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C Prives

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 p53: puzzle and paradigm. Genes Dev 1996 13.16
2 Wild-type p53 activates transcription in vitro. Nature 1992 11.39
3 Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 1998 10.89
4 DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 1997 10.52
5 Identification of p53 as a sequence-specific DNA-binding protein. Science 1991 6.60
6 Cell-free translation of simian virus 40 early messenger RNA coding for viral T-antigen. Proc Natl Acad Sci U S A 1977 6.57
7 A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev 1999 6.34
8 The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 2000 5.72
9 E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev 1998 4.60
10 p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev 1996 3.98
11 Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol 1998 3.61
12 Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication. Cell 1991 3.59
13 Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ 2006 3.53
14 Drosophila p53 is a structural and functional homolog of the tumor suppressor p53. Cell 2000 3.41
15 Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element. Genes Dev 1992 3.37
16 PML is induced by oncogenic ras and promotes premature senescence. Genes Dev 2000 3.35
17 The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen. Cell 1989 3.01
18 Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. Proc Natl Acad Sci U S A 1990 2.77
19 Differential affinities of simian virus 40 large tumor antigen for DNA. Proc Natl Acad Sci U S A 1980 2.75
20 Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes Dev 1997 2.70
21 A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Mol Cell Biol 2001 2.69
22 A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein. Genes Dev 1993 2.53
23 DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization. EMBO J 1999 2.50
24 Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases. Nature 1995 2.47
25 p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Mol Cell Biol 1999 2.41
26 High mobility group protein-1 (HMG-1) is a unique activator of p53. Genes Dev 1998 2.40
27 Pro-proliferative FoxM1 is a target of p53-mediated repression. Oncogene 2009 2.32
28 Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53. Genes Dev 1992 2.29
29 Species-specific in vitro synthesis of DNA containing the polyoma virus origin of replication. Proc Natl Acad Sci U S A 1986 2.16
30 Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus. Cell 1995 2.13
31 The p53 protein is an unusually shaped tetramer that binds directly to DNA. Proc Natl Acad Sci U S A 1993 2.11
32 The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. Mol Cell 1998 2.08
33 A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis. Mol Cell Biol 1996 1.98
34 Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function? Oncogene 2007 1.97
35 Mutant p53 proteins bind DNA abnormally in vitro. Oncogene 1991 1.96
36 p53 down-regulates CHK1 through p21 and the retinoblastoma protein. Mol Cell Biol 2001 1.93
37 A small subclass of SV40 T antigen binds to the viral origin of replication. Cell 1982 1.86
38 DNA-binding properties of simian virus 40 T-antigen mutants defective in viral DNA replication. Mol Cell Biol 1983 1.76
39 Different forms of simian virus 40 large tumor antigen varying in their affinities for DNA. J Virol 1982 1.72
40 Discrete regions of simian virus 40 large T antigen are required for nonspecific and viral origin-specific DNA binding. J Virol 1982 1.71
41 Assembly of functional U1 and U2 human-amphibian hybrid snRNPs in Xenopus laevis oocytes. Science 1988 1.70
42 Cell-cycle related regulation of poly(A) polymerase by phosphorylation. Nature 1996 1.69
43 Splicing pathways of SV40 mRNAs in X. laevis oocytes differ in their requirements for snRNPs. Cell 1984 1.69
44 Cellular and cell-free synthesis of simian virus 40 T-antigens in permissive and transformed cells. J Virol 1978 1.66
45 Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation. J Virol 1995 1.63
46 At the crossroads of inflammation and tumorigenesis. J Exp Med 1999 1.61
47 Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo. EMBO J 1999 1.59
