Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner.

PubWeight™: 1.88‹?› | Rank: Top 3%

🔗 View Article (PMC 3613612)

Published in Genes Dev on March 15, 2013

Authors

Stefan H Stricker1, Andrew Feber, Pär G Engström, Helena Carén, Kathreena M Kurian, Yasuhiro Takashima, Colin Watts, Michael Way, Peter Dirks, Paul Bertone, Austin Smith, Stephan Beck, Steven M Pollard

Author Affiliations

1: Department of Cancer Biology, UCL Cancer Institute, University College London, London WC1E 6BT, United Kingdom.

Articles citing this

Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells. Cell (2014) 4.04

Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma. Cancer Cell (2013) 2.98

Chromatin dynamics during cellular reprogramming. Nature (2013) 1.79

Age-associated epigenetic drift: implications, and a case of epigenetic thrift? Hum Mol Genet (2013) 1.76

Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease. Cell Stem Cell (2016) 1.74

An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma. Cell Rep (2013) 1.35

Brain tumor stem cells: Molecular characteristics and their impact on therapy. Mol Aspects Med (2013) 1.14

Function of oncogenes in cancer development: a changing paradigm. EMBO J (2013) 1.02

DNMT-dependent suppression of microRNA regulates the induction of GBM tumor-propagating phenotype by Oct4 and Sox2. Oncogene (2014) 0.98

The yin and yang of kidney development and Wilms' tumors. Genes Dev (2015) 0.95

Dissecting the role of aberrant DNA methylation in human leukaemia. Nat Commun (2015) 0.93

Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest. Stem Cell Reports (2015) 0.93

Using induced pluripotent stem cells as a tool for modelling carcinogenesis. World J Stem Cells (2015) 0.88

A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1. PLoS One (2013) 0.86

An epigenetic gateway to brain tumor cell identity. Nat Neurosci (2015) 0.85

Reprogramming of human cancer cells to pluripotency for models of cancer progression. EMBO J (2015) 0.85

Differentiation and transdifferentiation potentials of cancer stem cells. Oncotarget (2015) 0.82

Pre-Clinical Models of Diffuse Intrinsic Pontine Glioma. Front Oncol (2015) 0.82

Applications of iPSCs in Cancer Research. Biomark Insights (2015) 0.81

Deregulated proliferation and differentiation in brain tumors. Cell Tissue Res (2014) 0.80

hiPSC-derived iMSCs: NextGen MSCs as an advanced therapeutically active cell resource for regenerative medicine. J Cell Mol Med (2016) 0.80

Reprogramming cancer cells to pluripotency: an experimental tool for exploring cancer epigenetics. Epigenetics (2014) 0.79

Prognostic and predictive biomarkers in adult and pediatric gliomas: toward personalized treatment. Front Oncol (2014) 0.79

Biomarkers for glioma immunotherapy: the next generation. J Neurooncol (2015) 0.78

Is lineage decision-making restricted during tumoral reprograming of haematopoietic stem cells? Oncotarget (2015) 0.77

In vitro models of cancer stem cells and clinical applications. BMC Cancer (2016) 0.77

Induced pluripotent stem cell technology for dissecting the cancer epigenome. Cancer Sci (2015) 0.77

Current status in cancer cell reprogramming and its clinical implications. J Cancer Res Clin Oncol (2016) 0.77

Patient-derived induced pluripotent stem cells in cancer research and precision oncology. Nat Med (2016) 0.77

Reprogramming strategies for the establishment of novel human cancer models. Cell Cycle (2016) 0.77

Multiple sclerosis: getting personal with induced pluripotent stem cells. Cell Death Dis (2015) 0.77

Crosstalk between stem cell and cell cycle machineries. Curr Opin Cell Biol (2015) 0.76

Echoes of the embryo: using the developmental biology toolkit to study cancer. Dis Model Mech (2016) 0.76

Present and future challenges of induced pluripotent stem cells. Philos Trans R Soc Lond B Biol Sci (2015) 0.75

Glioblastoma Stem-Like Cells: Characteristics, Microenvironment, and Therapy. Front Pharmacol (2016) 0.75

Sendai virus-mediated expression of reprogramming factors promotes plasticity of human neuroblastoma cells. Cancer Sci (2015) 0.75

Epigenetics: Methylation reboot. Nat Rev Cancer (2013) 0.75

Convection enhanced delivery of panobinostat (LBH589)-loaded pluronic nano-micelles prolongs survival in the F98 rat glioma model. Int J Nanomedicine (2017) 0.75

Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation. Elife (2016) 0.75

Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response. Stem Cell Reports (2017) 0.75

In vitro anticancer drug test: A new method emerges from the model of glioma stem cells. Toxicol Rep (2014) 0.75

Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression. Proc Natl Acad Sci U S A (2017) 0.75

