1
|
The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene.
|
Cell
|
1999
|
7.99
|
2
|
A model for the mechanism of human topoisomerase I.
|
Science
|
1998
|
4.10
|
3
|
Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups.
|
Am J Hum Genet
|
2001
|
3.51
|
4
|
Simultaneous recovery of RNA and DNA from soils and sediments.
|
Appl Environ Microbiol
|
2001
|
2.38
|
5
|
Quantum criticality and nodal superconductivity in the FeAs-based superconductor KFe2As2.
|
Phys Rev Lett
|
2010
|
1.68
|
6
|
Dark matter search results from the CDMS II experiment.
|
Science
|
2010
|
1.57
|
7
|
Seven human immunodeficiency virus (HIV) antigen-antibody combination assays: evaluation of HIV seroconversion sensitivity and subtype detection.
|
J Clin Microbiol
|
2001
|
1.45
|
8
|
Evolution of an organophosphate-degrading enzyme: a comparison of natural and directed evolution.
|
Protein Eng
|
2003
|
1.40
|
9
|
Transmembrane insertion of the colicin Ia hydrophobic hairpin.
|
J Membr Biol
|
1997
|
1.23
|
10
|
Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis.
|
Scand J Rheumatol
|
2009
|
1.17
|
11
|
Epigenetics, disease, and therapeutic interventions.
|
Ageing Res Rev
|
2006
|
1.14
|
12
|
1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).
|
Bioorg Med Chem Lett
|
2001
|
1.14
|
13
|
Crystal structure of human osteoclast cathepsin K complex with E-64.
|
Nat Struct Biol
|
1997
|
1.13
|
14
|
IAM chromatography: an in vitro screen for predicting drug membrane permeability.
|
J Med Chem
|
1995
|
1.10
|
15
|
MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma.
|
Oncogene
|
2011
|
1.10
|
16
|
First direct observation of muon antineutrino disappearance.
|
Phys Rev Lett
|
2011
|
1.07
|
17
|
Measurement of the neutrino mass splitting and flavor mixing by MINOS.
|
Phys Rev Lett
|
2011
|
1.07
|
18
|
Active site cavity of herpesvirus proteases revealed by the crystal structure of herpes simplex virus protease/inhibitor complex.
|
Biochemistry
|
1997
|
1.04
|
19
|
Tracking intracavernously injected adipose-derived stem cells to bone marrow.
|
Int J Impot Res
|
2011
|
0.99
|
20
|
Phospholipid immobilization on solid surfaces.
|
Anal Chem
|
1994
|
0.98
|
21
|
Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents.
|
Bioorg Med Chem Lett
|
2001
|
0.97
|
22
|
Neurotrophic effect of bone marrow mesenchymal stem cells for erectile dysfunction in diabetic rats.
|
Int J Androl
|
2012
|
0.96
|
23
|
Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway.
|
Cell Death Differ
|
2006
|
0.95
|
24
|
Serologic survey of giant pandas (Ailuropoda melanoleuca), and domestic dogs and cats in the Wolong Reserve, China.
|
J Wildl Dis
|
1994
|
0.95
|
25
|
Oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B-cell transformation and survival of Pim-deficient cells.
|
Oncogene
|
2010
|
0.93
|
26
|
Distribution of two HIV-1-resistant polymorphisms (SDF1-3'A and CCR2-64I) in East Asian and world populations and its implication in AIDS epidemiology.
|
Am J Hum Genet
|
1999
|
0.93
|
27
|
Point-of-care oral-based diagnostics.
|
Oral Dis
|
2011
|
0.91
|
28
|
Persistence of psychosine in brain lipid rafts is a limiting factor in the therapeutic recovery of a mouse model for Krabbe disease.
|
J Neurosci Res
|
2010
|
0.91
|
29
|
Antibodies against the GB virus C envelope 2 protein before liver transplantation protect against GB virus C de novo infection.
|
Hepatology
|
1998
|
0.90
|
30
|
Expression, purification, and crystallization of the Escherichia coli selenomethionyl beta-ketoacyl-acyl carrier protein synthase III.