48 Splicing of SV40 early pre-mRNA to large T and small t mRNAs utilizes different patterns of lariat branch sites. Cell 1987 1.57
49 A role for p53 in base excision repair. EMBO J 2001 1.56
50 p53 accumulates but is functionally impaired when DNA synthesis is blocked. Proc Natl Acad Sci U S A 2001 1.55
51 p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis. Cancer Res 1995 1.47
52 Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation. Genes Dev 1993 1.45
53 U2 snRNA sequences that bind U2-specific proteins are dispensable for the function of U2 snRNP in splicing. Genes Dev 1989 1.43
54 Alternative splicing of SV40 early pre-mRNA is determined by branch site selection. Genes Dev 1988 1.42
55 In vitro splicing of simian virus 40 early pre mRNA. Nucleic Acids Res 1986 1.40
56 Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen. Proc Natl Acad Sci U S A 1990 1.39
57 P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation. Oncogene 2006 1.37
58 The C-terminus of p53: the more you learn the less you know. Nat Struct Biol 2001 1.34
59 Regulation of mutant p53 temperature-sensitive DNA binding. J Biol Chem 1996 1.34
60 The transforming activity of simian virus 40 large tumor antigen. Biochim Biophys Acta 1994 1.32
61 Simian virus 40 and polyomavirus large tumor antigens have different requirements for high-affinity sequence-specific DNA binding. J Virol 1985 1.31
62 p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. Mol Cell Biol 1997 1.31
63 Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo. Mol Cell Biol 1996 1.31
64 Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay. Oncogene 1998 1.29
65 DNA binding and sedimentation properties of SV40 T antigens synthesized in vivo and in vitro. Cold Spring Harb Symp Quant Biol 1980 1.27
66 Inhibition of poly(A) polymerase requires p34cdc2/cyclin B phosphorylation of multiple consensus and non-consensus sites. EMBO J 1998 1.26
67 Inhibition of viral protein synthesis in monkey cells treated with interferon late in simian virus 40 lytic cycle. Cell 1977 1.25
68 DNA binding properties of simian virus 40 T-antigens synthesized in vivo and in vitro. J Virol 1980 1.24
69 p53 tumor suppressor protein regulates the levels of huntingtin gene expression. Oncogene 2006 1.23
70 Complex formation between p53 and replication protein A inhibits the sequence-specific DNA binding of p53 and is regulated by single-stranded DNA. Mol Cell Biol 1997 1.22
71 Covalent and noncovalent modifiers of the p53 protein. Cell Mol Life Sci 1999 1.17
72 A role of cyclin G in the process of apoptosis. Oncogene 1999 1.16
73 p53 responsive elements in human retrotransposons. Oncogene 2009 1.15
74 Binding of p53 and p105-RB is not sufficient for oncogenic transformation by a hybrid polyomavirus-simian virus 40 large T antigen. J Virol 1990 1.13
75 The DNA-binding properties of polyomavirus large T antigen are altered by ATP and other nucleotides. J Virol 1991 1.10
76 Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein. Nucleic Acids Res 1996 1.08
77 p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A. Mol Cell Biol 1996 1.08
78 Helicase, DNA-binding, and immunological properties of replication-defective simian virus 40 mutant T antigens. J Virol 1989 1.07
79 pBR322 DNA inhibits simian virus 40 gene expression in Xenopus laevis oocytes. Nucleic Acids Res 1987 1.03
80 Simian virus 40 (SV40) T antigen binds specifically to double-stranded DNA but not to single-stranded DNA or DNA/RNA hybrids containing the SV40 regulatory sequences. J Virol 1988 1.02
81 ATP induces the assembly of polyoma large tumor antigen into hexamers. Virology 1991 1.02
82 The N terminus of p53 regulates its dissociation from DNA. J Biol Chem 2000 1.02
83 Cyclin a-CDK phosphorylation regulates MDM2 protein interactions. J Biol Chem 2001 1.01
84 A comparison of the translation of Mengo virus RNA and globin mRNA in krebs ascites cell-free extracts. FEBS Lett 1972 1.00
85 Study of the functional activities concomitantly retained by the 115,000 Mr super T antigen, an evolutionary variant of simian virus 40 large T antigen expressed in transformed rat cells. J Virol 1983 0.99
