Published in Ann N Y Acad Sci on March 01, 2010
Gene disruption of the calcium channel Orai1 results in inhibition of osteoclast and osteoblast differentiation and impairs skeletal development. Lab Invest (2012) 1.04
Stimulation of Ca2+-channel Orai1/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1). FASEB J (2011) 0.93
Functional osteoclast attachment requires inositol-1,4,5-trisphosphate receptor-associated cGMP-dependent kinase substrate. Lab Invest (2010) 0.82
The Involvement of TRP Channels in Bone Homeostasis. Front Endocrinol (Lausanne) (2012) 0.81
Osteopenia due to enhanced cathepsin K release by BK channel ablation in osteoclasts. PLoS One (2011) 0.80
Insights into bone health in Duchenne muscular dystrophy. Bonekey Rep (2012) 0.75
FSH directly regulates bone mass. Cell (2006) 4.64
TSH is a negative regulator of skeletal remodeling. Cell (2003) 4.34
Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a. Proc Natl Acad Sci U S A (2002) 3.59
Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5. J Neurochem (2003) 2.20
Cardiac Na+ current regulation by pyridine nucleotides. Circ Res (2009) 1.87
Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling. J Clin Invest (2012) 1.77
Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging. Circulation (2005) 1.74
Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta. J Cell Biol (2003) 1.69
Thyroid-stimulating hormone induces a Wnt-dependent, feed-forward loop for osteoblastogenesis in embryonic stem cell cultures. Proc Natl Acad Sci U S A (2011) 1.67
Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells. Stem Cells (2005) 1.66
Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation. Proc Natl Acad Sci U S A (2006) 1.64
Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice. J Clin Invest (2003) 1.63
Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage. Proc Natl Acad Sci U S A (2010) 1.60
Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth. Hum Mol Genet (2007) 1.56
Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes. Proc Natl Acad Sci U S A (2013) 1.54
Delayed paced ventricular activation in the long QT syndrome is associated with ventricular fibrillation. Heart Rhythm (2006) 1.53
Conduction slowing contributes to spontaneous ventricular arrhythmias in intrinsically active murine RyR2-P2328S hearts. J Cardiovasc Electrophysiol (2012) 1.53
Na+/H+ exchanger regulatory factor 1 (NHERF1) directly regulates osteogenesis. J Biol Chem (2012) 1.52
Molecular regulation of mechanotransduction. Biochem Biophys Res Commun (2005) 1.51
Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss. Proc Natl Acad Sci U S A (2008) 1.46
Deletion of the metabolic transcriptional coactivator PGC1β induces cardiac arrhythmia. Cardiovasc Res (2011) 1.46
Paced ventricular electrogram fractionation predicts sudden cardiac death in hypertrophic cardiomyopathy. Eur Heart J (2008) 1.44
Oxytocin is an anabolic bone hormone. Proc Natl Acad Sci U S A (2009) 1.44
Interleukin 12 a key immunoregulatory cytokine in infection applications. Int J Mol Sci (2010) 1.41
Osteoclast signalling pathways. Biochem Biophys Res Commun (2005) 1.36
Interferon-inducible protein 9 (CXCL11)-induced cell motility in keratinocytes requires calcium flux-dependent activation of mu-calpain. Mol Cell Biol (2005) 1.35
Genotype-phenotype correlation in 1,507 families with congenital adrenal hyperplasia owing to 21-hydroxylase deficiency. Proc Natl Acad Sci U S A (2013) 1.31
DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism. J Bone Miner Res (2013) 1.31
Temperature dependence of human ether-a-go-go-related gene K+ currents. Am J Physiol Cell Physiol (2006) 1.29
BMP-12 treatment of adult mesenchymal stem cells in vitro augments tendon-like tissue formation and defect repair in vivo. PLoS One (2011) 1.29
Structure-phenotype correlations of human CYP21A2 mutations in congenital adrenal hyperplasia. Proc Natl Acad Sci U S A (2013) 1.28
TNFalpha mediates the skeletal effects of thyroid-stimulating hormone. Proc Natl Acad Sci U S A (2006) 1.27
Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a. J Physiol (2005) 1.27
PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells. J Biol Chem (2007) 1.26
ACTH protects against glucocorticoid-induced osteonecrosis of bone. Proc Natl Acad Sci U S A (2010) 1.26
Parathyroid hormone receptor directly interacts with dishevelled to regulate beta-Catenin signaling and osteoclastogenesis. J Biol Chem (2010) 1.25
Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1. J Physiol (2003) 1.21
A quantitative analysis of cell volume and resting potential determination and regulation in excitable cells. J Physiol (2004) 1.21
Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/- murine hearts modelling the Brugada syndrome. J Physiol (2007) 1.19
Efficacy and tolerability of intravenous ibandronate injections in postmenopausal osteoporosis: 2-year results from the DIVA study. J Rheumatol (2008) 1.18
Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia. Proc Natl Acad Sci U S A (2013) 1.17
TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging. Circ Arrhythm Electrophysiol (2011) 1.17
