Published in Cell Metab on December 01, 2010
Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol (2012) 4.86
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol Cell (2012) 2.54
Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science (2013) 2.49
Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov (2012) 2.22
Sirtuins mediate mammalian metabolic responses to nutrient availability. Nat Rev Endocrinol (2012) 2.12
Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A (2013) 2.01
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99
SIRT1 and other sirtuins in metabolism. Trends Endocrinol Metab (2013) 1.90
Energy metabolism in the liver. Compr Physiol (2014) 1.88
Widespread and enzyme-independent Nε-acetylation and Nε-succinylation of proteins in the chemical conditions of the mitochondrial matrix. J Biol Chem (2013) 1.78
Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. PLoS One (2011) 1.73
Mechanistic insights into the regulation of metabolic enzymes by acetylation. J Cell Biol (2012) 1.71
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab (2013) 1.70
Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia. J Clin Invest (2014) 1.63
Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling. Antioxid Redox Signal (2012) 1.60
From sirtuin biology to human diseases: an update. J Biol Chem (2012) 1.60
TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest (2014) 1.58
The SirT3 divining rod points to oxidative stress. Mol Cell (2011) 1.58
Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. J Biol Chem (2012) 1.58
The emerging and diverse roles of sirtuins in cancer: a clinical perspective. Onco Targets Ther (2013) 1.57
Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases. Mol Cell (2014) 1.56
Cyclophilin D modulates mitochondrial acetylome. Circ Res (2013) 1.53
Protein lysine acylation and cysteine succination by intermediates of energy metabolism. ACS Chem Biol (2012) 1.49
Metabolism and the circadian clock converge. Physiol Rev (2013) 1.47
Mouse SIRT3 attenuates hypertrophy-related lipid accumulation in the heart through the deacetylation of LCAD. PLoS One (2015) 1.44
Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. J Proteome Res (2012) 1.41
Mitochondrial protein acetylation regulates metabolism. Essays Biochem (2012) 1.40
Ketone bodies as signaling metabolites. Trends Endocrinol Metab (2013) 1.37
Sirtuins: guardians of mammalian healthspan. Trends Genet (2014) 1.36
Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis. Sci Rep (2012) 1.35
Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure. Circulation (2016) 1.33
Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene. J Biol Chem (2011) 1.31
Ketone body metabolism and cardiovascular disease. Am J Physiol Heart Circ Physiol (2013) 1.29
SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta (2011) 1.28
Mitochondrial metabolism, sirtuins, and aging. Cold Spring Harb Perspect Biol (2012) 1.25
Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation. J Biol Chem (2013) 1.20
Mammalian sirtuins and energy metabolism. Int J Biol Sci (2011) 1.17
Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications. Crit Rev Biochem Mol Biol (2013) 1.17
A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab (2012) 1.16
Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3. PLoS One (2012) 1.13
The sirtuin family's role in aging and age-associated pathologies. J Clin Invest (2013) 1.12
NAD⁺ metabolism: a therapeutic target for age-related metabolic disease. Crit Rev Biochem Mol Biol (2013) 1.11
Metabolic regulation by SIRT3: implications for tumorigenesis. Trends Mol Med (2012) 1.10
Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation. J Biol Chem (2011) 1.09
Mitochondrial sirtuins and their relationships with metabolic disease and cancer. Antioxid Redox Signal (2015) 1.09
Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site. J Biol Chem (2013) 1.07
Friedreich's ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase. Hum Mol Genet (2012) 1.07
Circadian clocks and metabolism. Handb Exp Pharmacol (2013) 1.07
Ketogenic diets, mitochondria, and neurological diseases. J Lipid Res (2014) 1.04
SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target. Mol Cell (2015) 1.03
Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation. Handb Exp Pharmacol (2011) 1.02
Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions. EMBO J (2015) 1.01
SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2. Aging (Albany NY) (2011) 1.01
Fine tuning our cellular factories: sirtuins in mitochondrial biology. Cell Metab (2011) 1.00
Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease. Curr Opin Clin Nutr Metab Care (2012) 0.99
Sirtuin regulation in aging and injury. Biochim Biophys Acta (2015) 0.98
Nutrient sensing and the circadian clock. Trends Endocrinol Metab (2012) 0.98
Metabolic and neuropsychiatric effects of calorie restriction and sirtuins. Annu Rev Physiol (2012) 0.98
Protein acetylation in metabolism - metabolites and cofactors. Nat Rev Endocrinol (2015) 0.97
Aberrant protein acylation is a common observation in inborn errors of acyl-CoA metabolism. J Inherit Metab Dis (2014) 0.97
Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. Front Aging Neurosci (2013) 0.97
Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma. PLoS One (2012) 0.96
CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease. PLoS One (2012) 0.96
SIRT3 mediates multi-tissue coupling for metabolic fuel switching. Cell Metab (2015) 0.95
Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart. Am J Physiol Heart Circ Physiol (2011) 0.94
The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging. J Mol Cell Cardiol (2011) 0.94
Sirt1: def-eating senescence? Cell Cycle (2012) 0.94
Age-related decrease in the mitochondrial sirtuin deacetylase Sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging rat model. PLoS One (2014) 0.93
Comparing Conformational Ensembles Using the Kullback-Leibler Divergence Expansion. J Chem Theory Comput (2012) 0.93
Mitochondrial sirtuins and metabolic homeostasis. Best Pract Res Clin Endocrinol Metab (2012) 0.92
Role of mitochondria in nonalcoholic fatty liver disease. Int J Mol Sci (2014) 0.91
Sirtuins, metabolism, and cancer. Front Pharmacol (2012) 0.91
Regulation of sirtuin function by posttranslational modifications. Front Pharmacol (2012) 0.91
Mechanisms and Dynamics of Protein Acetylation in Mitochondria. Trends Biochem Sci (2016) 0.91
Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity. Free Radic Biol Med (2012) 0.90
The human sirtuin family: evolutionary divergences and functions. Hum Genomics (2011) 0.90
Metabolic changes associated with the long winter fast dominate the liver proteome in 13-lined ground squirrels. Physiol Genomics (2014) 0.90
Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity. J Cell Biol (2014) 0.90
Improving insulin sensitivity with HDAC inhibitor. Diabetes (2013) 0.90
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab (2016) 0.89
Regulation of skeletal muscle oxidative capacity and muscle mass by SIRT3. PLoS One (2014) 0.89
Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondria. Front Physiol (2014) 0.89
Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. Mol Aspects Med (2013) 0.89
Turn up the power - pharmacological activation of mitochondrial biogenesis in mouse models. Br J Pharmacol (2014) 0.88
Ethanol metabolism modifies hepatic protein acylation in mice. PLoS One (2013) 0.87
Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation. J Clin Invest (2014) 0.86
SIRT3: A Central Regulator of Mitochondrial Adaptation in Health and Disease. Genes Cancer (2013) 0.86
Sirtuins and pyridine nucleotides. Circ Res (2012) 0.86
Cellular Links between Neuronal Activity and Energy Homeostasis. Front Pharmacol (2012) 0.85
Site specific identification of endogenous S-nitrosocysteine proteomes. J Proteomics (2013) 0.84
SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway. Age (Dordr) (2013) 0.83
Sirtuin biology and relevance to diabetes treatment. Diabetes Manag (Lond) (2012) 0.83
Hepatic fatty acid trafficking: multiple forks in the road. Adv Nutr (2013) 0.82
Lysine Acetylation Activates Mitochondrial Aconitase in the Heart. Biochemistry (2015) 0.82
β-hydroxybutyrate: much more than a metabolite. Diabetes Res Clin Pract (2014) 0.82
Sirtuins, a promising target in slowing down the ageing process. Biogerontology (2017) 0.80
Normalization of NAD+ Redox Balance as a Therapy for Heart Failure. Circulation (2016) 0.80
Mitochondrial sirtuins as therapeutic targets for age-related disorders. Genes Cancer (2013) 0.80
Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc. Endocrinology (2012) 0.80
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol (2008) 38.00
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell (2007) 17.98
A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations. J Comput Chem (2003) 15.88
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A (2004) 9.33
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat Biotechnol (2004) 7.69
Regulation of hepatic fatty acid oxidation and ketone body production. Annu Rev Biochem (1980) 7.03
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci U S A (2006) 7.00
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A (2008) 6.53
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science (2010) 6.04
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A (2006) 5.96
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat Med (2004) 5.04
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem (2005) 4.80
Structural basis for control by phosphorylation. Chem Rev (2001) 3.53
Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev (2000) 3.32
MSQuant, an open source platform for mass spectrometry-based quantitative proteomics. J Proteome Res (2010) 2.40
ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. J Clin Invest (2004) 2.08
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis. Biochem J (1999) 1.77
Distinguish protein decoys by using a scoring function based on a new AMBER force field, short molecular dynamics simulations, and the generalized born solvent model. Proteins (2004) 1.74
Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue. FASEB J (2007) 1.55
3-Hydroxy-3-methylgutaryl-CoA synthase. Participation of acetyl-S-enzyme and enzyme-S-hydroxymethylgutaryl-SCoA intermediates in the reaction. J Biol Chem (1977) 1.35
Strengths of hydrogen bonds involving phosphorylated amino acid side chains. J Am Chem Soc (2007) 1.31
Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling. Proc Natl Acad Sci U S A (2008) 1.25
Acetylation of mitochondrial proteins. Methods Enzymol (2009) 1.24
R.E.DD.B.: a database for RESP and ESP atomic charges, and force field libraries. Nucleic Acids Res (2007) 1.21
3-Hydroxy-3-methylglutaryl-coenzyme A synthase from ox liver. Purification, molecular and catalytic properties. Biochem J (1985) 1.19
Glucagon activates mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in vivo by decreasing the extent of succinylation of the enzyme. Eur J Biochem (1990) 1.18