Articles cited by this

The hallmarks of cancer. Cell (2000) 113.05

Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42

Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature (2008) 75.40

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell (2010) 39.09

The epigenomics of cancer. Cell (2007) 30.91

Identification of a cancer stem cell in human brain tumors. Cancer Res (2003) 24.02

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell (2010) 16.12

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell (2006) 15.16

Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res (2004) 14.73

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature (2012) 10.99

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet (2006) 10.47

The epigenetic progenitor origin of human cancer. Nat Rev Genet (2006) 9.65

Epigenetic stem cell signature in cancer. Nat Genet (2006) 9.62

Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature (2009) 9.29

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet (2004) 7.78

Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature (2008) 7.07

Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell (2009) 6.77

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell (2012) 6.71

Altered methylation patterns in cancer cell genomes: cause or consequence? Cancer Cell (2002) 3.09

DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma. J Natl Cancer Inst (2010) 2.87

A microarray-based DNA methylation study of glioblastoma multiforme. Epigenetics (2009) 2.21

Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer Cell (2005) 2.17

Defined factors induce reprogramming of gastrointestinal cancer cells. Proc Natl Acad Sci U S A (2009) 2.11

Generation of iPSCs from cultured human malignant cells. Blood (2010) 1.99

HTqPCR: high-throughput analysis and visualization of quantitative real-time PCR data in R. Bioinformatics (2009) 1.87

An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours. J Neurosci Methods (2009) 1.82

Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture. Mol Cell Neurosci (2008) 1.62

Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons. PLoS One (2012) 1.46

Cancer stem cells: at the headwaters of tumor development. Annu Rev Pathol (2007) 1.45

The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein. Oncogene (2001) 1.45

Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2. Genomics (2000) 1.44

Downregulation of RUNX3 and TES by hypermethylation in glioblastoma. Oncogene (2006) 1.41

Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding. Mol Cell (2007) 1.36

Downregulation of the KIP family members p27(KIP1) and p57(KIP2) by SKP2 and the role of methylation in p57(KIP2) inactivation in nonsmall cell lung cancer. Int J Cancer (2006) 1.21

The hallmarks of CDKN1C (p57, KIP2) in cancer. Biochim Biophys Acta (2011) 1.18

DNA hypermethylation accompanied by transcriptional repression in follicular lymphoma. Genes Chromosomes Cancer (2009) 1.16

Digital transcriptome profiling of normal and glioblastoma-derived neural stem cells identifies genes associated with patient survival. Genome Med (2012) 1.11

Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia. Mol Cancer (2010) 0.92

Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma. Epigenetics (2011) 0.91

Aberrant epigenetic silencing of tumor suppressor genes is reversed by direct reprogramming. Stem Cells (2010) 0.89

Frequent hypermethylation and loss of heterozygosity of the testis derived transcript gene in ovarian cancer. Cancer Sci (2010) 0.86

CpG islands and double-minute chromosomes. Genomics (1998) 0.83

DNA methylation of polycomb group target genes in cores taken from breast cancer centre and periphery. Breast Cancer Res Treat (2009) 0.82

Articles by these authors

Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72

Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell (2003) 20.16

The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44

DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08

Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet (2006) 17.19

A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63

BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell (2003) 13.47

Nanog safeguards pluripotency and mediates germline development. Nature (2007) 13.01

Complete MHC haplotype sequencing for common disease gene mapping. Genome Res (2004) 12.09

Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol (2003) 9.41

Niche-independent symmetrical self-renewal of a mammalian tissue stem cell. PLoS Biol (2005) 9.12

Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol (2008) 8.55

Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96

Nanog is the gateway to the pluripotent ground state. Cell (2009) 7.27

Naive and primed pluripotent states. Cell Stem Cell (2009) 7.15

The DNA sequence of the human X chromosome. Nature (2005) 6.97

The transcriptional activity of human Chromosome 22. Genes Dev (2003) 6.82

Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell (2009) 6.77

Capture of authentic embryonic stem cells from rat blastocysts. Cell (2008) 6.60

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res (2010) 6.03

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02

Gene map of the extended human MHC. Nat Rev Genet (2004) 6.01

The transcriptional and epigenomic foundations of ground state pluripotency. Cell (2012) 5.87

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proc Natl Acad Sci U S A (2013) 5.68

FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development (2007) 5.62

Klf4 reverts developmentally programmed restriction of ground state pluripotency. Development (2009) 5.49

Capturing pluripotency. Cell (2008) 5.08

Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol (2002) 5.00

DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project. PLoS Biol (2004) 4.96

A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data. Bioinformatics (2012) 4.95

An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs). Genome Res (2008) 4.84

Germline rates of de novo meiotic deletions and duplications causing several genomic disorders. Nat Genet (2007) 4.59

