Published in Nature on March 04, 2010
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell (2010) 5.73
Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol (2012) 4.86
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. Cancer Cell (2011) 3.71
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem Sci (2010) 3.17
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol Cell (2011) 2.84
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab (2010) 2.77
Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Rep (2012) 2.66
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol Cell (2012) 2.54
Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science (2013) 2.49
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A (2011) 2.41
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci (2010) 2.37
Regulation of intermediary metabolism by protein acetylation. Trends Biochem Sci (2010) 2.36
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol Cell (2011) 2.29
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY) (2010) 2.27
Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov (2012) 2.22
Retracted Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3. J Cell Sci (2010) 2.14
Sirtuins mediate mammalian metabolic responses to nutrient availability. Nat Rev Endocrinol (2012) 2.12
Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studies. PLoS One (2014) 2.02
Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A (2013) 2.01
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99
SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell (2013) 1.99
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. Biochem J (2011) 1.96
SIRT1 and other sirtuins in metabolism. Trends Endocrinol Metab (2013) 1.90
Energy metabolism in the liver. Compr Physiol (2014) 1.88
The nexus of chromatin regulation and intermediary metabolism. Nature (2013) 1.87
Calorie restriction and sirtuins revisited. Genes Dev (2013) 1.79
Widespread and enzyme-independent Nε-acetylation and Nε-succinylation of proteins in the chemical conditions of the mitochondrial matrix. J Biol Chem (2013) 1.78
SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status. J Biol Chem (2012) 1.77
Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. PLoS One (2011) 1.73
Lipid-induced mitochondrial stress and insulin action in muscle. Cell Metab (2012) 1.71
Mechanistic insights into the regulation of metabolic enzymes by acetylation. J Cell Biol (2012) 1.71
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nat Med (2012) 1.69
SIRT3 reverses aging-associated degeneration. Cell Rep (2013) 1.65
The search for antiaging interventions: from elixirs to fasting regimens. Cell (2014) 1.63
SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts. Am J Physiol Heart Circ Physiol (2014) 1.60
Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling. Antioxid Redox Signal (2012) 1.60
From sirtuin biology to human diseases: an update. J Biol Chem (2012) 1.60
TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest (2014) 1.58
Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. J Biol Chem (2012) 1.58
The SirT3 divining rod points to oxidative stress. Mol Cell (2011) 1.58
Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice. EMBO J (2012) 1.58
The emerging and diverse roles of sirtuins in cancer: a clinical perspective. Onco Targets Ther (2013) 1.57
Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases. Mol Cell (2014) 1.56
Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Mol Cell Proteomics (2012) 1.55
The dynamic regulation of NAD metabolism in mitochondria. Trends Endocrinol Metab (2012) 1.55
Cyclophilin D modulates mitochondrial acetylome. Circ Res (2013) 1.53
Protein lysine acylation and cysteine succination by intermediates of energy metabolism. ACS Chem Biol (2012) 1.49
Sorting out functions of sirtuins in cancer. Oncogene (2013) 1.47
Metabolism and the circadian clock converge. Physiol Rev (2013) 1.47
SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells. J Biol Chem (2010) 1.46
Mouse SIRT3 attenuates hypertrophy-related lipid accumulation in the heart through the deacetylation of LCAD. PLoS One (2015) 1.44
Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. J Proteome Res (2012) 1.41
Sirtuins at a glance. J Cell Sci (2011) 1.41
Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress. Aging (Albany NY) (2011) 1.40
Mitochondrial protein acetylation regulates metabolism. Essays Biochem (2012) 1.40
Acetylation-dependent regulation of Skp2 function. Cell (2012) 1.40
Metabolic shifts in residual breast cancer drive tumor recurrence. J Clin Invest (2017) 1.38
Sirtuins: guardians of mammalian healthspan. Trends Genet (2014) 1.36
4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification. Chem Res Toxicol (2011) 1.35
Sirtuin catalysis and regulation. J Biol Chem (2012) 1.35
Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis. Sci Rep (2012) 1.35
Redox regulation of mitochondrial function. Antioxid Redox Signal (2012) 1.34
SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity. Free Radic Biol Med (2010) 1.33
Small-molecule allosteric activators of sirtuins. Annu Rev Pharmacol Toxicol (2013) 1.31
