Published in Nat Genet on September 02, 2012
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Genetic studies of body mass index yield new insights for obesity biology. Nature (2015) 8.27
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
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Gene expression changes with age in skin, adipose tissue, blood and brain. Genome Biol (2013) 1.34
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Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nat Commun (2014) 1.28
Extent, causes, and consequences of small RNA expression variation in human adipose tissue. PLoS Genet (2012) 1.28
Novel locus including FGF21 is associated with dietary macronutrient intake. Hum Mol Genet (2013) 1.27
A role for noncoding variation in schizophrenia. Cell Rep (2014) 1.26
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. Ann Rheum Dis (2014) 1.25
Resolving the polymorphism-in-probe problem is critical for correct interpretation of expression QTL studies. Nucleic Acids Res (2013) 1.25
The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue. PLoS One (2013) 1.25
Identification of CAD candidate genes in GWAS loci and their expression in vascular cells. J Lipid Res (2013) 1.23
Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Nat Genet (2015) 1.23
Expression quantitative trait loci: present and future. Philos Trans R Soc Lond B Biol Sci (2013) 1.20
Quantitative variability of 342 plasma proteins in a human twin population. Mol Syst Biol (2015) 1.20
Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. Nat Commun (2014) 1.20
Differential methylation of the TRPA1 promoter in pain sensitivity. Nat Commun (2014) 1.19
Large-scale identification of sequence variants influencing human transcription factor occupancy in vivo. Nat Genet (2015) 1.16
Whole-genome sequence-based analysis of thyroid function. Nat Commun (2015) 1.16
Genetic effects on gene expression across human tissues. Nature (2017) 1.13
Genetic and environmental exposures constrain epigenetic drift over the human life course. Genome Res (2014) 1.13
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. Nat Genet (2014) 1.13
Genetic interactions affecting human gene expression identified by variance association mapping. Elife (2014) 1.12
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension. Hum Mol Genet (2014) 1.10
Genotype-environment interactions reveal causal pathways that mediate genetic effects on phenotype. PLoS Genet (2013) 1.09
Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33. Hum Mol Genet (2014) 1.09
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Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types. Hum Mol Genet (2014) 1.08
Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice. Circulation (2015) 1.08
Cis and trans effects of human genomic variants on gene expression. PLoS Genet (2014) 1.06
An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins. Nat Commun (2014) 1.06
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Two susceptibility loci identified for prostate cancer aggressiveness. Nat Commun (2015) 1.06
Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. Am J Hum Genet (2014) 1.06
A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy. Hum Mol Genet (2014) 1.05
Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors. PLoS Genet (2015) 1.03
Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice. Circ Cardiovasc Genet (2014) 1.03
Refining susceptibility loci of chronic obstructive pulmonary disease with lung eqtls. PLoS One (2013) 1.02
The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway. Diabetes (2013) 1.02
Global properties and functional complexity of human gene regulatory variation. PLoS Genet (2013) 1.02
Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma. Nat Genet (2016) 1.02
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat Genet (2015) 1.02
Functional genomic annotation of genetic risk loci highlights inflammation and epithelial biology networks in CKD. J Am Soc Nephrol (2014) 1.01
Analysis of allele-specific expression in mouse liver by RNA-Seq: a comparison with Cis-eQTL identified using genetic linkage. Genetics (2013) 1.00
Systematic identification of genetic influences on methylation across the human life course. Genome Biol (2016) 1.00
The importance of p53 pathway genetics in inherited and somatic cancer genomes. Nat Rev Cancer (2016) 0.98
Transcriptome study of differential expression in schizophrenia. Hum Mol Genet (2013) 0.97
Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits. Hum Mol Genet (2013) 0.97
A trans-ethnic genome-wide association study identifies gender-specific loci influencing pediatric aBMD and BMC at the distal radius. Hum Mol Genet (2015) 0.96
Association of Parkinson disease with structural and regulatory variants in the HLA region. Am J Hum Genet (2013) 0.96
Omics technologies and the study of human ageing. Nat Rev Genet (2013) 0.95
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Hum Mol Genet (2015) 0.94
Assessing allele-specific expression across multiple tissues from RNA-seq read data. Bioinformatics (2015) 0.94
Melanoma risk loci as determinants of melanoma recurrence and survival. J Transl Med (2013) 0.94
Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. Mol Psychiatry (2014) 0.94
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nat Commun (2016) 0.94
Genome-wide association study identifies multiple susceptibility loci for glioma. Nat Commun (2015) 0.93
