Published in J Bone Miner Res on January 01, 2014
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The increasingly complex regulation of adipocyte differentiation. Exp Biol Med (Maywood) (2015) 0.79
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Loss of Rictor with aging in osteoblasts promotes age-related bone loss. Cell Death Dis (2016) 0.75
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Targeting P38 Pathway Regulates Bony Formation via MSC Recruitment during Mandibular Distraction Osteogenesis in Rats. Int J Med Sci (2016) 0.75
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Low-Dose, Long-Wave UV Light Does Not Affect Gene Expression of Human Mesenchymal Stem Cells. PLoS One (2015) 0.75
Low intensity vibration mitigates tumor progression and protects bone quantity and quality in a murine model of myeloma. Bone (2016) 0.75
Microtopographical cues promote peripheral nerve regeneration via transient mTORC2 activation. Acta Biomater (2017) 0.75
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Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science (2003) 12.41
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol (2004) 12.12
Local force and geometry sensing regulate cell functions. Nat Rev Mol Cell Biol (2006) 11.29
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell (2006) 10.50
Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol (2001) 9.73
Inhibition of adipogenesis by Wnt signaling. Science (2000) 9.72
Growth factors, matrices, and forces combine and control stem cells. Science (2009) 8.46
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature (2010) 6.25
The two TORCs and Akt. Dev Cell (2007) 6.17
Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner. Nat Cell Biol (2008) 5.87
Regulation of bone mass by Wnt signaling. J Clin Invest (2006) 5.59
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat Cell Biol (2011) 4.59
Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. Cell (2010) 4.19
Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells. J Cell Biol (2007) 4.03
Restriction of receptor movement alters cellular response: physical force sensing by EphA2. Science (2010) 3.72
Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. Biochem J (2005) 3.58
Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation. J Cell Biol (2010) 3.56
The structure and regulation of vinculin. Trends Cell Biol (2006) 3.52
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell (2005) 3.01
mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion. Dev Cell (2010) 2.56
Actin stress fibers--assembly, dynamics and biological roles. J Cell Sci (2012) 2.33
Mechanical signals as anabolic agents in bone. Nat Rev Rheumatol (2010) 1.95
Phosphoinositide 3-kinases in cell migration. Biol Cell (2009) 1.95
Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal. Endocrinology (2008) 1.91
Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology (2007) 1.82
Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesity. J Bone Miner Res (2009) 1.67
Mechanical regulation of signaling pathways in bone. Gene (2012) 1.65
Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis. Nat Cell Biol (2012) 1.58
Vinculin promotes cell spreading by mechanically coupling integrins to the cytoskeleton. Exp Cell Res (1997) 1.58
The mechanical environment of bone marrow: a review. Ann Biomed Eng (2008) 1.57
Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (2011) 1.56
Mechanical loading regulates NFATc1 and beta-catenin signaling through a GSK3beta control node. J Biol Chem (2009) 1.49
Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells. J Bone Miner Res (2007) 1.48
Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells. J Bone Miner Res (2011) 1.38
Integrin connections to the cytoskeleton through talin and vinculin. Biochem Soc Trans (2008) 1.30
Mechanical signal influence on mesenchymal stem cell fate is enhanced by incorporation of refractory periods into the loading regimen. J Biomech (2010) 1.29
Proteomics exploration reveals that actin is a signaling target of the kinase Akt. Mol Cell Proteomics (2006) 1.21
Endoplasmic reticulum is a main localization site of mTORC2. Biochem Biophys Res Commun (2011) 1.17
Deconvoluting mTOR biology. Cell Cycle (2012) 1.16
Mechanical activation of β-catenin regulates phenotype in adult murine marrow-derived mesenchymal stem cells. J Orthop Res (2010) 1.12
Formation of focal adhesions on fibronectin promotes fluid shear stress induction of COX-2 and PGE2 release in MC3T3-E1 osteoblasts. J Appl Physiol (1985) (2004) 1.07
