Published in Drug Metab Dispos on April 26, 2010
Targeting the HGF/Met signaling pathway in cancer therapy. Expert Opin Ther Targets (2012) 1.45
The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5. Drug Metab Dispos (2012) 0.99
A simple litmus test for aldehyde oxidase metabolism of heteroarenes. J Med Chem (2014) 0.91
Predicting intrinsic clearance for drugs and drug candidates metabolized by aldehyde oxidase. Mol Pharm (2013) 0.89
Role of biotransformation in drug-induced toxicity: influence of intra- and inter-species differences in drug metabolism. Drug Metab Pharmacokinet (2010) 0.88
Unexpected renal toxicity associated with SGX523, a small molecule inhibitor of MET. Invest New Drugs (2012) 0.86
Absolute quantification of aldehyde oxidase protein in human liver using liquid chromatography-tandem mass spectrometry. Mol Pharm (2013) 0.84
The c-Met Tyrosine Kinase Inhibitor JNJ-38877605 Causes Renal Toxicity through Species-Specific Insoluble Metabolite Formation. Clin Cancer Res (2015) 0.82
Design, Synthesis, and Biological Evaluation of Novel Imidazo[1,2-a]pyridine Derivatives as Potent c-Met Inhibitors. ACS Med Chem Lett (2015) 0.78
Interspecies differences in the metabolism of methotrexate: An insight into the active site differences between human and rabbit aldehyde oxidase. Biochem Pharmacol (2015) 0.77
Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity. Drug Metab Dispos (2016) 0.76
Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison. Invest New Drugs (2016) 0.75
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell (2007) 17.98
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
The detection of monkeypox in humans in the Western Hemisphere. N Engl J Med (2004) 6.32
Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biol Psychiatry (2005) 3.85
Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases. Lancet (2013) 3.77
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance. Proc Natl Acad Sci U S A (2007) 3.32
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab (2010) 2.77
Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nat Med (2013) 2.74
Calorie restriction alters mitochondrial protein acetylation. Aging Cell (2009) 2.73
A randomized controlled trial of Licartin for preventing hepatoma recurrence after liver transplantation. Hepatology (2007) 2.66
Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases. Sci Signal (2010) 2.64
Acceptance of and barriers to voluntary HIV counselling and testing among adults in Guizhou province, China. AIDS (2007) 2.35
A tale of two clades: monkeypox viruses. J Gen Virol (2005) 2.24
Oligomerization of the EGF receptor investigated by live cell fluorescence intensity distribution analysis. Biophys J (2007) 2.23
Antidepressant effect on connectivity of the mood-regulating circuit: an FMRI study. Neuropsychopharmacology (2005) 2.16
[Malaria situation in the People's Republic of China in 2010]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (2011) 2.13
Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression. Psychiatry Res (2009) 2.08
Computational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers. BMC Genomics (2009) 2.02
Severe eczema vaccinatum in a household contact of a smallpox vaccinee. Clin Infect Dis (2008) 2.00
Genomic and functional evidence for an ARID1A tumor suppressor role. Genes Chromosomes Cancer (2007) 1.99
Extended interhuman transmission of monkeypox in a hospital community in the Republic of the Congo, 2003. Am J Trop Med Hyg (2005) 1.91
Genome sequence diversity and clues to the evolution of variola (smallpox) virus. Science (2006) 1.84
Structural and functional characterization of disulfide isoforms of the human IgG2 subclass. J Biol Chem (2008) 1.80
Anisotropic self-assembly of spherical polymer-grafted nanoparticles. Nat Mater (2009) 1.77
IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells. Proc Natl Acad Sci U S A (2002) 1.69
Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia. Cancer Res (2005) 1.69
Monkeypox zoonotic associations: insights from laboratory evaluation of animals associated with the multi-state US outbreak. Am J Trop Med Hyg (2007) 1.67
Identification of cavities on protein surface using multiple computational approaches for drug binding site prediction. Bioinformatics (2011) 1.56
