Published in Methods on April 10, 2010
Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96
Methylome analysis using MeDIP-seq with low DNA concentrations. Nat Protoc (2012) 1.70
5-Hydroxymethylcytosine: a new kid on the epigenetic block? Mol Syst Biol (2011) 1.29
Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma. Genome Med (2013) 1.23
Differential methylation of the TRPA1 promoter in pain sensitivity. Nat Commun (2014) 1.19
A comparison of the whole genome approach of MeDIP-seq to the targeted approach of the Infinium HumanMethylation450 BeadChip(®) for methylome profiling. PLoS One (2012) 1.16
Human-specific CpG "beacons" identify loci associated with human-specific traits and disease. Epigenetics (2012) 1.07
Genome-wide methylation profiling identifies hypermethylated biomarkers in high-grade cervical intraepithelial neoplasia. Epigenetics (2012) 0.98
A meta-analysis on age-associated changes in blood DNA methylation: results from an original analysis pipeline for Infinium 450k data. Aging (Albany NY) (2015) 0.88
Using animal models to disentangle the role of genetic, epigenetic, and environmental influences on behavioral outcomes associated with maternal anxiety and depression. Front Psychiatry (2011) 0.84
Integrated virus-host methylome analysis in head and neck squamous cell carcinoma. Epigenetics (2013) 0.84
DNA methylation analysis of murine hematopoietic side population cells during aging. Epigenetics (2013) 0.83
Human-specific epigenetic variation in the immunological Leukotriene B4 Receptor (LTB4R/BLT1) implicated in common inflammatory diseases. Genome Med (2014) 0.83
Assessment of patient-derived tumour xenografts (PDXs) as a discovery tool for cancer epigenomics. Genome Med (2014) 0.79
Next generation sequencing: advances in characterizing the methylome. Genes (Basel) (2010) 0.78
Alteration of Gene Expression, DNA Methylation, and Histone Methylation in Free Radical Scavenging Networks in Adult Mouse Hippocampus following Fetal Alcohol Exposure. PLoS One (2016) 0.77
A Study of Alterations in DNA Epigenetic Modifications (5mC and 5hmC) and Gene Expression Influenced by Simulated Microgravity in Human Lymphoblastoid Cells. PLoS One (2016) 0.76
Inter-individual methylation variability in differentially methylated regions between maternal whole blood and first trimester CVS. Mol Cytogenet (2014) 0.76
Genome-wide epigenomic profiling for biomarker discovery. Clin Epigenetics (2016) 0.75
Human ESC/iPSC-based "Omics" and Bioinformatics for Translational Research. Drug Discov Today Dis Models (2012) 0.75
A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet (2007) 20.22
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet (2009) 18.90
A large genome center's improvements to the Illumina sequencing system. Nat Methods (2008) 15.56
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet (2005) 15.37
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet (2009) 10.54
Phenotypic plasticity and the epigenetics of human disease. Nature (2007) 10.37
An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs). Genome Res (2008) 4.84
The methylome: approaches for global DNA methylation profiling. Trends Genet (2008) 3.16
Methylated DNA immunoprecipitation (MeDIP). Methods Mol Biol (2009) 2.17
The potential role of epigenomic dysregulation in complex human disease. Trends Genet (2007) 1.63
Future impact of integrated high-throughput methylome analyses on human health and disease. J Genet Genomics (2008) 1.07
Generation of a genomic tiling array of the human major histocompatibility complex (MHC) and its application for DNA methylation analysis. BMC Med Genomics (2008) 1.04
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72
DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Complete MHC haplotype sequencing for common disease gene mapping. Genome Res (2004) 12.09
Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96
The DNA sequence of the human X chromosome. Nature (2005) 6.97
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res (2010) 6.03
Gene map of the extended human MHC. Nat Rev Genet (2004) 6.01
DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project. PLoS Biol (2004) 4.96
A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data. Bioinformatics (2012) 4.95
An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs). Genome Res (2008) 4.84
Germline rates of de novo meiotic deletions and duplications causing several genomic disorders. Nat Genet (2007) 4.59