Bone marrow fat accumulation after 60 days of bed rest persisted 1 year after activities were resumed along with hemopoietic stimulation: the Women International Space Simulation for Exploration study. J Appl Physiol (1985) (2009) 1.06
Mechanically induced focal adhesion assembly amplifies anti-adipogenic pathways in mesenchymal stem cells. Stem Cells (2011) 1.04
Targeting of the Akt/PKB kinase to the actin skeleton. Cell Mol Life Sci (2003) 1.03
Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein. J Biol Chem (2011) 0.97
Paxillin enables attachment-independent tyrosine phosphorylation of focal adhesion kinase and transformation by RAS. J Biol Chem (2011) 0.92
Mechanical input restrains PPARγ2 expression and action to preserve mesenchymal stem cell multipotentiality. Bone (2012) 0.91
Mechanotransduction and focal adhesions. Cell Biol Int (2012) 0.91
Isolation of focal adhesion proteins for biochemical and proteomic analysis. Methods Mol Biol (2012) 0.89
Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha. J Biol Chem (2001) 1.99
Mechanical signals as anabolic agents in bone. Nat Rev Rheumatol (2010) 1.95
Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal. Endocrinology (2008) 1.91
Mechanical regulation of signaling pathways in bone. Gene (2012) 1.65
R4 RGS proteins: regulation of G-protein signaling and beyond. Pharmacol Ther (2007) 1.63
Beta-catenin levels influence rapid mechanical responses in osteoblasts. J Biol Chem (2008) 1.60
Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1. Dev Cell (2007) 1.56
beta2-microglobulin is a signaling and growth-promoting factor for human prostate cancer bone metastasis. Cancer Res (2006) 1.55
Endothelial dysfunction: associations with exposure to ambient fine particles in diabetic individuals. Environ Health Perspect (2008) 1.53
Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program. Bone (2004) 1.53
Mechanical loading regulates NFATc1 and beta-catenin signaling through a GSK3beta control node. J Biol Chem (2009) 1.49
Human osteocalcin and bone sialoprotein mediating osteomimicry of prostate cancer cells: role of cAMP-dependent protein kinase A signaling pathway. Cancer Res (2005) 1.41
Rib fractures and death from deletion of osteoblast βcatenin in adult mice is rescued by corticosteroids. PLoS One (2013) 1.39
Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways. J Biol Chem (2006) 1.37
Beta2-microglobulin promotes the growth of human renal cell carcinoma through the activation of the protein kinase A, cyclic AMP-responsive element-binding protein, and vascular endothelial growth factor axis. Clin Cancer Res (2006) 1.34
Mechanical signal influence on mesenchymal stem cell fate is enhanced by incorporation of refractory periods into the loading regimen. J Biomech (2010) 1.29
The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis. Am J Physiol Endocrinol Metab (2004) 1.29
Malignant pancreatic tumors: incidence and outcome in 58 pediatric patients. J Pediatr Surg (2009) 1.21
Role of PECAM-1 in arteriogenesis and specification of preexisting collaterals. Circ Res (2010) 1.20
Characterization of medroxyprogesterone and DMBA-induced multilineage mammary tumors by gene expression profiling. Mol Carcinog (2005) 1.17
Integration of the NfkappaB p65 subunit into the vitamin D receptor transcriptional complex: identification of p65 domains that inhibit 1,25-dihydroxyvitamin D3-stimulated transcription. J Cell Biochem (2004) 1.17
Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13. Nat Immunol (2007) 1.14
Mechanical activation of β-catenin regulates phenotype in adult murine marrow-derived mesenchymal stem cells. J Orthop Res (2010) 1.12
TEM analysis of the nanostructure of normal and osteoporotic human trabecular bone. Bone (2003) 1.07
RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling. J Biol Chem (2009) 1.06
Mechanically induced focal adhesion assembly amplifies anti-adipogenic pathways in mesenchymal stem cells. Stem Cells (2011) 1.04
Response to mechanical strain in an immortalized pre-osteoblast cell is dependent on ERK1/2. J Cell Physiol (2006) 1.03
The zinc finger transcription factor Ovol2 acts downstream of the bone morphogenetic protein pathway to regulate the cell fate decision between neuroectoderm and mesendoderm. J Biol Chem (2013) 1.03
Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1. Proc Natl Acad Sci U S A (2010) 1.02
Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor. J Immunol (2010) 1.01
Caveolin-1 knockout mice have increased bone size and stiffness. J Bone Miner Res (2007) 1.01