|
Biochem Biophys Res Commun
|
2000
|
0.90
|
31
|
Histone modifications and methyl-CpG-binding domain protein levels at the TNFSF7 (CD70) promoter in SLE CD4+ T cells.
|
Lupus
|
2011
|
0.87
|
32
|
Exercise-induced changes of the capillaries in the cortex of middle-aged rats.
|
Neuroscience
|
2013
|
0.87
|
33
|
Determination and analysis of antigenic epitopes of prostate specific antigen (PSA) and human glandular kallikrein 2 (hK2) using synthetic peptides and computer modeling.
|
Protein Sci
|
1998
|
0.86
|
34
|
Polymorphism in both X and Y box motifs controls level of expression of HLA-DRB1 genes.
|
Immunogenetics
|
1996
|
0.85
|
35
|
Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A.
|
Proc Natl Acad Sci U S A
|
1993
|
0.85
|
36
|
Active site and exosite binding of alpha-thrombin.
|
Blood Coagul Fibrinolysis
|
1993
|
0.85
|
37
|
Membrane partition coefficients chromatographically measured using immobilized artificial membrane surfaces.
|
Anal Chem
|
1995
|
0.85
|
38
|
Purification and characterization from rat kidney membranes of a novel platelet-activating factor (PAF)-dependent transacetylase that catalyzes the hydrolysis of PAF, formation of PAF analogs, and C2-ceramide.
|
J Biol Chem
|
1999
|
0.83
|
39
|
PO149, a new member of pollen pectate lyase-like gene family from alfalfa.
|
Plant Mol Biol
|
1996
|
0.83
|
40
|
Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis.
|
Clin Exp Rheumatol
|
1994
|
0.83
|
41
|
Multiple target-specific molecular imaging agents detect liver cancer in a preclinical model.
|
Curr Mol Med
|
2012
|
0.82
|
42
|
Molecular basis for lack of expression of HLA class I antigens in human small-cell lung carcinoma cell lines.
|
Int J Cancer
|
1996
|
0.82
|
43
|
Effects of preshipping management on measures of stress and performance of beef steers during feedlot receiving.
|
J Anim Sci
|
2008
|
0.82
|
44
|
Multiple target-specific molecular agents for detection and image analysis of breast cancer characteristics in mice.
|
Curr Mol Med
|
2013
|
0.82
|
45
|
Polymorphism in the upstream regulatory region and level of expression of HLA-DRB genes.
|
Mol Immunol
|
1994
|
0.82
|
46
|
Effects of an enriched environment on myelin sheaths in the white matter of rats during normal aging: A stereological study.
|
Neuroscience
|
2013
|
0.82
|
47
|
Search for weakly interacting massive particles with the first five-tower data from the cryogenic dark matter search at the soudan underground laboratory.
|
Phys Rev Lett
|
2009
|
0.82
|
48
|
Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain.
|
Neuroscience
|
2007
|
0.81
|
49
|
Results from a low-energy analysis of the CDMS II germanium data.
|
Phys Rev Lett
|
2011
|
0.81
|
50
|
Dynamic process of apoptosis in adult rat cardiomyocytes analyzed using 48-hour videomicroscopy and electron microscopy: beating and rate are associated with the apoptotic process.
|
Am J Pathol
|
2001
|
0.81
|
51
|
Antienvelope antibodies are protective against GBV-C reinfection: evidence from the liver transplant model.
|
J Med Virol
|
1998
|
0.81
|
52
|
Poly(ADP-ribose) polymerase inhibition protects epileptic hippocampal neurons from apoptosis via suppressing Akt-mediated apoptosis-inducing factor translocation in vitro.
|
Neuroscience
|
2012
|
0.80
|
53
|
Polymorphism in the upstream regulatory regions of HLA-DRB genes.
|
Immunogenetics
|
1993
|
0.80
|
54
|
The creation of stable cell lines expressing Ebola virus glycoproteins and the matrix protein VP40 and generating Ebola virus-like particles utilizing an ecdysone inducible mammalian expression system.
|
J Virol Methods
|
2008
|
0.80
|
55
|
[The synthesis and immunosuppressive effects of steroid-peptide linkers].
