Published in Trends Cell Biol on March 30, 2010
Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers. Gastroenterology (2011) 2.33
Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev (2010) 2.28
Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence. Cancer Res (2011) 1.29
Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis. Cancer Res (2013) 1.18
Quantitative proteomics reveals that Hsp90 inhibition preferentially targets kinases and the DNA damage response. Mol Cell Proteomics (2011) 1.12
Human placental trophoblast invasion and differentiation: a particular focus on Wnt signaling. Front Genet (2013) 1.11
Transcriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a. PLoS Genet (2012) 1.02
Wnt5a is strongly expressed at the leading edge in non-melanoma skin cancer, forming active gradients, while canonical Wnt signalling is repressed. PLoS One (2012) 1.02
WNT5A-NFAT signaling mediates resistance to apoptosis in pancreatic cancer. Neoplasia (2013) 0.96
Wnt5a as an effector of TGFβ in mammary development and cancer. J Mammary Gland Biol Neoplasia (2011) 0.96
E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells. Pigment Cell Melanoma Res (2013) 0.95
Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling. J Biol Chem (2013) 0.94
Role of Wnt5a-Ror2 signaling in morphogenesis of the metanephric mesenchyme during ureteric budding. Mol Cell Biol (2014) 0.92
Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression. J Biol Chem (2011) 0.92
Short-range Wnt5 signaling initiates specification of sea urchin posterior ectoderm. Development (2013) 0.91
Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis. Dev Biol (2012) 0.91
Role of the wnt pathway in thyroid cancer. Front Endocrinol (Lausanne) (2012) 0.91
Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies. Tissue Barriers (2013) 0.90
An autocrine Wnt5a-Ror signaling loop mediates sympathetic target innervation. Dev Biol (2013) 0.90
TGF-β-activated kinase 1 (TAK1) signaling regulates TGF-β-induced WNT-5A expression in airway smooth muscle cells via Sp1 and β-catenin. PLoS One (2014) 0.89
Human embryonic stem cell-derived cardiomyocytes migrate in response to gradients of fibronectin and Wnt5a. Stem Cells Dev (2013) 0.87
The role of EMMPRIN expression in ovarian epithelial carcinomas. Cell Cycle (2013) 0.87
WNT-5A: signaling and functions in health and disease. Cell Mol Life Sci (2015) 0.86
Challenging role of Wnt5a and its signaling pathway in cancer metastasis (Review). Exp Ther Med (2014) 0.86
Wnt5a controls Notch1 signaling through CaMKII-mediated degradation of the SMRT corepressor protein. J Biol Chem (2012) 0.85
Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration. Sci Signal (2011) 0.85
Extracellular Calcium-Sensing Receptor Inhibition of Intestinal EpithelialTNF Signaling Requires CaSR-Mediated Wnt5a/Ror2 Interaction. Front Physiol (2011) 0.82
MiR-217 mediates the protective effects of the dopamine D2 receptor on fibrosis in human renal proximal tubule cells. Hypertension (2015) 0.82
Targeting of Noncanonical Wnt5a Signaling by AP-1 Blocker Dominant-Negative Jun When It Inhibits Skin Carcinogenesis. Genes Cancer (2012) 0.82
Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs. Proc Natl Acad Sci U S A (2015) 0.81
The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-γ in colitis. Sci Rep (2015) 0.80
Rear-polarized Wnt5a-receptor-actin-myosin-polarity (WRAMP) structures promote the speed and persistence of directional cell migration. Mol Biol Cell (2017) 0.80
PITX2 and non-canonical Wnt pathway interaction in metastatic prostate cancer. Clin Exp Metastasis (2013) 0.80
In utero exposure to TCDD alters Wnt signaling during mouse prostate development: linking ventral prostate agenesis to downregulated β-catenin signaling. Toxicol Sci (2014) 0.80
KLF4 transcriptionally activates non-canonical WNT5A to control epithelial stratification. Sci Rep (2016) 0.79
Wnt2 complements Wnt/β-catenin signaling in colorectal cancer. Oncotarget (2015) 0.78
