Published in Science on January 12, 2007
On the replication of genetic associations: timing can be everything! Am J Hum Genet (2008) 3.32
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Hum Mol Genet (2008) 3.24
The genetic contribution to non-syndromic human obesity. Nat Rev Genet (2009) 2.70
Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. PLoS One (2008) 2.67
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet (2007) 2.35
The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. Obesity (Silver Spring) (2009) 2.34
Association of the FTO gene with BMI. Obesity (Silver Spring) (2008) 1.79
From monogenic to polygenic obesity: recent advances. Eur Child Adolesc Psychiatry (2010) 1.49
Multilocus lod scores in large pedigrees: combination of exact and approximate calculations. Hum Hered (2007) 1.46
Recent progress in the genetics of common obesity. Br J Clin Pharmacol (2009) 1.40
Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program. Diabetologia (2008) 1.27
Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort. Diabetes (2008) 1.26
The genetics of human obesity. Ann N Y Acad Sci (2013) 1.22
Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry. Obesity (Silver Spring) (2009) 1.19
Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design? PLoS Genet (2009) 1.18
Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes. PLoS One (2008) 1.17
Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing. Pharmacogenomics (2007) 1.12
Genomics and genome-wide association studies: an integrative approach to expression QTL mapping. Genomics (2008) 1.04
Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample. BMC Med Genet (2007) 0.98
Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS). BMC Med Genet (2010) 0.96
Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children. BMC Med Genet (2013) 0.96
INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men. BMC Med Genet (2008) 0.94
INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study. Obesity (Silver Spring) (2009) 0.89
The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts. BMC Med Genet (2009) 0.87
Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry. BMC Med Genet (2009) 0.86
Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age. Metabolism (2009) 0.84
A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans. BMC Med Genet (2009) 0.83
Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R. Eur J Hum Genet (2014) 0.82
Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations. BMC Med Genet (2009) 0.80
Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes. BMC Med Genet (2009) 0.80
The Genetics of Pediatric Obesity. Trends Endocrinol Metab (2015) 0.78
Genetic association study with metabolic syndrome and metabolic-related traits in a cross-sectional sample and a 10-year longitudinal sample of chinese elderly population. PLoS One (2014) 0.77
Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity. Hum Genet (2015) 0.77
Association of INSIG2 polymorphism with overweight and LDL in children. PLoS One (2015) 0.76
The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk. BMC Cancer (2010) 0.75
INSIG2 is Associated with Lower Gain in Weight-for-Length Between Birth and Age 6 Months. Clin Med Pediatr (2009) 0.75
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet (2008) 6.97
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet (2008) 6.75
A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry (2012) 6.34
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genet (2008) 6.26
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. Nat Genet (2008) 4.67
Cohort profile: the study of health in Pomerania. Int J Epidemiol (2010) 4.38
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet (2012) 3.73
Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet (2012) 3.71
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet (2010) 3.21
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
Identification of genetic loci associated with Helicobacter pylori serologic status. JAMA (2013) 3.15
The predictive value of different measures of obesity for incident cardiovascular events and mortality. J Clin Endocrinol Metab (2010) 3.12
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease. Nat Genet (2007) 2.75
CUBN is a gene locus for albuminuria. J Am Soc Nephrol (2011) 2.70
TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. Science (2012) 2.66
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature (2011) 2.59
Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genet (2010) 2.24
Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch Intern Med (2012) 2.24
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet (2012) 2.12
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA (2009) 2.10
Glyburide and glimepiride pharmacokinetics in subjects with different CYP2C9 genotypes. Clin Pharmacol Ther (2002) 2.01