Tanapox infection in a college student. N Engl J Med (2004) 1.56
Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344. J Immunol (2005) 1.49
Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J Immunol (2010) 1.47
A comprehensive listing of bioactivation pathways of organic functional groups. Curr Drug Metab (2005) 1.47
Reciprocal effects of antidepressant treatment on activity and connectivity of the mood regulating circuit: an FMRI study. J Neuropsychiatry Clin Neurosci (2007) 1.42
Comparison of patients hospitalized with influenza A subtypes H7N9, H5N1, and 2009 pandemic H1N1. Clin Infect Dis (2014) 1.40
The prevalence of prostatitis-like symptoms in China. J Urol (2009) 1.33
Manipulating broad-spectrum disease resistance by suppressing pathogen-induced auxin accumulation in rice. Plant Physiol (2010) 1.33
Chasing Jenner's vaccine: revisiting cowpox virus classification. PLoS One (2011) 1.33
Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications. Cancer Res (2002) 1.32
Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. Mol Cell Biol (2006) 1.29
Lectin microarrays identify cell-specific and functionally significant cell surface glycan markers. Glycobiology (2008) 1.28
Expression profiling and integrative analysis of the CESA/CSL superfamily in rice. BMC Plant Biol (2010) 1.27
Activity of the isolated HIV RNase H domain and specific inhibition by N-hydroxyimides. Biochem Biophys Res Commun (2004) 1.27
Human monkeypox infection: a family cluster in the midwestern United States. J Infect Dis (2004) 1.26
Virus-host interactions: from systems biology to translational research. Curr Opin Microbiol (2009) 1.23
Targeting radioimmunotherapy of hepatocellular carcinoma with iodine (131I) metuximab injection: clinical phase I/II trials. Int J Radiat Oncol Biol Phys (2006) 1.23
Molecular epidemiological surveys of H5 subtype highly pathogenic avian influenza viruses in poultry in China during 2007-2009. J Gen Virol (2010) 1.21
Matrix metalloproteinase-activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity. Mol Cancer Ther (2005) 1.20
Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cerevisiae. J Med Chem (2003) 1.17
A software channel compression technique for faster reconstruction with many channels. Magn Reson Imaging (2007) 1.17
Representation of objects in space by two classes of hippocampal pyramidal cells. J Gen Physiol (2004) 1.16
IL-15 is a growth factor and an activator of CD8 memory T cells. Ann N Y Acad Sci (2002) 1.15
Treatment of chronic prostatitis in Chinese men. Asian J Androl (2009) 1.15
MiR-378 is an independent prognostic factor and inhibits cell growth and invasion in colorectal cancer. BMC Cancer (2014) 1.14
The regulation of hepatitis C virus (HCV) internal ribosome-entry site-mediated translation by HCV replicons and nonstructural proteins. J Gen Virol (2003) 1.14
Population structure and linkage disequilibrium of a mini core set of maize inbred lines in China. Theor Appl Genet (2008) 1.13
The phylogenetics and ecology of the orthopoxviruses endemic to North America. PLoS One (2009) 1.12
A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3. Clin Cancer Res (2011) 1.12
The pharmacokinetics, pharmacodynamics, and safety of baricitinib, an oral JAK 1/2 inhibitor, in healthy volunteers. J Clin Pharmacol (2014) 1.11
QTL analysis for yield components and kernel-related traits in maize across multi-environments. Theor Appl Genet (2011) 1.11
A rice gene of de novo origin negatively regulates pathogen-induced defense response. PLoS One (2009) 1.10
Knockdown of Rab5a expression decreases cancer cell motility and invasion through integrin-mediated signaling pathway. J Biomed Sci (2011) 1.10
Development and genetic mapping of SSR markers in foxtail millet [Setaria italica (L.) P. Beauv.]. Theor Appl Genet (2009) 1.10
Preliminary clinical activity of a topical JAK1/2 inhibitor in the treatment of psoriasis. J Am Acad Dermatol (2012) 1.09
Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus. J Infect Dis (2005) 1.09
Identification of a male-specific Amplified Fragment Length Polymorphism (AFLP) and a Sequence Characterized Amplified Region (SCAR) marker in Eucommia ulmoides Oliv. Int J Mol Sci (2011) 1.08
