Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.

PubWeight™: 2.30‹?› | Rank: Top 2%

🔗 View Article (PMC 2862164)

Published in Nat Genet on April 06, 2010

Authors

Rachel M Freathy1, Dennis O Mook-Kanamori, Ulla Sovio, Inga Prokopenko, Nicholas J Timpson, Diane J Berry, Nicole M Warrington, Elisabeth Widen, Jouke Jan Hottenga, Marika Kaakinen, Leslie A Lange, Jonathan P Bradfield, Marjan Kerkhof, Julie A Marsh, Reedik Mägi, Chih-Mei Chen, Helen N Lyon, Mirna Kirin, Linda S Adair, Yurii S Aulchenko, Amanda J Bennett, Judith B Borja, Nabila Bouatia-Naji, Pimphen Charoen, Lachlan J M Coin, Diana L Cousminer, Eco J C de Geus, Panos Deloukas, Paul Elliott, David M Evans, Philippe Froguel, Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Beate Glaser, Christopher J Groves, Anna-Liisa Hartikainen, Neelam Hassanali, Joel N Hirschhorn, Albert Hofman, Jeff M P Holly, Elina Hyppönen, Stavroula Kanoni, Bridget A Knight, Jaana Laitinen, Cecilia M Lindgren, Meta-Analyses of Glucose and Insulin-related traits Consortium, Wendy L McArdle, Paul F O'Reilly, Craig E Pennell, Dirkje S Postma, Anneli Pouta, Adaikalavan Ramasamy, Nigel W Rayner, Susan M Ring, Fernando Rivadeneira, Beverley M Shields, David P Strachan, Ida Surakka, Anja Taanila, Carla Tiesler, Andre G Uitterlinden, Cornelia M van Duijn, Wellcome Trust Case Control Consortium, Alet H Wijga, Gonneke Willemsen, Haitao Zhang, Jianhua Zhao, James F Wilson, Eric A P Steegers, Andrew T Hattersley, Johan G Eriksson, Leena Peltonen, Karen L Mohlke, Struan F A Grant, Hakon Hakonarson, Gerard H Koppelman, George V Dedoussis, Joachim Heinrich, Matthew W Gillman, Lyle J Palmer, Timothy M Frayling, Dorret I Boomsma, George Davey Smith, Chris Power, Vincent W V Jaddoe, Marjo-Riitta Jarvelin, Early Growth Genetics (EGG) Consortium, Mark I McCarthy

Author Affiliations

1: Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.

Articles citing this

Five years of GWAS discovery. Am J Hum Genet (2012) 12.97

Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97

New genetic loci link adipose and insulin biology to body fat distribution. Nature (2015) 3.38

The genetics of type 2 diabetes: what have we learned from GWAS? Ann N Y Acad Sci (2010) 3.09

The Generation R Study: design and cohort update 2012. Eur J Epidemiol (2012) 2.84

Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet (2012) 2.34

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet (2012) 1.90

The Generation R Study: design and cohort update 2010. Eur J Epidemiol (2010) 1.85

Replication of a genome-wide association study of birth weight in preterm neonates. J Pediatr (2011) 1.45

DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age. Epigenetics (2011) 1.33

Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight. Diabetologia (2010) 1.28

The Generation R Study: Biobank update 2015. Eur J Epidemiol (2014) 1.26

Physiologic characterization of type 2 diabetes-related loci. Curr Diab Rep (2010) 1.24

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Hum Mol Genet (2013) 1.19

Association of birth weight with polymorphisms in the IGF2, H19, and IGF2R genes. Pediatr Res (2010) 1.13

Fetal and infant origins of asthma. Eur J Epidemiol (2012) 1.11

Children of the 90s: Coming of age. Nature (2012) 1.10

Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies. Int J Endocrinol (2014) 1.04

Airborne PM2.5 chemical components and low birth weight in the northeastern and mid-Atlantic regions of the United States. Environ Health Perspect (2012) 1.04

Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. BMC Med Genet (2010) 1.04

Genome-wide association study to identify the genetic determinants of otitis media susceptibility in childhood. PLoS One (2012) 1.02

Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetes. PLoS One (2011) 1.01

Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA (2016) 1.00

Maternal inheritance of a promoter variant in the imprinted PHLDA2 gene significantly increases birth weight. Am J Hum Genet (2012) 0.98

A novel common variant in DCST2 is associated with length in early life and height in adulthood. Hum Mol Genet (2014) 0.98

The genomics of preterm birth: from animal models to human studies. Genome Med (2013) 0.95

Approaches for drawing causal inferences from epidemiological birth cohorts: a review. Early Hum Dev (2014) 0.95

Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. Hum Mol Genet (2014) 0.94

The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study. Hum Mol Genet (2013) 0.92

Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals. PLoS One (2010) 0.92

Genetics of type 2 diabetes in European populations. J Diabetes (2012) 0.89

Absence of birth-weight lowering effect of ADCY5 and near CCNL, but association of impaired glucose-insulin homeostasis with ADCY5 in Asian Indians. PLoS One (2011) 0.87

Developmental origins of adult metabolic disease: The Indian scenario, driving toward a unified hypothesis. Indian J Endocrinol Metab (2012) 0.86

A54T polymorphism in the fatty acid binding protein 2 studies in a Saudi population with type 2 diabetes mellitus. Lipids Health Dis (2014) 0.86

Effects of genetic variants in ADCY5, GIPR, GCKR and VPS13C on early impairment of glucose and insulin metabolism in children. PLoS One (2011) 0.86

Paternal metabolic and cardiovascular risk factors for fetal growth restriction: a case-control study. Diabetes Care (2013) 0.86

Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits. Am J Med Genet B Neuropsychiatr Genet (2012) 0.85

Altered expression of the imprinted transcription factor PLAGL1 deregulates a network of genes in the human IUGR placenta. Hum Mol Genet (2014) 0.85

Recent progress in the use of genetics to understand links between type 2 diabetes and related metabolic traits. Genome Biol (2013) 0.83

A common genetic variant at 15q25 modifies the associations of maternal smoking during pregnancy with fetal growth: the generation R study. PLoS One (2012) 0.83

The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge. PLoS One (2011) 0.83

Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates. Epigenetics (2015) 0.82

Genetic risk score for prediction of newborn adiposity and large-for-gestational-age birth. J Clin Endocrinol Metab (2014) 0.81

Epigenetic profiles in children with a neural tube defect; a case-control study in two populations. PLoS One (2013) 0.81

Pregnancy Complications and the Risk of Metabolic Syndrome for the Offspring. Curr Cardiovasc Risk Rep (2013) 0.81

Fetal growth and body size genes and risk of childhood acute lymphoblastic leukemia. Cancer Causes Control (2012) 0.80

Genetic variants in LEKR1 and GALNT10 modulate sex-difference in carotid intima-media thickness: a genome-wide interaction study. Atherosclerosis (2015) 0.79

Passive rGE or Developmental Gene-Environment Cascade? An Investigation of the Role of Xenobiotic Metabolism Genes in the Association Between Smoke Exposure During Pregnancy and Child Birth Weight. Behav Genet (2016) 0.79

The heritability of beta cell function parameters in a mixed meal test design. Diabetologia (2011) 0.79

Variation in the maternal corticotrophin releasing hormone-binding protein (CRH-BP) gene and birth weight in Blacks, Hispanics and Whites. PLoS One (2012) 0.78

Differences in the heritability of growth and growth velocity during infancy and associations with FTO variants. Obesity (Silver Spring) (2011) 0.77

Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics. J Perinatol (2011) 0.77

The Generation R Study: design and cohort update 2017. Eur J Epidemiol (2017) 0.77

The 2nd Schizophrenia International Research Society Conference, 10-14 April 2010, Florence, Italy: summaries of oral sessions. Schizophr Res (2010) 0.76

The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size. PLoS One (2012) 0.76

ADCY5 gene expression in adipose tissue is related to obesity in men and mice. PLoS One (2015) 0.76

Newborn size and body composition as predictors of insulin resistance and diabetes in the parents: Parthenon Birth Cohort Study, Mysore, India. Diabetes Care (2012) 0.76

Stress-sensitive neurosignalling in depression: an integrated network biology approach to candidate gene selection for genetic association analysis. Ment Illn (2012) 0.76

Molecular diagnosis of maturity onset diabetes of the young in India. Indian J Endocrinol Metab (2013) 0.76

No evidence for copy number and methylation variation in H19 and KCNQ10T1 imprinting control regions in children born small for gestational age. BMC Med Genet (2014) 0.75

Genetic determinants of adiponectin regulation revealed by pregnancy. Obesity (Silver Spring) (2017) 0.75

Genetic and functional evidence for a locus controlling otitis media at chromosome 10q26.3. BMC Med Genet (2014) 0.75

Evaluating the transferability of 15 European-derived fasting plasma glucose SNPs in Mexican children and adolescents. Sci Rep (2016) 0.75

Does FTO have a paradoxical effect in fetal life? BMC Genet (2014) 0.75

The Prenatal Environment in Twin Studies: A Review on Chorionicity. Behav Genet (2016) 0.75

Genetic and epigenetic catalysts in early-life programming of adult cardiometabolic disorders. Diabetes Metab Syndr Obes (2014) 0.75