|
Yao Xue Xue Bao
|
1998
|
0.79
|
56
|
CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK.
|
Cell Mol Life Sci
|
2008
|
0.79
|
57
|
Stearidonic acid-enriched flax oil reduces the growth of human breast cancer in vitro and in vivo.
|
Breast Cancer Res Treat
|
2014
|
0.79
|
58
|
Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors.
|
Bioorg Med Chem Lett
|
2007
|
0.78
|
59
|
A single fas gene mutation changes lupus onset, severity, location, and molecular abnormalities in mice.
|
Curr Mol Med
|
2015
|
0.78
|
60
|
Prevalence of XMRV nucleic acid and antibody in HIV-1-Infected men and in men at risk for HIV-1 Infection.
|
Adv Virol
|
2011
|
0.78
|
61
|
[Effects of processing on antioxidation of Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati].
|
Zhongguo Zhong Yao Za Zhi
|
2001
|
0.77
|
62
|
[Effect of melatonin on mean blood pressure and heart rate in morphine withdrawal rats].
|
Yao Xue Xue Bao
|
1998
|
0.77
|
63
|
Effects of forage neutral detergent fiber and yeast culture on performance of cows during early lactation.
|
J Dairy Sci
|
2001
|
0.77
|
64
|
Active to sterile neutrino mixing limits from neutral-current interactions in MINOS.
|
Phys Rev Lett
|
2011
|
0.77
|
65
|
Evaluation of a new third-generation ARCHITECT rHTLV-I/II assay for blood screening and diagnosis.
|
Diagn Microbiol Infect Dis
|
2010
|
0.77
|
66
|
Role of protein kinase C, K(ATP) channels and DNA fragmentation in the infarct size-reducing effects of the free radical scavenger T-0970.
|
Clin Exp Pharmacol Physiol
|
2001
|
0.77
|
67
|
Surgical treatment of bone tumors in conjunction with microwave-induced hyperthermia and adjuvant immunotherapy. A preliminary report.
|
Chin Med J (Engl)
|
1996
|
0.77
|
68
|
The digestive fate of Escherichia coli glutamate dehydrogenase deoxyribonucleic acid from transgenic corn in diets fed to weanling pigs.
|
J Anim Sci
|
2006
|
0.77
|
69
|
Improved search for Muon-neutrino to electron-neutrino oscillations in MINOS.
|
Phys Rev Lett
|
2011
|
0.77
|
70
|
Activation of antitumor cytotoxic T lymphocytes by fusion of patient-derived dendritic cells with autologous osteosarcoma.
|
Exp Oncol
|
2005
|
0.76
|
71
|
Y box-binding trans-regulatory nuclear proteins and susceptibility to rheumatoid arthritis.
|
Clin Exp Rheumatol
|
1997
|
0.76
|
72
|
Quantitation of thyroid-stimulating hormone receptor mRNA with real-time PCR for early diagnosis of papillary thyroid microcarcinoma.
|
Neoplasma
|
2010
|
0.76
|
73
|
Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: inhibition and crystal structure of a complex.
|
Bioorg Med Chem Lett
|
1999
|
0.76
|
74
|
[The effect of nimodipine on retinal blood flow in pregnancy induced hypertension].
|
Zhonghua Fu Chan Ke Za Zhi
|
1998
|
0.76
|
75
|
Chronic treatment with vascular endothelial growth factor preserves agonist-evoked vascular responses in the streptozotocin-induced diabetic rat.
|
Diabetologia
|
2006
|
0.76
|
76
|
Sequence-specific interactions of the nuclear proteins with polymorphic upstream regulatory regions of HLA-DRB genes.
|
Transplant Proc
|
1993
|
0.75
|
77
|
Changes in serum leptin levels in chronic renal failure patients with metabolic acidosis.
|
J Ren Nutr
|
2001
|
0.75
|
78
|
siRNA silencing of gene expression in trabecular meshwork: RhoA siRNA reduces IOP in mice.
|
Curr Mol Med
|
2012
|
0.75
|
79
|
BP neural network classification for bleeding detection in wireless capsule endoscopy.
