Published in J Cell Biochem on June 01, 2010
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Mechanical regulation of signaling pathways in bone. Gene (2012) 1.65
Review of Signaling Pathways Governing MSC Osteogenic and Adipogenic Differentiation. Scientifica (Cairo) (2013) 1.51
Rib fractures and death from deletion of osteoblast βcatenin in adult mice is rescued by corticosteroids. PLoS One (2013) 1.39
Wnt signaling in bone formation and its therapeutic potential for bone diseases. Ther Adv Musculoskelet Dis (2013) 1.25
The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification. Dev Cell (2011) 1.03
Wnt signaling and orthopedics, an overview. Acta Orthop (2011) 0.95
Epigenetic Plasticity Drives Adipogenic and Osteogenic Differentiation of Marrow-derived Mesenchymal Stem Cells. J Biol Chem (2016) 0.89
Low magnitude mechanical signals mitigate osteopenia without compromising longevity in an aged murine model of spontaneous granulosa cell ovarian cancer. Bone (2012) 0.86
Adaptive and Injury Response of Bone to Mechanical Loading. Bonekey Osteovision (2012) 0.85
Nucleocytoplasmic shuttling of cytoskeletal proteins: molecular mechanism and biological significance. Int J Cell Biol (2011) 0.84
Three-dimensional multipotent progenitor cell aggregates for expansion, osteogenic differentiation and 'in vivo' tracing with AAV vector serotype 6. Gene Ther (2012) 0.83
Polycystin-1 mediates mechanical strain-induced osteoblastic mechanoresponses via potentiation of intracellular calcium and Akt/β-catenin pathway. PLoS One (2014) 0.82
Gata2 Is a Rheostat for Mesenchymal Stem Cell Fate in Male Mice. Endocrinology (2016) 0.76
Mechanosignaling in bone health, trauma and inflammation. Antioxid Redox Signal (2013) 0.76
The molecular basis of bone mechanotransduction. J Musculoskelet Neuronal Interact (2016) 0.75
The Role of Semaphorin 3A in Bone Remodeling. Front Cell Neurosci (2017) 0.75
Exercise Regulation of Marrow Adipose Tissue. Front Endocrinol (Lausanne) (2016) 0.75
The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol (2004) 24.63
Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell (2001) 11.99
High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med (2002) 11.28
The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med (2003) 10.67
Inhibition of adipogenesis by Wnt signaling. Science (2000) 9.72
Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell (2005) 8.16
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64
Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development (2006) 7.08
Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell (2005) 6.90
A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet (2001) 6.56
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell (2008) 5.93
Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science (2005) 5.68
PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest (2004) 5.29
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am J Hum Genet (2001) 4.97
Lack of beta-catenin affects mouse development at gastrulation. Development (1995) 4.95
Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab (2007) 4.64
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev (2008) 4.38
Retracted A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol (2007) 3.97
Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development (2004) 3.89
Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem (2005) 3.88
Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J Bone Miner Res (2009) 3.69
Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest (2002) 3.29
Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone. J Biol Chem (2006) 3.10
The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Mol Endocrinol (2004) 3.09
The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J Biol Chem (2006) 3.04
Wnt signaling from development to disease: insights from model systems. Cold Spring Harb Perspect Biol (2009) 2.42
Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha. J Biol Chem (2007) 2.24
Molecular pathways mediating mechanical signaling in bone. Gene (2005) 2.17
Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth. Proc Natl Acad Sci U S A (2003) 2.01
Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal. Endocrinology (2008) 1.91
Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone. J Bone Miner Res (2009) 1.85
Wnt signaling inhibits adipogenesis through beta-catenin-dependent and -independent mechanisms. J Biol Chem (2005) 1.85
Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology (2007) 1.82
TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro. J Bone Miner Res (2005) 1.68
Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesity. J Bone Miner Res (2009) 1.67
Beta-catenin levels influence rapid mechanical responses in osteoblasts. J Biol Chem (2008) 1.60
WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair. Am J Pathol (2004) 1.53
Adhesive and signaling functions of cadherins and catenins in vertebrate development. Cold Spring Harb Perspect Biol (2009) 1.52
Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains. J Biol Chem (2000) 1.51
Mechanical loading regulates NFATc1 and beta-catenin signaling through a GSK3beta control node. J Biol Chem (2009) 1.49
Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells. J Bone Miner Res (2007) 1.48
Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells. J Cell Biol (2009) 1.44
