Published in J Biomed Biotechnol on May 04, 2010
Dysregulated pH: a perfect storm for cancer progression. Nat Rev Cancer (2011) 3.10
Role of monocarboxylate transporters in human cancers: state of the art. J Bioenerg Biomembr (2012) 1.70
Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer. BMC Cancer (2011) 1.39
Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study. Neoplasia (2011) 1.29
3-Bromopyruvate: targets and outcomes. J Bioenerg Biomembr (2012) 1.27
The human proton-coupled folate transporter: Biology and therapeutic applications to cancer. Cancer Biol Ther (2012) 1.16
The biological function and clinical utilization of CD147 in human diseases: a review of the current scientific literature. Int J Mol Sci (2014) 1.15
Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer. PLoS One (2013) 1.07
The spatial organization of proton and lactate transport in a rat brain tumor. PLoS One (2011) 1.05
Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate. J Bioenerg Biomembr (2012) 0.95
Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer. BJU Int (2012) 0.95
Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy. Cancer Metastasis Rev (2014) 0.91
Cell volume regulation in epithelial physiology and cancer. Front Physiol (2013) 0.90
Metabolic changes during ovarian cancer progression as targets for sphingosine treatment. Exp Cell Res (2013) 0.88
DNA methylation in promoter region as biomarkers in prostate cancer. Methods Mol Biol (2012) 0.88
Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma. Oncoscience (2015) 0.84
Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function. Sci Rep (2015) 0.83
Prognostic Indications of Elevated MCT4 and CD147 across Cancer Types: A Meta-Analysis. Biomed Res Int (2015) 0.83
Expression patterns of emmprin and monocarboxylate transporter-1 in ovarian epithelial tumors. Virchows Arch (2012) 0.82
Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status. Oncotarget (2015) 0.82
Elucidation of how cancer cells avoid acidosis through comparative transcriptomic data analysis. PLoS One (2013) 0.81
Increased H⁺ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression. Elife (2015) 0.80
Novel Approaches to Imaging Tumor Metabolism. Cancer J (2015) 0.80
Monocarboxylate transporters in the brain and in cancer. Biochim Biophys Acta (2016) 0.79
CD147 expression in advanced cutaneous squamous cell carcinoma. J Cutan Pathol (2012) 0.79
Mitochondrial Metabolism as a Treatment Target in Anaplastic Thyroid Cancer. Semin Oncol (2015) 0.79
Low-salt diet and cyclosporine nephrotoxicity: changes in kidney cell metabolism. J Proteome Res (2012) 0.79
Characterization of monocarboxylate transporter activity in hepatocellular carcinoma. World J Gastroenterol (2014) 0.79
Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix. BMC Cancer (2014) 0.79
Reprogramming energy metabolism and inducing angiogenesis: co-expression of monocarboxylate transporters with VEGF family members in cervical adenocarcinomas. BMC Cancer (2015) 0.78
Crucial residue involved in L-lactate recognition by human monocarboxylate transporter 4 (hMCT4). PLoS One (2013) 0.78
Should EMT of Cancer Cells Be Understood as Epithelial-Myeloid Transition? J Cancer (2014) 0.77
Prognostic significance of monocarboxylate transporter expression in oral cavity tumors. Cell Cycle (2016) 0.77
Lactate production by the mammalian blastocyst: manipulating the microenvironment for uterine implantation and invasion? Bioessays (2015) 0.77
Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors. Oncotarget (2015) 0.77
Nitric oxide and pH modulation in gynaecological cancer. J Cell Mol Med (2016) 0.76
Exercise-induced changes in tumour LDH-B and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice. J Physiol (2015) 0.76
Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis. BMC Cancer (2016) 0.75
Overexpression of CD44 is associated with the occurrence and migration of non-small cell lung cancer. Mol Med Rep (2016) 0.75
MCT1 in Invasive Ductal Carcinoma: Monocarboxylate Metabolism and Aggressive Breast Cancer. Front Cell Dev Biol (2017) 0.75
The metabolic microenvironment of melanomas: Prognostic value of MCT1 and MCT4. Cell Cycle (2016) 0.75
Regulation of glycolysis in head and neck squamous cell carcinoma. Postdoc J (2017) 0.75
Analysis of the binding moiety mediating the interaction between monocarboxylate transporters and carbonic anhydrase II. J Biol Chem (2015) 0.75