Mitochondria as a drug target in ischemic heart disease and cardiomyopathy. Circ Res (2012) 1.31
Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene. J Biol Chem (2011) 1.31
Peroxisome proliferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype. J Biol Chem (2011) 1.30
SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta (2011) 1.28
Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1α. Neurobiol Dis (2012) 1.26
A molecular mechanism for direct sirtuin activation by resveratrol. PLoS One (2012) 1.26
Mitochondrial metabolism, sirtuins, and aging. Cold Spring Harb Perspect Biol (2012) 1.25
Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. Diabetes (2013) 1.22
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3. Nat Commun (2015) 1.21
Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation. J Biol Chem (2013) 1.20
Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock. Cell (2014) 1.20
Structure-based development of novel sirtuin inhibitors. Aging (Albany NY) (2011) 1.19
Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture. PLoS One (2011) 1.18
SIRT3 substrate specificity determined by peptide arrays and machine learning. ACS Chem Biol (2010) 1.17
Mammalian sirtuins and energy metabolism. Int J Biol Sci (2011) 1.17
Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications. Crit Rev Biochem Mol Biol (2013) 1.17
Protective effects and mechanisms of sirtuins in the nervous system. Prog Neurobiol (2011) 1.14
Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3. PLoS One (2012) 1.13
Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose deacylase: solution structure and catalytic properties. J Biol Chem (2011) 1.12
SIRT3 functions in the nucleus in the control of stress-related gene expression. Mol Cell Biol (2012) 1.12
The sirtuin family's role in aging and age-associated pathologies. J Clin Invest (2013) 1.12
Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype. Circ Res (2012) 1.11
NAD⁺ metabolism: a therapeutic target for age-related metabolic disease. Crit Rev Biochem Mol Biol (2013) 1.11
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside. Eur Heart J (2015) 1.11
Mitochondrial longevity pathways. Biochim Biophys Acta (2011) 1.11
Circadian acetylome reveals regulation of mitochondrial metabolic pathways. Proc Natl Acad Sci U S A (2013) 1.11
Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning. PLoS One (2011) 1.10
Metabolic regulation by SIRT3: implications for tumorigenesis. Trends Mol Med (2012) 1.10
Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis. Antioxid Redox Signal (2013) 1.09
Cardiac anaplerosis in health and disease: food for thought. Cardiovasc Res (2011) 1.09
Mitochondrial SIRT3 and heart disease. Cardiovasc Res (2010) 1.09
SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth. J Biol Chem (2013) 1.09
Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation. J Biol Chem (2011) 1.09
Exploring the therapeutic space around NAD+. J Cell Biol (2012) 1.09
Mitochondrial sirtuins and their relationships with metabolic disease and cancer. Antioxid Redox Signal (2015) 1.09
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell (2006) 11.38
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
Regulation of hepatic fatty acid oxidation and ketone body production. Annu Rev Biochem (1980) 7.03
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci U S A (2006) 7.00
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A (2008) 6.53
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A (2006) 5.96
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol (2002) 5.37
Conserved metabolic regulatory functions of sirtuins. Cell Metab (2008) 3.86
Sirtuins as potential targets for metabolic syndrome. Nature (2006) 3.38
Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients. Diabetes (2005) 3.36
Lipid oxidation is reduced in obese human skeletal muscle. Am J Physiol Endocrinol Metab (2000) 2.89
Calorie restriction alters mitochondrial protein acetylation. Aging Cell (2009) 2.73
Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance. Proc Natl Acad Sci U S A (2007) 2.69
Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation. Proc Natl Acad Sci U S A (1998) 2.22
Database of mRNA gene expression profiles of multiple human organs. Genome Res (2005) 2.11
Mammalian mitochondrial beta-oxidation. Biochem J (1996) 2.06
Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted mice. PLoS Genet (2005) 2.03
Gestational, pathologic and biochemical differences between very long-chain acyl-CoA dehydrogenase deficiency and long-chain acyl-CoA dehydrogenase deficiency in the mouse. Hum Mol Genet (2001) 1.93
Nonalcoholic fatty liver disease is a risk factor for type 2 diabetes in middle-aged Japanese men. Diabetes Care (2007) 1.90
Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice. Proc Natl Acad Sci U S A (2004) 1.80
Fluorometric assay of acyl-CoA dehydrogenases in normal and mutant human fibroblasts. Biochem Med (1985) 1.64
Significant correlations between severe fatty liver and risk factors for metabolic syndrome. J Gastroenterol Hepatol (2007) 1.36
Adipose tissue gene expression profiles in ob/ob mice treated with leptin. Life Sci (2008) 1.20