Fluid shear stress induces beta-catenin signaling in osteoblasts. Calcif Tissue Int (2004) 1.42
Crosstalk between Wnt and bone morphogenic protein signaling: a turbulent relationship. Dev Dyn (2010) 1.33
Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice. J Cell Sci (2009) 1.29
Prostaglandin promotion of osteocyte gap junction function through transcriptional regulation of connexin 43 by glycogen synthase kinase 3/beta-catenin signaling. Mol Cell Biol (2010) 1.24
Mechanical strain inhibits expression of osteoclast differentiation factor by murine stromal cells. Am J Physiol Cell Physiol (2000) 1.11
Resveratrol augments the canonical Wnt signaling pathway in promoting osteoblastic differentiation of multipotent mesenchymal cells. Exp Cell Res (2009) 1.08
Cell-cell adhesion and signaling through cadherins: connecting bone cells in their microenvironment. J Bone Miner Res (2006) 1.08
Caveolin-1 knockout mice have increased bone size and stiffness. J Bone Miner Res (2007) 1.01
Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors. BMC Dev Biol (2009) 0.99
Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha. J Biol Chem (2001) 1.99
Mechanical signals as anabolic agents in bone. Nat Rev Rheumatol (2010) 1.95
Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal. Endocrinology (2008) 1.91
Mechanical regulation of signaling pathways in bone. Gene (2012) 1.65
Beta-catenin levels influence rapid mechanical responses in osteoblasts. J Biol Chem (2008) 1.60
Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program. Bone (2004) 1.53
Mechanical loading regulates NFATc1 and beta-catenin signaling through a GSK3beta control node. J Biol Chem (2009) 1.49
Rib fractures and death from deletion of osteoblast βcatenin in adult mice is rescued by corticosteroids. PLoS One (2013) 1.39
Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways. J Biol Chem (2006) 1.37
Mechanical signal influence on mesenchymal stem cell fate is enhanced by incorporation of refractory periods into the loading regimen. J Biomech (2010) 1.29
The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis. Am J Physiol Endocrinol Metab (2004) 1.29
Role of PECAM-1 in arteriogenesis and specification of preexisting collaterals. Circ Res (2010) 1.20
Integration of the NfkappaB p65 subunit into the vitamin D receptor transcriptional complex: identification of p65 domains that inhibit 1,25-dihydroxyvitamin D3-stimulated transcription. J Cell Biochem (2004) 1.17
Mechanical activation of β-catenin regulates phenotype in adult murine marrow-derived mesenchymal stem cells. J Orthop Res (2010) 1.12
TEM analysis of the nanostructure of normal and osteoporotic human trabecular bone. Bone (2003) 1.07
mTORC2 regulates mechanically induced cytoskeletal reorganization and lineage selection in marrow-derived mesenchymal stem cells. J Bone Miner Res (2014) 1.04
Mechanically induced focal adhesion assembly amplifies anti-adipogenic pathways in mesenchymal stem cells. Stem Cells (2011) 1.04
Response to mechanical strain in an immortalized pre-osteoblast cell is dependent on ERK1/2. J Cell Physiol (2006) 1.03
Detection of endothelial nitric oxide release with the 2,3-diaminonapthalene assay. Free Radic Biol Med (2003) 0.98
Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells. J Cell Biochem (2004) 0.98
Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein. J Biol Chem (2011) 0.97
Indomethacin promotes adipogenesis of mesenchymal stem cells through a cyclooxygenase independent mechanism. J Cell Biochem (2010) 0.95
Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells. Endocrinology (2003) 0.92
Mechanical input restrains PPARγ2 expression and action to preserve mesenchymal stem cell multipotentiality. Bone (2012) 0.91
Effects of titanium particle size on osteoblast functions in vitro and in vivo. Proc Natl Acad Sci U S A (2005) 0.91
Nitric oxide donors inhibit luciferase expression in a promoter-independent fashion. J Biol Chem (2003) 0.88
Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells. Stem Cells (2013) 0.88
Adeno-associated viral delivery of a metabolically regulated insulin transgene to hepatocytes. Mol Cell Endocrinol (2007) 0.87
Mechanical strain downregulates C/EBPβ in MSC and decreases endoplasmic reticulum stress. PLoS One (2012) 0.87
Low magnitude mechanical signals mitigate osteopenia without compromising longevity in an aged murine model of spontaneous granulosa cell ovarian cancer. Bone (2012) 0.86
Mechanical Signals As a Non-Invasive Means to Influence Mesenchymal Stem Cell Fate, Promoting Bone and Suppressing the Fat Phenotype. Bonekey Osteovision (2009) 0.86
The role of nitric oxide in the mechanical repression of RANKL in bone stromal cells. Bone (2008) 0.85
Vibration therapy: clinical applications in bone. Curr Opin Endocrinol Diabetes Obes (2014) 0.80
Stand UP! J Clin Endocrinol Metab (2010) 0.78
SEM and TEM study of the hierarchical structure of C57BL/6J and C3H/HeJ mice trabecular bone. Bone (2004) 0.78
Protein kinase inhibitor γ reciprocally regulates osteoblast and adipocyte differentiation by downregulating leukemia inhibitory factor. Stem Cells (2013) 0.77
Regulation of skeletal remodeling by biomechanical input. Osteoporos Int (2003) 0.76
Veterans Administration support for medical research: opinions of the endangered species of physician-scientists. FASEB J (2004) 0.75