Cancer stem cells: an evolving concept. Nat Rev Cancer (2012) 4.57

Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene (2004) 4.40

Nanog promotes transfer of pluripotency after cell fusion. Nature (2006) 4.38

Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25

Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo. Development (2009) 4.25

The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol (2010) 4.25

Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature (2012) 4.13

Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet (2011) 3.95

Distribution of NF-kappaB-binding sites across human chromosome 22. Proc Natl Acad Sci U S A (2003) 3.89

An integrated approach for finding overlooked genes in yeast. Nat Biotechnol (2002) 3.88

Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression. RNA (2010) 3.85

Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell (2007) 3.58

Stat3 activation is limiting for reprogramming to ground state pluripotency. Cell Stem Cell (2010) 3.42

An epigenetic signature in peripheral blood predicts active ovarian cancer. PLoS One (2009) 3.33

Oct4 and LIF/Stat3 additively induce Krüppel factors to sustain embryonic stem cell self-renewal. Cell Stem Cell (2009) 3.27

Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae. Genes Dev (2002) 3.27

Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation. Nat Cell Biol (2011) 3.25

BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24

Multi-species microarrays reveal the effect of sequence divergence on gene expression profiles. Genome Res (2005) 3.23

Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila. Cell (2008) 3.18

Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell (2013) 3.15

Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates. Genome Res (2007) 3.11

Arrays of ultraconserved non-coding regions span the loci of key developmental genes in vertebrate genomes. BMC Genomics (2004) 3.08

Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling. Science (2004) 3.08

Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus. Stem Cells (2006) 3.07

Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal. Cell Stem Cell (2012) 3.03

Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev Cell (2004) 2.96

Systematic evaluation of spliced alignment programs for RNA-seq data. Nat Methods (2013) 2.92

Molecular fossils in the human genome: identification and analysis of the pseudogenes in chromosomes 21 and 22. Genome Res (2002) 2.89

Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells. Cancer Cell (2008) 2.87

Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice. Proc Natl Acad Sci U S A (2003) 2.86

A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms. Am J Hum Genet (2005) 2.85

RNAdb--a comprehensive mammalian noncoding RNA database. Nucleic Acids Res (2005) 2.84

Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. PLoS Genet (2006) 2.80

Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome. Nat Genet (2012) 2.80

F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells. Immunity (2012) 2.72

PeakAnalyzer: genome-wide annotation of chromatin binding and modification loci. BMC Bioinformatics (2010) 2.65

Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Nat Biotechnol (2002) 2.64

A superhighway to virus infection. Cell (2006) 2.58

Towards practical, high-capacity, low-maintenance information storage in synthesized DNA. Nature (2013) 2.56

Naive pluripotency is associated with global DNA hypomethylation. Nat Struct Mol Biol (2013) 2.49

Cohesin-mediated interactions organize chromosomal domain architecture. EMBO J (2013) 2.48

Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs. PLoS Genet (2006) 2.48

Role of Krüppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J Biol Chem (2005) 2.45

SRC mediates a switch from microtubule- to actin-based motility of vaccinia virus. Science (2004) 2.44

Target hub proteins serve as master regulators of development in yeast. Genes Dev (2006) 2.39

Activation of MDA5 requires higher-order RNA structures generated during virus infection. J Virol (2009) 2.37

Issues in the analysis of oligonucleotide tiling microarrays for transcript mapping. Trends Genet (2005) 2.36

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus. BMC Med Genomics (2010) 2.34

CREB binds to multiple loci on human chromosome 22. Mol Cell Biol (2004) 2.28

RNAdb 2.0--an expanded database of mammalian non-coding RNAs. Nucleic Acids Res (2006) 2.27

Validated germline-competent embryonic stem cell lines from nonobese diabetic mice. Nat Med (2009) 2.26

ChAMP: 450k Chip Analysis Methylation Pipeline. Bioinformatics (2013) 2.21

NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment. Cell Stem Cell (2012) 2.15

REST regulates distinct transcriptional networks in embryonic and neural stem cells. PLoS Biol (2008) 2.12

NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression. EMBO J (2011) 2.09

From genome to epigenome. Hum Mol Genet (2005) 2.03

Zebrafish mutants identify an essential role for laminins in notochord formation. Development (2002) 2.03

Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nat Biotechnol (2010) 2.03

Global changes in STAT target selection and transcription regulation upon interferon treatments. Genes Dev (2005) 2.01

A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann Neurol (2007) 1.99

Genesis of embryonic stem cells. Philos Trans R Soc Lond B Biol Sci (2003) 1.97

Pluripotency in the embryo and in culture. Cold Spring Harb Perspect Biol (2012) 1.93

Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. Proc Natl Acad Sci U S A (2009) 1.93