Published in J Pharmacol Exp Ther on May 04, 2010
Effects of nicotinic acid on gene expression: potential mechanisms and implications for wanted and unwanted effects of the lipid-lowering drug. J Clin Endocrinol Metab (2011) 0.90
Liver fat reduction with niacin is influenced by DGAT-2 polymorphisms in hypertriglyceridemic patients. J Lipid Res (2012) 0.84
Serum lipoprotein changes in dogs with renal disease. J Vet Intern Med (2014) 0.80
Effects of phenotypic and genotypic factors on the lipid responses to niacin in Chinese patients with dyslipidemia. Medicine (Baltimore) (2015) 0.77
Prone positioning in severe acute respiratory distress syndrome. N Engl J Med (2013) 12.37
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet (2003) 11.67
A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med (2015) 11.05
Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med (2015) 5.59
Open lung biopsy in nonresolving ARDS frequently identifies diffuse alveolar damage regardless of the severity stage and may have implications for patient management. Intensive Care Med (2014) 3.03
Quantitative analysis of acid-base disorders in patients with chronic respiratory failure in stable or unstable respiratory condition. Respir Care (2010) 2.69
Apolipoprotein B100 metabolism in autosomal-dominant hypercholesterolemia related to mutations in PCSK9. Arterioscler Thromb Vasc Biol (2004) 2.37
Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells. J Lipid Res (2005) 1.79
Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c. J Biol Chem (2006) 1.60
Effect of activated protein C on pulmonary blood flow and cytokine production in experimental acute lung injury. Intensive Care Med (2007) 1.57
Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia. Hum Mutat (2005) 1.54
Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody. Circ Cardiovasc Genet (2015) 1.50
Performance of the coughassist insufflation-exsufflation device in the presence of an endotracheal tube or tracheostomy tube: a bench study. Respir Care (2011) 1.41
Evaluation of recruited lung volume at inspiratory plateau pressure with PEEP using bedside digital chest X-ray in patients with acute lung injury/ARDS. Respir Care (2013) 1.40
Expiratory flow-volume loop profile and patient outcome in chronic obstructive pulmonary disease in acute respiratory failure: a prospective observational study in a single intensive care unit. Respiration (2011) 1.39
Residual macrovascular risk in 2013: what have we learned? Cardiovasc Diabetol (2014) 1.20
Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9. J Biol Chem (2008) 1.16
Efficacy and safety of alirocumab in patients with heterozygous familial hypercholesterolemia not adequately controlled with current lipid-lowering therapy: design and rationale of the ODYSSEY FH studies. Cardiovasc Drugs Ther (2014) 1.15
Intronic mutations outside of Alu-repeat-rich domains of the LDL receptor gene are a cause of familial hypercholesterolemia. Hum Genet (2002) 1.14
Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia. Arterioscler Thromb Vasc Biol (2009) 1.12
Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes. FEBS Lett (2008) 1.03
High protein intake reduces intrahepatocellular lipid deposition in humans. Am J Clin Nutr (2009) 1.01
Efficacy and safety of recruitment maneuvers in acute respiratory distress syndrome. Ann Intensive Care (2011) 1.00
Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor. Endocrinology (2006) 1.00
PCSK9 and LDL cholesterol: unravelling the target to design the bullet. Trends Biochem Sci (2008) 1.00
Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults. Nutr Metab (Lond) (2011) 0.97
Weight loss in obese dogs: evaluation of a high-protein, low-carbohydrate diet. J Nutr (2002) 0.96
Carotid and femoral atherosclerotic plaques show different morphology. Atherosclerosis (2011) 0.96
PCSK9 dominant negative mutant results in increased LDL catabolic rate and familial hypobetalipoproteinemia. Arterioscler Thromb Vasc Biol (2009) 0.95
Effects of green tea on insulin sensitivity, lipid profile and expression of PPARalpha and PPARgamma and their target genes in obese dogs. Br J Nutr (2007) 0.94
Production rates and metabolism of short-chain fatty acids in the colon and whole body using stable isotopes. Proc Nutr Soc (2003) 0.94
Description of a large family with autosomal dominant hypercholesterolemia associated with the APOE p.Leu167del mutation. Hum Mutat (2012) 0.94
Effect of atorvastatin on apolipoprotein B100 containing lipoprotein metabolism in type-2 diabetes. J Pharmacol Exp Ther (2003) 0.93
Rapid weight loss with a high-protein low-energy diet allows the recovery of ideal body composition and insulin sensitivity in obese dogs. J Nutr (2004) 0.93
WSAVA Nutritional Assessment Guidelines. J Small Anim Pract (2011) 0.92
Effect of low-fat, fermented milk enriched with plant sterols on serum lipid profile and oxidative stress in moderate hypercholesterolemia. Am J Clin Nutr (2007) 0.92
Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model. J Lipid Res (2009) 0.92
A fourth locus for autosomal dominant hypercholesterolemia maps at 16q22.1. Eur J Hum Genet (2010) 0.91
PCSK9: a promising therapeutic target for dyslipidemias? Trends Endocrinol Metab (2006) 0.90
Perinatal undernutrition-induced obesity is independent of the developmental programming of feeding. Physiol Behav (2008) 0.89
Resistant starch modulates in vivo colonic butyrate uptake and its oxidation in rats with dextran sulfate sodium-induced colitis. J Nutr (2004) 0.88
Lipid profile and insulin sensitivity in rats fed with high-fat or high-fructose diets. Br J Nutr (2011) 0.87
Evaluation of body composition in dogs by isotopic dilution using a low-cost technique, Fourier-transform infrared spectroscopy. J Nutr (2002) 0.87
Selective uptake of high density lipoproteins cholesteryl ester in the dog, a species lacking in cholesteryl ester transfer protein activity; An in vivo approach using stable isotopes. Comp Biochem Physiol B Biochem Mol Biol (2004) 0.87
Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets. Nutr Metab (Lond) (2013) 0.87
Postprandial response of plasma insulin, amylin and acylated ghrelin to various test meals in lean and obese cats. Br J Nutr (2010) 0.86
Association between plasma PCSK9 and gamma-glutamyl transferase levels in diabetic patients. Atherosclerosis (2010) 0.86
Effect of glutamine on glutathione kinetics in vivo in dogs. J Nutr Biochem (2006) 0.86
PCSK9 is expressed in pancreatic delta-cells and does not alter insulin secretion. Biochem Biophys Res Commun (2009) 0.86
Lipoproteins abnormalities in obese insulin-resistant dogs. Metabolism (2003) 0.85
Comparing three pedagogical approaches to psychomotor skills acquisition. Am J Surg (2011) 0.84
Spontaneous hormonal variations in male cats following gonadectomy. J Feline Med Surg (2006) 0.84
Use of advanced cluster analysis to characterize fish consumption patterns and methylmercury dietary exposures from fish and other sea foods among pregnant women. J Expo Sci Environ Epidemiol (2009) 0.84
Lack of association between plasma PCSK9 and LDL-apoB100 catabolism in patients with uncontrolled type 2 diabetes. Atherosclerosis (2011) 0.83
Quality of life with diabetes-associated foot complications: comparison between lower-limb amputation and chronic foot ulceration. Foot Ankle Int (2008) 0.83
Fenofibrate lowers lipid parameters in obese dogs. J Nutr (2006) 0.83
Cholesterol lowering effect of a soy drink enriched with plant sterols in a French population with moderate hypercholesterolemia. Lipids Health Dis (2008) 0.83
The effects of obesity-associated insulin resistance on mRNA expression of peroxisome proliferator-activated receptor-gamma target genes, in dogs. Br J Nutr (2007) 0.83
High protein intake affects lean body mass but not energy expenditure in nonobese neutered cats. J Nutr (2004) 0.82
Serum insulin-like growth factor type 1 concentrations in healthy dogs and dogs with spontaneous primary hypothyroidism. Vet J (2011) 0.81
[Radiotherapy and atherosclerosis: current data and issues]. Med Sci (Paris) (2010) 0.81
Thiazolidinedione use is not associated with worse cardiovascular outcomes: a study in 28,332 high risk patients with diabetes in routine clinical practice: brief title: thiazolidinedione use and mortality. Int J Cardiol (2012) 0.81
WSAVA Nutritional Assessment Guidelines. Compend Contin Educ Vet (2011) 0.80
Indirect prediction of total body water content in healthy adult Beagles by single-frequency bioelectrical impedance analysis. Am J Vet Res (2015) 0.80
Influence of different levels and sources of resistant starch on faecal quality of dogs of various body sizes. Br J Nutr (2011) 0.80
Does enteral glutamine modulate whole-body leucine kinetics in hypercatabolic dogs in a fed state? Metabolism (2002) 0.79
Do infants and toddlers prefer nasal swabs or washes for specimen collection? Pediatr Infect Dis J (2010) 0.78
Ventriculitis revealing Bing-Neel syndrome in a patient without Waldenstrom's macroglobulinemia. Clin Neurol Neurosurg (2012) 0.78
Effect of citrus polyphenol- and curcumin-supplemented diet on inflammatory state in obese cats. Br J Nutr (2011) 0.78
Gastric emptying rate is inversely related to body weight in dog breeds of different sizes. J Nutr (2004) 0.78
Diet-induced dyslipidemia impairs reverse cholesterol transport in hamsters. Eur J Clin Invest (2011) 0.77
Serum resistance to singlet oxygen in patients with diabetes mellitus in comparison to healthy donors. Metabolism (2011) 0.77
Low rate of production of apolipoproteins B100 and AI in 2 patients with Anderson disease (chylomicron retention disease). Arterioscler Thromb Vasc Biol (2012) 0.77
Atorvastatin increases intestinal cholesterol absorption in dogs. J Nutr (2006) 0.77
Obesity induced during sexual maturation is linked to LDL-triacylglycerols in Yucatan miniature swine. Br J Nutr (2005) 0.77