 0.75