Published in J Biomed Biotechnol on March 30, 2010
Prediction of B-cell linear epitopes with a combination of support vector machine classification and amino acid propensity identification. J Biomed Biotechnol (2011) 1.05
Impact of immunization technology and assay application on antibody performance--a systematic comparative evaluation. PLoS One (2011) 0.91
In vitro and in vivo studies for assessing the immune response and protection-inducing ability conferred by Fasciola hepatica-derived synthetic peptides containing B- and T-cell epitopes. PLoS One (2014) 0.82
On the meaning of affinity limits in B-cell epitope prediction for antipeptide antibody-mediated immunity. Adv Bioinformatics (2012) 0.81
A mechanistic, multiscale mathematical model of immunogenicity for therapeutic proteins: part 2-model applications. CPT Pharmacometrics Syst Pharmacol (2014) 0.81
Benchmarking B-cell epitope prediction with quantitative dose-response data on antipeptide antibodies: towards novel pharmaceutical product development. Biomed Res Int (2014) 0.76
Expressing Redundancy among Linear-Epitope Sequence Data Based on Residue-Level Physicochemical Similarity in the Context of Antigenic Cross-Reaction. Adv Bioinformatics (2016) 0.75
Prediction of protein antigenic determinants from amino acid sequences. Proc Natl Acad Sci U S A (1981) 32.98
Measuring the accuracy of diagnostic systems. Science (1988) 27.46
Immunogenic structure of the influenza virus hemagglutinin. Cell (1982) 8.93
Intrinsically disordered protein. J Mol Graph Model (2001) 8.54
Coupling of folding and binding for unstructured proteins. Curr Opin Struct Biol (2002) 6.53
Linking folding and binding. Curr Opin Struct Biol (2009) 5.19
Natively unfolded proteins. Curr Opin Struct Biol (2005) 4.39
Improved method for predicting linear B-cell epitopes. Immunome Res (2006) 4.32
Intrinsic disorder and functional proteomics. Biophys J (2006) 3.84
Epitopes on protein antigens: misconceptions and realities. Cell (1990) 3.32
The antiviral activity of antibodies in vitro and in vivo. Adv Immunol (2001) 3.29
Thermodynamics of structural stability and cooperative folding behavior in proteins. Adv Protein Chem (1992) 3.24
Flavors of protein disorder. Proteins (2003) 2.72
The unfoldomics decade: an update on intrinsically disordered proteins. BMC Genomics (2008) 2.72
Benchmarking B cell epitope prediction: underperformance of existing methods. Protein Sci (2004) 2.70
More than one reason to rethink the use of peptides in vaccine design. Nat Rev Drug Discov (2007) 2.68
Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence. Proc Natl Acad Sci U S A (2009) 2.59
Developing countries face double burden of disease. Bull World Health Organ (2004) 2.45
Occupancy and mechanism in antibody-mediated neutralization of animal viruses. J Gen Virol (2002) 2.21
CEP: a conformational epitope prediction server. Nucleic Acids Res (2005) 2.14
Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains). Proc Natl Acad Sci U S A (1986) 2.13
Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools. J Mol Recognit (2007) 2.02
Synthetic peptides as antigens: pitfalls of conjugation methods. J Immunol Methods (1985) 1.76
Predicting antigenic determinants in proteins: looking for unidimensional solutions to a three-dimensional problem? Pept Res (1995) 1.70
HIV-1 neutralization: mechanisms and relevance to vaccine design. Curr HIV Res (2007) 1.65
Protein folding revisited. A polypeptide chain at the folding-misfolding-nonfolding cross-roads: which way to go? Cell Mol Life Sci (2003) 1.59
Histidine-aromatic interactions in barnase. Elevation of histidine pKa and contribution to protein stability. J Mol Biol (1992) 1.57
The curation guidelines of the immune epitope database and analysis resource. Cytometry A (2008) 1.56
Mechanisms of antibody binding to a protein. Science (1987) 1.55