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25
The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol (2010) 4.25
Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet (2011) 3.95
Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell (2007) 3.58
An epigenetic signature in peripheral blood predicts active ovarian cancer. PLoS One (2009) 3.33
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms. Am J Hum Genet (2005) 2.85
Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. PLoS Genet (2006) 2.80
Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus. BMC Med Genomics (2010) 2.34
ChAMP: 450k Chip Analysis Methylation Pipeline. Bioinformatics (2013) 2.21
From genome to epigenome. Hum Mol Genet (2005) 2.03
Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nat Biotechnol (2010) 2.03
A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann Neurol (2007) 1.99
Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PLoS One (2010) 1.93
Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner. Genes Dev (2013) 1.88
Age-associated epigenetic drift: implications, and a case of epigenetic thrift? Hum Mol Genet (2013) 1.76
Genome-wide DNA methylation analysis of archival formalin-fixed paraffin-embedded tissue using the Illumina Infinium HumanMethylation27 BeadChip. Methods (2010) 1.71
Methylome analysis using MeDIP-seq with low DNA concentrations. Nat Protoc (2012) 1.70
Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors. Genome Res (2011) 1.60
Single haplotype analysis demonstrates rapid evolution of the killer immunoglobulin-like receptor (KIR) loci in primates. Genome Res (2005) 1.56
Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface. J Biol Chem (2009) 1.50
Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer. Hum Mol Genet (2008) 1.47
Sites of differential DNA methylation between placenta and peripheral blood: molecular markers for noninvasive prenatal diagnosis of aneuploidies. Am J Pathol (2009) 1.46
A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. Genomics (2002) 1.28
Identification of a single killer immunoglobulin-like receptor (KIR) gene in the porcine leukocyte receptor complex on chromosome 6q. Immunogenetics (2006) 1.26
An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways. Sci Rep (2013) 1.26
Comparative genomic analysis of two avian (quail and chicken) MHC regions. J Immunol (2004) 1.24
Plant and animal endemism in the eastern Andean slope: challenges to conservation. BMC Ecol (2012) 1.22
The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur J Immunol (2003) 1.22
Resources for methylome analysis suitable for gene knockout studies of potential epigenome modifiers. Gigascience (2012) 1.22
Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2. Nat Commun (2013) 1.21
A common variant associated with dyslexia reduces expression of the KIAA0319 gene. PLoS Genet (2009) 1.20
Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammation. Int J Biochem Cell Biol (2008) 1.18
Future potential of the Human Epigenome Project. Expert Rev Mol Diagn (2004) 1.17
DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta. J Biol Chem (2010) 1.15
A functional methylome map of ulcerative colitis. Genome Res (2012) 1.15
Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs. Age (Dordr) (2014) 1.12
Using high-density DNA methylation arrays to profile copy number alterations. Genome Biol (2014) 1.11
Human-specific CpG "beacons" identify loci associated with human-specific traits and disease. Epigenetics (2012) 1.07
Future impact of integrated high-throughput methylome analyses on human health and disease. J Genet Genomics (2008) 1.07
Functional interpretation of non-coding sequence variation: concepts and challenges. Bioessays (2013) 1.06
A genome-wide survey of Major Histocompatibility Complex (MHC) genes and their paralogues in zebrafish. BMC Genomics (2005) 1.06
A novel system of polymorphic and diverse NK cell receptors in primates. PLoS Genet (2009) 1.06
Different evolutionary histories of the two classical class I genes BF1 and BF2 illustrate drift and selection within the stable MHC haplotypes of chickens. J Immunol (2007) 1.05
Advances in the identification and analysis of allele-specific expression. Genome Med (2009) 1.05
MHC-linked and un-linked class I genes in the wallaby. BMC Genomics (2009) 1.04