ORF virus infection in children: clinical characteristics, transmission, diagnostic methods, and future therapeutics. Pediatr Infect Dis J (2007) 1.08
Metabolism, excretion, and pharmacokinetics of [14C]INCB018424, a selective Janus tyrosine kinase 1/2 inhibitor, in humans. Drug Metab Dispos (2010) 1.08
The evaluation of metastatic lymph node ratio staging system in gastric cancer. Gastric Cancer (2012) 1.08
The pharmacokinetics, pharmacodynamics, and safety of orally dosed INCB018424 phosphate in healthy volunteers. J Clin Pharmacol (2011) 1.07
Cloning and characterization of a maize bZIP transcription factor, ZmbZIP72, confers drought and salt tolerance in transgenic Arabidopsis. Planta (2011) 1.06
Overexpression of Toll-like receptor 2/4 on monocytes modulates the activities of CD4(+)CD25(+) regulatory T cells in chronic hepatitis B virus infection. Virology (2009) 1.04
Differential miRNA expression and their target genes between NGX6-positive and negative colon cancer cells. Mol Cell Biochem (2010) 1.04
Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs). Biochem Biophys Res Commun (2006) 1.04
Crystal structure of the actin-binding domain of alpha-actinin 1: evaluating two competing actin-binding models. J Struct Biol (2006) 1.03
Inertial properties of hominoid limb segments. J Anat (2006) 1.03
Binary colloidal structures assembled through Ising interactions. Nat Commun (2012) 1.02
Arabinose substitution degree in xylan positively affects lignocellulose enzymatic digestibility after various NaOH/H2SO4 pretreatments in Miscanthus. Bioresour Technol (2012) 1.01
Serum high mobility group box protein 1 as a clinical marker for non-small cell lung cancer. Respir Med (2009) 1.01
Metabolic profiling analysis of a D-galactosamine/lipopolysaccharide-induced mouse model of fulminant hepatic failure. J Proteome Res (2007) 1.01
Real-time PCR assay to identify variants of Vaccinia virus: implications for the diagnosis of bovine vaccinia in Brazil. J Virol Methods (2008) 1.01
LncRNA2Function: a comprehensive resource for functional investigation of human lncRNAs based on RNA-seq data. BMC Genomics (2015) 1.01
High-pass GRAPPA: an image support reduction technique for improved partially parallel imaging. Magn Reson Med (2008) 1.01
Massive sorghum collection genotyped with SSR markers to enhance use of global genetic resources. PLoS One (2013) 1.01
A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response. Mol Cell Biol (2008) 1.00
Comparison of inverse-dynamics musculo-skeletal models of AL 288-1 Australopithecus afarensis and KNM-WT 15000 Homo ergaster to modern humans, with implications for the evolution of bipedalism. J Hum Evol (2004) 1.00
In vivo administration of artificial antigen-presenting cells activates low-avidity T cells for treatment of cancer. Cancer Res (2009) 1.00
Glucose biosensor based on multi-wall carbon nanotubes and screen printed carbon electrodes. Biosens Bioelectron (2004) 0.99
Complementary spatial firing in place cell-interneuron pairs. J Physiol (2010) 0.99
Circulating CD4+CD25high regulatory T cells and expression of PD-1 and BTLA on CD4+ T cells in patients with chronic hepatitis B virus infection. Viral Immunol (2010) 0.99
[Measurement of sialic acid from lipoproteins and human plasma by liquid chromatography-tandem mass spectrometry]. Se Pu (2014) 0.99
Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular carcinoma proliferation and invasion. Mol Cell Biol (2011) 0.99
An Integrated Model for Patient Care and Clinical Trials (IMPACT) to support clinical research visit scheduling workflow for future learning health systems. J Biomed Inform (2013) 0.99
Molecular characterization and functions of fatty acid and retinoid binding protein gene (Ab-far-1) in Aphelenchoides besseyi. PLoS One (2013) 0.99
Acid stabilization of Bacillus licheniformis alpha amylase through introduction of mutations. Appl Microbiol Biotechnol (2008) 0.98
Monkeypox outbreak diagnostics and implications for vaccine protective effect. Nat Med (2006) 0.98
Fine genetic characterization of elite maize germplasm using high-throughput SNP genotyping. Theor Appl Genet (2013) 0.98
A selective inhibitor of Drp1, mdivi-1, acts against cerebral ischemia/reperfusion injury via an anti-apoptotic pathway in rats. Neurosci Lett (2013) 0.97