Published in Hum Mol Genet on July 16, 2010
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat Genet (2012) 4.41
A rare variant in MYH6 is associated with high risk of sick sinus syndrome. Nat Genet (2011) 3.94
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55
The Rotterdam Study: 2012 objectives and design update. Eur J Epidemiol (2011) 3.26
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat Genet (2013) 1.86
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet (2013) 1.72
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Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13,372 participants. Heart Rhythm (2012) 1.43
Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals. PLoS Genet (2011) 1.38
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Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nat Genet (2016) 1.22
Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. Circulation (2014) 1.11
Factor structure underlying components of allostatic load. PLoS One (2012) 1.03
Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study. PLoS One (2012) 0.98
A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids. J Lipid Res (2012) 0.97
Genetic locus on mouse chromosome 7 controls elevated heart rate. Physiol Genomics (2012) 0.94
Genetic copy number variants in myocardial infarction patients with hyperlipidemia. BMC Genomics (2011) 0.89
Fear and C-reactive protein cosynergize annual pulse increases in healthy adults. Proc Natl Acad Sci U S A (2014) 0.88
Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart. PLoS One (2014) 0.88
Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. Am J Clin Nutr (2014) 0.88
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Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans. Cardiovasc Res (2012) 0.87
A draft de novo genome assembly for the northern bobwhite (Colinus virginianus) reveals evidence for a rapid decline in effective population size beginning in the Late Pleistocene. PLoS One (2014) 0.87
Detection of pleiotropy through a Phenome-wide association study (PheWAS) of epidemiologic data as part of the Environmental Architecture for Genes Linked to Environment (EAGLE) study. PLoS Genet (2014) 0.87
Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography. Hum Mol Genet (2013) 0.85
Genome-wide compendium and functional assessment of in vivo heart enhancers. Nat Commun (2016) 0.83
The genetics of sudden cardiac death. Annu Rev Genomics Hum Genet (2012) 0.81
A genome-wide association study to identify genomic modulators of rate control therapy in patients with atrial fibrillation. Am J Cardiol (2014) 0.79
The anatomical distribution of genetic associations. Nucleic Acids Res (2015) 0.78
Endophenotype best practices. Int J Psychophysiol (2016) 0.78
Mapping genetic variants associated with beta-adrenergic responses in inbred mice. PLoS One (2012) 0.78
Autonomic dysfunction determines stress-induced cardiovascular and immune complications in mice. J Am Heart Assoc (2015) 0.77
Desaturase and elongase-limiting endogenous long-chain polyunsaturated fatty acid biosynthesis. Curr Opin Clin Nutr Metab Care (2016) 0.77
PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c. Nucleic Acids Res (2016) 0.76
Cumulative effects of common genetic variants on risk of sudden cardiac death. Int J Cardiol Heart Vasc (2015) 0.76
Replication of the Association of the 6q22.31c Locus near GJA1 with Pulse Rate in the Korean Population. Genomics Inform (2012) 0.75
Exploiting population samples to enhance genome-wide association studies of disease. Genetics (2014) 0.75
Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans. Hum Mol Genet (2016) 0.75
Discovery of novel heart rate-associated loci using the Exome Chip. Hum Mol Genet (2017) 0.75
Temporal Reduction in Chronotropic Index Predicts Risk of Cardiovascular Death Among Healthy Middle-Aged Men: a 28-Year Follow-Up Study. J Am Heart Assoc (2016) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature (2009) 33.26
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Practical aspects of imputation-driven meta-analysis of genome-wide association studies. Hum Mol Genet (2008) 13.26
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Control of stress-dependent cardiac growth and gene expression by a microRNA. Science (2007) 12.08
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet (2008) 12.07
Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet Epidemiol (2008) 11.28
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet (2009) 8.42
Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature (1993) 8.20
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet (2009) 7.65
Genomic control, a new approach to genetic-based association studies. Theor Popul Biol (2001) 6.90
The Rotterdam Study: objectives and design update. Eur J Epidemiol (2007) 5.78
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet (2008) 5.23
Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet (2009) 5.20
MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest (2009) 4.39
Resting heart rate in cardiovascular disease. J Am Coll Cardiol (2007) 4.14
Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. Proc Natl Acad Sci U S A (2005) 4.14
Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet (2006) 4.13
Heart rate and cardiovascular mortality: the Framingham Study. Am Heart J (1987) 4.12
Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet (2009) 4.10
Genome-wide association study of PR interval. Nat Genet (2010) 3.73
The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system. Circ Res (2001) 3.68