Mouse models for disorders of mitochondrial fatty acid beta-oxidation. ILAR J (2002) 1.16
Disturbed hepatic carbohydrate management during high metabolic demand in medium-chain acyl-CoA dehydrogenase (MCAD)-deficient mice. Hepatology (2008) 1.04
Evidence for impaired gluconeogenesis in very long-chain acyl-CoA dehydrogenase-deficient mice. Horm Metab Res (2006) 1.02
Assays of fatty acid beta-oxidation activity. Methods Cell Biol (2007) 1.01
Identification and importance of brown adipose tissue in adult humans. N Engl J Med (2009) 20.57
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell (2007) 17.98
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab (2009) 11.46
Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol (2006) 10.67
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab (2008) 9.74
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science (2013) 8.81
Developmental origin of fat: tracking obesity to its source. Cell (2007) 8.80
Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (2003) 8.53
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell (2003) 8.34
Suppression of aging in mice by the hormone Klotho. Science (2005) 8.11
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab (2008) 7.97
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J (2007) 7.30
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes (2002) 7.17
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature (2008) 6.82
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A (2003) 6.46
The detection of monkeypox in humans in the Western Hemisphere. N Engl J Med (2004) 6.32
The mechanism and regulation of chromosomal V(D)J recombination. Cell (2002) 6.28
Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol (2008) 6.23
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J (2003) 6.11
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A (2006) 5.96
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68
DNA repair, genome stability, and aging. Cell (2005) 5.52
Towards an HIV cure: a global scientific strategy. Nat Rev Immunol (2012) 5.52
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol (2002) 5.37
Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell (2003) 5.26
Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature (2003) 5.20
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell (2002) 5.19
Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A (2009) 5.19
Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab (2008) 5.07
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A (2002) 5.07
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat Med (2004) 5.04
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell (2002) 5.01
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab (2010) 4.97
Evidence for a role of developmental genes in the origin of obesity and body fat distribution. Proc Natl Acad Sci U S A (2006) 4.81
Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature (2008) 4.70
From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol (2006) 4.58
Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab (2007) 4.51
Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci U S A (2002) 4.40
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35
NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J (2005) 4.35
Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biol Chem (2005) 4.32
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol (2006) 4.32
Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem (2005) 4.30
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell (2002) 4.29
In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J (2002) 4.28
The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins. Sci Transl Med (2011) 4.24
Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov (2010) 4.23
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol (2004) 4.14
Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem (2003) 4.12
Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res (2008) 4.09
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol (2004) 4.04
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell (2005) 4.04
Lipid droplets and cellular lipid metabolism. Annu Rev Biochem (2012) 4.02
Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell (2012) 4.02
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature (2004) 3.94
Conserved metabolic regulatory functions of sirtuins. Cell Metab (2008) 3.86
Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biol Psychiatry (2005) 3.85
Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell (2007) 3.82
A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82
Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell (2011) 3.81
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol (2004) 3.79
Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases. Lancet (2013) 3.77
Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women. Diabetes Care (2009) 3.69
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab (2007) 3.69
Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med (2008) 3.66
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52