|
J Med Eng Technol
|
2009
|
0.75
|
80
|
Novel tiO2 nanocatalysts for wastewater purification: tapping energy from the sun.
|
Water Sci Technol
|
2006
|
0.75
|
81
|
[Hyperplasia of chromaffin cells in adrenocortical hyperplasia and adenoma].
|
Zhonghua Wai Ke Za Zhi
|
2000
|
0.75
|
82
|
Skeletal muscle-specific expression of human blood coagulation factor IX rescues factor IX deficiency mouse by AAV-mediated gene transfer.
|
Sci China C Life Sci
|
1999
|
0.75
|
83
|
Construction and high expression of retroviral vector with human clotting factor IX cDNA in vitro.
|
Sci China B
|
1995
|
0.75
|
84
|
[Effect of yuanhua on isolated uterine strips in unpregnant rats].
|
Zhongguo Zhong Yao Za Zhi
|
1998
|
0.75
|
85
|
T-0162, a novel free radical scavenger, reduces myocardial infarct size in rabbits.
|
Clin Exp Pharmacol Physiol
|
2000
|
0.75
|
86
|
[Clinical application of implanting nitinol alloy endotracheal stent in the treatment of tracheobronchial.].
|
Zhongguo Fei Ai Za Zhi
|
2000
|
0.75
|
87
|
[Single nucleotide polymorphism in beta2-adrenoceptor gene and the distribution in Chinese Han ethnic group].
|
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
|
2001
|
0.75
|
88
|
[Determination of the polymorphism of DXS102 locus and its application in gene diagnosis].
|
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
|
1998
|
0.75
|
89
|
Role of p53 in aziridinylbenzoquinone-induced p21waf1 expression.
|
Oncogene
|
1998
|
0.75
|
90
|
[An uni-dimensional ordinal coma scale].
|
Hua Xi Yi Ke Da Xue Xue Bao
|
1994
|
0.75
|
91
|
Crystallization of Escherichia coli beta-ketoacyl-ACP synthase III and the use of a dry flash-cooling technique for data collection.
|
Acta Crystallogr D Biol Crystallogr
|
2000
|
0.75
|
92
|
HLA-D region genes and susceptibility to rheumatoid arthritis.
|
Transplant Proc
|
1997
|
0.75
|
93
|
Molecular analysis of novel HLA-DR2.DQwl haplotypes in Asian Indians.
|
Tissue Antigens
|
1992
|
0.75
|
94
|
[Causes of intraocular lens removal].
|
Zhonghua Yan Ke Za Zhi
|
1995
|
0.75
|
95
|
Gene therapy for hemophilia B mediated by recombinant adeno-associated viral vector with hFIXR338A, a high catalytic activity mutation of human coagulation factor IX.
|
Sci China C Life Sci
|
2001
|
0.75
|
96
|
[Characterization of human coagulation factor IX cDNA expressed in cultured cells and in transgenic mice].
|
Yi Chuan Xue Bao
|
1995
|
0.75
|
97
|
Kinetic analysis of RNA editing of Newcastle disease virus P gene in the early period of infection.
|
Acta Virol
|
2016
|
0.75
|
98
|
Injecting skin fibroblasts into muscles to express human clotting factor IX cDNA.
|
Sci China C Life Sci
|
1998
|
0.75
|
99
|
[Determination of puerarin in gegen ginlian tablets by RP-HPLC].
|
Zhongguo Zhong Yao Za Zhi
|
1996
|
0.75
|
100
|
Mode and role of cell death during progression of atherosclerotic lesions in hypercholesterolemic rabbits.
|
Heart Vessels
|
1999
|
0.75
|
101
|
[Vitrectomy for treatment of retinal detachment caused by macular hole].
|
Zhonghua Yan Ke Za Zhi
|
1998
|
0.75
|
102
|
Environmental hazard analysis and effective remediation of highway seepage.
|
J Hazard Mater
|
2006
|
0.75
|
103
|
Autoantibodies to Abl and Bcr proteins.
|
Leukemia
|
2000
|
0.75
|
104
|
Regulation of human clotting factor IX cDNA expression in transgenic mice.
