Published in Lancet on May 08, 2010
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J (2011) 3.00
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management. Lancet Diabetes Endocrinol (2013) 2.60
Demystifying the management of hypertriglyceridaemia. Nat Rev Cardiol (2013) 2.17
Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects. Am J Epidemiol (2015) 2.14
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. PLoS One (2012) 1.96
Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. Eur Heart J (2011) 1.73
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 1.72
Association of the Apolipoprotein A5 Gene -1131T>C Polymorphism with Serum Lipids in Korean Subjects: Impact of Sasang Constitution. Evid Based Complement Alternat Med (2011) 1.63
Genetic determinants of plasma triglycerides. J Lipid Res (2010) 1.63
Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in Europeans. The MORGAM Prospective Cohort Project. PLoS One (2014) 1.54
Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population. PLoS One (2015) 1.51
Mendelian randomization of blood lipids for coronary heart disease. Eur Heart J (2014) 1.51
Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia. Am J Clin Nutr (2010) 1.47
Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study. J Am Coll Cardiol (2016) 1.46
Very low density lipoprotein cholesterol associates with coronary artery calcification in type 2 diabetes beyond circulating levels of triglycerides. Atherosclerosis (2014) 1.45
Lipid parameters for measuring risk of cardiovascular disease. Nat Rev Cardiol (2011) 1.43
log(TG)/HDL-C is related to both residual cardiometabolic risk and β-cell function loss in type 2 diabetes males. Cardiovasc Diabetol (2010) 1.35
Triglycerides and heart disease: still a hypothesis? Arterioscler Thromb Vasc Biol (2011) 1.32
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. J Med Genet (2013) 1.26
Residual macrovascular risk in 2013: what have we learned? Cardiovasc Diabetol (2014) 1.20
Hypertriglyceridemia: a too long unfairly neglected major cardiovascular risk factor. Cardiovasc Diabetol (2014) 1.14
Fibrates are an essential part of modern anti-dyslipidemic arsenal: spotlight on atherogenic dyslipidemia and residual risk reduction. Cardiovasc Diabetol (2012) 1.10
Amerindian-specific regions under positive selection harbour new lipid variants in Latinos. Nat Commun (2014) 1.02
The atherogenic dyslipidemia ratio [log(TG)/HDL-C] is associated with residual vascular risk, beta-cell function loss and microangiopathy in type 2 diabetes females. Lipids Health Dis (2012) 1.01
Apolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion. J Biomed Res (2014) 1.00
Hepatic lipase, high density lipoproteins, and hypertriglyceridemia. Am J Pathol (2011) 1.00
An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia. Arterioscler Thromb Vasc Biol (2011) 0.99
Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies. Am J Clin Nutr (2016) 0.98
Options for basing Dietary Reference Intakes (DRIs) on chronic disease endpoints: report from a joint US-/Canadian-sponsored working group. Am J Clin Nutr (2016) 0.97
Nonfasting triglycerides and risk of cardiovascular death in men and women from the Norwegian Counties Study. Eur J Epidemiol (2010) 0.97
Association of genetic variants influencing lipid levels with coronary artery disease in Japanese individuals. PLoS One (2012) 0.94
Intravenous injection of apolipoprotein A-V reconstituted high-density lipoprotein decreases hypertriglyceridemia in apoav-/- mice and requires glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1. Arterioscler Thromb Vasc Biol (2010) 0.93
Role of innate immune response in non-alcoholic Fatty liver disease: metabolic complications and therapeutic tools. Front Immunol (2014) 0.92
Effects of APOA5 -1131T>C (rs662799) on fasting plasma lipids and risk of metabolic syndrome: evidence from a case-control study in China and a meta-analysis. PLoS One (2013) 0.92
Are we getting to lipid targets in real life? Arch Med Sci (2010) 0.90
Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes. BMC Med Genomics (2012) 0.90
Lipoprotein metabolism in nonalcoholic fatty liver disease. J Biomed Res (2012) 0.90
