SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.

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Published in Mol Cancer Ther on April 06, 2010

Authors

Barrie Peck1, Chun-Yuan Chen, Ka-Kei Ho, Paolo Di Fruscia, Stephen S Myatt, R Charles Coombes, Matthew J Fuchter, Chwan-Deng Hsiao, Eric W-F Lam

Author Affiliations

1: Cancer Research-UK Laboratory, Department of Surgery and Cancer, MRC Cyclotron Building, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.

Associated clinical trials:

Anticancer Activity of Nicotinamide on Lung Cancer | NCT02416739

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