Published in Expert Rev Clin Immunol on March 01, 2010
C1-inhibitor in Allergic ASThma Patients (CAST) | NCT03051698
Complement: a key system for immune surveillance and homeostasis. Nat Immunol (2010) 10.37
Complement in immune and inflammatory disorders: pathophysiological mechanisms. J Immunol (2013) 2.10
Complement, a target for therapy in inflammatory and degenerative diseases. Nat Rev Drug Discov (2015) 1.16
A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci. PLoS One (2012) 0.92
Induced sputum proteome in healthy subjects and asthmatic patients. J Allergy Clin Immunol (2011) 0.90
Clinical presentation, pathogenesis, diagnosis, and treatment of epidermolysis bullosa acquisita. ISRN Dermatol (2013) 0.88
Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage. Front Immunol (2015) 0.83
Complement components as potential therapeutic targets for asthma treatment. Respir Med (2014) 0.79
Properdin Contributes to Allergic Airway Inflammation through Local C3a Generation. J Immunol (2015) 0.79
Treatment with the C5a receptor/CD88 antagonist PMX205 reduces inflammation in a murine model of allergic asthma. Int Immunopharmacol (2014) 0.78
Impaired Cell Cycle Regulation in a Natural Equine Model of Asthma. PLoS One (2015) 0.78
Complement system in lung disease. Am J Respir Cell Mol Biol (2014) 0.78
Dysregulation of complement system and CD4+ T cell activation pathways implicated in allergic response. PLoS One (2013) 0.77
Complement activation and expression during chronic relapsing experimental autoimmune encephalomyelitis in the Biozzi ABH mouse. Clin Exp Immunol (2015) 0.76
Microglia-Induced Maladaptive Plasticity Can Be Modulated by Neuropeptides In Vivo. Neural Plast (2015) 0.75
Invariant Natural Killer T Cells Play a Role in Chemotaxis, Complement Activation and Mucus Production in a Mouse Model of Airway Hyperreactivity and Inflammation. PLoS One (2015) 0.75
New twist on an ancient innate immune pathway. Immunity (2013) 0.75
Complement mediators: key regulators of airway tissue remodeling in asthma. J Transl Med (2015) 0.75
Cytokine Responses to Specific Immunotherapy in House Dust Mite-Induced Allergic Rhinitis Patients. Inflammation (2015) 0.75
Effect of Processing Intensity on Immunologically Active Bovine Milk Serum Proteins. Nutrients (2017) 0.75
PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol (2008) 19.24
Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol (1999) 5.51
Role of C5a in inflammatory responses. Annu Rev Immunol (2005) 4.38
In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med (2005) 4.34
Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med (2004) 4.34
Asthma: an epidemic of dysregulated immunity. Nat Immunol (2002) 4.00
Interleukin-13 in asthma pathogenesis. Immunol Rev (2004) 3.69
Complement-targeted therapeutics. Nat Biotechnol (2007) 3.24
Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nat Rev Immunol (2008) 3.17
A genome-wide search for asthma susceptibility loci in ethnically diverse populations. The Collaborative Study on the Genetics of Asthma (CSGA). Nat Genet (1997) 3.08
CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. J Exp Med (2005) 3.03
The role of the anaphylatoxins in health and disease. Mol Immunol (2009) 2.95
Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma. Hum Mol Genet (1998) 2.57
A role for the C3a anaphylatoxin receptor in the effector phase of asthma. Nature (2000) 2.24
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. J Clin Invest (2006) 2.15
Genetics of asthma and hay fever in Australian twins. Am Rev Respir Dis (1990) 2.12
Pharmacological targeting of anaphylatoxin receptors during the effector phase of allergic asthma suppresses airway hyperresponsiveness and airway inflammation. J Immunol (2005) 1.94
Peanuts can contribute to anaphylactic shock by activating complement. J Allergy Clin Immunol (2009) 1.84
B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism. J Immunol (2004) 1.61
Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. J Immunol (2001) 1.47
Time to draw breath: asthma-susceptibility genes are identified. Nat Rev Genet (2004) 1.44
Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy. J Immunol (2002) 1.40
Complement and Toll-like receptors: key regulators of adaptive immune responses. Mol Immunol (2006) 1.40
Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible mice. PLoS One (2008) 1.38
Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction. Blood (2007) 1.37
The role of complement in danger sensing and transmission. Immunol Res (2006) 1.36
The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma. Mol Immunol (2004) 1.35
Complement factors C3a and C5a are increased in bronchoalveolar lavage fluid after segmental allergen provocation in subjects with asthma. Am J Respir Crit Care Med (2001) 1.34
Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation. Blood (2008) 1.33
