Published in J Clin Endocrinol Metab on May 01, 2010
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am J Hum Genet (2001) 4.97
Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem (2007) 4.74
Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab (2007) 4.64
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J Biol Chem (2005) 4.13
Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. J Exp Med (2004) 3.88
Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J Bone Miner Res (2009) 3.69
Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Res (2005) 2.61
Low-level, high-frequency mechanical signals enhance musculoskeletal development of young women with low BMD. J Bone Miner Res (2006) 2.22
Molecular pathways mediating mechanical signaling in bone. Gene (2005) 2.17
Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals. Proc Natl Acad Sci U S A (2007) 2.04
Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss. J Clin Endocrinol Metab (2010) 1.98
Mechanical signals as anabolic agents in bone. Nat Rev Rheumatol (2010) 1.95
Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal. Endocrinology (2008) 1.91
Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology (2007) 1.82
The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low-magnitude mechanical stimuli. FASEB J (2001) 1.68
Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesity. J Bone Miner Res (2009) 1.67
Resistance exercise as a countermeasure to disuse-induced bone loss. J Appl Physiol (1985) (2004) 1.61
Beta-catenin levels influence rapid mechanical responses in osteoblasts. J Biol Chem (2008) 1.60
Mechanical loading regulates NFATc1 and beta-catenin signaling through a GSK3beta control node. J Biol Chem (2009) 1.49
Exercise when young provides lifelong benefits to bone structure and strength. J Bone Miner Res (2007) 1.40
Longitudinal study of bone turnover after acute spinal cord injury. J Clin Endocrinol Metab (1998) 1.21
Alendronate prevents bone loss in patients with acute spinal cord injury: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab (2007) 1.13
Marrow changes in paraplegic patients. Calcif Tissue Int (1984) 1.02
Low-level, high-frequency mechanical signals enhance musculoskeletal development of young women with low BMD. J Bone Miner Res (2006) 2.22
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Low magnitude mechanical loading is osteogenic in children with disabling conditions. J Bone Miner Res (2004) 2.15
Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha. J Biol Chem (2001) 1.99
Mechanical signals as anabolic agents in bone. Nat Rev Rheumatol (2010) 1.95
Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal. Endocrinology (2008) 1.91
Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude. J Biomech (2006) 1.87
Low-level accelerations applied in the absence of weight bearing can enhance trabecular bone formation. J Orthop Res (2007) 1.73
Fluid pressure gradients, arising from oscillations in intramedullary pressure, is correlated with the formation of bone and inhibition of intracortical porosity. J Biomech (2003) 1.69
Short applications of very low-magnitude vibrations attenuate expansion of the intervertebral disc during extended bed rest. Spine J (2009) 1.65
Mechanical regulation of signaling pathways in bone. Gene (2012) 1.65
Beta-catenin levels influence rapid mechanical responses in osteoblasts. J Biol Chem (2008) 1.60
Enhancement of the adolescent murine musculoskeletal system using low-level mechanical vibrations. J Appl Physiol (1985) (2008) 1.55
Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program. Bone (2004) 1.53
Mechanical loading regulates NFATc1 and beta-catenin signaling through a GSK3beta control node. J Biol Chem (2009) 1.49
Rib fractures and death from deletion of osteoblast βcatenin in adult mice is rescued by corticosteroids. PLoS One (2013) 1.39
Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways. J Biol Chem (2006) 1.37
Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeleton. FASEB J (2002) 1.37
The pathway of bone fluid flow as defined by in vivo intramedullary pressure and streaming potential measurements. Ann Biomed Eng (2002) 1.29
Mechanical signal influence on mesenchymal stem cell fate is enhanced by incorporation of refractory periods into the loading regimen. J Biomech (2010) 1.29
The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis. Am J Physiol Endocrinol Metab (2004) 1.29
Genetically based influences on the site-specific regulation of trabecular and cortical bone morphology. J Bone Miner Res (2004) 1.25
Genetically linked site-specificity of disuse osteoporosis. J Bone Miner Res (2004) 1.20
Role of PECAM-1 in arteriogenesis and specification of preexisting collaterals. Circ Res (2010) 1.20
