Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity.

PubWeight™: 1.50‹?› | Rank: Top 4%

🔗 View Article (PMID 20404009)

Published in J Pharmacol Exp Ther on April 19, 2010

Authors

Tadashi Ishibashi1, Tomoko Horisawa, Kumiko Tokuda, Takeo Ishiyama, Masaaki Ogasa, Rie Tagashira, Kenji Matsumoto, Hiroyuki Nishikawa, Yoko Ueda, Satoko Toma, Hitomi Oki, Norihiko Tanno, Ikutaro Saji, Akira Ito, Yukihiro Ohno, Mitsutaka Nakamura

Author Affiliations

1: Pharmacology Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., Suita, Osaka, Japan.

Articles citing this

Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model. Drug Test Anal (2012) 1.13

Lurasidone in the treatment of schizophrenia: a 6-week, placebo-controlled study. Psychopharmacology (Berl) (2012) 1.10

The role of serotonin in the NMDA receptor antagonist models of psychosis and cognitive impairment. Psychopharmacology (Berl) (2011) 1.09

Comparative pharmacology of antipsychotics possessing combined dopamine D2 and serotonin 5-HT1A receptor properties. Psychopharmacology (Berl) (2011) 1.00

Effects of the selective 5-HT7 receptor antagonist SB-269970 and amisulpride on ketamine-induced schizophrenia-like deficits in rats. PLoS One (2013) 0.91

Clinical potential of lurasidone in the management of schizophrenia. Ther Clin Risk Manag (2011) 0.90

Critical appraisal of lurasidone in the management of schizophrenia. Neuropsychiatr Dis Treat (2012) 0.90

Lurasidone for the treatment of bipolar depression: an evidence-based review. Neuropsychiatr Dis Treat (2015) 0.85

The serotonin receptor 7 and the structural plasticity of brain circuits. Front Behav Neurosci (2014) 0.84

The role of 5-HT1A receptors in phencyclidine (PCP)-induced novel object recognition (NOR) deficit in rats. Psychopharmacology (Berl) (2012) 0.84

Weight change during long-term treatment with lurasidone: pooled analysis of studies in patients with schizophrenia. Int Clin Psychopharmacol (2015) 0.83

In Vitro and In Vivo Characterization of the Alkaloid Nuciferine. PLoS One (2016) 0.82

Lurasidone as a potential therapy for bipolar disorder. Neuropsychiatr Dis Treat (2013) 0.82

The novel antipsychotic drug lurasidone enhances N-methyl-D-aspartate receptor-mediated synaptic responses. Mol Pharmacol (2011) 0.82

5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders. Front Cell Neurosci (2014) 0.82

A double-blind, placebo-controlled, randomized withdrawal study of lurasidone for the maintenance of efficacy in patients with schizophrenia. J Psychopharmacol (2015) 0.81

Evaluation of dopamine D₂/D₃ and serotonin 5-HT₂A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography. Psychopharmacology (Berl) (2012) 0.80

Treating comorbid anxiety and depression: Psychosocial and pharmacological approaches. World J Psychiatry (2015) 0.80

Modulation of neuronal plasticity following chronic concomitant administration of the novel antipsychotic lurasidone with the mood stabilizer valproic acid. Psychopharmacology (Berl) (2012) 0.79

Synthesis and in vitro evaluation of oxindole derivatives as potential radioligands for 5-HT(7) receptor imaging with PET. ACS Chem Neurosci (2012) 0.79

The role of different serotonin receptor subtypes in seizure susceptibility. Exp Brain Res (2013) 0.79

Daytime sleepiness associated with lurasidone and quetiapine XR: results from a randomized double-blind, placebo-controlled trial in patients with schizophrenia. CNS Spectr (2013) 0.78

Lurasidone: a novel antipsychotic agent for the treatment of schizophrenia and bipolar depression. BJPsych Bull (2015) 0.78