The role of the REG4 gene and its encoding product in ovarian epithelial carcinoma. BMC Cancer (2015) 0.78
Gone without the WNT: a requirement for WNT5A in germ cell migration and testis development. Biol Reprod (2012) 0.77
Thyroid hormone-regulated Wnt5a/Ror2 signaling is essential for dedifferentiation of larval epithelial cells into adult stem cells in the Xenopus laevis intestine. PLoS One (2014) 0.77
Wnt5a-Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16-CXCR6 axis. Cancer Sci (2016) 0.77
Non-canonical WNT signalling in the lung. J Biochem (2015) 0.76
Wnt signaling is involved in 6-benzylthioinosine-induced AML cell differentiation. BMC Cancer (2014) 0.76
Prickle3 synergizes with Wtip to regulate basal body organization and cilia growth. Sci Rep (2016) 0.76
Sulf1 has ligand-dependent effects on canonical and non-canonical Wnt signalling. J Cell Sci (2015) 0.76
Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with β-catenin-dependent and β-catenin-independent signaling pathways. Oncotarget (2016) 0.76
miR‑542‑3p overexpression is associated with enhanced osteosarcoma cell proliferation and migration ability by targeting Van Gogh‑like 2. Mol Med Rep (2014) 0.76
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness. Sci Rep (2017) 0.75
4-HPR impairs bladder cancer cell migration and invasion by interfering with the Wnt5a/JNK and Wnt5a/MMP-2 signaling pathways. Oncol Lett (2016) 0.75
Correlation of Wnt5a expression with histopathological grade/stage in urothelial carcinoma of the bladder. Diagn Pathol (2013) 0.75
Microglia-induced activation of non-canonical Wnt signaling aggravates neurodegeneration in demyelinating disorders. Mol Cell Biol (2016) 0.75
Regulation of lipid synthesis by the RNA helicase Mov10 controls Wnt5a production. Oncogenesis (2015) 0.75
The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity. PLoS One (2015) 0.75
A significant association exists between receptor tyrosine kinase-like orphan receptor 2 gene variants and the OPG/RANKL ratio in human plasma. Osteoporos Int (2011) 0.75
Wingless ligand 5a is a critical regulator of placental growth and survival. Sci Rep (2016) 0.75
The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle. J Biol Chem (2017) 0.75
Modulation of microRNA processing by p53. Nature (2009) 7.88
Retracted DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nat Cell Biol (2007) 4.45
The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells (2003) 4.11
Retracted A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol (2007) 3.97
Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis. Nat Med (2012) 3.46
Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev Cell (2011) 3.12
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev Cell (2008) 2.89
Retracted Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol Cell (2009) 2.48
Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell (2006) 2.39
The role of leptin in the development of the cerebral cortex in mouse embryos. Endocrinology (2005) 1.89
Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development. Development (2008) 1.74
Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A. J Biol Chem (2008) 1.72
Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration. J Cell Biol (2006) 1.67
Ror2 expression in squamous cell carcinoma and epithelial dysplasia of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2009) 1.67
Pulmonary hypertension in adult Alk1 heterozygous mice due to oxidative stress. Cardiovasc Res (2011) 1.59
Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling. J Biol Chem (2009) 1.52
Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex. J Biol Chem (2004) 1.46
Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling. Biochem Biophys Res Commun (2006) 1.41
Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia development by concerted actions of BMP signaling [corrected]. Development (2003) 1.38
Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization. Mol Cell Biol (2010) 1.32
Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of carcinoma cells following Snail-mediated epithelial-mesenchymal transition. Genes Cells (2011) 1.30
Expression and function of the Ror-family receptor tyrosine kinases during development: lessons from genetic analyses of nematodes, mice, and humans. J Recept Signal Transduct Res (2003) 1.23
The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon. J Biol Chem (2004) 1.22
Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2. Genes Cells (2007) 1.19
Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol Biol (2008) 1.18
Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome. Dev Dyn (2004) 1.18
Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase. J Biol Chem (2008) 1.11
Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1. J Biol Chem (2006) 1.10
The mouse ortholog of EFHC1 implicated in juvenile myoclonic epilepsy is an axonemal protein widely conserved among organisms with motile cilia and flagella. FEBS Lett (2005) 1.09
Ror2 is required for midgut elongation during mouse development. Dev Dyn (2010) 1.06
Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system. Mol Cell Biol (2008) 1.04
Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2. Genes Cells (2004) 1.03
The receptor tyrosine kinase Ror2 associates with the melanoma-associated antigen (MAGE) family protein Dlxin-1 and regulates its intracellular distribution. J Biol Chem (2003) 0.98
Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal. J Biol Chem (2005) 0.97
Neuronal lineage-specific induction of phospholipase Cepsilon expression in the developing mouse brain. Eur J Neurosci (2003) 0.96
Hypoxia-inducible factor-1alpha induces cell cycle arrest of endothelial cells. Genes Cells (2002) 0.96
Highly cooperative dependence of sarco/endoplasmic reticulum calcium ATPase SERCA2a pump activity on cytosolic calcium in living cells. J Biol Chem (2011) 0.95
Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded. Dev Dyn (2010) 0.95
L-ornithine derived polyamines in cystic fibrosis airways. PLoS One (2012) 0.95
Inositol 1,4,5-trisphosphate receptor regulates replication, differentiation, infectivity and virulence of the parasitic protist Trypanosoma cruzi. Mol Microbiol (2013) 0.93
Receptor-selective diffusion barrier enhances sensitivity of astrocytic processes to metabotropic glutamate receptor stimulation. Sci Signal (2012) 0.93
Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer. Proc Natl Acad Sci U S A (2011) 0.92
Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression. J Biol Chem (2011) 0.92
Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae). J Agric Food Chem (2003) 0.89
CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions. Proc Natl Acad Sci U S A (2013) 0.89
Ecdysone receptor-dependent gene regulation mediates histone poly(ADP-ribosyl)ation. Biochem Biophys Res Commun (2004) 0.88
Intracellular HMGB1 transactivates the human IL1B gene promoter through association with an Ets transcription factor PU.1. Eur J Haematol (2008) 0.87
Ryanodine receptor calcium release channels: lessons from structure-function studies. FEBS J (2013) 0.86
Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium. Proc Natl Acad Sci U S A (2011) 0.85
Ror family receptor tyrosine kinases regulate the maintenance of neural progenitor cells in the developing neocortex. J Cell Sci (2012) 0.85
Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition of tubular epithelial cells during renal fibrosis. Genes Cells (2013) 0.85
RNA-binding protein hoip accelerates polyQ-induced neurodegeneration in Drosophila. Biosci Biotechnol Biochem (2008) 0.83
Themes and variations in ER/SR calcium release channels: structure and function. Physiology (Bethesda) (2012) 0.83
Membrane-bound form of fractalkine induces IFN-gamma production by NK cells. Eur J Immunol (2003) 0.83
Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor. Biochem Biophys Res Commun (2008) 0.83
Juvenile hormones antagonize ecdysone actions through co-repressor recruitment to EcR/USP heterodimers. Biochem Biophys Res Commun (2004) 0.82
Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity. Proc Natl Acad Sci U S A (2009) 0.82
Genetic analysis of vascular factors in Alzheimer's disease. Ann N Y Acad Sci (2002) 0.81
H-Ras/mitogen-activated protein kinase pathway inhibits integrin-mediated adhesion and induces apoptosis in osteoblasts. J Biol Chem (2002) 0.81
Retracted Activation of facultatively silenced Drosophila loci associates with increased acetylation of histone H2AvD. Genes Cells (2008) 0.81
Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation. Biochem J (2010) 0.80
Role for adapter proteins in costimulatory signals of CD2 and IL-2 on NK cell activation. Mol Immunol (2002) 0.80
Pulmonary hypertension in the newborn GTP cyclohydrolase I-deficient mouse. Free Radic Biol Med (2011) 0.80
Neurotrophic effect of gonadotropin-releasing hormone on neurite extension and neuronal migration of embryonic gonadotropin-releasing hormone neurons in chick olfactory nerve bundle culture. J Neurosci Res (2009) 0.80
Molecular characterization of the 5'-UTR of retinal dystrophin reveals a cryptic intron that regulates translational activity. Mol Vis (2010) 0.80
Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats. Am J Physiol Heart Circ Physiol (2012) 0.79
Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling. Genes Cells (2007) 0.79
Hormonal repression of miRNA biosynthesis through a nuclear steroid hormone receptor. Adv Exp Med Biol (2010) 0.79
Analysis of Wnt/planar cell polarity pathway in cultured cells. Methods Mol Biol (2012) 0.78
Regulation of the cell proliferation and migration as extra-pituitary functions of GnRH. Gen Comp Endocrinol (2012) 0.78
A novel genetic system for analysis of co-activators for the N-terminal transactivation function domain of the human androgen receptor. Biosci Biotechnol Biochem (2004) 0.78
Identification of N-acetyl Proline-Glycine-Proline (acPGP) in human serum of adults and newborns by liquid chromatography-tandem mass spectrometry. Clin Chim Acta (2009) 0.78
Molecular cloning and characterization of a gonadotropin-releasing hormone receptor in the guinea pig, Cavia porcellus. Gen Comp Endocrinol (2004) 0.77
Hormonal Repression of miRNA Biosynthesis Through a Nuclear Steroid Hormone Receptor. Adv Exp Med Biol (2011) 0.77
Constitutive association of MyD88 to IRAK in HTLV-I-transformed T cells. Exp Hematol (2007) 0.77
Tetrahydrobiopterin deficiency induces gastroparesis in newborn mice. Am J Physiol Gastrointest Liver Physiol (2013) 0.77
[Relationship between abnormalities of genes involved in DNA damage responses and malignant tumors/autoimmune diseases]. Nihon Rinsho Meneki Gakkai Kaishi (2006) 0.77
[Regulation of cellular responses by non-canonical Wnt signaling]. Clin Calcium (2013) 0.76
Critical role of Frizzled1 in age-related alterations of Wnt/β-catenin signal in myogenic cells during differentiation. Genes Cells (2014) 0.76
Prolonging in utero-like oxygenation after birth diminishes oxidative stress in the lung and brain of mice pups. Redox Biol (2013) 0.76
Structure-activity relationships of flavonoids as potential inhibitors of glycogen phosphorylase. J Agric Food Chem (2008) 0.76
Acute gastritis associated with invading Helicobacter heilmannii organisms from a previously homeless cat. J Clin Gastroenterol (2008) 0.75
Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B. J Physiol Sci (2011) 0.75
Constitutive tyrosine and serine phosphorylation of STAT4 in T-cells transformed with HTLV-I. Genes Cells (2005) 0.75
Reliability of Total Bilirubin Measurements in Whole Blood from Preterm Neonates Using a Blood Gas Analyzer. Clin Lab (2016) 0.75
Physical interactions of Dmnk with Orb: implications in the regulated localization of Orb by Dmnk during oogenesis and embryogenesis. Biochem Biophys Res Commun (2002) 0.75
[A case of breast adenocarcinoma changed to squamous cell carcinoma after neoadjuvant chemotherapy]. Gan To Kagaku Ryoho (2012) 0.75
Speech feature extraction method using subband-based periodicity and nonperiodicity decomposition. J Acoust Soc Am (2006) 0.75