Variability in the pKa of histidine side-chains correlates with burial within proteins. Proteins (2002) 1.54
A model for neutralization of viruses based on antibody coating of the virion surface. Curr Top Microbiol Immunol (2001) 1.54
Predicting location of continuous epitopes in proteins from their primary structures. Methods Enzymol (1991) 1.48
Consequences of dichotomization. Pharm Stat (2009) 1.43
Characterization of antisera to a synthetic carboxyl-terminal peptide of the glucose transporter protein. J Biol Chem (1988) 1.42
High-resolution immunogold localization of AMPA type glutamate receptor subunits at synaptic and non-synaptic sites in rat hippocampus. Neuroscience (1995) 1.40
Curation of complex, context-dependent immunological data. BMC Bioinformatics (2006) 1.36
Immunoinformatics comes of age. PLoS Comput Biol (2006) 1.35
Neutralization of animal virus infectivity by antibody. Arch Virol (2007) 1.34
Structure and kinetics of a transient antibody binding intermediate reveal a kinetic discrimination mechanism in antigen recognition. Proc Natl Acad Sci U S A (2005) 1.29
The protein non-folding problem: amino acid determinants of intrinsic order and disorder. Pac Symp Biocomput (2001) 1.29
Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease. Proc Natl Acad Sci U S A (1991) 1.29
Histidine residues at the N- and C-termini of alpha-helices: perturbed pKas and protein stability. Biochemistry (1992) 1.28
Binding of intrinsically disordered proteins is not necessarily accompanied by a structural transition to a folded form. Biochimie (2006) 1.26
Localization of an immune functional site on staphylococcal enterotoxin A using the synthetic peptide approach. J Immunol (1989) 1.25
Synthetic peptides of Shiga toxin B subunit induce antibodies which neutralize its biological activity. Infect Immun (1988) 1.23
Reconciling binding mechanisms of intrinsically disordered proteins. Biochem Biophys Res Commun (2009) 1.19
Emerging and re-emerging infectious diseases: influenza as a prototype of the host-pathogen balancing act. Cell (2006) 1.19
Limitations of induced folding in molecular recognition by intrinsically disordered proteins. Chemphyschem (2009) 1.13
Site-directed anti-peptide antibodies define the topography of the beta-adrenergic receptor. J Biol Chem (1989) 1.12
The role of structure in antibody cross-reactivity between peptides and folded proteins. J Mol Biol (1998) 1.12
Immunoinformatics may lead to a reappraisal of the nature of B cell epitopes and of the feasibility of synthetic peptide vaccines. J Mol Recognit (2006) 1.07
Studies on the topology of the renal type II NaPi-cotransporter. Pflugers Arch (1999) 1.05
Cryptic and exposed invariable regions of VlsE, the variable surface antigen of Borrelia burgdorferi sl. J Bacteriol (2000) 1.02
Cell surface expression of the Alzheimer disease-related presenilin proteins. Proc Natl Acad Sci U S A (1997) 1.01
Genome-derived vaccines. Expert Rev Vaccines (2004) 1.01
Caveats for the use of surface-adsorbed protein antigen to test the specificity of antibodies. J Immunol Methods (1992) 1.00
Application and limitations of the multiple antigen peptide (MAP) system in the production and evaluation of anti-peptide and anti-protein antibodies. J Immunol Methods (1992) 0.99
In situ topology of cytochrome b5 in the endoplasmic reticulum membrane. J Biochem (1996) 0.97
Entropic effects of disulphide bonds on protein stability. Nat Struct Biol (1994) 0.96
The growing incidence of cancer: role of lifestyle and screening detection (Review). Int J Oncol (2007) 0.96
Structure-activity relationships in peptide-antibody complexes: implications for epitope prediction and development of synthetic peptide vaccines. Curr Med Chem (2009) 0.94
Identification of linear B-cell determinants of pertussis toxin associated with the receptor recognition site of the S3 subunit. Infect Immun (1991) 0.93