Intratumoral lactate metabolism in Barrett's esophagus and adenocarcinoma. Oncotarget (2017) 0.75
Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications. Oncotarget (2016) 0.75
Evaluation of MCT1, MCT4 and CD147 Genes in Peripheral Blood Cells of Breast Cancer Patients and Their Potential Use as Diagnostic and Prognostic Markers. Int J Mol Sci (2017) 0.75
MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis. Oncotarget (2016) 0.75
GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior. Oncotarget (2017) 0.75
On the origin of cancer cells. Science (1956) 49.55
Why do cancers have high aerobic glycolysis? Nat Rev Cancer (2004) 20.60
The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch (2003) 3.81
CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J (2000) 3.12
CD44 in cancer progression: adhesion, migration and growth regulation. J Mol Histol (2004) 2.71
Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. Cancer Res (2006) 2.68
Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231. Cancer Res (2007) 2.19
cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1. J Biol Chem (1995) 2.12
EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair. Biochimie (2005) 2.10
Endurance training, expression, and physiology of LDH, MCT1, and MCT4 in human skeletal muscle. Am J Physiol Endocrinol Metab (2000) 1.85
Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse. Invest Ophthalmol Vis Sci (2003) 1.83
Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem (2005) 1.79
CD147 immunoglobulin superfamily receptor function and role in pathology. Exp Mol Pathol (2007) 1.77
Cellular pH regulators: potentially promising molecular targets for cancer chemotherapy. Cancer Treat Rev (2003) 1.76
Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. Semin Cancer Biol (2008) 1.76
High incidence of EMMPRIN expression in human tumors. Int J Cancer (2006) 1.74
Emmprin (basigin/CD147): matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression. Pathol Int (2006) 1.71
Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas. Virchows Arch (2008) 1.71
Regulation of intracellular pH in human melanoma: potential therapeutic implications. Mol Cancer Ther (2002) 1.57
Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: an in vitro study. Neurosurgery (2004) 1.52
Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance. Drug Resist Updat (2008) 1.49
The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma. Mol Pharmacol (2006) 1.49
Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma. Histopathology (2010) 1.44
Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia. Proc Natl Acad Sci U S A (2005) 1.44
Expression and membrane localization of MCT isoforms along the length of the human intestine. Am J Physiol Cell Physiol (2005) 1.31
GLUT-1 expression in ovarian carcinoma: association with survival and response to chemotherapy. Cancer (2001) 1.27
Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells. Cancer Res (2009) 1.26
Reduced expression of GNA11 and silencing of MCT1 in human breast cancers. Oncology (2003) 1.20
Expression of monocarboxylate transporter MCT1 in normal and neoplastic human CNS tissues. Neuroreport (2001) 1.18
Increasing expression of monocarboxylate transporters 1 and 4 along progression to invasive cervical carcinoma. Int J Gynecol Pathol (2008) 1.18
Lung cancer: a comparative study of metabolism related protein expression in cancer cells and tumor associated stroma. Cancer Biol Ther (2007) 1.18
Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of the mouse, rat, and humans, with special reference to slc5a8. Biomed Res (2006) 1.14
The prognostic value of CD147/EMMPRIN is associated with monocarboxylate transporter 1 co-expression in gastric cancer. Eur J Cancer (2009) 1.13
Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy. Br J Cancer (2002) 1.13
Monocarboxylate transporters 1 and 4 are associated with CD147 in cervical carcinoma. Dis Markers (2009) 1.01
Regulation of monocarboxylate transporter 1 (MCT1) promoter by butyrate in human intestinal epithelial cells: involvement of NF-kappaB pathway. J Cell Biochem (2008) 1.00
Monocarboxylate transporters in subsarcolemmal and intermyofibrillar mitochondria. Biochem Biophys Res Commun (2004) 1.00
Identification of a monocarboxylate transporter isoform type 1 (MCT1) on the luminal membrane of human and pig colon. Biochem Soc Trans (1998) 0.89
Kinetic analysis of butyrate transport in human colon adenocarcinoma cells reveals two different carrier-mediated mechanisms. Biochem J (2008) 0.89