86 p53 represses Sp1 DNA binding and HIV-LTR directed transcription. Cell Mol Biol (Noisy-le-grand) 1997 0.99
87 DNA helicase and duplex DNA fragment unwinding activities of polyoma and simian virus 40 large T antigen display similarities and differences. J Biol Chem 1991 0.99
88 p53 inhibits DNA replication in vitro in a DNA-binding-dependent manner. Mol Cell Biol 1995 0.99
89 An excised SV40 intron accumulates and is stable in Xenopus laevis oocytes. Genes Dev 1988 0.98
90 Functional dissection of p53 tumor suppressor protein. Methods Enzymol 1997 0.97
91 The replication functions of polyomavirus large tumor antigen are regulated by phosphorylation. J Virol 1993 0.96
92 Association of simian virus 40 T antigen with the nuclear matrix of infected and transformed monkey cells. Mol Cell Biol 1984 0.96
93 Oligonucleotide-targeted degradation of U1 and U2 snRNAs reveals differential interactions of simian virus 40 pre-mRNAs with snRNPs. Nucleic Acids Res 1989 0.96
94 Expression of polyomavirus large T antigen by using a baculovirus vector. J Virol 1987 0.96
95 DNA damage enables p73. Nature 1999 0.94
96 Phosphorylation and active ATP hydrolysis are not required for SV40 T antigen hexamer formation. J Biol Chem 1993 0.94
97 Poly(A) polymerase phosphorylation is dependent on novel interactions with cyclins. Mol Cell Biol 2000 0.93
98 Molecular biology. Getting p53 out of the nucleus. Science 2001 0.93
99 Baculovirus p33 binds human p53 and enhances p53-mediated apoptosis. J Virol 1999 0.92
100 Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus. Oncogene 2007 0.91
101 Transcriptional regulation by p53 and p73. Cold Spring Harb Symp Quant Biol 2005 0.91
102 A unique subpopulation of murine DNA polymerase alpha/primase specifically interacts with polyomavirus T antigen and stimulates DNA replication. Mol Cell Biol 1994 0.90
103 Xenopus laevis p53 protein: sequence-specific DNA binding, transcriptional regulation and oligomerization are evolutionarily conserved. Oncogene 1995 0.89
104 Regulation of p53 after different forms of stress and at different cell cycle stages. Cold Spring Harb Symp Quant Biol 2000 0.89
105 P53 and PML: new partners in tumor suppression. Trends Cell Biol 2001 0.88
106 p53: upstream, downstream and off stream. Review of the 8th p53 workshop (Dundee, July 5-9, 1996). Biochim Biophys Acta 1996 0.87
107 Thermally inactivated simian virus 40 tsA58 mutant T antigen cannot initiate viral DNA replication in vitro. J Virol 1990 0.85
108 Cyclin-dependent kinase regulation of the replication functions of polyomavirus large T antigen. J Virol 1997 0.84
109 The retinoblastoma protein alters the phosphorylation state of polyomavirus large T antigen in murine cell extracts and inhibits polyomavirus origin DNA replication. J Virol 1999 0.83
110 Murine polyomavirus and simian virus 40 large T antigens produce different structural alterations in viral origin DNA. J Virol 1995 0.83
111 Regulation of simian virus 40 gene expression in Xenopus laevis oocytes. Mol Cell Biol 1985 0.83
112 A subclass of polyomavirus middle tumor antigen binds to DNA cellulose. J Virol 1986 0.82
113 Unusual properties of a replication-defective mutant SV40 large T antigen. Virology 1993 0.80
114 Developmental expression and co-localization of cyclin G1 and the B' subunits of protein phosphatase 2a in neurons. Brain Res Mol Brain Res 1999 0.80
115 Two conditional tsA mutant simian virus 40 T antigens display marked differences in thermal inactivation. J Virol 1992 0.80
116 Primary rat cells expressing a hybrid polyomavirus-simian virus 40 large T antigen have altered growth properties. J Virol 1993 0.78
117 SV40 T-antigen-binding sites within the 5'-flanking regions of human U1 and U2 genes. Gene 1991 0.78
118 Effect of cerebral stimulation on biosynthesis of nucleotides and RNA in brain slices in vitro. Biochim Biophys Acta 1969 0.77
119 Proceedings: Purification and translation of mRNA coding for SV40 proteins. Isr J Med Sci 1975 0.75
120 Effects of cerebral stimulation on the biosynthesis in vitro of nucleotides and RNA in brain. Nature 1969 0.75
121 Murine p53 inhibits the function but not the formation of SV40 T antigen hexamers and stimulates T antigen RNA helicase activity. Chromosoma 1992 0.75