PubRank

Hugh Watkins

Author PubWeight™ 332.47‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010 23.08
2 Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 2010 20.01
3 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010 17.89
4 Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011 13.25
5 Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009 12.44
6 Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet 2012 12.10
7 Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N Engl J Med 2009 8.73
8 Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 2012 7.59
9 Left ventricular non-compaction: insights from cardiovascular magnetic resonance imaging. J Am Coll Cardiol 2005 5.63
10 Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med 2014 5.47
11 Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA 2009 5.32
12 Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet 2010 5.31
13 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC). Eur Heart J 2014 5.21
14 Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet 2009 4.97
15 Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med 2014 4.94
16 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet 2012 4.73
17 Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet 2012 4.63
18 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet 2012 4.37
19 HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Heart Rhythm 2011 4.31
20 Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. Hum Mol Genet 2007 4.09
21 Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes 2010 4.07
22 Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy. Eur J Heart Fail 2010 3.90
23 Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med 2016 3.88
24 Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet 2011 3.40
25 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet 2013 3.25
26 Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 2012 3.21
27 Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet 2011 3.18
28 Modernising medical careers, medical training application service, and the postgraduate medical education and training board: time for the emperors to don their clothes. Lancet 2007 3.12
29 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet 2012 3.04
30 Myocardial tissue characterization using magnetic resonance noncontrast t1 mapping in hypertrophic and dilated cardiomyopathy. Circ Cardiovasc Imaging 2012 3.01
31 FTO genotype is associated with phenotypic variability of body mass index. Nature 2012 2.77
32 Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies. Lancet 2004 2.55
33 HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Europace 2011 2.54
34 Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet 2012 2.53
35 Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 2004 2.40
36 Cardiac myosin binding protein C: its role in physiology and disease. Circ Res 2004 2.38
37 Genetically determined height and coronary artery disease. N Engl J Med 2015 2.24
38 Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 2011 2.21
39 Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study. J Am Coll Cardiol 2013 2.18
40 Identification of novel interactions between domains of Myosin binding protein-C that are modulated by hypertrophic cardiomyopathy missense mutations. Circ Res 2002 2.13
41 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet 2012 1.96
42 Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy. Circulation 2010 1.96
43 Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterized by impaired energy metabolism irrespective of the degree of hypertrophy. J Am Coll Cardiol 2003 1.84
44 Identification and functional characterization of cardiac troponin I as a novel disease gene in autosomal dominant dilated cardiomyopathy. Circ Res 2009 1.83
45 Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy. J Am Coll Cardiol 2010 1.83
46 Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments. Circ Res 2007 1.80
47 Personalized medicine: hope or hype? Eur Heart J 2012 1.80
48 Mutations of the light meromyosin domain of the beta-myosin heavy chain rod in hypertrophic cardiomyopathy. Circ Res 2002 1.77
49 Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation 2013 1.77
50 A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One 2012 1.72
51 Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study. Circ Cardiovasc Genet 2009 1.71
52 Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype. J Biol Chem 2005 1.70
53 Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion. Trends Genet 2003 1.62
54 Subunit composition of AMPK trimers present in the cytokinetic apparatus: Implications for drug target identification. Cell Cycle 2012 1.57
55 Evidence for microvascular dysfunction in hypertrophic cardiomyopathy: new insights from multiparametric magnetic resonance imaging. Circulation 2007 1.54
56 Evidence from human myectomy samples that MYBPC3 mutations cause hypertrophic cardiomyopathy through haploinsufficiency. Circ Res 2009 1.52
57 Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke 2013 1.51
58 Embryonic expression of AMPK γ subunits and the identification of a novel γ2 transcript variant in adult heart. J Mol Cell Cardiol 2012 1.45