|
Sci China B
|
1995
|
0.75
|
105
|
Study of thrombopoietin for gene therapy of thrombocytopenia.
|
Sci China C Life Sci
|
1999
|
0.75
|
106
|
Expression and regulation of hFIX minigene and cDNA driven by beta-casein gene in mouse mammary gland.
|
Sci China C Life Sci
|
1998
|
0.75
|
107
|
[Study on the quality standards for xianghe suppository].
|
Zhong Yao Cai
|
2001
|
0.75
|
108
|
Effect of diazepam on the contents of amino acids and free radical during ischemia/reperfusion injury.
|
J Tongji Med Univ
|
2001
|
0.75
|
109
|
Suicide effect on rat gliomas mediated by recombinant adenovirus thymidine kinase/acyclovir system.
|
Chin Med J (Engl)
|
1998
|
0.75
|
110
|
[The inhibitory effect of melatonin on morphine withdrawal syndromes and serum monoamines in morphine dependent mice].
|
Zhonghua Yi Xue Za Zhi
|
1998
|
0.75
|
111
|
[An experimental investigation of inhibition of interferon on lens epithelial cell growth in vitro].
|
Zhonghua Yan Ke Za Zhi
|
1999
|
0.75
|
112
|
[Effect of Acorus tatarinowii Schott. on gastrointestinal myoelectric activity in rats].
|
Zhongguo Zhong Yao Za Zhi
|
1998
|
0.75
|
113
|
[Effect of acetylcholine receptor antibody derived from myasthenia gravis on the rat central neuronal nicotinic acetylcholine receptor].
|
Zhonghua Nei Ke Za Zhi
|
1997
|
0.75
|
114
|
Immunoassays to study prevalence of antibody against GB virus C in blood donors.
|
J Virol Methods
|
1997
|
0.75
|
115
|
Constitutive expression of human coagulating factor IX in HeLa cells by homologous recombination of the promoter.
|
Sci China C Life Sci
|
2001
|
0.75
|
116
|
[Simultaneous determination of europium and copper in rare earth oxide by use AAS-PLS method].
|
Guang Pu Xue Yu Guang Pu Fen Xi
|
1999
|
0.75
|
117
|
Cloning and expression of canine clotting factor IX cDNAin vitro mediated by retroviral vector.
|
Sci China C Life Sci
|
1999
|
0.75
|
118
|
[Bone scintigraphy in evaluating revascularization of the heat-devitalised autografts in adult dogs].
|
Zhonghua Wai Ke Za Zhi
|
1998
|
0.75
|
119
|
Search for axions with the CDMS experiment.
|
Phys Rev Lett
|
2009
|
0.75
|
120
|
[Isolation and mapping of arbitrary single copy DNA fragment located on human chromosome 11p11-q11].
|
Yi Chuan Xue Bao
|
1990
|
0.75
|
121
|
[Thymosin and tumors].
|
Zhonghua Bing Li Xue Za Zhi
|
2001
|
0.75
|
122
|
High expression of human clotting factor IX cDNA in myoblasts C2C12 cells and C3H mice.
|
Sci China C Life Sci
|
1997
|
0.75
|
123
|
Improved measurement of muon antineutrino disappearance in MINOS.
|
Phys Rev Lett
|
2012
|
0.75
|
124
|
[Differentiated microcarcinoma of the thyroid gland in 45 cases].
|
Lin Chuang Er Bi Yan Hou Ke Za Zhi
|
2001
|
0.75
|
125
|
Measurement of neutrino and antineutrino oscillations using beam and atmospheric data in MINOS.
|
Phys Rev Lett
|
2013
|
0.75
|
126
|
Polymorphism of DXS102 locus in Chinese population and its application to gene diagnosis in hemophilia B family.
|
Chin Med J (Engl)
|
1998
|
0.75
|
127
|
[Experience of endoscopic sinus operation on 74 cases].
|
Lin Chuang Er Bi Yan Hou Ke Za Zhi
|
1999
|
0.75
|
128
|
Electron neutrino and antineutrino appearance in the full MINOS data sample.
|
Phys Rev Lett
|
2013
|
0.75
|