Quantitative biochemical analysis of lactate dehydrogenase in human ovarian tissues: correlation with tumor grade. Int J Gynecol Cancer (2005) 0.83
Placental leucine aminopeptidase (P-LAP) and glucose transporter 4 (GLUT4) expression in benign, borderline, and malignant ovarian epithelia. Gynecol Oncol (2005) 0.79
A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration. Nat Cell Biol (2007) 2.85
A distinct spectrum of copy number aberrations in pediatric high-grade gliomas. Clin Cancer Res (2010) 2.37
Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype. J Clin Pathol (2011) 2.33
Pathology of ovarian cancers in BRCA1 and BRCA2 carriers. Clin Cancer Res (2004) 2.17
Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN. Cancer Discov (2013) 1.93
Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas. Virchows Arch (2008) 1.71
Role of monocarboxylate transporters in human cancers: state of the art. J Bioenerg Biomembr (2012) 1.70
p63, cytokeratin 5, and P-cadherin: three molecular markers to distinguish basal phenotype in breast carcinomas. Virchows Arch (2005) 1.69
MicroRNA history: discovery, recent applications, and next frontiers. Mutat Res (2011) 1.66
Epithelial E- and P-cadherins: role and clinical significance in cancer. Biochim Biophys Acta (2012) 1.64
Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions. BMC Cancer (2010) 1.58
Loss of caveolin-1 and gain of MCT4 expression in the tumor stroma: key events in the progression from an in situ to an invasive breast carcinoma. Cell Cycle (2013) 1.52
CD147 immunohistochemistry discriminates between reactive mesothelial cells and malignant mesothelioma. Diagn Cytopathol (2012) 1.51
Response to treatment in a prospective cohort of patients with large ulcerated lesions suspected to be Buruli Ulcer (Mycobacterium ulcerans disease). PLoS Negl Trop Dis (2010) 1.48
Overexpression of platelet-derived growth factor receptor alpha in breast cancer is associated with tumour progression. Breast Cancer Res (2005) 1.47
Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma. Histopathology (2010) 1.44
Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development. PLoS One (2009) 1.44
Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity. J Pathol (2005) 1.40
MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature. Cancer Res (2010) 1.40
Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer. BMC Cancer (2011) 1.39
Mutation analysis of B-RAF gene in human gliomas. Acta Neuropathol (2004) 1.39
Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells. Gastroenterology (2012) 1.38
Expression and prognostic significance of CK19 in canine malignant mammary tumours. Vet J (2009) 1.38
Fine-needle aspiration, an efficient sampling technique for bacteriological diagnosis of nonulcerative Buruli ulcer. J Clin Microbiol (2009) 1.34
Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma. Neuro Oncol (2011) 1.31
BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis? BMC Cancer (2008) 1.30
Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets. Neuro Oncol (2012) 1.29
Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours. Breast Cancer Res (2009) 1.28
Glypicans shunt the Wingless signal between local signalling and further transport. Development (2005) 1.27
EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines. Clin Cancer Res (2009) 1.24
Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas. Cancer Res (2013) 1.23
Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma. Cancer Res (2010) 1.21
Increasing expression of monocarboxylate transporters 1 and 4 along progression to invasive cervical carcinoma. Int J Gynecol Pathol (2008) 1.18
Producing cells retain and recycle Wingless in Drosophila embryos. Curr Biol (2002) 1.18
Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological types. J Clin Pathol (2012) 1.14
The prognostic value of CD147/EMMPRIN is associated with monocarboxylate transporter 1 co-expression in gastric cancer. Eur J Cancer (2009) 1.13
Nonoptical massive parallel DNA sequencing of BRCA1 and BRCA2 genes in a diagnostic setting. Hum Mutat (2013) 1.12
Importance of TP53 codon 72 and intron 3 duplication 16bp polymorphisms in prediction of susceptibility on breast cancer. BMC Cancer (2008) 1.08
Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix. Gynecol Oncol (2007) 1.06
Is morphology alone able to predict BRAF-mutated malignancies on thyroid FNAC? Virchows Arch (2014) 1.06