Association of the apolipoprotein A5 gene -1131 T>C polymorphism with fasting blood lipids: a meta-analysis in 37859 subjects. BMC Med Genet (2010) 0.88
Changes in HDL cholesterol and cardiovascular outcomes after lipid modification therapy. Heart (2012) 0.88
Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia. Am J Hum Genet (2013) 0.87
Evaluation of the gene-age interactions in HDL cholesterol, LDL cholesterol, and triglyceride levels: the impact of the SORT1 polymorphism on LDL cholesterol levels is age dependent. Atherosclerosis (2011) 0.87
Relationship of APOA5, PPARγ and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood. Lipids Health Dis (2011) 0.86
Serum triglycerides and risk for death in Stage 3 and Stage 4 chronic kidney disease. Nephrol Dial Transplant (2012) 0.85
Selecting instruments for Mendelian randomization in the wake of genome-wide association studies. Int J Epidemiol (2016) 0.85
Association between triglycerides and cardiovascular events in primary populations: a meta-regression analysis and synthesis of evidence. Vasc Health Risk Manag (2013) 0.84
The use of fasting vs. non-fasting triglyceride concentration for estimating the prevalence of high LDL-cholesterol and metabolic syndrome in population surveys. BMC Med Res Methodol (2011) 0.84
Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke. Neurology (2015) 0.84
Impact of daily Chlorella consumption on serum lipid and carotenoid profiles in mildly hypercholesterolemic adults: a double-blinded, randomized, placebo-controlled study. Nutr J (2014) 0.83
Adipocyte triglyceride turnover is independently associated with atherogenic dyslipidemia. J Am Heart Assoc (2012) 0.82
Apolipoprotein A5 gene variants and the risk of coronary heart disease: a case‑control study and meta‑analysis. Mol Med Rep (2013) 0.82
Association of apolipoprotein A5 gene -1131T>C polymorphism with the risk of metabolic syndrome in Korean subjects. Biomed Res Int (2013) 0.82
A Review of Clinical Practice Guidelines for the Management of Hypertriglyceridemia: A Focus on High Dose Omega-3 Fatty Acids. Adv Ther (2016) 0.81
Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice. Atherosclerosis (2015) 0.81
Surprises From Genetic Analyses of Lipid Risk Factors for Atherosclerosis. Circ Res (2016) 0.81
Rare APOA5 promoter variants associated with paradoxical HDL cholesterol decrease in response to fenofibric acid therapy. J Lipid Res (2013) 0.81
Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model. Sci Rep (2015) 0.81
Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium. Int J Epidemiol (2015) 0.80
Triglyceride-rich lipoproteins as a causal factor for cardiovascular disease. Vasc Health Risk Manag (2016) 0.80
Hypertriglyceridemia and Cardiovascular Diseases: Revisited. Korean Circ J (2016) 0.80
Rare LPL gene variants attenuate triglyceride reduction and HDL cholesterol increase in response to fenofibric acid therapy in individuals with mixed dyslipidemia. Atherosclerosis (2014) 0.79
Risk prediction with triglycerides in patients with stable coronary disease on statin treatment. Clin Res Cardiol (2014) 0.79
Triglycerides on the rise: should we swap seats on the seesaw? Eur Heart J (2014) 0.79
The association between APOA5 haplotypes and plasma lipids is not modified by energy or fat intake: the Czech HAPIEE study. Nutr Metab Cardiovasc Dis (2013) 0.79
Lipoprotein subclass profiles in young adults born preterm at very low birth weight. Lipids Health Dis (2013) 0.79
Novel unbiased equations to calculate triglyceride-rich lipoprotein cholesterol from routine non-fasting lipids. Cardiovasc Diabetol (2014) 0.79
Saroglitazar for the treatment of hypertrig-lyceridemia in patients with type 2 diabetes: current evidence. Diabetes Metab Syndr Obes (2015) 0.78
Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia. J Lipid Res (2013) 0.78
Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women. J Am Heart Assoc (2015) 0.78
Multidimensional regulation of lipoprotein lipase: impact on biochemical and cardiovascular phenotypes. J Lipid Res (2016) 0.77
Epidemiology of cardiovascular disease: recent novel outlooks on risk factors and clinical approaches. Expert Rev Cardiovasc Ther (2016) 0.77
Atherogenic dyslipidemia and combination pharmacotherapy in diabetes: recent clinical trials. Rev Diabet Stud (2013) 0.77
