Published in Pharmacogenet Genomics on June 01, 2010
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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Cohort profile: the study of health in Pomerania. Int J Epidemiol (2010) 4.38
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell (2005) 4.02
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Identification of genetic loci associated with Helicobacter pylori serologic status. JAMA (2013) 3.15
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
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Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
CUBN is a gene locus for albuminuria. J Am Soc Nephrol (2011) 2.70
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Heparin-induced thrombocytopenia and cardiac surgery. Ann Thorac Surg (2003) 2.40
Anucleate platelets generate progeny. Blood (2010) 2.24
Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors. J Neurochem (2011) 2.11
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA (2009) 2.10
Donor exposures in recipients of pooled platelet concentrates. N Engl J Med (2013) 2.01
Glyburide and glimepiride pharmacokinetics in subjects with different CYP2C9 genotypes. Clin Pharmacol Ther (2002) 2.01
CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects. Clin Pharmacol Ther (2004) 1.99
Comment on "A common genetic variant is associated with adult and childhood obesity". Science (2007) 1.93
Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. Pharm Res (2008) 1.93
New approaches to in vitro models of blood-brain barrier drug transport. Drug Discov Today (2003) 1.86
A genome-wide association study of metabolic traits in human urine. Nat Genet (2011) 1.84
A genome-wide association study identifies three loci associated with mean platelet volume. Am J Hum Genet (2008) 1.81
Platelet factor 4 binds to bacteria, [corrected] inducing antibodies cross-reacting with the major antigen in heparin-induced thrombocytopenia. Blood (2010) 1.76
Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics (2002) 1.75
Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. Invest Ophthalmol Vis Sci (2007) 1.73
SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation. J Am Soc Nephrol (2009) 1.70
A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro. J Neurochem (2004) 1.69
Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet (2012) 1.68
Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet (2010) 1.67
The severity of trauma determines the immune response to PF4/heparin and the frequency of heparin-induced thrombocytopenia. Blood (2009) 1.65
Multiple loci are associated with white blood cell phenotypes. PLoS Genet (2011) 1.65
Megakaryocyte impairment by eptifibatide-induced antibodies causes prolonged thrombocytopenia. Blood (2009) 1.64
Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4. Blood (2013) 1.56
Antigen-positive platelet transfusion in neonatal alloimmune thrombocytopenia (NAIT). Blood (2006) 1.54
A new, accurate predictive model for incident hypertension. J Hypertens (2013) 1.53
Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters. Drug Metab Dispos (2010) 1.53
Heparin-induced thrombocytopenia: temporal pattern of thrombocytopenia in relation to initial use or reexposure to heparin. Chest (2002) 1.53
Functional significance of a hereditary adenine insertion variant in the 5'-UTR of the endothelin-1 gene. Pharmacogenetics (2003) 1.51
Protease-activated receptor-2 regulates the innate immune response to viral infection in a coxsackievirus B3-induced myocarditis. J Am Coll Cardiol (2013) 1.50
Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities. Drug Metab Dispos (2011) 1.49
Fc(gamma) receptors IIa on cardiomyocytes and their potential functional relevance in dilated cardiomyopathy. J Am Coll Cardiol (2007) 1.48
Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome. Nat Genet (2011) 1.47
MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier. Brain Pathol (2007) 1.45
Platelet receptor and clotting factor polymorphisms as genetic risk factors for thromboembolic complications in heparin-induced thrombocytopenia. Pharmacogenetics (2003) 1.45
Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD. Blood (2012) 1.45
Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology (2003) 1.44
Myocardial gene expression profiles and cardiodepressant autoantibodies predict response of patients with dilated cardiomyopathy to immunoadsorption therapy. Eur Heart J (2012) 1.44
Heparin-induced thrombocytopenia: further evidence for a unique immune response. Blood (2012) 1.44
Anti-platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux or enoxaparin. Blood (2005) 1.43
Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development. Pharm Res (2007) 1.43
The diagnostic value of the anti-PF4/heparin immunoassay high-dose heparin confirmatory test in cardiac surgery patients. Anesth Analg (2011) 1.42
The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease. Curr Alzheimer Res (2004) 1.42
egc-Encoded superantigens from Staphylococcus aureus are neutralized by human sera much less efficiently than are classical staphylococcal enterotoxins or toxic shock syndrome toxin. Infect Immun (2004) 1.41
Stereoselective disposition of talinolol in man. J Pharm Sci (2002) 1.40
Organic cation transporter 3: expression in failing and nonfailing human heart and functional characterization. J Cardiovasc Pharmacol (2011) 1.39
A variant of the Sebastian platelet syndrome with unique neutrophil inclusions. Platelets (2002) 1.38
Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions. J Cell Physiol (2009) 1.38
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genet (2011) 1.30
MYH9-related platelet disorders. Semin Thromb Hemost (2009) 1.30
Profiling of alterations in platelet proteins during storage of platelet concentrates. Transfusion (2007) 1.30
The temporal profile of the anti-PF4/heparin immune response. Blood (2008) 1.28
Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver. Pharm Res (2006) 1.28
Platelet transfusion in hematology, oncology and surgery. Dtsch Arztebl Int (2014) 1.26
Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol Pharm (2011) 1.25
Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta. J Neurosci (2009) 1.24
The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol. Clin Pharmacol Ther (2002) 1.23
Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation. J Am Coll Cardiol (2010) 1.23
Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of ABCG2 (BCRP). Drug Metab Dispos (2006) 1.22
Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5). Drug Metab Rev (2005) 1.22
Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice. Cancer Res (2009) 1.21
Staphylococcus aureus carriers neutralize superantigens by antibodies specific for their colonizing strain: a potential explanation for their improved prognosis in severe sepsis. J Infect Dis (2006) 1.21
The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells. J Biol Chem (2008) 1.21
Close approximation of two platelet factor 4 tetramers by charge neutralization forms the antigens recognized by HIT antibodies. Arterioscler Thromb Vasc Biol (2006) 1.21