The Rotterdam Study: 2010 objectives and design update. Eur J Epidemiol (2009) 3.44
High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ Res (2006) 3.42
Several common variants modulate heart rate, PR interval and QRS duration. Nat Genet (2010) 3.34
Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker. Circulation (2009) 2.58
The association of resting heart rate with cardiovascular, cancer and all-cause mortality. Eight year follow-up of 3527 male Israeli employees (the CORDIS Study) Eur Heart J (2000) 2.25
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA (2009) 2.10
Relation of heart rate at rest and long-term (>20 years) death rate in initially healthy middle-aged men. Am J Cardiol (2008) 2.03
Resting heart rate is a risk factor for cardiovascular and noncardiovascular mortality: the Chicago Heart Association Detection Project in Industry. Am J Epidemiol (1999) 2.00
Resting heart rate as a low tech predictor of coronary events in women: prospective cohort study. BMJ (2009) 1.99
Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly. Circulation (2002) 1.91
Mutation in myosin heavy chain 6 causes atrial septal defect. Nat Genet (2005) 1.76
Role of gap junctions in the propagation of the cardiac action potential. Cardiovasc Res (2004) 1.75
Titin mutations as the molecular basis for dilated cardiomyopathy. Biochem Biophys Res Commun (2002) 1.70
Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases. Circ Res (2008) 1.68
Alpha-myosin heavy chain: a sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy. Circulation (2005) 1.67
Heritability of ECG measurements in adult male twins. J Electrocardiol (1998) 1.64
Protein kinase d in the cardiovascular system: emerging roles in health and disease. Circ Res (2008) 1.59
A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. Am J Hum Genet (2002) 1.46
Heritability of heart rate variability: the Framingham Heart Study. Circulation (1999) 1.41
Identification of connexin43 (alpha1) gap junction gene mutations in patients with hypoplastic left heart syndrome by denaturing gradient gel electrophoresis (DGGE). Mutat Res (2001) 1.29
Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. PLoS One (2009) 1.28
Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. J Biol Chem (2006) 1.26
Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement. Eur J Epidemiol (2009) 1.25
Heritability of QT interval: how much is explained by genes for resting heart rate? J Cardiovasc Electrophysiol (2007) 1.25
The SoxD transcription factors--Sox5, Sox6, and Sox13--are key cell fate modulators. Int J Biochem Cell Biol (2009) 1.21
Bivariate genetic modeling of cardiovascular stress reactivity: does stress uncover genetic variance? Psychosom Med (2007) 1.16
Resting heart rate as a predictive risk factor for sudden death in middle-aged men. Cardiovasc Res (2001) 1.15
Cloning and characterization of SOX5, a new member of the human SOX gene family. Genomics (1996) 1.12
Structural basis for Ufm1 processing by UfSP1. J Biol Chem (2008) 1.04
Major quantitative trait locus for resting heart rate maps to a region on chromosome 4. Hypertension (2004) 1.02
Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study. Ann Hum Genet (2006) 1.01
Tissue-specific mRNA expression profiles of human solute carrier 35 transporters. Drug Metab Pharmacokinet (2009) 0.94
Combined effect of resting heart rate and physical activity on ischaemic heart disease: mortality follow-up in a population study (the HUNT study, Norway). J Epidemiol Community Health (2010) 0.94
Arachidonic acid-induced Ca2+ release from isolated sarcoplasmic reticulum. Biochem Pharmacol (1993) 0.91
Differential subunit composition of the G protein-activated inward-rectifier potassium channel during cardiac development. J Clin Invest (2004) 0.90
Relation of heart rate at rest and mortality in the Women's Health and Aging Study. Am J Cardiol (2003) 0.85
Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program. BMC Med Genet (2006) 0.85
Polymorphisms in multiple genes are associated with resting heart rate in a stepwise allele-dependent manner. Heart Rhythm (2008) 0.84
Evidence for a gene influencing heart rate on chromosome 4 among hypertensives. Hum Genet (2002) 0.84
Cloning, tissue distribution, and functional expression of the human G protein beta 4-subunit. Physiol Genomics (2002) 0.83
The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction. FEBS Lett (2003) 0.81
Genome-wide scan to identify quantitative trait loci for baseline resting heart rate and its response to endurance exercise training: the HERITAGE Family Study. Int J Sports Med (2006) 0.78
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
Multi-Ethnic Study of Atherosclerosis: objectives and design. Am J Epidemiol (2002) 35.63
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Structure validation by Calpha geometry: phi,psi and Cbeta deviation. Proteins (2003) 32.38
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49
Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet (2010) 26.48
Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet (2012) 25.96
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med (2006) 23.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet (2008) 19.55
Heart disease and stroke statistics--2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation (2006) 19.43
Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation (2010) 19.30
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med (2008) 18.34
GenABEL: an R library for genome-wide association analysis. Bioinformatics (2007) 18.10
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89