Portuguese students' knowledge of antibiotics: a cross-sectional study of secondary school and university students in Braga. BMC Public Health (2009) 1.05
P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells. Cancer Res (2004) 1.05
Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas. PLoS One (2012) 1.04
Vitamin D and the mammary gland: a review on its role in normal development and breast cancer. Breast Cancer Res (2012) 1.02
DNA repair polymorphisms might contribute differentially on familial and sporadic breast cancer susceptibility: a study on a Portuguese population. Breast Cancer Res Treat (2006) 1.02
PIKing the right isoform: the emergent role of the p110beta subunit in breast cancer. Virchows Arch (2010) 1.01
Monocarboxylate transporters 1 and 4 are associated with CD147 in cervical carcinoma. Dis Markers (2009) 1.01
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs). J Bioenerg Biomembr (2012) 1.00
p63 expression in solid cell nests of the thyroid: further evidence for a stem cell origin. Mod Pathol (2003) 0.99
DNA repair gene polymorphisms and susceptibility to familial breast cancer in a group of patients from Campinas, Brazil. Genet Mol Res (2005) 0.99
P-cadherin is coexpressed with CD44 and CD49f and mediates stem cell properties in basal-like breast cancer. Stem Cells (2012) 0.99
Prognostic value of MGMT promoter methylation in glioblastoma patients treated with temozolomide-based chemoradiation: a Portuguese multicentre study. Oncol Rep (2010) 0.99
Adherence to cervical and breast cancer programs is crucial to improving screening performance. Rural Remote Health (2009) 0.99
Apocrine carcinoma of the breast: a comprehensive review. Histol Histopathol (2013) 0.99
Analysis of BRCA1 and BRCA2 mutations in Brazilian breast cancer patients with positive family history. Sao Paulo Med J (2005) 0.99
Molecular alterations of KIT oncogene in gliomas. Cell Oncol (2007) 0.99
Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma. BMC Cancer (2009) 0.98
p40: a p63 isoform useful for lung cancer diagnosis - a review of the physiological and pathological role of p63. Acta Cytol (2012) 0.98
A school-based human papillomavirus vaccination program in barretos, Brazil: final results of a demonstrative study. PLoS One (2013) 0.97
Nottingham Prognostic Index in triple-negative breast cancer: a reliable prognostic tool? BMC Cancer (2011) 0.96
Insights into angiogenesis in non-small cell lung cancer: molecular mechanisms, polymorphic genes, and targeted therapies. Recent Pat Anticancer Drug Discov (2012) 0.95
Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate. J Bioenerg Biomembr (2012) 0.95
P-cadherin, vimentin and CK14 for identification of basal-like phenotype in breast carcinomas: an immunohistochemical study. Histol Histopathol (2010) 0.95
Evaluation of HER2 in breast cancer: reality and expectations. Expert Opin Med Diagn (2009) 0.95
P-cadherin role in normal breast development and cancer. Int J Dev Biol (2011) 0.94
Increased risk of oncogenic human papillomavirus infections and incident high-grade cervical intraepithelial neoplasia among smokers: experience from the Latin American screening study. Sex Transm Dis (2009) 0.94
Self-collection for high-risk HPV detection in Brazilian women using the careHPV™ test. Gynecol Oncol (2013) 0.93
P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model. J Pathol (2013) 0.93
1Alpha,25-dihydroxyvitamin D3 induces de novo E-cadherin expression in triple-negative breast cancer cells by CDH1-promoter demethylation. Anticancer Res (2012) 0.93
Expression of CK19 in invasive breast carcinomas of special histological types: implications for the use of one-step nucleic acid amplification. J Clin Pathol (2011) 0.93
Benign and malignant apocrine lesions of the breast. Expert Rev Anticancer Ther (2012) 0.93
Opportunistic screening for skin cancer using a mobile unit in Brazil. BMC Dermatol (2011) 0.92
Awareness and knowledge of HPV, cervical cancer, and vaccines in young women after first delivery in São Paulo, Brazil--a cross-sectional study. BMC Womens Health (2010) 0.92
Angiogenesis: now and then. APMIS (2004) 0.91
P-cadherin expression is associated with high-grade ductal carcinoma in situ of the breast. Virchows Arch (2002) 0.91
DNA copy number profiles of gastric cancer precursor lesions. BMC Genomics (2007) 0.91
Predictive biomarkers of bacillus calmette-guérin immunotherapy response in bladder cancer: where are we now? Adv Urol (2012) 0.91