Published in J Exp Med on May 10, 2010
Complement: a key system for immune surveillance and homeostasis. Nat Immunol (2010) 10.37
Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1. Nat Med (2012) 1.93
Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells. Nat Immunol (2012) 1.74
Hypomethylation of the IL17RC promoter associates with age-related macular degeneration. Cell Rep (2012) 1.28
Overview of complement activation and regulation. Semin Nephrol (2013) 1.26
Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis. FASEB J (2011) 1.19
Regulation and function of innate and adaptive interleukin-17-producing cells. EMBO Rep (2012) 1.14
Differential role of the interleukin-17 axis and neutrophils in resolution of inhalational anthrax. Infect Immun (2011) 1.07
Relative contributions of dectin-1 and complement to immune responses to particulate β-glucans. J Immunol (2012) 1.07
MyD88-dependent production of IL-17F is modulated by the anaphylatoxin C5a via the Akt signaling pathway. FASEB J (2011) 1.01
Opposing roles for complement component C5a in tumor progression and the tumor microenvironment. J Immunol (2012) 0.98
Complement regulation of T cell immunity. Immunol Res (2012) 0.95
Pivotal roles of GM-CSF in autoimmunity and inflammation. Mediators Inflamm (2015) 0.93
Functional roles for C5a and C5aR but not C5L2 in the pathogenesis of human and experimental cerebral malaria. Infect Immun (2013) 0.93
Abrogated RANKL expression in properdin-deficient mice is associated with better outcome from collagen-antibody-induced arthritis. Arthritis Res Ther (2012) 0.92
Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice. Proc Natl Acad Sci U S A (2014) 0.92
A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci. PLoS One (2012) 0.92
Inflammation and bone destruction in arthritis: synergistic activity of immune and mesenchymal cells in joints. Front Immunol (2012) 0.91
Inflammatory cytokines in eyes with uveal melanoma and relation with macrophage infiltration. Invest Ophthalmol Vis Sci (2010) 0.91
Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells. PLoS One (2014) 0.85
The "ins and outs" of complement-driven immune responses. Immunol Rev (2016) 0.84
Periodontitis and Porphyromonas gingivalis in preclinical stage of arthritis patients. PLoS One (2015) 0.83
Regulatory effects of C5a on IL-17A, IL-17F, and IL-23. Front Immunol (2013) 0.82
Bone formation and resorption are both increased in experimental autoimmune arthritis. PLoS One (2012) 0.81
Complement regulation of T-cell alloimmunity. Semin Nephrol (2013) 0.81
Reduced graft-versus-host disease in C3-deficient mice is associated with decreased donor Th1/Th17 differentiation. Biol Blood Marrow Transplant (2012) 0.81
Induction of M2-like macrophages in recipient NOD-scid mice by allogeneic donor CD4(+)CD25(+) regulatory T cells. Cell Mol Immunol (2012) 0.81
Genetics of SLE: functional relevance for monocytes/macrophages in disease. Clin Dev Immunol (2012) 0.81
Applications of polymeric adjuvants in studying autoimmune responses and vaccination against infectious diseases. J R Soc Interface (2013) 0.81
Strong viremia control in vaccinated macaques does not prevent gradual Th17 cell loss from central memory. Vaccine (2011) 0.81
SKG arthritis as a model for evaluating therapies in rheumatoid arthritis with special focus on bone changes. Rheumatol Int (2012) 0.80
Negative regulation of pulmonary Th17 responses by C3a anaphylatoxin during allergic inflammation in mice. PLoS One (2012) 0.80
Complement anaphylatoxins as immune regulators in cancer. Cancer Med (2014) 0.79
T cell activation by terminal complex of complement and immune complexes. J Biol Chem (2011) 0.79
A sweet spot to control complement-induced inflammation. Nat Med (2012) 0.79
Complement modulation of T cell immune responses during homeostasis and disease. J Leukoc Biol (2014) 0.79
Complement regulates conventional DC-mediated NK-cell activation by inducing TGF-β1 in Gr-1+ myeloid cells. Eur J Immunol (2012) 0.79
The complement receptor CD46 tips the scales in T(H)1 self-control. Nat Immunol (2010) 0.78
Complement regulation of T-cell alloimmunity. Curr Opin Organ Transplant (2011) 0.78
Rapid-onset clinical and mechanistic effects of anti-C5aR treatment in the mouse collagen-induced arthritis model. Clin Exp Immunol (2014) 0.77
Systemic but no local effects of combined zoledronate and parathyroid hormone treatment in experimental autoimmune arthritis. PLoS One (2014) 0.77
Autoantibody-mediated arthritis in the absence of C3 and activating Fcγ receptors: C5 is activated by the coagulation cascade. Arthritis Res Ther (2012) 0.77