Interrelationship of trabecular mechanical and microstructural properties in sheep trabecular bone. J Biomech (2005) 1.17
Integration of the NfkappaB p65 subunit into the vitamin D receptor transcriptional complex: identification of p65 domains that inhibit 1,25-dihydroxyvitamin D3-stimulated transcription. J Cell Biochem (2004) 1.17
Combining high-resolution micro-computed tomography with material composition to define the quality of bone tissue. Curr Osteoporos Rep (2003) 1.16
Small oscillatory accelerations, independent of matrix deformations, increase osteoblast activity and enhance bone morphology. PLoS One (2007) 1.12
Mechanical activation of β-catenin regulates phenotype in adult murine marrow-derived mesenchymal stem cells. J Orthop Res (2010) 1.12
TEM analysis of the nanostructure of normal and osteoporotic human trabecular bone. Bone (2003) 1.07
mTORC2 regulates mechanically induced cytoskeletal reorganization and lineage selection in marrow-derived mesenchymal stem cells. J Bone Miner Res (2014) 1.04
Mechanically induced focal adhesion assembly amplifies anti-adipogenic pathways in mesenchymal stem cells. Stem Cells (2011) 1.04
Response to mechanical strain in an immortalized pre-osteoblast cell is dependent on ERK1/2. J Cell Physiol (2006) 1.03
Adaptations of trabecular bone to low magnitude vibrations result in more uniform stress and strain under load. Ann Biomed Eng (2003) 1.01
Genetic variations that regulate bone morphology in the male mouse skeleton do not define its susceptibility to mechanical unloading. Bone (2004) 1.00
Beta-catenin--a supporting role in the skeleton. J Cell Biochem (2010) 0.99
Detection of endothelial nitric oxide release with the 2,3-diaminonapthalene assay. Free Radic Biol Med (2003) 0.98
Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells. J Cell Biochem (2004) 0.98
Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein. J Biol Chem (2011) 0.97
Postural instability caused by extended bed rest is alleviated by brief daily exposure to low magnitude mechanical signals. Gait Posture (2011) 0.97
Indomethacin promotes adipogenesis of mesenchymal stem cells through a cyclooxygenase independent mechanism. J Cell Biochem (2010) 0.95
Low magnitude and high frequency mechanical loading prevents decreased bone formation responses of 2T3 preosteoblasts. J Cell Biochem (2009) 0.94
Evaluation of trabecular mechanical and microstructural properties in human calcaneal bone of advanced age using mechanical testing, microCT, and DXA. J Biomech (2007) 0.93
Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells. Endocrinology (2003) 0.92
Mechanical input restrains PPARγ2 expression and action to preserve mesenchymal stem cell multipotentiality. Bone (2012) 0.91
High-frequency, low-magnitude vibrations suppress the number of blood vessels per muscle fiber in mouse soleus muscle. J Appl Physiol (1985) (2005) 0.91
Effects of titanium particle size on osteoblast functions in vitro and in vivo. Proc Natl Acad Sci U S A (2005) 0.91
Nitric oxide donors inhibit luciferase expression in a promoter-independent fashion. J Biol Chem (2003) 0.88
Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells. Stem Cells (2013) 0.88
Adeno-associated viral delivery of a metabolically regulated insulin transgene to hepatocytes. Mol Cell Endocrinol (2007) 0.87
Mechanical strain downregulates C/EBPβ in MSC and decreases endoplasmic reticulum stress. PLoS One (2012) 0.87
Low magnitude mechanical signals mitigate osteopenia without compromising longevity in an aged murine model of spontaneous granulosa cell ovarian cancer. Bone (2012) 0.86
Mechanical Signals As a Non-Invasive Means to Influence Mesenchymal Stem Cell Fate, Promoting Bone and Suppressing the Fat Phenotype. Bonekey Osteovision (2009) 0.86
Brief daily exposure to low-intensity vibration mitigates the degradation of the intervertebral disc in a frequency-specific manner. J Appl Physiol (1985) (2011) 0.86
The role of nitric oxide in the mechanical repression of RANKL in bone stromal cells. Bone (2008) 0.85
Vibration therapy: clinical applications in bone. Curr Opin Endocrinol Diabetes Obes (2014) 0.80
SEM and TEM study of the hierarchical structure of C57BL/6J and C3H/HeJ mice trabecular bone. Bone (2004) 0.78
Protein kinase inhibitor γ reciprocally regulates osteoblast and adipocyte differentiation by downregulating leukemia inhibitory factor. Stem Cells (2013) 0.77
Functional adaptation to loading of a single bone is neuronally regulated and involves multiple bones. J Bone Miner Res (2008) 0.77
Regulation of skeletal remodeling by biomechanical input. Osteoporos Int (2003) 0.76
Veterans Administration support for medical research: opinions of the endangered species of physician-scientists. FASEB J (2004) 0.75