PubRank

Randall S Johnson

Author PubWeight™ 230.86‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 2003 9.12
2 HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 2008 8.01
3 HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 2011 6.32
4 NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 2008 6.13
5 Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell 2010 4.90
6 Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest 2007 4.80
7 Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest 2004 3.90
8 The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 2003 3.89
9 Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell 2002 3.86
10 Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature 2008 3.82
11 HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest 2005 3.77
12 The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest 2007 3.76
13 A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature 2008 3.74
14 Hypoxia: a key regulator of angiogenesis in cancer. Cancer Metastasis Rev 2007 3.71
15 Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest 2007 3.61
16 Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A 2007 3.51
17 Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med 2005 3.43
18 Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest 2007 3.40
19 Interdependence of hypoxic and innate immune responses. Nat Rev Immunol 2009 3.29
20 Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 2004 3.28
21 Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev Cell 2002 3.23
22 Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Mol Cell Biol 2003 3.10
23 HIF-1 as a target for drug development. Nat Rev Drug Discov 2003 3.07
24 Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res 2007 3.01
25 Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J Immunol 2007 2.76
26 VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nat Med 2006 2.67
27 Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell 2013 2.58
28 A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Proc Natl Acad Sci U S A 2004 2.56
29 Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell 2008 2.54
30 VEGFA is necessary for chondrocyte survival during bone development. Development 2004 2.54
31 Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res 2010 2.48
32 O2 regulates stem cells through Wnt/β-catenin signalling. Nat Cell Biol 2010 2.45
33 Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev 2010 2.26
34 Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol 2005 2.25
35 Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia. J Neurosci 2007 2.24
36 The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. Oncogene 2003 2.22
37 Hypoxic induction of Ctgf is directly mediated by Hif-1. Am J Physiol Renal Physiol 2004 2.19
38 Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Mol Cell Biol 2003 2.12
39 c-Jun is essential for organization of the epidermal leading edge. Dev Cell 2003 2.00
40 Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol 2003 1.99
41 Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. J Cell Biol 2007 1.95
42 HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes. J Cell Sci 2003 1.93
43 HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development 2007 1.91
44 Hypoxia inducible factor (HIF) function in innate immunity and infection. J Mol Med (Berl) 2007 1.90
45 Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen. Nat Immunol 2013 1.86
46 Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage. J Neurosci 2005 1.75
47 TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood 2006 1.74
48 Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood 2009 1.70
49 HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis. Proc Natl Acad Sci U S A 2013 1.67
50 HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice. J Hepatol 2011 1.64
51 The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab 2010 1.64
52 Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene 2008 1.61
53 Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development 2004 1.58
54 Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart. FASEB J 2004 1.53
55 The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels. Cell Microbiol 2006 1.50
56 Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol 2004 1.48
57 Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood 2013 1.48
58 Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts. Gene Expr 2003 1.45
59 Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. J Clin Invest 2011 1.44
60 The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. J Clin Invest 2009 1.40
61 Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc Natl Acad Sci U S A 2005 1.38
62 Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol 2004 1.36
63 HIF-1 and hypoxic response: the plot thickens. Curr Opin Genet Dev 2004 1.34
64 Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina. Glia 2010 1.31
65 Role of the hypoxia inducible factors HIF in iron metabolism. Cell Cycle 2008 1.31
66 Role of HIF-1alpha in skeletal development. Ann N Y Acad Sci 2010 1.27
67 Pharmacologic augmentation of hypoxia-inducible factor-1alpha with mimosine boosts the bactericidal capacity of phagocytes. J Infect Dis 2008 1.26
68 A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection. J Mol Med (Berl) 2012 1.24
69 Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance. Cancer J 2002 1.23
70 Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein. Mol Cell Biol 2008 1.23