Calcineurin regulates bone formation by the osteoblast. Proc Natl Acad Sci U S A (2005) 1.16
Estrogen inhibits RANKL-stimulated osteoclastic differentiation of human monocytes through estrogen and RANKL-regulated interaction of estrogen receptor-alpha with BCAR1 and Traf6. Exp Cell Res (2009) 1.15
TSH and bone loss. Ann N Y Acad Sci (2006) 1.12
FSH-receptor isoforms and FSH-dependent gene transcription in human monocytes and osteoclasts. Biochem Biophys Res Commun (2010) 1.12
Expression and function of TNF-family proteins and receptors in human osteoblasts. Bone (2003) 1.12
Mechanisms balancing skeletal matrix synthesis and degradation. Biochem J (2002) 1.12
Physiological loading of joints prevents cartilage degradation through CITED2. FASEB J (2010) 1.12
Induction of a program gene expression during osteoblast differentiation with strontium ranelate. Biochem Biophys Res Commun (2007) 1.11
Follistatin-like protein 1 is a mesenchyme-derived inflammatory protein and may represent a biomarker for systemic-onset juvenile rheumatoid arthritis. Arthritis Rheum (2010) 1.10
The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts. Pflugers Arch (2007) 1.10
Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice. J Cardiovasc Electrophysiol (2005) 1.10
Sudden death in noncoronary heart disease is associated with delayed paced ventricular activation. Circulation (2003) 1.09
Noninvasive prenatal diagnosis of congenital adrenal hyperplasia using cell-free fetal DNA in maternal plasma. J Clin Endocrinol Metab (2014) 1.09
The thyroid-stimulating hormone receptor: impact of thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies on multimerization, cleavage, and signaling. Endocrinol Metab Clin North Am (2009) 1.08
Adenosine A(1) receptors regulate bone resorption in mice: adenosine A(1) receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A(1) receptor-knockout mice. Arthritis Rheum (2010) 1.08
Membrane potential stabilization in amphibian skeletal muscle fibres in hypertonic solutions. J Physiol (2003) 1.08
Osteoclasts are important for bone angiogenesis. Blood (2009) 1.08
Matrix metalloproteinase-1 treatment of muscle fibrosis. Acta Biomater (2008) 1.07
Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol (2012) 1.07
SCN5A and sinoatrial node pacemaker function. Cardiovasc Res (2007) 1.06
Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function. J Bone Miner Res (2006) 1.06
Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6. J Physiol (2003) 1.06
TNF regulates cellular NAD+ metabolism in primary macrophages. Biochem Biophys Res Commun (2006) 1.06
Mapping of reentrant spontaneous polymorphic ventricular tachycardia in a Scn5a+/- mouse model. Am J Physiol Heart Circ Physiol (2011) 1.06
Effects of L-type Ca2+ channel antagonism on ventricular arrhythmogenesis in murine hearts containing a modification in the Scn5a gene modelling human long QT syndrome 3. J Physiol (2006) 1.05
Bone marrow oxytocin mediates the anabolic action of estrogen on the skeleton. J Biol Chem (2012) 1.05
Recent developments in the management of patients at risk for sudden cardiac death. Postgrad Med (2011) 1.04
Gene disruption of the calcium channel Orai1 results in inhibition of osteoclast and osteoblast differentiation and impairs skeletal development. Lab Invest (2012) 1.04
Blocking antibody to the β-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis. Proc Natl Acad Sci U S A (2012) 1.04
Physiological studies of cortical spreading depression. Biol Rev Camb Philos Soc (2006) 1.03
Increased right ventricular repolarization gradients promote arrhythmogenesis in a murine model of Brugada syndrome. J Cardiovasc Electrophysiol (2010) 1.03
Disordered osteoclast formation and function in a CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption. FASEB J (2003) 1.03
Negative regulation of RANKL-induced osteoclastic differentiation in RAW264.7 Cells by estrogen and phytoestrogens. J Biol Chem (2005) 1.02
Calcium and bone disease. Biofactors (2011) 1.02
Osteoclastogenesis, bone resorption, and osteoclast-based therapeutics. J Bone Miner Res (2003) 1.02
Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca(2+) homeostasis. Am J Physiol Heart Circ Physiol (2005) 1.02
Gaucher disease gene GBA functions in immune regulation. Proc Natl Acad Sci U S A (2012) 1.02
Action potential wavelength restitution predicts alternans and arrhythmia in murine Scn5a(+/-) hearts. J Physiol (2013) 1.02
Tenascin cytotactin epidermal growth factor-like repeat binds epidermal growth factor receptor with low affinity. J Cell Physiol (2007) 1.02
Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties. Prog Biophys Mol Biol (2009) 1.02
Atrial fibrillation and bisphosphonate therapy. J Bone Miner Res (2010) 1.02
Osteoclastic differentiation and function regulated by old and new pathways. Rev Endocr Metab Disord (2006) 1.01
Determinants of myocardial conduction velocity: implications for arrhythmogenesis. Front Physiol (2013) 1.01
TNF-induced gene expression oscillates in time. Biochem Biophys Res Commun (2008) 1.01