Hepatitis B and C virus infection and the risk of atherosclerosis in a general population. Atherosclerosis (2004) 2.01
CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects. Clin Pharmacol Ther (2004) 1.99
Genome-wide association study reveals three susceptibility loci for common migraine in the general population. Nat Genet (2011) 1.98
Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels. Hepatology (2009) 1.97
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet (2011) 1.92
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav (2014) 1.90
Low serum testosterone levels are associated with increased risk of mortality in a population-based cohort of men aged 20-79. Eur Heart J (2010) 1.88
A genome-wide association study of metabolic traits in human urine. Nat Genet (2011) 1.84
A genome-wide association study identifies three loci associated with mean platelet volume. Am J Hum Genet (2008) 1.81
Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Prog Neuropsychopharmacol Biol Psychiatry (2009) 1.77
Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics (2002) 1.75
Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet (2012) 1.68
Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet (2010) 1.67
Multiple loci are associated with white blood cell phenotypes. PLoS Genet (2011) 1.65
Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians. Hepatology (2010) 1.65
The impact of tooth loss on general health related to quality of life among elderly Pomeranians: results from the study of health in Pomerania (SHIP-O). Int J Prosthodont (2005) 1.63
Inverse association between serum free thyroxine levels and hepatic steatosis: results from the Study of Health in Pomerania. Thyroid (2012) 1.62
Regional disparities of hypertension prevalence and management within Germany. J Hypertens (2006) 1.60
Trauma, posttraumatic stress disorder, and physical illness: findings from the general population. Psychosom Med (2009) 1.58
The association of tooth loss with all-cause and circulatory mortality. Is there a benefit of replaced teeth? A systematic review and meta-analysis. Clin Oral Investig (2011) 1.55
Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters. Drug Metab Dispos (2010) 1.53
A new, accurate predictive model for incident hypertension. J Hypertens (2013) 1.53
Gender differences in the relationship between periodontal disease, tooth loss, and atherosclerosis. Stroke (2004) 1.53
Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus. Hepatology (2013) 1.53
Relation of parity with common carotid intima-media thickness among women of the Study of Health in Pomerania. Stroke (2005) 1.52
Cumulative impact of common genetic variants and other risk factors on colorectal cancer risk in 42,103 individuals. Gut (2012) 1.52
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS Genet (2012) 1.52
Fracture Risk and Risk Factors for Osteoporosis. Dtsch Arztebl Int (2015) 1.51
The association between fatty liver disease and blood pressure in a population-based prospective longitudinal study. J Hypertens (2010) 1.51
Functional significance of a hereditary adenine insertion variant in the 5'-UTR of the endothelin-1 gene. Pharmacogenetics (2003) 1.51
Protease-activated receptor-2 regulates the innate immune response to viral infection in a coxsackievirus B3-induced myocarditis. J Am Coll Cardiol (2013) 1.50
Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence. Digestion (2005) 1.46
MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier. Brain Pathol (2007) 1.45
Low testosterone concentrations in men contribute to the gender gap in cardiovascular morbidity and mortality. Gend Med (2012) 1.45
The influence of dynamic occlusal interferences on probing depth and attachment level: results of the Study of Health in Pomerania (SHIP). J Periodontol (2006) 1.45
Candidate genetic markers and the risk of restenosis after coronary angioplasty. Clin Sci (Lond) (2004) 1.45
Genetic determinants of serum testosterone concentrations in men. PLoS Genet (2011) 1.45
Myocardial gene expression profiles and cardiodepressant autoantibodies predict response of patients with dilated cardiomyopathy to immunoadsorption therapy. Eur Heart J (2012) 1.44
Inverse association between periodontitis and respiratory allergies in patients with type 1 diabetes mellitus. J Clin Periodontol (2008) 1.43
Urinary albumin excretion, even within the normal range, predicts an increase in left ventricular mass over the following 5 years. Kidney Int (2010) 1.42
The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease. Curr Alzheimer Res (2004) 1.42
The prevalence of undiagnosed thyroid disorders in a previously iodine-deficient area. Thyroid (2003) 1.41
Treatment of erythropoietin-induced pure red cell aplasia: a retrospective study. Lancet (2004) 1.41