Immune sensitization to yeast antigens in ASCA-positive patients with Crohn's disease. Inflamm Bowel Dis (2004) 1.00
Beta-catenin--a supporting role in the skeleton. J Cell Biochem (2010) 0.99
Detection of endothelial nitric oxide release with the 2,3-diaminonapthalene assay. Free Radic Biol Med (2003) 0.98
Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells. J Cell Biochem (2004) 0.98
Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein. J Biol Chem (2011) 0.97
Indomethacin promotes adipogenesis of mesenchymal stem cells through a cyclooxygenase independent mechanism. J Cell Biochem (2010) 0.95
Mechanical regulation of chondrogenesis. Stem Cell Res Ther (2013) 0.93
Visualizing human prostate cancer cells in mouse skeleton using bioconjugated near-infrared fluorescent quantum dots. Urology (2009) 0.93
Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells. Endocrinology (2003) 0.92
Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise. Bone (2014) 0.92
Mechanical input restrains PPARγ2 expression and action to preserve mesenchymal stem cell multipotentiality. Bone (2012) 0.91
Effects of titanium particle size on osteoblast functions in vitro and in vivo. Proc Natl Acad Sci U S A (2005) 0.91
PPARgamma and PPARdelta as Modulators of Neoplasia and Cell Fate. PPAR Res (2008) 0.91
Naive T cells sense the cysteine protease allergen papain through protease-activated receptor 2 and propel TH2 immunity. J Allergy Clin Immunol (2012) 0.89
Spontaneous extraperitoneal haemorrhage: computed tomography diagnosis and treatment by selective arterial embolization. Australas Radiol (2004) 0.89
Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canalicular system. J Bone Miner Res (2014) 0.89
RGS16 attenuates pulmonary Th2/Th17 inflammatory responses. J Immunol (2012) 0.89
Non-invasive bioluminescent detection of prostate cancer growth and metastasis in a bigenic transgenic mouse model. Prostate (2007) 0.88
Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells. Stem Cells (2013) 0.88
Nitric oxide donors inhibit luciferase expression in a promoter-independent fashion. J Biol Chem (2003) 0.88
Adeno-associated viral delivery of a metabolically regulated insulin transgene to hepatocytes. Mol Cell Endocrinol (2007) 0.87
Mechanical strain downregulates C/EBPβ in MSC and decreases endoplasmic reticulum stress. PLoS One (2012) 0.87
Brief daily exposure to low-intensity vibration mitigates the degradation of the intervertebral disc in a frequency-specific manner. J Appl Physiol (1985) (2011) 0.86
Mechanical Signals As a Non-Invasive Means to Influence Mesenchymal Stem Cell Fate, Promoting Bone and Suppressing the Fat Phenotype. Bonekey Osteovision (2009) 0.86
Low magnitude mechanical signals mitigate osteopenia without compromising longevity in an aged murine model of spontaneous granulosa cell ovarian cancer. Bone (2012) 0.86
Pediatric penetrating cardiac injury from abuse: a case report. Pediatr Surg Int (2007) 0.85
Incidence and outcomes of malignant pediatric lung neoplasms. J Surg Res (2009) 0.85
The role of nitric oxide in the mechanical repression of RANKL in bone stromal cells. Bone (2008) 0.85
Heterotaxy syndrome: defining contemporary disease trends. Pediatr Cardiol (2010) 0.85
GATA transcription factors regulate the expression of the human eosinophil-derived neurotoxin (RNase 2) gene. J Biol Chem (2009) 0.84
Evaluation of assays for perinuclear antineutrophilic cytoplasmic antibodies and antibodies to Saccharomyces cerevisiae in dogs with inflammatory bowel disease. Am J Vet Res (2004) 0.84
The potential benefits and inherent risks of vibration as a non-drug therapy for the prevention and treatment of osteoporosis. Curr Osteoporos Rep (2013) 0.83
Synaptic and extrasynaptic location of the receptor tyrosine kinase met during postnatal development in the mouse neocortex and hippocampus. J Comp Neurol (2013) 0.83
Cotargeting tumor and tumor endothelium effectively inhibits the growth of human prostate cancer in adenovirus-mediated antiangiogenesis and oncolysis combination therapy. Cancer Gene Ther (2005) 0.82
Varying whole body vibration amplitude differentially affects tendon and ligament structural and material properties. J Biomech (2013) 0.82
Multiple exposures to unloading decrease bone's responsivity but compound skeletal losses in C57BL/6 mice. Am J Physiol Regul Integr Comp Physiol (2012) 0.81
Vibration therapy: clinical applications in bone. Curr Opin Endocrinol Diabetes Obes (2014) 0.80
Value of computed tomographic angiography in neck and extremity pediatric vascular trauma. J Pediatr Surg (2009) 0.80