Generation of a genomic tiling array of the human major histocompatibility complex (MHC) and its application for DNA methylation analysis. BMC Med Genomics (2008) 1.04
The leukocyte receptor complex in chicken is characterized by massive expansion and diversification of immunoglobulin-like Loci. PLoS Genet (2006) 1.01
Characterization of the chicken C-type lectin-like receptors B-NK and B-lec suggests that the NK complex and the MHC share a common ancestral region. J Immunol (2005) 1.01
Epigenetic variation and inheritance in mammals. Curr Opin Genet Dev (2006) 1.00
Identification of the ancestral killer immunoglobulin-like receptor gene in primates. BMC Genomics (2006) 0.99
Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection. Sci Transl Med (2011) 0.99
The epigenomic interface between genome and environment in common complex diseases. Brief Funct Genomics (2010) 0.96
A comparison of tagging methods and their tagging space. Hum Mol Genet (2005) 0.96
Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer. Oncogene (2002) 0.95
Cancer epigenome. Adv Genet (2010) 0.95
Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest. Stem Cell Reports (2015) 0.93
Recruitment of heterogeneous nuclear ribonucleoprotein A1 in vivo to the LMP/TAP region of the major histocompatibility complex. J Biol Chem (2002) 0.92
Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters. 1990. J Immunol (2008) 0.91
Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex. Hum Mol Genet (2003) 0.90
Genome-wide screen for differential DNA methylation associated with neural cell differentiation in mouse. PLoS One (2011) 0.90
Gene body methylation of the dimethylarginine dimethylamino-hydrolase 2 (Ddah2) gene is an epigenetic biomarker for neural stem cell differentiation. Epigenetics (2009) 0.89
The tammar wallaby major histocompatibility complex shows evidence of past genomic instability. BMC Genomics (2011) 0.88
Chicken TAP genes differ from their human orthologues in locus organisation, size, sequence features and polymorphism. Immunogenetics (2005) 0.88
Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex. Genome Res (2008) 0.88
Evolution and comparative analysis of the MHC Class III inflammatory region. BMC Genomics (2006) 0.87
The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer. BMC Genet (2002) 0.86
Complex transcription and splicing of odorant receptor genes. J Biol Chem (2003) 0.85
Methylome analysis identifies a Wilms tumor epigenetic biomarker detectable in blood. Genome Biol (2014) 0.85
Evolutionary vignettes of natural killer cell receptors. Curr Opin Immunol (2007) 0.85
Sequencing and comparative analysis of the gorilla MHC genomic sequence. Database (Oxford) (2013) 0.85
Integrated virus-host methylome analysis in head and neck squamous cell carcinoma. Epigenetics (2013) 0.84
The good, the bad and the ugly: epigenetic mechanisms in glioblastoma. Mol Aspects Med (2012) 0.84
Replication of the association of HLA-B7 with Alzheimer's disease: a role for homozygosity? J Neuroinflammation (2006) 0.80
Immunogenomics: molecular hide and seek. Hum Genomics (2006) 0.79
Preview. A shore sign of reprogramming. Cell Stem Cell (2009) 0.78
Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex. Genet Test (2008) 0.78
Comments on: Interpretation of genome-wide infinium methylation data from ligated DNA in formalin-fixed paraffin-embedded paired tumor and normal tissue. BMC Res Notes (2012) 0.78
Human-specific CpG 'beacons' identify human-specific prefrontal cortex H3K4me3 chromatin peaks. Epigenomics (2014) 0.78
Mucosal transcriptomics implicates under expression of BRINP3 in the pathogenesis of ulcerative colitis. Inflamm Bowel Dis (2014) 0.77
Isolation and characterization of 10 MHC Class I-associated microsatellite loci in tammar wallaby (Macropus eugenii). Mol Ecol Resour (2009) 0.77
A-Z of methylome analysis. Methods (2010) 0.77
High levels of genetic variation at MHC class II DBB loci in the tammar wallaby (Macropus eugenii). Immunogenetics (2008) 0.77
Bolivianine, a new sesterpene with an unusual skeleton from Hedyosmum angustifolium, and its isomer, isobolivianine. Org Lett (2007) 0.75
Replication timing profile reflects the distinct functional and genomic features of the MHC class II region. Cell Cycle (2007) 0.75
Efficient Hybrid Image Warping for High Frame-Rate Stereoscopic Rendering. IEEE Trans Vis Comput Graph (2017) 0.75
Accessing HLA sequencing data through the 6ace database. Methods Mol Biol (2003) 0.75