Published in J Biol Chem on April 12, 2010
Structure and activity of the acid-sensing ion channels. Am J Physiol Cell Physiol (2012) 1.25
Identification of epithelial Na+ channel (ENaC) intersubunit Cl- inhibitory residues suggests a trimeric alpha gamma beta channel architecture. J Biol Chem (2010) 1.03
Insights into the mechanism of pore opening of acid-sensing ion channel 1a. J Biol Chem (2011) 1.03
Modulation of acid-sensing ion channels: molecular mechanisms and therapeutic potential. Int J Physiol Pathophysiol Pharmacol (2011) 0.96
Impact of recovery from desensitization on acid-sensing ion channel-1a (ASIC1a) current and response to high frequency stimulation. J Biol Chem (2012) 0.91
Translational strategies for neuroprotection in ischemic stroke--focusing on acid-sensing ion channel 1a. Transl Stroke Res (2014) 0.86
TRPM7 is regulated by halides through its kinase domain. Cell Mol Life Sci (2013) 0.83
Functional modifications of acid-sensing ion channels by ligand-gated chloride channels. PLoS One (2011) 0.81
Ion conduction and selectivity in acid-sensing ion channel 1. J Gen Physiol (2014) 0.81
Identification of extracellular domain residues required for epithelial Na+ channel activation by acidic pH. J Biol Chem (2012) 0.81
Acid-sensing ion channels are tuned to follow high-frequency stimuli. J Physiol (2016) 0.80
The Thumb Domain Mediates Acid-sensing Ion Channel Desensitization. J Biol Chem (2016) 0.78
Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition. Am J Physiol Cell Physiol (2012) 0.78
Structural mechanisms underlying the function of epithelial sodium channel/acid-sensing ion channel. Curr Opin Nephrol Hypertens (2011) 0.78
Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gating. Proc Natl Acad Sci U S A (2017) 0.75
Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature (2007) 8.04
Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell (2004) 6.15
The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron (2002) 4.11
Acid-sensing ion channels: advances, questions and therapeutic opportunities. Trends Neurosci (2006) 3.95
Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Proc Natl Acad Sci U S A (2002) 3.05
Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning. J Neurosci (2003) 3.05
Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons. Nat Neurosci (2001) 2.77
Actions of some anions on electrical properties and mechanical threshold of frog twitch muscle. J Physiol (1968) 2.68
NS21: re-defined and modified supplement B27 for neuronal cultures. J Neurosci Methods (2008) 2.68
pH Dependency and desensitization kinetics of heterologously expressed combinations of acid-sensing ion channel subunits. J Biol Chem (2003) 2.30
Acid-sensing ion channels in sensory perception. J Biol Chem (2007) 2.25
Protons open acid-sensing ion channels by catalyzing relief of Ca2+ blockade. Neuron (2003) 2.24
Seizure termination by acidosis depends on ASIC1a. Nat Neurosci (2008) 2.18
Lyotropic anions. Na channel gating and Ca electrode response. J Gen Physiol (1983) 2.18
Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons. J Biol Chem (2004) 2.15
Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death. Neuron (2005) 2.07
Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions. J Gen Physiol (1998) 2.02
Acid-evoked currents in cardiac sensory neurons: A possible mediator of myocardial ischemic sensation. Circ Res (1999) 1.95
Restoring Acid-sensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses. J Neurosci (2008) 1.90
ASIC-like, proton-activated currents in rat hippocampal neurons. J Physiol (2002) 1.82
Cystic fibrosis transmembrane conductance regulator. Physical basis for lyotropic anion selectivity patterns. J Gen Physiol (1999) 1.60
Calcium ion as a cofactor in Na channel gating. Proc Natl Acad Sci U S A (1991) 1.60
Extracellular pH changes during spreading depression and cerebral ischemia: mechanisms of brain pH regulation. J Cereb Blood Flow Metab (1984) 1.53
ATP extracellular concentrations are increased in the rat striatum during in vivo ischemia. Neurochem Int (2005) 1.53
Extracellular ion concentrations during spreading depression and ischemia in the rat brain cortex. Acta Physiol Scand (1981) 1.45
Extracellular chloride regulates the epithelial sodium channel. J Biol Chem (2009) 1.40
A conformation change in the extracellular domain that accompanies desensitization of acid-sensing ion channel (ASIC) 3. J Gen Physiol (2007) 1.38
Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior. J Neurosci (2009) 1.29
Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration. J Biol Chem (2009) 1.28
Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel (ASIC) 1a. J Physiol (2007) 1.28
An acid-sensing ion channel that detects ischemic pain. Braz J Med Biol Res (2005) 1.24
Modulation of ASIC channels in rat cerebellar Purkinje neurons by ischaemia-related signals. J Physiol (2002) 1.24
Dynorphin opioid peptides enhance acid-sensing ion channel 1a activity and acidosis-induced neuronal death. J Neurosci (2009) 1.22
Brain cortical fatty acids and phospholipids during and following complete and severe incomplete ischemia. J Neurochem (1982) 1.13
Acidification of interstitial fluid in hippocampal formation caused by seizures and by spreading depression. Brain Res (1984) 1.13
Functional properties and pharmacological inhibition of ASIC channels in the human SJ-RH30 skeletal muscle cell line. J Physiol (2004) 1.12
Gating of acid-sensitive ion channel-1: release of Ca2+ block vs. allosteric mechanism. J Gen Physiol (2006) 1.12
Brain anaerobic lactate production: a suicide note or a survival kit? Dev Neurosci (1998) 0.99
Cl- and Na+ homeostasis during anoxia in rat hypoglossal neurons: intracellular and extracellular in vitro studies. J Physiol (1992) 0.90
ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation. Pain (2006) 1.79
Acid-sensing ion channels contribute to transduction of extracellular acidosis in rat carotid body glomus cells. Circ Res (2007) 1.69
ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95. J Neurosci (2009) 1.33
Stomatin modulates gating of acid-sensing ion channels. J Biol Chem (2004) 1.24
PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. J Biol Chem (2004) 1.19
Acid-sensing ion channels (ASICs) in mouse skeletal muscle afferents are heteromers composed of ASIC1a, ASIC2, and ASIC3 subunits. FASEB J (2012) 1.09
ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons. Circ Res (2009) 1.05
Simultaneous disruption of mouse ASIC1a, ASIC2 and ASIC3 genes enhances cutaneous mechanosensitivity. PLoS One (2012) 1.02
Selective targeting of ASIC3 using artificial miRNAs inhibits primary and secondary hyperalgesia after muscle inflammation. Pain (2011) 0.99
Acid-sensing ion channel 3 (ASIC3) cell surface expression is modulated by PSD-95 within lipid rafts. Am J Physiol Cell Physiol (2008) 0.97
ASICs Do Not Play a Role in Maintaining Hyperalgesia Induced by Repeated Intramuscular Acid Injections. Pain Res Treat (2011) 0.89
Identification of extracellular domain residues required for epithelial Na+ channel activation by acidic pH. J Biol Chem (2012) 0.81
Coxsackievirus and adenovirus receptor (CAR) mediates trafficking of acid sensing ion channel 3 (ASIC3) via PSD-95. Biochem Biophys Res Commun (2012) 0.79
Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition. Am J Physiol Cell Physiol (2012) 0.78
Effect of deep tissue incision on pH responses of afferent fibers and dorsal root ganglia innervating muscle. Anesthesiology (2013) 0.76
Percutaneous penetration and genotoxicity of 4,4'-methylenedianiline through rat and human skin in vitro. Toxicology (2004) 0.75