Complement factor 3 mediates particulate matter-induced airway hyperresponsiveness. Am J Respir Cell Mol Biol (2002) 1.32
Cutting edge: the absence of C3 demonstrates a role for complement in Th2 effector functions in a murine model of pulmonary allergy. J Immunol (2001) 1.27
Drug evaluation: the C5a receptor antagonist PMX-53. Curr Opin Mol Ther (2006) 1.26
Factors influencing the prevalence of asthma among first degree relatives of extrinsic and intrinsic asthmatics. Thorax (1979) 1.22
A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells. J Immunol (2009) 1.19
Importance of genetic factors in adolescent asthma: a population-based twin-family study. Am J Respir Crit Care Med (1998) 1.18
Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. Hum Genet (2004) 1.17
Properdin: New roles in pattern recognition and target clearance. Mol Immunol (2008) 1.16
Activation of human mast cells by aggregated IgG through FcgammaRI: additive effects of C3a. Clin Immunol (2004) 1.15
Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response. J Clin Invest (2005) 1.15
Complement regulates inhalation tolerance at the dendritic cell/T cell interface. Mol Immunol (2006) 1.14
A protective role for the fifth complement component (c5) in allergic airway disease. Am J Respir Crit Care Med (2006) 1.09
Generation of anaphylatoxins through proteolytic processing of C3 and C5 by house dust mite protease. J Allergy Clin Immunol (1997) 1.08
Development of murine allergic asthma is dependent upon B7-2 costimulation. J Immunol (1998) 1.08
Complement activation by cigarette smoke. Am J Physiol (1991) 1.08
Contribution of anaphylatoxin C5a to late airway responses after repeated exposure of antigen to allergic rats. J Immunol (2001) 1.03
Complement activation is critical to airway hyperresponsiveness after acute ozone exposure. Am J Respir Crit Care Med (2003) 1.03
The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen. J Clin Invest (2004) 1.03
Complement factors c3a, c4a, and c5a in chronic obstructive pulmonary disease and asthma. Am J Respir Cell Mol Biol (2004) 1.02
The C3a receptor antagonist SB 290157 has agonist activity. Immunol Lett (2005) 1.01
Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophils. J Immunol (2000) 1.00
Evidence for genetic associations between asthma, atopy, and bronchial hyperresponsiveness: a study of 8- to 18-yr-old twins. Am J Respir Crit Care Med (2000) 0.98
C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression. J Virol (2006) 0.96
Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families. Genes Immun (2006) 0.96
Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice. J Immunol (2009) 0.94
Inhibition of complement activation decreases airway inflammation and hyperresponsiveness. Am J Respir Crit Care Med (2003) 0.94
Complexities of the genetics of asthma. Am J Respir Crit Care Med (1997) 0.93
Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice. Respir Res (2006) 0.92
New insights into the role of the complement pathway in allergy and asthma. Curr Allergy Asthma Rep (2005) 0.91
Activation of human serum complement with allergens. I. Generation of C3a, C4a, and C5a and induction of human neutrophil aggregation. J Allergy Clin Immunol (1987) 0.90
Role of dendritic cell synthesis of complement in the allospecific T cell response. Mol Immunol (2006) 0.90
Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a. J Immunol (1999) 0.88
IL-4 down-regulates anaphylatoxin receptors in monocytes and dendritic cells and impairs anaphylatoxin-induced migration in vivo. J Immunol (2003) 0.87
Complement activation by diesel exhaust particles (DEP). Biol Pharm Bull (1998) 0.83
Genetic association study between mbl2 and asthma phenotypes in Chinese children. Pediatr Allergy Immunol (2006) 0.82
Complement activation by house dust: reduced reactivity of serum complement in patients with bronchial asthma. Int Arch Allergy Appl Immunol (1991) 0.81
Mannose binding lectin gene polymorphisms and asthma. Clin Exp Allergy (2007) 0.81
Contribution of anaphylatoxins to allergic inflammation in human lungs. Microbiol Immunol (2005) 0.78
Functional roles for C5a receptors in sepsis. Nat Med (2008) 3.33
CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. J Exp Med (2005) 3.03
The role of the anaphylatoxins in health and disease. Mol Immunol (2009) 2.95
Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation. Blood (2002) 2.62
C5a negatively regulates toll-like receptor 4-induced immune responses. Immunity (2005) 2.24
Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet (2005) 2.20
Staphylococcal complement evasion by various convertase-blocking molecules. J Exp Med (2007) 2.03
The CD46-Jagged1 interaction is critical for human TH1 immunity. Nat Immunol (2012) 1.97
An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD). Hum Mol Genet (2010) 1.95
