Published in Cell Cycle on April 01, 2010
HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell (2007) 6.50
The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. Nat Cell Biol (2005) 2.52
KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis. Hum Mol Genet (2002) 2.28
Aurora A kinase (AURKA) in normal and pathological cell division. Cell Mol Life Sci (2012) 1.84
CAS proteins in normal and pathological cell growth control. Cell Mol Life Sci (2009) 1.84
Synthetic lethal screen of an EGFR-centered network to improve targeted therapies. Sci Signal (2010) 1.64
Cell cycle-dependent ciliogenesis and cancer. Cancer Res (2008) 1.54
NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res (2009) 1.53
Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells. Proc Natl Acad Sci U S A (2002) 1.52
A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9. Cancer Res (2007) 1.48
Selective Raf inhibition in cancer therapy. Expert Opin Ther Targets (2007) 1.44
Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1. Proc Natl Acad Sci U S A (2004) 1.42
Dissection of HEF1-dependent functions in motility and transcriptional regulation. J Cell Sci (2002) 1.29
Primary cilia and the cell cycle. Methods Cell Biol (2009) 1.28
HEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks. Cell Cycle (2006) 1.25
Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle. Mol Biol Cell (2006) 1.19
Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis. Mol Biol Cell (2012) 1.13
Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein. EMBO J (2003) 1.12
Aurora A kinase activity influences calcium signaling in kidney cells. J Cell Biol (2011) 1.10
Interdependence of cell attachment and cell cycle signaling. Curr Opin Cell Biol (2006) 1.08
A novel Cas family member, HEPL, regulates FAK and cell spreading. Mol Biol Cell (2008) 1.07
Targeting EGFR resistance networks in head and neck cancer. Cell Signal (2009) 1.07
The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. J Immunol (2003) 1.06
NEDD9 and BCAR1 negatively regulate E-cadherin membrane localization, and promote E-cadherin degradation. PLoS One (2011) 1.06
A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels. Mol Cell Biol (2003) 1.06
The extracellular matrix and ciliary signaling. Curr Opin Cell Biol (2012) 1.03
The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies. Cell Mol Life Sci (2012) 0.99
Activation of p21-activated kinase 1-nuclear factor kappaB signaling by Kaposi's sarcoma-associated herpes virus G protein-coupled receptor during cellular transformation. Cancer Res (2003) 0.99
Rapid calcium-dependent activation of Aurora-A kinase. Nat Commun (2010) 0.98
Mechanisms of tumor resistance to EGFR-targeted therapies. Expert Opin Ther Targets (2009) 0.96
Enhanced genetic instability and dasatinib sensitivity in mammary tumor cells lacking NEDD9. Cancer Res (2010) 0.96
Detection of peptides, proteins, and drugs that selectively interact with protein targets. Genome Res (2002) 0.96
In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors. Mol Cancer Ther (2007) 0.92
Autoinhibited proteins as promising drug targets. J Cell Biochem (2004) 0.92
Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. Cancer Discov (2012) 0.90
Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease. Proc Natl Acad Sci U S A (2013) 0.90
Human enhancer of invasion-cluster, a coiled-coil protein required for passage through mitosis. Mol Cell Biol (2004) 0.89
Chemotherapy and signaling: How can targeted therapies supercharge cytotoxic agents? Cancer Biol Ther (2010) 0.89
Aurora kinases in head and neck cancer. Lancet Oncol (2013) 0.89
Network analysis identifies an HSP90-central hub susceptible in ovarian cancer. Clin Cancer Res (2013) 0.88
Protein-intrinsic and signaling network-based sources of resistance to EGFR- and ErbB family-targeted therapies in head and neck cancer. Drug Resist Updat (2011) 0.86
The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1. PLoS One (2012) 0.86
Dcas supports cell polarization and cell-cell adhesion complexes in development. PLoS One (2010) 0.83
Structure, stability, and function of hDim1 investigated by NMR, circular dichroism, and mutational analysis. Biochemistry (2003) 0.83
Comment on "epidermal growth factor receptor is essential for toll-like receptor 3 signaling". Sci Signal (2012) 0.82
Quantification of excision repair cross-complementing group 1 and survival in p16-negative squamous cell head and neck cancers. Clin Cancer Res (2013) 0.82
A gene expression system offering multiple levels of regulation: the Dual Drug Control (DDC) system. BMC Biotechnol (2004) 0.82
CAS proteins in health and disease: an update. IUBMB Life (2014) 0.82
Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein. Mol Cell Biol (2007) 0.82
Issues in interpreting the in vivo activity of Aurora-A. Expert Opin Ther Targets (2014) 0.80
Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human transcription repressor ERH. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.80
A ciliary timer for S-phase entry. Nat Rev Mol Cell Biol (2007) 0.78
A combined yeast/bacteria two-hybrid system: development and evaluation. Mol Cell Proteomics (2005) 0.78
Development of a yeast two-hybrid screen for selection of human Ras-Raf protein interaction inhibitors. Methods Mol Biol (2005) 0.78
Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.78
Integrating in silico resources to map a signaling network. Methods Mol Biol (2014) 0.75
A bacterial/yeast merged two-hybrid system: protocol for yeast screening with single or parallel baits. Methods Mol Biol (2007) 0.75
From correlation to causality: microarrays, cancer, and cancer treatment. Biotechniques (2003) 0.75
A bacterial/yeast merged two-hybrid system: protocol for bacterial screening. Methods Mol Biol (2007) 0.75
Analysis and manipulation of intracellular signaling cascades. Methods (2004) 0.75
Yeast screens for inhibitors of Ras-Raf interaction and characterization of MCP inhibitors of Ras-Raf interaction. Methods Enzymol (2006) 0.75