Published in Chromosoma on January 01, 1992
Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F. Mol Cell Biol (1990) 7.33
Oncogenic forms of p53 inhibit p53-regulated gene expression. Science (1992) 6.73
Identification of p53 as a sequence-specific DNA-binding protein. Science (1991) 6.60
A transcriptionally active DNA-binding site for human p53 protein complexes. Mol Cell Biol (1992) 6.56
DNA helicase activity of SV40 large tumor antigen. EMBO J (1986) 6.08
Topography of simian virus 40 A protein-DNA complexes: arrangement of pentanucleotide interaction sites at the origin of replication. J Virol (1983) 5.00
Binding and unwinding--how T antigen engages the SV40 origin of DNA replication. Cell (1990) 4.65
ATP-dependent assembly of double hexamers of SV40 T antigen at the viral origin of DNA replication. Nature (1989) 4.64
Enzymatic activities associated with a purified simian virus 40 T antigen-related protein. Proc Natl Acad Sci U S A (1979) 3.82
Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication. Cell (1991) 3.59
Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element. Genes Dev (1992) 3.37
p53 and DNA polymerase alpha compete for binding to SV40 T antigen. Nature (1987) 3.34
The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen. Cell (1989) 3.01
The unwinding of duplex regions in DNA by the simian virus 40 large tumor antigen-associated DNA helicase activity. J Biol Chem (1988) 2.80
A poly(dT)-stimulated ATPase activity associated with simian virus 40 large T antigen. J Biol Chem (1979) 2.74
Mouse p53 inhibits SV40 origin-dependent DNA replication. Nature (1987) 2.71
p53: oncogene or anti-oncogene? Genes Dev (1990) 2.60
Essential contact residues within SV40 large T antigen binding sites I and II identified by alkylation-interference. Cell (1984) 2.59
RNA unwinding activity of SV40 large T antigen. Cell (1989) 2.53
ATP-dependent formation of a specialized nucleoprotein structure by simian virus 40 (SV40) large tumor antigen at the SV40 replication origin. Proc Natl Acad Sci U S A (1987) 2.49
Mammalian p53 can function as a transcription factor in yeast. Nucleic Acids Res (1992) 2.07
Cooperative assembly of simian virus 40 T-antigen hexamers on functional halves of the replication origin. J Virol (1991) 1.78
Expression and complex formation of simian virus 40 large T antigen and mouse p53 in insect cells. J Virol (1988) 1.72
Tumor suppressor genes: the p53 and retinoblastoma sensitivity genes and gene products. Biochim Biophys Acta (1990) 1.66
The nucleotide binding site detected by affinity labeling in the large T proteins of polyoma and SV40 viruses is distinct from their ATPase catalytic site. J Biol Chem (1984) 1.61
Mouse p53 blocks SV40 DNA replication in vitro and downregulates T antigen DNA helicase activity. Oncogene (1988) 1.53
Mutation of the serine 312 phosphorylation site does not alter the ability of mouse p53 to inhibit simian virus 40 DNA replication in vivo. J Virol (1990) 1.00
Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature (1988) 19.07
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem (1999) 14.59
p53: puzzle and paradigm. Genes Dev (1996) 13.16
Wild-type p53 activates transcription in vitro. Nature (1992) 11.39
Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell (1997) 10.52
Regulation of translation initiation by FRAP/mTOR. Genes Dev (2001) 9.40
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature (1994) 9.30
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev (1999) 8.14
Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency. Cell (1985) 7.95
Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap. Nature (1990) 7.74
Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F. Mol Cell Biol (1990) 7.33
The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Mol Cell Biol (1995) 6.99
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev (1998) 6.89
Identification of p53 as a sequence-specific DNA-binding protein. Science (1991) 6.60
Cell-free translation of simian virus 40 early messenger RNA coding for viral T-antigen. Proc Natl Acad Sci U S A (1977) 6.57
A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev (1999) 6.34
Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A. EMBO J (1992) 6.16
Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J (1996) 6.01
La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. J Virol (1993) 5.89
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev (2000) 5.72
PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science (1994) 5.62
Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev (2001) 5.37
A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. EMBO J (1998) 5.18
Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5' noncoding region. Mol Cell Biol (1988) 4.97
A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation. Genes Dev (1990) 4.96
Poliovirus mutant that does not selectively inhibit host cell protein synthesis. Mol Cell Biol (1985) 4.94
Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J (1995) 4.83
Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell (1997) 4.75
mTOR, translation initiation and cancer. Oncogene (2006) 4.68
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J (1999) 4.65
E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev (1998) 4.60
A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA. Proc Natl Acad Sci U S A (1978) 4.45
Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase. Science (1992) 4.42
Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation. Nature (1993) 4.38
Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus. Nat Med (2000) 4.37