Computational studies of protein regulation by post-translational phosphorylation. Curr Opin Struct Biol (2009) 1.16
Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. Cell Metab (2009) 1.11
Effects of posttranslational modifications on the structure and dynamics of histone H3 N-terminal Peptide. Biophys J (2008) 0.99
Multiscale Optimization of a Truncated Newton Minimization Algorithm and Application to Proteins and Protein-Ligand Complexes. J Chem Theory Comput (2007) 0.97
A visible wavelength spectrophotometric assay suitable for high-throughput screening of 3-hydroxy-3-methylglutaryl-CoA synthase. Anal Biochem (2009) 0.95
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell (2007) 17.98
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell (2003) 8.34
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J (2007) 7.30
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci U S A (2006) 7.00
Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics. Proc Natl Acad Sci U S A (2003) 6.87
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell (2003) 6.77
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
The detection of monkeypox in humans in the Western Hemisphere. N Engl J Med (2004) 6.32
The mechanism and regulation of chromosomal V(D)J recombination. Cell (2002) 6.28
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J (2003) 6.11
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A (2006) 5.96
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell (2010) 5.73
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68
DNA repair, genome stability, and aging. Cell (2005) 5.52
Towards an HIV cure: a global scientific strategy. Nat Rev Immunol (2012) 5.52
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol (2002) 5.37
Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell (2003) 5.26
Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature (2003) 5.20
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell (2002) 5.19
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A (2002) 5.07
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab (2010) 4.97
Mechanism of human SIRT1 activation by resveratrol. J Biol Chem (2005) 4.86
Novel procedure for modeling ligand/receptor induced fit effects. J Med Chem (2006) 4.74
NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J (2005) 4.35
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol (2006) 4.32
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell (2002) 4.29
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol (2004) 4.14
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol (2004) 4.04
Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell (2012) 4.02
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature (2004) 3.94
Conserved metabolic regulatory functions of sirtuins. Cell Metab (2008) 3.86
Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biol Psychiatry (2005) 3.85
Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell (2011) 3.81
Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases. Lancet (2013) 3.77
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52
Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev (2008) 3.46
Histone H3-K56 acetylation is catalyzed by histone chaperone-dependent complexes. Mol Cell (2007) 3.38
SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev (2007) 3.34
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance. Proc Natl Acad Sci U S A (2007) 3.32
HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals. Science (2010) 3.29
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol (2011) 3.21
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab (2005) 3.15
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev (2006) 3.12
Dysregulated pH: a perfect storm for cancer progression. Nat Rev Cancer (2011) 3.10
Activating Notch1 mutations in mouse models of T-ALL. Blood (2005) 3.08
Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol (2004) 3.00
Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. Proc Natl Acad Sci U S A (2007) 2.97
Mechanism and control of class-switch recombination. Trends Immunol (2002) 2.95
Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol (2007) 2.94
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature (2003) 2.92
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell (2007) 2.88
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol (2008) 2.85
The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics (2011) 2.83
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell (2012) 2.78
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74
Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nat Med (2013) 2.74
Calorie restriction alters mitochondrial protein acetylation. Aging Cell (2009) 2.73
The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst) (2004) 2.72
The role of DNA breaks in genomic instability and tumorigenesis. Immunol Rev (2003) 2.72
A randomized controlled trial of Licartin for preventing hepatoma recurrence after liver transplantation. Hepatology (2007) 2.66
Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation. Mol Cell Proteomics (2012) 2.66
Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases. Sci Signal (2010) 2.64
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature (2005) 2.63
CTCF-binding elements mediate control of V(D)J recombination. Nature (2011) 2.62
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol Cell (2012) 2.54
CpG methylation controls reactivation of HIV from latency. PLoS Pathog (2009) 2.51