59 Blood pressure loci identified with a gene-centric array. Am J Hum Genet 2011 1.44
60 Reviews of translational medicine and genomics in cardiovascular disease: new disease taxonomy and therapeutic implications cardiomyopathies: therapeutics based on molecular phenotype. J Am Coll Cardiol 2007 1.42
61 DNA testing for hypertrophic cardiomyopathy: a cost-effectiveness model. Eur Heart J 2010 1.40
62 Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy. J Biol Chem 2002 1.37
63 Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. Cell Metab 2012 1.35
64 Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice. Circulation 2005 1.33
65 Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice. Circulation 2005 1.30
66 Genome-wide mapping of susceptibility to coronary artery disease identifies a novel replicated locus on chromosome 17. PLoS Genet 2006 1.29
67 Disease pathways and novel therapeutic targets in hypertrophic cardiomyopathy. Circ Res 2011 1.28
68 Mutations in fast skeletal troponin I, troponin T, and beta-tropomyosin that cause distal arthrogryposis all increase contractile function. FASEB J 2006 1.27
69 Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. PLoS Med 2012 1.27
70 Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. Blood 2012 1.26
71 A novel common single nucleotide polymorphism in the promoter region of the C-reactive protein gene associated with the plasma concentration of C-reactive protein. Atherosclerosis 2005 1.26
72 Genome-wide linkage analysis of electrocardiographic and echocardiographic left ventricular hypertrophy in families with hypertension. Eur Heart J 2008 1.25
73 Truncated estrogen receptor alpha 46-kDa isoform in human endothelial cells: relationship to acute activation of nitric oxide synthase. Circulation 2003 1.25
74 Genotype at the -174G/C polymorphism of the interleukin-6 gene is associated with common carotid artery intimal-medial thickness: family study and meta-analysis. Stroke 2005 1.16
75 The effect of mutations in alpha-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments. J Biol Chem 2007 1.15
76 Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome. Am J Physiol Heart Circ Physiol 2005 1.14
77 Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism. J Am Coll Cardiol 2012 1.14
78 AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes. Circ Res 2012 1.14
79 A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy. PLoS Genet 2010 1.13
80 Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice. Circ Res 2013 1.13
81 Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study. Diabetes 2005 1.11
82 Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis. Arterioscler Thromb Vasc Biol 2010 1.09
83 Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr 2013 1.08
84 Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod. Biochem J 2007 1.08
85 Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Circ Res 2017 1.06
86 The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy. Cardiovasc Res 2008 1.06
87 Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia. Arterioscler Thromb Vasc Biol 2013 1.03
88 Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy. J Mol Cell Cardiol 2010 1.02
89 Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity. J Mol Cell Cardiol 2009 1.02
90 Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. J Am Coll Cardiol 2013 1.02
91 In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart. Cardiovasc Res 2012 1.01
92 Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes. Hypertension 2008 1.01
93 Medical training in the UK: sleepwalking to disaster. Lancet 2007 0.99
94 Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction. Cardiovasc Res 2012 0.97
95 Mechanisms of creatine depletion in chronically failing rat heart. J Mol Cell Cardiol 2005 0.97
96 Mutation analysis of AMP-activated protein kinase subunits in inherited cardiomyopathies: implications for kinase function and disease pathogenesis. J Mol Cell Cardiol 2003 0.97
97 Is Wolff-Parkinson-White syndrome a genetic disease? J Cardiovasc Electrophysiol 2005 0.96
98 Blunted myocardial oxygenation response during vasodilator stress in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 2013 0.95
99 The role of vascular myoglobin in nitrite-mediated blood vessel relaxation. Cardiovasc Res 2010 0.95
100 Genetic cardiomyopathies causing heart failure. Circ Res 2013 0.95
101 In vivo cardiac 1H-MRS in the mouse. Magn Reson Med 2004 0.94
102 Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk. Circ Cardiovasc Genet 2012 0.92
103 Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility. Biochem J 2002 0.91
104 Nprl3 is required for normal development of the cardiovascular system. Mamm Genome 2012 0.90
105 Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study. Blood 2009 0.89
106 Gender specific patterns of age-related decline in aortic stiffness: a cardiovascular magnetic resonance study including normal ranges. J Cardiovasc Magn Reson 2015 0.88
107 Hazardous alcohol consumption is associated with increased levels of B-type natriuretic peptide: evidence from two population-based studies. Eur J Epidemiol 2013 0.88
108 Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion. J Clin Endocrinol Metab 2004 0.87