71 Critical role of HIF-1alpha in keratinocyte defense against bacterial infection. J Invest Dermatol 2008 1.22
72 HIF-1alpha in endurance training: suppression of oxidative metabolism. Am J Physiol Regul Integr Comp Physiol 2007 1.22
73 Nonrenal regulation of EPO synthesis. Kidney Int 2009 1.20
74 A novel role for the hypoxia inducible transcription factor HIF-1alpha: critical regulation of inflammatory cell function. Cell Cycle 2003 1.20
75 pVHL function is essential for endothelial extracellular matrix deposition. Mol Cell Biol 2006 1.18
76 The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent. Mol Cell Biol 2002 1.12
77 HIF-1 in cell cycle regulation, apoptosis, and tumor progression. Antioxid Redox Signal 2003 1.12
78 Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature. PLoS One 2010 1.11
79 microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation. Proc Natl Acad Sci U S A 2012 1.11
80 Endothelial cell HIF-1α and HIF-2α differentially regulate metastatic success. Cancer Cell 2012 1.10
81 Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1alpha. Mol Pharmacol 2006 1.04
82 Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis. Proc Natl Acad Sci U S A 2010 1.03
83 Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development 2008 1.02
84 HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland. Development 2003 1.02
85 Physiologically low oxygen concentrations in fetal skin regulate hypoxia-inducible factor 1 and transforming growth factor-beta3. FASEB J 2002 1.00
86 HIF-1: an age-dependent regulator of lens cell proliferation. Invest Ophthalmol Vis Sci 2008 1.00
87 Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1. J Cell Biol 2005 1.00
88 HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite. Blood 2007 0.99
89 von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina. Development 2010 0.99
90 HIF-1alpha is necessary to support gluconeogenesis during liver regeneration. Biochem Biophys Res Commun 2009 0.98
91 Two HIFs may be better than one. Cancer Cell 2002 0.97
92 DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation. Mol Cell Biol 2005 0.95
93 von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase. Int J Oncol 2007 0.94
94 Hypoxia and metastasis in breast cancer. Curr Top Microbiol Immunol 2010 0.94
95 An unexpected role for hypoxic response: oxygenation and inflammation. Cell Cycle 2004 0.94
96 Glucose utilization is essential for hypoxia-inducible factor 1 alpha-dependent phosphorylation of c-Jun. Mol Cell Biol 2004 0.93
97 Loss of fibroblast HIF-1α accelerates tumorigenesis. Cancer Res 2012 0.92
98 The role of HIF-1 in hypoxic response in the skeletal muscle. Adv Exp Med Biol 2007 0.91
99 HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc Natl Acad Sci U S A 2013 0.90
100 A wound size-dependent effect of myeloid cell-derived vascular endothelial growth factor on wound healing. J Invest Dermatol 2010 0.90
101 A new notch in the HIF belt: how hypoxia impacts differentiation. Dev Cell 2005 0.90
102 ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1alpha (HIF-1alpha) binding and mediates HIF-1alpha expression by bafilomycin A1. Mol Pharmacol 2006 0.89
103 Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1alpha. Toxicol Lett 2005 0.89
104 Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice. Biochem Biophys Res Commun 2011 0.88
105 VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis. Am J Pathol 2010 0.87
106 Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis. Blood 2012 0.87
107 Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration. Eur J Immunol 2012 0.85
108 Myeloid hypoxia-inducible factor-1α is essential for skeletal muscle regeneration in mice. J Immunol 2013 0.85
109 The function of VEGF-A in lens development: formation of the hyaloid capillary network and protection against transient nuclear cataracts. Exp Eye Res 2008 0.84
110 In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage. J Biol Chem 2007 0.84
111 Activation of hypoxia-inducible factor-2 in adipocytes results in pathological cardiac hypertrophy. J Am Heart Assoc 2013 0.84
112 Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye. J Cell Biol 2011 0.83
113 HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination. J Mol Med (Berl) 2013 0.83
114 Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function. Proc Natl Acad Sci U S A 2012 0.83
115 Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function. J Mol Med (Berl) 2012 0.81
116 Hypoxia-inducible factor-1 is a determinant of lobular structure and oxygen consumption in the liver. Microcirculation 2013 0.81
117 In vitro liver tissue model established from transgenic mice: role of HIF-1alpha on hypoxic gene expression. Tissue Eng 2006 0.80
118 Transgenic models to understand hypoxia-inducible factor function. Methods Enzymol 2007 0.79
119 HIF-mediated endothelial response during cancer progression. Int J Hematol 2012 0.79
120 Waiting to inhale: HIF-1 modulates aerobic respiration. Cell 2007 0.77
121 Tumor vessels are Eph-ing complicated. Cancer Cell 2010 0.77
122 Kidney injury is independent of endothelial HIF-1α. J Mol Med (Berl) 2015 0.76
123 Endothelial hypoxic metabolism in carcinogenesis and dissemination: HIF-A isoforms are a NO metastatic phenomenon. Oncotarget 2013 0.75
124 Putting the tissue and environmental 'context' into differentiation and gene regulation. Curr Opin Genet Dev 2008 0.75
125 You don't need a PHD to grow a tumor. Dev Cell 2009 0.75
126 Lorenz Poellinger. Exp Cell Res 2017 0.75