Dose-response effects of marine omega-3 fatty acids on apolipoproteins, apolipoprotein-defined lipoprotein subclasses, and Lp-PLA2 in individuals with moderate hypertriglyceridemia. J Clin Lipidol (2014) 0.76
Genetics of Lipid and Lipoprotein Disorders and Traits. Curr Genet Med Rep (2016) 0.76
Psychological changes following weight loss in overweight and obese adults: a prospective cohort study. PLoS One (2014) 0.76
Triglyceride-mediated pathways and coronary heart disease. Lancet (2010) 0.76
Effect of energy expenditure on postprandial triacylglycerol in adolescent boys. Eur J Appl Physiol (2011) 0.76
Triglyceride-Rich Lipoproteins and Remnants: Targets for Therapy? Curr Cardiol Rep (2016) 0.76
Monitoring of lipids, enzymes, and creatine kinase in patients on lipid-lowering drug therapy. Curr Cardiol Rep (2013) 0.76
An APOC3 3'UTR variant associated with plasma triglycerides levels and coronary heart disease by creating a functional miR-4271 binding site. Sci Rep (2016) 0.76
What can we learn about lipoprotein metabolism and coronary heart disease from studying rare variants? Curr Opin Lipidol (2016) 0.76
VLDL Triglyceride Kinetics in Lean, Overweight, and Obese Men and Women. J Clin Endocrinol Metab (2016) 0.75
Promoter Polymorphism of Toll-Like Receptor 4 is Associated with a Decreased Risk of Coronary Artery Disease: A Case-Control Study in the Chinese Han Population. Med Sci Monit (2017) 0.75
APOA5 Q97X mutation identified through homozygosity mapping causes severe hypertriglyceridemia in a Chilean consanguineous family. BMC Med Genet (2012) 0.75
Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study. Sci Rep (2017) 0.75
Triglyceride-mediated pathways and coronary heart disease. Lancet (2010) 0.75
Apolipoprotein A5 and apolipoprotein C3 single nucleotide polymorphisms are correlated with an increased risk of coronary heart disease: a case-control and meta-analysis study. Lipids Health Dis (2015) 0.75
Triglycerides and stroke risk prediction: lessons from a prospective cohort study in german primary care patients. Front Neurol (2010) 0.75
Triglyceride-mediated pathways and coronary heart disease. Lancet (2010) 0.75
Triglyceride and cardiovascular risk: A critical appraisal. Indian J Endocrinol Metab (2016) 0.75
PROMETHEUS: an observational, cross-sectional, retrospective study of hypertriglyceridemia in Russia. Cardiovasc Diabetol (2015) 0.75
Lipoprotein lipase activity and interactions studied in human plasma by isothermal titration calorimetry. J Lipid Res (2016) 0.75
The concomitant use of second-generation antipsychotics and long-term antiretroviral therapy may be associated with increased cardiovascular risk. Psychiatry Res (2014) 0.75
Hypertriglyceridaemia and risk of coronary artery disease. Nat Rev Cardiol (2017) 0.75
Identification and characterization of cyclic AMP response element-binding protein H response element in the human apolipoprotein A5 gene promoter. Biomed Res Int (2013) 0.75
Austrian Lipid Consensus on the management of metabolic lipid disorders to prevent vascular complications: A joint position statement issued by eight medical societies. 2016 update. Wien Klin Wochenschr (2016) 0.75
Separate and Joint Associations of Shift Work and Sleep Quality with Lipids. Saf Health Work (2015) 0.75
Mendelian randomisation, triglycerides, and CHD. Lancet (2010) 0.75
Measuring inconsistency in meta-analyses. BMJ (2003) 128.20
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet (2008) 20.73
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol (2003) 16.71
Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. Circulation (1994) 12.24
Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA (2007) 11.98
Major lipids, apolipoproteins, and risk of vascular disease. JAMA (2009) 10.58
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation (2006) 6.17
Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies. Lancet (2008) 4.70
Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. JAMA (2008) 4.21
Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies. Int J Epidemiol (2010) 3.97
How independent are "independent" effects? Relative risk estimation when correlated exposures are measured imprecisely. J Clin Epidemiol (1991) 3.37
Clinical practice. Hypertriglyceridemia. N Engl J Med (2007) 3.28
Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia. N Engl J Med (2010) 3.17
Value of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study. J Am Coll Cardiol (2007) 2.29
Correcting for multivariate measurement error by regression calibration in meta-analyses of epidemiological studies. Stat Med (2009) 2.19
Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase. J Biol Chem (2005) 2.07
Lipids, lipid modifying agents and cardiovascular risk: a review of the evidence. Clin Endocrinol (Oxf) (2008) 1.73
The paradox of dysfunctional high-density lipoprotein. Curr Opin Lipidol (2007) 1.63
Strengthening causal inference in cardiovascular epidemiology through Mendelian randomization. Ann Med (2008) 1.51
Triacylglycerol-rich lipoproteins and the generation of small, dense low-density lipoprotein. Biochem Soc Trans (2003) 1.50
New perspectives on atherogenesis: role of abnormal triglyceride-rich lipoprotein metabolism. Circulation (2002) 1.38
Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families. J Biol Chem (2008) 1.26
Update on dyslipidemia. J Clin Endocrinol Metab (2007) 1.22
The functional interaction on in vitro gene expression of APOA5 SNPs, defining haplotype APOA52, and their paradoxical association with plasma triglyceride but not plasma apoAV levels. Biochim Biophys Acta (2008) 1.19
New approaches to target microsomal triglyceride transfer protein. Curr Opin Lipidol (2008) 1.18
Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation. Curr Opin Lipidol (2007) 1.15
DGAT inhibitors for obesity. Curr Opin Investig Drugs (2007) 1.06
Practical guidelines for familial combined hyperlipidemia diagnosis: an up-date. Vasc Health Risk Manag (2007) 1.03
Avian apolipoprotein A-V binds to LDL receptor gene family members. J Lipid Res (2007) 1.01
The -1131T>C SNP of the APOA5 gene modulates response to fenofibrate treatment in patients with the metabolic syndrome: a postprandial study. Atherosclerosis (2009) 1.00
Triglycerides and coronary heart disease: have recent insights yielded conclusive answers? Curr Opin Lipidol (2009) 1.00
Effectiveness of combined statin plus omega-3 fatty acid therapy for mixed dyslipidemia. Am J Cardiol (2008) 0.99
Impact of apolipoprotein A5 variants on statin treatment efficacy. Pharmacogenomics (2009) 0.96
Microsomal triglyceride transfer protein inhibition-friend or foe? Nat Clin Pract Cardiovasc Med (2008) 0.91
Apolipoprotein A-V genetic variation and plasma lipoprotein response to fibrates. Arterioscler Thromb Vasc Biol (2007) 0.89
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Ann Intern Med (2014) 12.79
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet (2009) 11.81
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Major lipids, apolipoproteins, and risk of vascular disease. JAMA (2009) 10.58
Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet (2009) 9.90
Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet (2011) 9.07
Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N Engl J Med (2009) 8.73
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Serious mental disorder in 23000 prisoners: a systematic review of 62 surveys. Lancet (2002) 7.43
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet (2008) 7.33
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Prevalence of serious mental disorder in 7000 refugees resettled in western countries: a systematic review. Lancet (2005) 6.88
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet (2009) 6.83
Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ (2007) 6.73
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet (2008) 6.72
Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis. Lancet (2005) 6.59
Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet (2007) 6.57
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49
C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation (2006) 6.17
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15
CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysis. JAMA (2011) 5.93
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Left ventricular non-compaction: insights from cardiovascular magnetic resonance imaging. J Am Coll Cardiol (2005) 5.63
Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA (2009) 5.63