Published in Nat Cell Biol on April 11, 2010
Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell (2013) 2.81
The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell (2012) 2.30
Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res (2011) 1.44
MYC and metastasis. Cancer Res (2011) 1.43
Posttranslational regulation of Akt in human cancer. Cell Biosci (2014) 1.27
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MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells. PLoS One (2012) 1.17
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PIWIL2 induces c-Myc expression by interacting with NME2 and regulates c-Myc-mediated tumor cell proliferation. Oncotarget (2014) 0.89
Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma. Oncogene (2011) 0.88
RHOA inactivation enhances Wnt signalling and promotes colorectal cancer. Nat Commun (2014) 0.87
E3-ligase Skp2 predicts poor prognosis and maintains cancer stem cell pool in nasopharyngeal carcinoma. Oncotarget (2014) 0.86
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Involvement of RhoA/ROCK1 signaling pathway in hyperglycemia-induced microvascular endothelial dysfunction in diabetic retinopathy. Int J Clin Exp Pathol (2014) 0.84
Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor. Nat Commun (2015) 0.83
The histone demethylase PHF8 is essential for cytoskeleton dynamics. Nucleic Acids Res (2012) 0.83
CUL1 promotes trophoblast cell invasion at the maternal-fetal interface. Cell Death Dis (2013) 0.83
The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma. Oncogene (2016) 0.83
p53 in cell invasion, podosomes, and invadopodia. Cell Adh Migr (2014) 0.82
Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells. Breast Cancer Res (2012) 0.82
Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex. Oncogene (2012) 0.82
Targeting ubiquitination for cancer therapies. Future Med Chem (2015) 0.82
SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice. Oncotarget (2015) 0.81
FBX8 Acts as an Invasion and Metastasis Suppressor and Correlates with Poor Survival in Hepatocellular Carcinoma. PLoS One (2013) 0.81
Transcriptional regulation of Rho GTPase signaling. Transcription (2012) 0.81
Regulation of c-Myc protein stability by proteasome activator REGγ. Cell Death Differ (2014) 0.80
A design principle underlying the paradoxical roles of E3 ubiquitin ligases. Sci Rep (2014) 0.79
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Deubiquitinating c-Myc: USP36 steps up in the nucleolus. Cell Cycle (2015) 0.77
Skp2 is required for Aurora B activation in cell mitosis and spindle checkpoint. Cell Cycle (2015) 0.77
Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer. PLoS One (2015) 0.77
Skp2 deficiency restricts the progression and stem cell features of castration-resistant prostate cancer by destabilizing Twist. Oncogene (2017) 0.76
The CASZ1/Egfl7 transcriptional pathway is required for RhoA expression in vascular endothelial cells. Small GTPases (2013) 0.76
SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Ser62. Oncogene (2015) 0.76
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NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction. Oncotarget (2016) 0.76
Cooperative antiproliferative effect of coordinated ectopic expression of DLC1 tumor suppressor protein and silencing of MYC oncogene expression in liver cancer cells: Therapeutic implications. Oncol Lett (2016) 0.76
Epigenetic therapy potential of suberoylanilide hydroxamic acid on invasive human non-small cell lung cancer cells. Oncotarget (2016) 0.75
All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy. BMC Complement Altern Med (2016) 0.75
The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination. Oncogene (2016) 0.75
ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA. Oncogene (2016) 0.75
RNAi-mediated silencing of the Skp-2 gene causes inhibition of growth and induction of apoptosis in human renal carcinoma cells. Int J Clin Exp Pathol (2014) 0.75
SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer. Oncogene (2016) 0.75
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Identification of miRNA biomarkers of pneumonia using RNA-sequencing and bioinformatics analysis. Exp Ther Med (2017) 0.75
Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer. Mol Cancer (2017) 0.75
Myc suppresses tumor invasion and cell migration by inhibiting JNK signaling. Oncogene (2017) 0.75
Gastrokine 1 inhibits gastric cancer cell migration and invasion by downregulating RhoA expression. Gastric Cancer (2016) 0.75
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Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev (2001) 6.36
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer (2008) 6.10
Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell (2008) 5.88
Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell (2009) 4.73
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The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science (2009) 4.63
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The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol Cell (2003) 3.87
Skp2 regulates Myc protein stability and activity. Mol Cell (2003) 3.85
TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat Cell Biol (2001) 3.69
Regulation of the cell cycle by SCF-type ubiquitin ligases. Semin Cell Dev Biol (2005) 3.08
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol (2009) 2.91
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Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity. Mol Cell Biol (2004) 1.90
A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter. Nat Cell Biol (2003) 1.82
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Skp2 suppresses p53-dependent apoptosis by inhibiting p300. Mol Cell (2008) 1.45
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