ADN-1184 a monoaminergic ligand with 5-HT(6/7) receptor antagonist activity: pharmacological profile and potential therapeutic utility. Br J Pharmacol (2014) 0.78

Prevention of the phencyclidine-induced impairment in novel object recognition in female rats by co-administration of lurasidone or tandospirone, a 5-HT(1A) partial agonist. Neuropsychopharmacology (2012) 0.78

Antipsychotic, antidepressant, and cognitive-impairment properties of antipsychotics: rat profile and implications for behavioral and psychological symptoms of dementia. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.78

Lurasidone exerts antidepressant properties in the chronic mild stress model through the regulation of synaptic and neuroplastic mechanisms in the rat prefrontal cortex. Int J Neuropsychopharmacol (2014) 0.78

Newer antipsychotics and upcoming molecules for schizophrenia. Eur J Clin Pharmacol (2013) 0.78

Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT1A Receptor Binding in the Hippocampus: Testing the "Two Hit" Hypothesis for the Development of Schizophrenia. ISRN Psychiatry (2012) 0.78

Management of bipolar I depression: clinical utility of lurasidone. Ther Clin Risk Manag (2015) 0.76

Determination of dopamine D₂ receptor occupancy by lurasidone using positron emission tomography in healthy male subjects. Psychopharmacology (Berl) (2013) 0.76

An evaluation of the effects of the novel antipsychotic drug lurasidone on glucose tolerance and insulin resistance: a comparison with olanzapine. PLoS One (2014) 0.76

Lurasidone for the treatment of depressive symptoms in schizophrenia: analysis of 4 pooled, 6-week, placebo-controlled studies. CNS Spectr (2014) 0.76

Lurasidone for the Treatment of Irritability Associated with Autistic Disorder. J Autism Dev Disord (2016) 0.76

The clinical utility of lurasidone in schizophrenia: patient considerations. Neuropsychiatr Dis Treat (2015) 0.75

Case report of a switch to mania induced by lurasidone. Ther Adv Psychopharmacol (2016) 0.75

Lurasidone: a new treatment option for bipolar depression-a review. Innov Clin Neurosci (2015) 0.75

The Incidence of Akathisia in the Treatment of Schizophrenia with Aripiprazole, Asenapine and Lurasidone: A Meta-Analysis. Curr Neuropharmacol (2015) 0.75

Dopamine Targeting Drugs for the Treatment of Schizophrenia: Past, Present and Future. Curr Top Med Chem (2016) 0.75

A 6-week, double-blind, placebo- and haloperidol-controlled, phase II study of lurasidone in patients with acute schizophrenia. Ther Adv Psychopharmacol (2015) 0.75

An Algorithm to Identify Target-Selective Ligands - A Case Study of 5-HT7/5-HT1A Receptor Selectivity. PLoS One (2016) 0.75

Update on the development of lurasidone as a treatment for patients with acute schizophrenia. Drug Des Devel Ther (2012) 0.75

ACS chemical neuroscience molecule spotlight on latuda (lurasidone; SM-13,496). ACS Chem Neurosci (2011) 0.75

Clozapine as a Model for Antipsychotic Development. Neurotherapeutics (2017) 0.75

Serotonin (5-HT)1A receptor agonism and 5-HT7 receptor antagonism ameliorate the subchronic phencyclidine-induced deficit in executive functioning in mice. Psychopharmacology (Berl) (2015) 0.75

Articles by these authors

Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex. Proc Natl Acad Sci U S A (2003) 3.37

Medial prefrontal cell activity signaling prediction errors of action values. Nat Neurosci (2007) 3.29

IL-33 is a crucial amplifier of innate rather than acquired immunity. Proc Natl Acad Sci U S A (2010) 3.07

A trial of the effect of micronutrient supplementation on treatment outcome, T cell counts, morbidity, and mortality in adults with pulmonary tuberculosis. J Infect Dis (2008) 2.77

Results of long segmental reconstruction of left anterior descending artery using left internal thoracic artery. Ann Thorac Surg (2012) 2.71

Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Circulation (2002) 2.65

The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc Natl Acad Sci U S A (2008) 2.30

STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem (2002) 2.28

Malignant Transformation of Hymenolepis nana in a Human Host. N Engl J Med (2015) 2.21

Neural basis of the undermining effect of monetary reward on intrinsic motivation. Proc Natl Acad Sci U S A (2010) 1.99

Intestinal cestodes. Curr Opin Infect Dis (2007) 1.94

Echinococcosis in Tibetan populations, western Sichuan Province, China. Emerg Infect Dis (2005) 1.89

DNA differential diagnosis of taeniasis and cysticercosis by multiplex PCR. J Clin Microbiol (2004) 1.83

Involvement of Propionibacterium acnes in the augmentation of lipogenesis in hamster sebaceous glands in vivo and in vitro. J Invest Dermatol (2009) 1.67

Airway epithelial cells produce B cell-activating factor of TNF family by an IFN-beta-dependent mechanism. J Immunol (2006) 1.67

Augmentation of lipogenesis by 15-deoxy-Delta12,14-prostaglandin J2 in hamster sebaceous glands: identification of cytochrome P-450-mediated 15-deoxy-Delta12,14-prostaglandin J2 production. J Invest Dermatol (2005) 1.64

Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils. Lab Invest (2008) 1.64

Lurasidone in the treatment of acute schizophrenia: a double-blind, placebo-controlled trial. J Clin Psychiatry (2009) 1.62

Functional analysis of the thymic stromal lymphopoietin variants in human bronchial epithelial cells. Am J Respir Cell Mol Biol (2008) 1.60

Distinct gene expression profiles characterize cellular phenotypes of follicle-associated epithelium and M cells. DNA Res (2005) 1.57

Prefrontal cell activities related to monkeys' success and failure in adapting to rule changes in a Wisconsin Card Sorting Test analog. J Neurosci (2006) 1.57

Loop-mediated isothermal amplification method for differentiation and rapid detection of Taenia species. J Clin Microbiol (2008) 1.55

IL-33 mediates inflammatory responses in human lung tissue cells. J Immunol (2010) 1.55

Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues. Hum Pathol (2008) 1.55

Alveolar echinococcosis: characterization of diagnostic antigen Em18 and serological evaluation of recombinant Em18. J Clin Microbiol (2002) 1.54

A prospective, multicenter, randomized trial to assess efficacy of pioglitazone on in-stent neointimal suppression in type 2 diabetes: POPPS (Prevention of In-Stent Neointimal Proliferation by Pioglitazone Study). JACC Cardiovasc Interv (2009) 1.50

Improvement of mild inflammatory changes of the facial skin induced by winter environment with daily applications of a moisturizing cream. A half-side test of biophysical skin parameters, cytokine expression pattern and the formation of cornified envelope. Dermatology (2003) 1.50

Sirolimus-eluting stent versus balloon angioplasty for sirolimus-eluting stent restenosis: Insights from the j-Cypher Registry. Circulation (2010) 1.49

Combination of hTERT and bmi-1, E6, or E7 induces prolongation of the life span of bone marrow stromal cells from an elderly donor without affecting their neurogenic potential. Mol Cell Biol (2005) 1.49

Intra-articular Injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defect. Stem Cells (2009) 1.45

Distinct roles for protease-activated receptors 1 and 2 in vasomotor modulation in rat superior mesenteric artery. Cardiovasc Res (2004) 1.45

Giant adrenal myelolipoma: report of a case. Surg Today (2004) 1.44

Lurasidone in the treatment of schizophrenia: a randomized, double-blind, placebo- and olanzapine-controlled study. Am J Psychiatry (2011) 1.40

Neural correlates of cognitive dissonance and choice-induced preference change. Proc Natl Acad Sci U S A (2010) 1.40

Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase. J Biol Chem (2004) 1.39

Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma. Am J Respir Cell Mol Biol (2010) 1.39

Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria. J Biol Chem (2004) 1.39

A protective role of hydrogen sulfide against oxidative stress in rat gastric mucosal epithelium. Toxicology (2007) 1.38

Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. PLoS Genet (2011) 1.38

Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells. Am J Respir Cell Mol Biol (2004) 1.38

Multiplex PCR for differential identification of broad tapeworms (Cestoda: Diphyllobothrium) infecting humans. J Clin Microbiol (2010) 1.35

Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease. Coron Artery Dis (2006) 1.33

Direct inhibition of endothelial nitric oxide synthase by hydrogen sulfide: contribution to dual modulation of vascular tension. Toxicology (2007) 1.33

Hydrogen sulfide as a novel nociceptive messenger. Pain (2007) 1.32

Phylogenetic systematics of the genus Echinococcus (Cestoda: Taeniidae). Int J Parasitol (2013) 1.31

Echinococcus shiquicus n. sp., a taeniid cestode from Tibetan fox and plateau pika in China. Int J Parasitol (2005) 1.30

Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretion. Hepatology (2009) 1.29

Design of novel inorganic-organic hybrid materials based on iron-chloranilate mononuclear complexes: characteristics of hydrogen-bond-supported layers toward the intercalation of guests. J Am Chem Soc (2003) 1.29

An essential role of cytosolic phospholipase A2alpha in prostaglandin E2-mediated bone resorption associated with inflammation. J Exp Med (2003) 1.29

Differential type I IFN-inducing abilities of wild-type versus vaccine strains of measles virus. J Immunol (2007) 1.29

Genetic characterization and phylogenetic position of Echinococcus felidis (Cestoda: Taeniidae) from the African lion. Int J Parasitol (2007) 1.27

State-of-the-art Echinococcus and Taenia: phylogenetic taxonomy of human-pathogenic tapeworms and its application to molecular diagnosis. Infect Genet Evol (2010) 1.27

Mesenchymal to embryonic incomplete transition of human cells by chimeric OCT4/3 (POU5F1) with physiological co-activator EWS. Exp Cell Res (2009) 1.26

Sympatric occurrence of Taenia solium, T. saginata, and T. asiatica, Thailand. Emerg Infect Dis (2007) 1.25

Community surveys and risk factor analysis of human alveolar and cystic echinococcosis in Ningxia Hui Autonomous Region, China. Bull World Health Organ (2006) 1.24

Geographic pattern of genetic variation in the fox tapeworm Echinococcus multilocularis. Parasitol Int (2009) 1.24

Insensitivity to social reputation in autism. Proc Natl Acad Sci U S A (2011) 1.24

Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma. Am J Respir Cell Mol Biol (2006) 1.23

HERC2 is an E3 ligase that targets BRCA1 for degradation. Cancer Res (2010) 1.23

Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients. J Immunol (2009) 1.23

Tumor-stromal cell contact promotes invasion of human uterine cervical carcinoma cells by augmenting the expression and activation of stromal matrix metalloproteinases. Gynecol Oncol (2004) 1.22

Serological monitoring of progression of alveolar echinococcosis with multiorgan involvement by use of recombinant Em18. J Clin Microbiol (2009) 1.20

Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation. J Exp Med (2010) 1.20

Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice. Biochem Pharmacol (2006) 1.19

A novel recombinant antigen for immunodiagnosis of human cystic echinococcosis. J Infect Dis (2003) 1.18

Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels. Pain (2009) 1.17

FGF2 triggers iris-derived lens regeneration in newt eye. Mech Dev (2004) 1.16

Close relationship between clinical regression and specific serology in the follow-up of patients with alveolar echinococcosis in different clinical stages. Am J Trop Med Hyg (2009) 1.16

Development of an immunochromatographic test to detect antibodies against recombinant Em18 for diagnosis of alveolar echinococcosis. J Clin Microbiol (2008) 1.16