Molecular recognition in the post-reductionist era. J Mol Recognit (2000) 0.93
Reductionism and the search for structure-function relationships in antibody molecules. J Mol Recognit (2002) 0.93
An in silico method using an epitope motif database for predicting the location of antigenic determinants on proteins in a structural context. J Mol Recognit (2005) 0.92
Advances in automatic, manual and microwave-assisted solid-phase peptide synthesis. Curr Opin Drug Discov Devel (2008) 0.90
Prediction of linear B-cell epitopes. Methods Mol Biol (2009) 0.89
B cell responses to a peptide epitope. X. Epitope selection in a primary response is thermodynamically regulated. J Immunol (2000) 0.89
Structural energetics of protein folding and binding. Curr Opin Biotechnol (2000) 0.89
Biological complexity emerges from the ashes of genetic reductionism. J Mol Recognit (2004) 0.87
Antipeptide antibodies confirm the topology of the human norepinephrine transporter. J Biol Chem (1995) 0.87
Reaction of staphylococcal alpha-toxin with peptide-induced antibodies. Infect Immun (1989) 0.87
The evolutionary consequences of plasticity in host-pathogen interactions. Theor Popul Biol (2006) 0.86
Predicting binding energetics from structure: looking beyond DeltaG degrees. Med Res Rev (1999) 0.86
Current status of short synthetic peptides as vaccines. Med Chem (2006) 0.86
Discovery and implications of the immunogenicity of free small synthetic peptides: powerful tools for manipulating the immune system and for production of antibodies and T cells of preselected submolecular specificities. Crit Rev Immunol (1985) 0.85
B cell epitope mapping using synthetic peptides. Curr Protoc Immunol (2004) 0.85
Antibody epitope mapping using SPOT peptide arrays. Methods Mol Biol (2009) 0.84
Epitope mapping of a protein using the Geysen (PEPSCAN) procedure. Methods Mol Biol (1994) 0.84
Production of antisera using peptide conjugates. Methods Mol Biol (1997) 0.84
Peptide mimotopes as candidate vaccines. Curr Opin Mol Ther (2000) 0.84
Pitfalls of reductionism in the design of peptide-based vaccines. Vaccine (2001) 0.84
Synthesis of peptides for use as immunogens. Methods Mol Biol (1998) 0.84
Predicting B cell epitope residues with network topology based amino acid indices. Genome Inform (2007) 0.83
Antigenic and immunogenic phage displayed mimotopes as substitute antigens: applications and limitations. Comb Chem High Throughput Screen (2001) 0.83
Mapping of neutralizing epitopes and the receptor binding site of human interleukin 1 beta. J Biol Chem (1993) 0.83
Immunization with a peptide having both T cell and conformationally restricted B cell epitopes elicits neutralizing antisera against a snake neurotoxin. J Immunol (1990) 0.83
Searching the NCBI databases using Entrez. Curr Protoc Hum Genet (2006) 0.83
Genuine and apparent cross-reaction of polyclonal antibodies to proteins and peptides. Eur J Biochem (1994) 0.83
A structural-energetic basis for B-cell epitope prediction. Protein Pept Lett (2006) 0.82
The twilight zone between protein order and disorder. Biophys J (2008) 0.82
Conjugation of haptens. Methods Mol Med (2008) 0.81
Development of an antipeptide antibody that binds to the C-terminal region of human CYP1B1. Drug Metab Dispos (1999) 0.81
Production of antisera to synthetic peptides. Methods Mol Biol (1994) 0.81
Immunization with peptide-protein conjugates: impact on benchmarking B-cell epitope prediction for vaccine design. Protein Pept Lett (2010) 0.81
Variability in the immunodetection of His-tagged recombinant proteins. Anal Biochem (2006) 0.80
Transition-state theory and secondary forces in antigen--antibody complexes. Biochemistry (1996) 0.79
Mimotopes of viral antigens and biologically important molecules as candidate vaccines and potential immunotherapeutics. Comb Chem High Throughput Screen (2002) 0.79
Genomics and vaccine development. Rev Sci Tech (2007) 0.78