Identification of a novel Parkinson's disease locus via stratified genome-wide association study. BMC Genomics (2014) 0.93
Genetic variant rs763361 regulates multiple sclerosis CD226 gene expression. Proc Natl Acad Sci U S A (2017) 0.90
RNA Sequencing and Analysis. Cold Spring Harb Protoc (2015) 0.90
Mapping short DNA sequencing reads and calling variants using mapping quality scores. Genome Res (2008) 157.44
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Merlin--rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet (2001) 53.16
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol (2010) 26.41
Population genomics of human gene expression. Nat Genet (2007) 24.49
A genome-wide association study of global gene expression. Nat Genet (2007) 22.98
Genetics of gene expression and its effect on disease. Nature (2008) 21.35
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
GenABEL: an R library for genome-wide association analysis. Bioinformatics (2007) 18.10
Mapping determinants of human gene expression by regional and genome-wide association. Nature (2005) 17.24
The fine-scale structure of recombination rate variation in the human genome. Science (2004) 17.05
Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet (2010) 14.81
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Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
A survey of genetic human cortical gene expression. Nat Genet (2007) 12.04
Common regulatory variation impacts gene expression in a cell type-dependent manner. Science (2009) 11.28
Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nat Genet (2007) 11.09
Family-based association tests for genomewide association scans. Am J Hum Genet (2007) 10.67
Genetic determinants of hair, eye and skin pigmentation in Europeans. Nat Genet (2007) 8.79
A genotype calling algorithm for the Illumina BeadArray platform. Bioinformatics (2007) 8.03
Genetics and beyond--the transcriptome of human monocytes and disease susceptibility. PLoS One (2010) 7.48
Genomewide rapid association using mixed model and regression: a fast and simple method for genomewide pedigree-based quantitative trait loci association analysis. Genetics (2007) 7.09
ProbABEL package for genome-wide association analysis of imputed data. BMC Bioinformatics (2010) 6.46
The architecture of gene regulatory variation across multiple human tissues: the MuTHER study. PLoS Genet (2011) 5.95
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Common sequence variants on 20q11.22 confer melanoma susceptibility. Nat Genet (2008) 3.79
The UK Adult Twin Registry (TwinsUK). Twin Res Hum Genet (2006) 3.72
Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals. Am J Hum Genet (2010) 3.28
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes. Nat Genet (2011) 3.20
A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort. Genome Res (2011) 3.00
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature (2010) 2.88
Single-tissue and cross-tissue heritability of gene expression via identity-by-descent in related or unrelated individuals. PLoS Genet (2011) 2.53
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet (2010) 2.30
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Synthetic associations are unlikely to account for many common disease genome-wide association signals. PLoS Biol (2011) 2.00
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The use of linear mixed models to estimate variance components from data on twin pairs by maximum likelihood. Twin Res (2004) 1.48
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. EMBO J (2009) 1.33
The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits. PLoS One (2011) 1.18
The Sequence Alignment/Map format and SAMtools. Bioinformatics (2009) 232.39
Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics (2009) 190.94
Mapping short DNA sequencing reads and calling variants using mapping quality scores. Genome Res (2008) 157.44
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
Accurate whole human genome sequencing using reversible terminator chemistry. Nature (2008) 90.20
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Finding the missing heritability of complex diseases. Nature (2009) 67.95
The Pfam protein families database. Nucleic Acids Res (2004) 56.46
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
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The Pfam protein families database. Nucleic Acids Res (2002) 51.34
The diploid genome sequence of an Asian individual. Nature (2008) 46.29
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet (2008) 43.63
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Pfam: clans, web tools and services. Nucleic Acids Res (2006) 34.83
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
A high-resolution recombination map of the human genome. Nat Genet (2002) 28.66
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature (2003) 26.58
The variant call format and VCFtools. Bioinformatics (2011) 25.88
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science (2007) 23.38
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
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Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
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Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet (2007) 19.18
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89