Published in Cell Microbiol on February 01, 2006
Interdependence of hypoxic and innate immune responses. Nat Rev Immunol (2009) 3.29
Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses. Cell Host Microbe (2010) 1.90
Host cell manipulation by the human pathogen Toxoplasma gondii. Cell Mol Life Sci (2008) 1.49
Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence. APMIS (2009) 1.36
Toxoplasmosis-associated neovascular lesions treated successfully with ranibizumab and antiparasitic therapy. Arch Ophthalmol (2008) 1.30
Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection. PLoS One (2008) 1.22
Changes in the expression of human cell division autoantigen-1 influence Toxoplasma gondii growth and development. PLoS Pathog (2006) 1.19
Modulation of the host cell proteome by the intracellular apicomplexan parasite Toxoplasma gondii. Infect Immun (2007) 1.18
A patatin-like protein protects Toxoplasma gondii from degradation in activated macrophages. Mol Microbiol (2006) 1.12
Toxoplasma: the next 100years. Microbes Infect (2008) 1.12
Transcriptomic signature of Leishmania infected mice macrophages: a metabolic point of view. PLoS Negl Trop Dis (2012) 1.09
Toxoplasma gondii rhoptry discharge correlates with activation of the early growth response 2 host cell transcription factor. Infect Immun (2008) 1.04
Discovery of a novel Toxoplasma gondii conoid-associated protein important for parasite resistance to reactive nitrogen intermediates. J Immunol (2012) 1.01
Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15. Infect Immun (2013) 0.98
Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling. J Biol Chem (2010) 0.98
Infection with Toxoplasma gondii bradyzoites has a diminished impact on host transcript levels relative to tachyzoite infection. Infect Immun (2006) 0.94
Forward genetic screening identifies a small molecule that blocks Toxoplasma gondii growth by inhibiting both host- and parasite-encoded kinases. PLoS Pathog (2014) 0.94
The Skp1 protein from Toxoplasma is modified by a cytoplasmic prolyl 4-hydroxylase associated with oxygen sensing in the social amoeba Dictyostelium. J Biol Chem (2012) 0.92
The secreted kinase ROP18 defends Toxoplasma's border. Bioessays (2011) 0.91
Toxoplasma gondii development of its replicative niche: in its host cell and beyond. Eukaryot Cell (2014) 0.89
Host cell invasion by Toxoplasma gondii is temporally regulated by the host microtubule cytoskeleton. Eukaryot Cell (2010) 0.88
Regulation of IDO activity by oxygen supply: inhibitory effects on antimicrobial and immunoregulatory functions. PLoS One (2013) 0.88
Lytic Cycle of Toxoplasma gondii: 15 Years Later. Annu Rev Microbiol (2015) 0.88
Macrophages: plastic solutions to environmental heterogeneity. Inflamm Res (2013) 0.87
The level of H₂O₂ type oxidative stress regulates virulence of Theileria-transformed leukocytes. Cell Microbiol (2013) 0.83
Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro. Dis Model Mech (2013) 0.82
Hypoxia-Inducible Factor (HIF) as a Pharmacological Target for Prevention and Treatment of Infectious Diseases. Infect Dis Ther (2014) 0.82
Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis. Cytokine (2014) 0.81
Implications of hypoxic microenvironments during invasive aspergillosis. Med Mycol (2010) 0.81
IRF-5-Mediated Inflammation Limits CD8+ T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection. PLoS Pathog (2015) 0.80
The role of DNA microarrays in Toxoplasma gondii research, the causative agent of ocular toxoplasmosis. J Ocul Biol Dis Infor (2009) 0.80
Oxygen sensing by protozoans: how they catch their breath. Curr Opin Microbiol (2015) 0.78
Host metabolism regulates growth and differentiation of Toxoplasma gondii. Int J Parasitol (2012) 0.78
Hypoxic stress, hepatocytes and CACO-2 viability and susceptibility to Shigella flexneri invasion. Rev Inst Med Trop Sao Paulo (2013) 0.77
Toxoplasma Effectors Targeting Host Signaling and Transcription. Clin Microbiol Rev (2017) 0.75
Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity. Antimicrob Agents Chemother (2016) 0.75
HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis. PLoS Pathog (2017) 0.75
Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer. Sci Rep (2017) 0.75
Modulation of host HIF-1α activity and the tryptophan pathway contributes to the anti-Toxoplasma gondii potential of nanoparticles. Biochem Biophys Rep (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell (2009) 14.40
HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell (2008) 8.01
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer (2011) 6.32
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature (2008) 6.13
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med (2006) 6.04
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell (2010) 4.90
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest (2007) 4.80
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest (2004) 3.90
The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell (2003) 3.89
Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell (2002) 3.86
Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature (2008) 3.82
HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest (2005) 3.77
The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest (2007) 3.76
A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature (2008) 3.74
Hypoxia: a key regulator of angiogenesis in cancer. Cancer Metastasis Rev (2007) 3.71
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest (2007) 3.61
Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. J Exp Med (2006) 3.52
Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A (2007) 3.51
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med (2005) 3.43
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest (2007) 3.40
Interdependence of hypoxic and innate immune responses. Nat Rev Immunol (2009) 3.29
Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell (2004) 3.28
Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev Cell (2002) 3.23
Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Mol Cell Biol (2003) 3.10
HIF-1 as a target for drug development. Nat Rev Drug Discov (2003) 3.07
Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res (2007) 3.01
Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J Immunol (2007) 2.76
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nat Med (2006) 2.67
The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality. Nat Genet (2005) 2.66
Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell (2013) 2.58
A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Proc Natl Acad Sci U S A (2004) 2.56
Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell (2008) 2.54
VEGFA is necessary for chondrocyte survival during bone development. Development (2004) 2.54
Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res (2010) 2.48
O2 regulates stem cells through Wnt/β-catenin signalling. Nat Cell Biol (2010) 2.45
The Development and validation of a self-administered quality-of-life outcome measure for young, active patients with symptomatic hip disease: the International Hip Outcome Tool (iHOT-33). Arthroscopy (2012) 2.33
The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization. Biochem J (2007) 2.27
Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev (2010) 2.26
Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol (2005) 2.25
Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia. J Neurosci (2007) 2.24
The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. Oncogene (2003) 2.22
Hypoxic induction of Ctgf is directly mediated by Hif-1. Am J Physiol Renal Physiol (2004) 2.19
Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol (2010) 2.17
Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells. Science (2008) 2.15
Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Mol Cell Biol (2003) 2.12
c-Jun is essential for organization of the epidermal leading edge. Dev Cell (2003) 2.00
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol (2003) 1.99
Radiation oncology: a century of achievements. Nat Rev Cancer (2004) 1.98
Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis. Cancer Res (2006) 1.97
Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. J Cell Biol (2007) 1.95
HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes. J Cell Sci (2003) 1.93
HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development (2007) 1.91
Hypoxia inducible factor (HIF) function in innate immunity and infection. J Mol Med (Berl) (2007) 1.90
Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen. Nat Immunol (2013) 1.86
Myosin A tail domain interacting protein (MTIP) localizes to the inner membrane complex of Plasmodium sporozoites. J Cell Sci (2003) 1.85
Sites of interaction between aldolase and thrombospondin-related anonymous protein in plasmodium. Mol Biol Cell (2003) 1.83
Toxoplasma gondii asexual development: identification of developmentally regulated genes and distinct patterns of gene expression. Eukaryot Cell (2002) 1.81
Plasmodium yoelii sporozoites with simultaneous deletion of P52 and P36 are completely attenuated and confer sterile immunity against infection. Infect Immun (2007) 1.79
Immediate/early response to Trypanosoma cruzi infection involves minimal modulation of host cell transcription. J Biol Chem (2001) 1.78
Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage. J Neurosci (2005) 1.75
TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood (2006) 1.74
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood (2009) 1.70
HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis. Proc Natl Acad Sci U S A (2013) 1.67
Golgi biogenesis in Toxoplasma gondii. Nature (2002) 1.67
HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice. J Hepatol (2011) 1.64
The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab (2010) 1.64
Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole. Mol Microbiol (2010) 1.61
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene (2008) 1.61
Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development (2004) 1.58
Targeted deletion of SAP1 abolishes the expression of infectivity factors necessary for successful malaria parasite liver infection. Mol Microbiol (2008) 1.56
Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart. FASEB J (2004) 1.53
Activation of NF-kappaB by Toxoplasma gondii correlates with increased expression of antiapoptotic genes and localization of phosphorylated IkappaB to the parasitophorous vacuole membrane. J Cell Sci (2003) 1.52
A cleavable propeptide influences Toxoplasma infection by facilitating the trafficking and secretion of the TgMIC2-M2AP invasion complex. Mol Biol Cell (2006) 1.49
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol (2004) 1.48
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood (2013) 1.48
Apicomplexan gliding motility and host cell invasion: overhauling the motor model. Trends Parasitol (2004) 1.47
Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts. Gene Expr (2003) 1.45
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. J Clin Invest (2011) 1.44
Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells. J Exp Med (2009) 1.42
Spontaneous intracranial hypotension: recommendations for management. Can J Neurol Sci (2013) 1.41
The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. J Clin Invest (2009) 1.40
A member of a conserved Plasmodium protein family with membrane-attack complex/perforin (MACPF)-like domains localizes to the micronemes of sporozoites. Mol Biochem Parasitol (2004) 1.38
Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc Natl Acad Sci U S A (2005) 1.38
Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo/exocytic system of Toxoplasma gondii. Mol Microbiol (2010) 1.36
Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol (2004) 1.36
Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii. J Biol Chem (2008) 1.34
HIF-1 and hypoxic response: the plot thickens. Curr Opin Genet Dev (2004) 1.34
Role of the hypoxia inducible factors HIF in iron metabolism. Cell Cycle (2008) 1.31
Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina. Glia (2010) 1.31
Autophagy in protists. Autophagy (2011) 1.29
The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission. PLoS Pathog (2009) 1.28
Selective disruption of phosphatidylcholine metabolism of the intracellular parasite Toxoplasma gondii arrests its growth. J Biol Chem (2005) 1.27
Role of HIF-1alpha in skeletal development. Ann N Y Acad Sci (2010) 1.27
Pharmacologic augmentation of hypoxia-inducible factor-1alpha with mimosine boosts the bactericidal capacity of phagocytes. J Infect Dis (2008) 1.26
Cellular interactions of Plasmodium liver stage with its host mammalian cell. Int J Parasitol (2007) 1.25
A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection. J Mol Med (Berl) (2012) 1.24
Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance. Cancer J (2002) 1.23
Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein. Mol Cell Biol (2008) 1.23