How Can Genetic Studies Help Us to Understand Links Between Birth Weight and Type 2 Diabetes? Curr Diab Rep (2017) 0.75

Understanding heterogeneity in the effects of birth weight on adult cognition and wages. J Health Econ (2015) 0.75

The chromosome 3q25 locus associated with fetal adiposity is not associated with childhood adiposity. Nutr Diabetes (2014) 0.75

Transversions have larger regulatory effects than transitions. BMC Genomics (2017) 0.75

Utilization of genetic data can improve the prediction of type 2 diabetes incidence in a Swedish cohort. PLoS One (2017) 0.75

A Genome-wide Association Analysis in Four Populations Reveals Strong Genetic Heterogeneity For Birth Weight. Curr Genomics (2016) 0.75

Genetic Associations with Gestational Duration and Spontaneous Preterm Birth. N Engl J Med (2017) 0.75

Articles cited by this

Measuring inconsistency in meta-analyses. BMJ (2003) 128.20

Genomic control for association studies. Biometrics (1999) 64.39

A genome-wide association study of global gene expression. Nat Genet (2007) 22.98

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92

Determinants of low birth weight: methodological assessment and meta-analysis. Bull World Health Organ (1987) 16.26

Practical aspects of imputation-driven meta-analysis of genome-wide association studies. Hum Mol Genet (2008) 13.26

Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85

Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia (1993) 8.86

A practical classification of newborn infants by weight and gestational age. J Pediatr (1967) 4.09

The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease. Lancet (1999) 3.48

Type 2 diabetes: new genes, new understanding. Trends Genet (2008) 3.35

Meta-Analyst: software for meta-analysis of binary, continuous and diagnostic data. BMC Med Res Methodol (2009) 2.92

Genetic and environmental influences on birth weight, birth length, head circumference, and gestational age by use of population-based parent-offspring data. Am J Epidemiol (2007) 2.77

An update of the Swedish reference standards for weight, length and head circumference at birth for given gestational age (1977-1981). Acta Paediatr Scand (1992) 2.69

Fetal and early life growth and body mass index from birth to early adulthood in 1958 British cohort: longitudinal study. BMJ (2001) 2.67

Mutations in the glucokinase gene of the fetus result in reduced birth weight. Nat Genet (1998) 2.53

Early life factors and blood pressure at age 31 years in the 1966 northern Finland birth cohort. Hypertension (2004) 2.14

Intrauterine famine exposure and body proportions at birth: the Dutch Hunger Winter. Int J Epidemiol (2004) 2.09

Ecological and individual predictors of birthweight in a northern Finland birth cohort 1986. Paediatr Perinat Epidemiol (1997) 1.85

A System for Information Management in BioMedical Studies--SIMBioMS. Bioinformatics (2009) 1.60

Type 2 diabetes risk alleles are associated with reduced size at birth. Diabetes (2009) 1.58

Maternal smoking and its association with birth weight. Obstet Gynecol (2005) 1.55

Risk factors for shoulder dystocia. Obstet Gynecol (1985) 1.54

Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals. Am J Hum Genet (2007) 1.52

The structure, catalytic mechanism and regulation of adenylyl cyclase. Curr Opin Struct Biol (1998) 1.50

Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene. Diabetes (2009) 1.34

Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection. J Biol Chem (2008) 1.24

Adenylyl cyclases: structure, regulation and function in an enzyme superfamily. Mol Cell Endocrinol (1997) 1.21

Evidence of genetic regulation of fetal longitudinal growth. Early Hum Dev (2005) 1.19

Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. J Recept Signal Transduct Res (2002) 1.18

Father's effect on infant birth weight. Am J Obstet Gynecol (1998) 1.12

Etiology of individual differences in birth weight of twins as a function of maternal smoking during pregnancy. Twin Res (1998) 0.91

8-bromo-cyclicAMP stimulates glucose transporter-1 expression in a human choriocarcinoma cell line. J Endocrinol (2000) 0.91

The phenotype of the human materno-fetal endothelial barrier: molecular occupancy of paracellular junctions dictate permeability and angiogenic plasticity. J Anat (2002) 0.90

cAMP-Coupled riboflavin trafficking in placental trophoblasts: a dynamic and ordered process. Biochemistry (2006) 0.83

Articles by these authors

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95

A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39

Finding the missing heritability of complex diseases. Nature (2009) 67.95

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res (2010) 43.51

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88

A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97

Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30

Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20

Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83

Population genomics of human gene expression. Nat Genet (2007) 24.49

Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38

Origins and functional impact of copy number variation in the human genome. Nature (2009) 23.63

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08