Pharmacological targeting of anaphylatoxin receptors during the effector phase of allergic asthma suppresses airway hyperresponsiveness and airway inflammation. J Immunol (2005) 1.94
Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1. Nat Med (2012) 1.93
Peanuts can contribute to anaphylactic shock by activating complement. J Allergy Clin Immunol (2009) 1.84
Complement factor C5a mediates renal ischemia-reperfusion injury independent from neutrophils. J Immunol (2003) 1.71
Complement drives Th17 cell differentiation and triggers autoimmune arthritis. J Exp Med (2010) 1.62
C5a initiates the inflammatory cascade in immune complex peritonitis. J Immunol (2004) 1.57
Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. J Immunol (2005) 1.45
Complement and Toll-like receptors: key regulators of adaptive immune responses. Mol Immunol (2006) 1.40
The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma. Mol Immunol (2004) 1.35
C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. Eur J Immunol (2010) 1.34
Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE. J Clin Invest (2014) 1.24
C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism. J Biol Chem (2003) 1.22
A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells. J Immunol (2009) 1.19
C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation. Blood (2013) 1.18
A critical role for C5L2 in the pathogenesis of experimental allergic asthma. J Immunol (2010) 1.16
Phagocytosis of apoptotic cells by neutrophil granulocytes: diminished proinflammatory neutrophil functions in the presence of apoptotic cells. J Immunol (2009) 1.15
Regulation of human neutrophil Fcγ receptor IIa by C5a receptor promotes inflammatory arthritis in mice. Arthritis Rheum (2011) 1.09
Tolerance induction with T cell-dependent protein antigens induces regulatory sialylated IgGs. J Allergy Clin Immunol (2012) 1.06
T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies. J Clin Invest (2013) 1.06
MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice. J Exp Med (2011) 1.06
Functional basis for complement evasion by staphylococcal superantigen-like 7. Cell Microbiol (2010) 1.04
TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2. Eur J Immunol (2011) 1.00
Opposing regulatory roles of complement factor 5 in the development of bleomycin-induced pulmonary fibrosis. J Immunol (2005) 0.99
The immunoglobulin, IgG Fc receptor and complement triangle in autoimmune diseases. Immunobiology (2012) 0.98
Emerging treatments for pemphigoid diseases. Trends Mol Med (2013) 0.94
Genetic identification and functional validation of FcγRIV as key molecule in autoantibody-induced tissue injury. J Pathol (2012) 0.91
Impaired dendritic cell differentiation and maturation in the absence of C3. Mol Immunol (2007) 0.90
Sleep and circadian rhythm regulate circulating complement factors and immunoregulatory properties of C5a. Brain Behav Immun (2011) 0.90
Novel roles for complement receptors in T cell regulation and beyond. Mol Immunol (2013) 0.89
C5a receptor-dependent cell activation by physiological concentrations of desarginated C5a: insights from a novel label-free cellular assay. J Immunol (2012) 0.89
Staphylococcus aureus formyl peptide receptor-like 1 inhibitor (FLIPr) and its homologue FLIPr-like are potent FcγR antagonists that inhibit IgG-mediated effector functions. J Immunol (2013) 0.88
Anaphylatoxins coordinate innate and adaptive immune responses in allergic asthma. Semin Immunol (2013) 0.87
IL-4 down-regulates anaphylatoxin receptors in monocytes and dendritic cells and impairs anaphylatoxin-induced migration in vivo. J Immunol (2003) 0.87
C5a regulates NKT and NK cell functions in sepsis. J Immunol (2011) 0.87
B cells, dendritic cells, and macrophages are required to induce an autoreactive CD4 helper T cell response in experimental epidermolysis bullosa acquisita. J Immunol (2013) 0.86
Truncated and full-length thioredoxin-1 have opposing activating and inhibitory properties for human complement with relevance to endothelial surfaces. J Immunol (2012) 0.82
Structure-function studies of the C3a-receptor: C-terminal serine and threonine residues which influence receptor internalization and signaling. Eur J Immunol (2003) 0.81
The role of complement in the diagnosis and management of allergic rhinitis and allergic asthma. Curr Allergy Asthma Rep (2011) 0.81
Gc-globulin concentrations and C5 haplotype-tagging polymorphisms contribute to variations in serum activity of complement factor C5. Clin Biochem (2007) 0.81
The complement receptor CD46 tips the scales in T(H)1 self-control. Nat Immunol (2010) 0.78
A complement a day keeps the Fox(p3) away. Nat Immunol (2013) 0.77
Functional analysis of C5a effector responses in vitro and in vivo. Methods Mol Biol (2014) 0.75
Erratum: IgG1 protects against renal disease in a mouse model of cryoglobulinaemia. Nature (2015) 0.75