Endogenous opioid inhibition of proliferation of T and B cell subpopulations in response to immunization for experimental autoimmune encephalomyelitis. BMC Immunol (2015) 0.76
Expression of IL-27, Th1 and Th17 in patients with aplastic anemia. J Clin Immunol (2012) 0.76
CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis. Nat Commun (2015) 0.75
Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice. J Immunol (2016) 0.75
Phase 1b randomized, double-blind study of namilumab, an anti-granulocyte macrophage colony-stimulating factor monoclonal antibody, in mild-to-moderate rheumatoid arthritis. Arthritis Res Ther (2017) 0.75
The effect of Tlr4 and/or C3 deficiency and of neonatal gene therapy on skeletal disease in mucopolysaccharidosis VII mice. Mol Genet Metab (2014) 0.75
Investigation of the relationship between the onset of arthritis and uveitis in genetically predisposed SKG mice. Arthritis Res Ther (2015) 0.75
Th17 in Animal Models of Rheumatoid Arthritis. J Clin Med (2017) 0.75
The C5a/C5aR1 axis controls the development of experimental allergic asthma independent of LysM-expressing pulmonary immune cells. PLoS One (2017) 0.75
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol (2005) 30.22
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity (2006) 29.29
IL-17 and Th17 Cells. Annu Rev Immunol (2009) 23.02
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. N Engl J Med (2007) 12.24
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med (2007) 9.80
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol (2007) 8.92
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet (2005) 6.48
Role of C5a in inflammatory responses. Annu Rev Immunol (2005) 4.38
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature (2003) 4.22
The C5a chemoattractant receptor mediates mucosal defence to infection. Nature (1996) 3.73
Myeloid C-type lectins in innate immunity. Nat Immunol (2006) 3.41
Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity (2008) 3.36
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med (2007) 3.29
How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat Immunol (2002) 3.20
Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor. Science (1986) 2.84
A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med (2005) 2.80
Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood (2007) 2.72
Evolution of the lectin-complement pathway and its role in innate immunity. Nat Rev Immunol (2002) 2.51
C5a negatively regulates toll-like receptor 4-induced immune responses. Immunity (2005) 2.24
GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival. J Exp Med (2008) 1.99
Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice. J Exp Med (1996) 1.83
A crucial role for macrophages in the pathology of K/B x N serum-induced arthritis. Eur J Immunol (2005) 1.65
Structural insights into the innate immune recognition specificities of L- and H-ficolins. EMBO J (2007) 1.53
Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway. J Immunol (2008) 1.50
IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production. J Immunol (2008) 1.45
C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. Eur J Immunol (2010) 1.34
Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathway. J Immunol (2006) 1.10
Mast cell-expressed complement receptor, not TLR2, is the main detector of zymosan in peritonitis. Eur J Immunol (2007) 1.03
Mannan derivatives induce phenotypic and functional maturation of mouse dendritic cells. Immunology (2006) 1.03
A role for complement in feedback enhancement of antibody responses by IgG3. J Exp Med (2003) 0.92
Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 40.32
Regulatory T cells and immune tolerance. Cell (2008) 18.77
CTLA-4 control over Foxp3+ regulatory T cell function. Science (2008) 12.67
Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev (2006) 10.24
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature (2008) 10.15
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol (2002) 9.18
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity (2009) 9.01
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med (2005) 7.87
Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol (2012) 7.39
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature (2013) 6.77
Regulatory T cells in transplantation tolerance. Nat Rev Immunol (2003) 6.42
A promoter-level mammalian expression atlas. Nature (2014) 6.25
Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity (2009) 6.05
A role for Dicer in immune regulation. J Exp Med (2006) 5.81
Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med (2007) 5.58
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature (2007) 5.14
Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol (2009) 4.90
Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells. J Exp Med (2004) 4.77
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int Immunol (2004) 4.59
Regulatory T cells in tumor immunity. Int J Cancer (2010) 4.53
A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details. Mod Rheumatol (2011) 4.26
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature (2003) 4.22
Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J Immunol (2005) 3.95
Regulatory T cells: how do they suppress immune responses? Int Immunol (2009) 3.58
Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. J Exp Med (2008) 3.50
Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc Natl Acad Sci U S A (2008) 3.40
Natural regulatory T cells: mechanisms of suppression. Trends Mol Med (2007) 3.37
Functional roles for C5a receptors in sepsis. Nat Med (2008) 3.33
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med (2007) 3.29
Functional impairment of CD8(+) T cells by regulatory T cells during persistent retroviral infection. Immunity (2004) 3.10
CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. J Exp Med (2005) 3.03
The role of the anaphylatoxins in health and disease. Mol Immunol (2009) 2.95
Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis. Int Immunol (2006) 2.93
CD4+ Tregs and immune control. J Clin Invest (2004) 2.85
A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med (2005) 2.80
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity (2012) 2.78
An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol (2011) 2.69
Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model. Arthritis Rheum (2009) 2.64
Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation. Blood (2002) 2.62
Development and maintenance of regulatory T cells. Immunity (2013) 2.61
Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood (2005) 2.60
Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity (2007) 2.57
Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum. Mol Pharmacol (2002) 2.57
Etanercept-induced anti-Jo-1-antibody-positive polymyositis in a patient with rheumatoid arthritis: a case report and review of the literature. Clin Rheumatol (2010) 2.53
Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J Exp Med (2005) 2.51
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans. Proc Natl Acad Sci U S A (2013) 2.47
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. Nat Genet (2010) 2.34
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genet (2012) 2.31
Control of autoimmunity by naturally arising regulatory CD4+ T cells. Adv Immunol (2003) 2.28
Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthritis Res Ther (2010) 2.25
C5a negatively regulates toll-like receptor 4-induced immune responses. Immunity (2005) 2.24
Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet (2005) 2.20
Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J Clin Invest (2004) 2.16
Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol (2013) 2.13
IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells. Int Immunol (2004) 2.11
Autoantibodies to a 140-kd polypeptide, CADM-140, in Japanese patients with clinically amyopathic dermatomyositis. Arthritis Rheum (2005) 2.11
Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells. Immunity (2009) 2.05
Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells. Int Immunol (2004) 2.04
Staphylococcal complement evasion by various convertase-blocking molecules. J Exp Med (2007) 2.03
The CD46-Jagged1 interaction is critical for human TH1 immunity. Nat Immunol (2012) 1.97
An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD). Hum Mol Genet (2010) 1.95
Pharmacological targeting of anaphylatoxin receptors during the effector phase of allergic asthma suppresses airway hyperresponsiveness and airway inflammation. J Immunol (2005) 1.94
Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1. Nat Med (2012) 1.93
NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. J Immunol (2004) 1.92
Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J Immunol (2005) 1.88
Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells. J Immunol (2004) 1.86
Regulatory T cells, derived from naïve CD4+CD25- T cells by in vitro Foxp3 gene transfer, can induce transplantation tolerance. Transplantation (2005) 1.86
Foxp3: a critical regulator of the development and function of regulatory T cells. Microbes Infect (2004) 1.85
Long-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C. J Gastroenterol (2007) 1.85
Peanuts can contribute to anaphylactic shock by activating complement. J Allergy Clin Immunol (2009) 1.84
CD25+CD4+ T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene. Exp Hematol (2004) 1.84