109 Measured haplotype analysis of the aldosterone synthase gene and heart size. Eur J Hum Genet 2003 0.87
110 Differentiation of athlete's heart from pathological forms of cardiac hypertrophy by means of geometric indices derived from cardiovascular magnetic resonance. J Cardiovasc Magn Reson 2005 0.86
111 Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice - a one year longitudinal MRI study. J Cardiovasc Magn Reson 2008 0.86
112 Sex-specific characteristics of cardiac function, geometry, and mass in young adult elite athletes. J Magn Reson Imaging 2006 0.86
113 Functional significance of SRJ domain mutations in CITED2. PLoS One 2012 0.85
114 Prognostic value of plasma interleukin-6 concentrations and the -174 G > C and -572 G > C promoter polymorphisms of the interleukin-6 gene in patients with acute myocardial infarction treated with thrombolysis. Atherosclerosis 2004 0.85
115 Genetic clues to disease pathways in hypertrophic and dilated cardiomyopathies. Circulation 2003 0.85
116 The C-532T polymorphism of the angiotensinogen gene is associated with pulse pressure: a possible explanation for heterogeneity in genetic association studies of AGT and hypertension. Int J Epidemiol 2007 0.84
117 Multiple QTL influence the serum Lp(a) concentration: a genome-wide linkage screen in the PROCARDIS study. Eur J Hum Genet 2006 0.84
118 In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy. J Cardiovasc Magn Reson 2013 0.83
119 [2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy]. Kardiol Pol 2014 0.83
120 Localisation of AMPK γ subunits in cardiac and skeletal muscles. J Muscle Res Cell Motil 2013 0.82
121 Familial and phenotypic associations of the aldosterone Renin ratio. J Clin Endocrinol Metab 2009 0.81
122 Functional effects of the DCM mutant Gly159Asp troponin C in skinned muscle fibres. Pflugers Arch 2006 0.81
123 Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene. J Clin Endocrinol Metab 2006 0.81
124 Heart Rhythm UK position statement on clinical indications for implantable cardioverter defibrillators in adult patients with familial sudden cardiac death syndromes. Europace 2010 0.80
125 Changes in creatine transporter function during cardiac maturation in the rat. BMC Dev Biol 2010 0.79
126 Genetic variants from lipid-related pathways and risk for incident myocardial infarction. PLoS One 2013 0.79
127 A commonly occurring polymorphism upstream of the estrogen receptor alpha alters transcription and is associated with increased HDL. Atherosclerosis 2008 0.79
128 (31)P cardiac magnetic resonance spectroscopy during leg exercise at 3 Tesla. Int J Cardiovasc Imaging 2009 0.79
129 Coronary artery disease genetics: bigger is better. Eur Heart J 2004 0.79
130 A revised method of troponin exchange in permeabilised cardiac trabeculae using vanadate: functional consequences of a HCM-causing mutation in troponin I. J Muscle Res Cell Motil 2006 0.79
131 Common variation at the 11-β hydroxysteroid dehydrogenase type 1 gene is associated with left ventricular mass. Circ Cardiovasc Genet 2011 0.79
132 Hypertrophic cardiomyopathy in Noonan Syndrome closely mimics familial hypertrophic cardiomyopathy due to sarcomeric mutations. Int J Cardiovasc Imaging 2005 0.78
133 The prognostic impact of septal myectomy in obstructive hypertrophic cardiomyopathy. J Am Coll Cardiol 2005 0.78
134 Genotype at the P554L variant of the hexose-6 phosphate dehydrogenase gene is associated with carotid intima-medial thickness. PLoS One 2011 0.77
135 Assigning a causal role to genetic variants in hypertrophic cardiomyopathy. Circ Cardiovasc Genet 2013 0.77
136 Exercise-induced ventricular dysfunction in hypertrophic cardiomyopathy: stunning by any other name? Heart 2008 0.75
137 Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet 2016 0.75
138 Ascertainment strategies and genotype:phenotype correlations in hypertrophic cardiomyopathy. Circulation 2003 0.75
139 Response to letter regarding article, "myocardial tissue characterization using magnetic resonance noncontrast t1 mapping in hypertrophic and dilated cardiomyopathy". Circ Cardiovasc Imaging 2013 0.75
140 Determination of AMP-activated protein kinase phosphorylation sites in recombinant protein expressed using the pET28a vector: a cautionary tale. Protein Expr Purif 2009 0.75
141 Arrhythmogenic right ventricular cardiomyopathy type 6 (ARVC6): support for the locus assignment, narrowing of the critical region and mutation screening of three candidate genes. BMC Med Genet 2006 0.75
142 Combination of Whole Genome Sequencing, Linkage, and Functional Studies Implicates a Missense Mutation in Titin as a Cause of Autosomal Dominant Cardiomyopathy With Features of Left Ventricular Noncompaction. Circ Cardiovasc Genet 2016 0.75
143 Quantitative trait genetic linkage analysis of body mass index in familial coronary artery disease. Hum Hered 2008 0.75
144 Rare Variants in NR2F2 Cause Congenital Heart Defects in Humans. Am J Hum Genet 2016 0.75
145 Inherited Aortopathy Assessment in Relatives of Patients With a Bicuspid Aortic Valve. J Am Coll Cardiol 2017 0.75
146 Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure. J Biol Chem 2016 0.75