Molecular phylogeny of the genus Taenia (Cestoda: Taeniidae): proposals for the resurrection of Hydatigera Lamarck, 1816 and the creation of a new genus Versteria. Int J Parasitol (2013) 1.16

DNA differential diagnosis of human taeniid cestodes by base excision sequence scanning thymine-base reader analysis with mitochondrial genes. J Clin Microbiol (2002) 1.16

Evaluation of use of recombinant Em18 and affinity-purified Em18 for serological differentiation of alveolar echinococcosis from cystic echinococcosis and other parasitic infections. J Clin Microbiol (2003) 1.15

Evaluation of a loop-mediated isothermal amplification method using fecal specimens for differential detection of Taenia species from humans. J Clin Microbiol (2010) 1.15

In vitro and in vivo characterization of a novel semaphorin 3A inhibitor, SM-216289 or xanthofulvin. J Biol Chem (2003) 1.15

Performance and interview-based assessments of cognitive change in a randomized, double-blind comparison of lurasidone vs. ziprasidone. Schizophr Res (2011) 1.14

Usefulness of recombinant Em18-ELISA to evaluate efficacy of treatment in patients with alveolar echinococcosis. J Gastroenterol (2005) 1.14

Usefulness of hydatid cyst fluid of Echinococcus granulosus developed in mice with secondary infection for serodiagnosis of cystic Echinococcosis in humans. Clin Diagn Lab Immunol (2002) 1.13

Isolated intradural-extramedullary spinal cysticercosis: a case report. J Travel Med (2011) 1.13

Molecular cloning, expression, and serological evaluation of an 8-kilodalton subunit of antigen B from Echinococcus multilocularis. J Clin Microbiol (2004) 1.13

Lurasidone (SM-13496), a novel atypical antipsychotic drug, reverses MK-801-induced impairment of learning and memory in the rat passive-avoidance test. Eur J Pharmacol (2007) 1.12

Recent advances in characterization of Echinococcus antigen B. Parasitol Int (2005) 1.12

Isolation of polymorphic microsatellite loci from the tapeworm Echinococcus multilocularis. Infect Genet Evol (2003) 1.11

Recruitment of phosphorylated NPM1 to sites of DNA damage through RNF8-dependent ubiquitin conjugates. Cancer Res (2010) 1.10

Antitumor effect of resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol C. Carcinogenesis (2003) 1.10

Lurasidone in the treatment of schizophrenia: a 6-week, placebo-controlled study. Psychopharmacology (Berl) (2012) 1.10

Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits. Arthritis Res Ther (2010) 1.10

Specific IgG responses to recombinant antigen B and em18 in cystic and alveolar echinococcosis in china. Clin Vaccine Immunol (2009) 1.09

Widespread co-endemicity of human cystic and alveolar echinococcosis on the eastern Tibetan Plateau, northwest Sichuan/southeast Qinghai, China. Acta Trop (2009) 1.09

Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma. J Immunol (2012) 1.08

Cerebral sparganosis: the wandering lesion. Neurology (2010) 1.08

Phylogenetic relationships within Echinococcus and Taenia tapeworms (Cestoda: Taeniidae): an inference from nuclear protein-coding genes. Mol Phylogenet Evol (2011) 1.08

Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability. Eur J Immunol (2007) 1.07

Cell growth inhibitory effect of cinnamic acid derivatives from propolis on human tumor cell lines. Biol Pharm Bull (2003) 1.07

Neural retinal regeneration in the anuran amphibian Xenopus laevis post-metamorphosis: transdifferentiation of retinal pigmented epithelium regenerates the neural retina. Dev Biol (2006) 1.07

IL-33 and Airway Inflammation. Allergy Asthma Immunol Res (2011) 1.07

Primary hepatic peripheral T-cell lymphoma treated with corticosteroid. Intern Med (2011) 1.06

Effective cell-seeding technique using magnetite nanoparticles and magnetic force onto decellularized blood vessels for vascular tissue engineering. J Biosci Bioeng (2007) 1.06