A cellular protein that binds to the 5'-noncoding region of poliovirus RNA: implications for internal translation initiation. Genes Dev (1989) 4.35
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med (2001) 4.19
Regulation of translation by poliovirus. Adv Virus Res (1987) 4.08
p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev (1996) 3.98
TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function. Mol Cell Biol (1993) 3.85
Recognition of polyadenylate RNA by the poly(A)-binding protein. Cell (1999) 3.76
Involvement of eukaryotic initiation factor 4A in the cap recognition process. J Biol Chem (1983) 3.70
mRNAs containing extensive secondary structure in their 5' non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E. EMBO J (1992) 3.66
The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. RNA (2001) 3.65
Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. Mol Cell Biol (1997) 3.61
Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol (1998) 3.61
Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication. Cell (1991) 3.59
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. Nature (1998) 3.55
Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc Natl Acad Sci U S A (1996) 3.55
Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ (2006) 3.53
A novel functional human eukaryotic translation initiation factor 4G. Mol Cell Biol (1998) 3.49
The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis. Mol Cell Biol (1993) 3.48
Drosophila p53 is a structural and functional homolog of the tumor suppressor p53. Cell (2000) 3.41
Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element. Genes Dev (1992) 3.37
RNA-protein interactions in regulation of picornavirus RNA translation. Microbiol Rev (1996) 3.36
PML is induced by oncogenic ras and promotes premature senescence. Genes Dev (2000) 3.35
Cap-binding proteins of eukaryotic messenger RNA: functions in initiation and control of translation. Prog Nucleic Acid Res Mol Biol (1988) 3.30
Inactivation of cap-binding proteins accompanies the shut-off of host protein synthesis by poliovirus. Proc Natl Acad Sci U S A (1982) 3.26
Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. Mol Cell (1999) 3.21
The target of rapamycin (TOR) proteins. Proc Natl Acad Sci U S A (2001) 3.16
Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein. Nat Struct Biol (1997) 3.14
4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1996) 3.09
Proteolysis of the p220 component of the cap-binding protein complex is not sufficient for complete inhibition of host cell protein synthesis after poliovirus infection. J Virol (1987) 3.07
The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen. Cell (1989) 3.01
Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection. Proc Natl Acad Sci U S A (1998) 2.93
A cell cycle-dependent internal ribosome entry site. Mol Cell (2000) 2.91
Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region. Mol Cell Biol (2000) 2.89
A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. Cell (2000) 2.83
Cap-dependent RNA splicing in a HeLa nuclear extract. Proc Natl Acad Sci U S A (1985) 2.82
Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP. Proc Natl Acad Sci U S A (1979) 2.81
Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. EMBO J (1995) 2.78
Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. Proc Natl Acad Sci U S A (1990) 2.77
Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E. Mol Cell Biol (1993) 2.75
Structural and functional analysis of the ribosome landing pad of poliovirus type 2: in vivo translation studies. J Virol (1991) 2.75
Differential affinities of simian virus 40 large tumor antigen for DNA. Proc Natl Acad Sci U S A (1980) 2.75
The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nat Cell Biol (2001) 2.73
Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes Dev (1997) 2.70
eIF4G dramatically enhances the binding of eIF4E to the mRNA 5'-cap structure. J Biol Chem (1997) 2.70
A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Mol Cell Biol (2001) 2.69
A new translational regulator with homology to eukaryotic translation initiation factor 4G. EMBO J (1997) 2.66
The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k. Mol Cell Biol (1997) 2.66
Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR. J Biol Chem (1999) 2.65
Mutational analysis of the 5' non-coding region of human immunodeficiency virus type 1: effects of secondary structure on translation. EMBO J (1988) 2.65
mTOR signaling to translation. Curr Top Microbiol Immunol (2004) 2.62
Mutational analysis of upstream AUG codons of poliovirus RNA. J Virol (1988) 2.55
A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein. Genes Dev (1993) 2.53
Translation in mammalian cells of a gene linked to the poliovirus 5' noncoding region. Science (1988) 2.53
A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus. Proc Natl Acad Sci U S A (1992) 2.53
DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization. EMBO J (1999) 2.50
Translational repression by a novel partner of human poly(A) binding protein, Paip2. Mol Cell (2001) 2.49
Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases. Nature (1995) 2.47
Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus. Proc Natl Acad Sci U S A (1996) 2.47
Purification of a factor that restores translation of vesicular stomatitis virus mRNA in extracts from poliovirus-infected HeLa cells. Proc Natl Acad Sci U S A (1980) 2.46
A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. Mol Cell (2001) 2.43
Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: a novel translational control mechanism. Cell (1989) 2.43