Published in Neoplasia on July 01, 2011
Targeting lactate metabolism for cancer therapeutics. J Clin Invest (2013) 2.14
Role of monocarboxylate transporters in human cancers: state of the art. J Bioenerg Biomembr (2012) 1.70
Tumor glycolysis as a target for cancer therapy: progress and prospects. Mol Cancer (2013) 1.57
Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets. Neuro Oncol (2012) 1.29
Anticancer agents that counteract tumor glycolysis. ChemMedChem (2012) 1.17
GBM's multifaceted landscape: highlighting regional and microenvironmental heterogeneity. Neuro Oncol (2014) 1.04
Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters. J Mol Med (Berl) (2015) 1.02
Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner. Oncogene (2013) 0.91
Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy. Cancer Metastasis Rev (2014) 0.91
Overcoming intratumor heterogeneity of polygenic cancer drug resistance with improved biomarker integration. Neoplasia (2012) 0.89
3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects. J Bioenerg Biomembr (2012) 0.87
Role of monocarboxylate transporters in drug delivery to the brain. Curr Pharm Des (2014) 0.85
Targeting lactate transport suppresses in vivo breast tumour growth. Oncotarget (2015) 0.83
A novel approach to the discovery of survival biomarkers in glioblastoma using a joint analysis of DNA methylation and gene expression. Epigenetics (2014) 0.82
Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport. Mol Cancer Ther (2014) 0.82
Increased H⁺ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression. Elife (2015) 0.80
Low-cost media formulation for culture of brain tumor spheroids (neurospheres). Biotechniques (2013) 0.80
Lactate transporters in the context of prostate cancer metabolism: what do we know? Int J Mol Sci (2014) 0.79
Malignancy-associated metabolic profiling of human glioma cell lines using 1H NMR spectroscopy. Mol Cancer (2014) 0.79
D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects. J Bioenerg Biomembr (2012) 0.78
Crucial residue involved in L-lactate recognition by human monocarboxylate transporter 4 (hMCT4). PLoS One (2013) 0.78
The sweet trap in tumors: aerobic glycolysis and potential targets for therapy. Oncotarget (2016) 0.78
Portuguese propolis disturbs glycolytic metabolism of human colorectal cancer in vitro. BMC Complement Altern Med (2013) 0.78
Cancer subclonal genetic architecture as a key to personalized medicine. Neoplasia (2013) 0.78
Aligned chitosan-polycaprolactone polyblend nanofibers promote the migration of glioblastoma cells. Adv Healthc Mater (2013) 0.77
Relationship between NADPH and Th1/Th2 ratio in patients with non-Hodgkin lymphoma who have been exposed to pesticides. J Blood Med (2015) 0.77
Non-invasive metabolic imaging of brain tumours in the era of precision medicine. Nat Rev Clin Oncol (2016) 0.77
Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas. Oncotarget (2016) 0.77
A Lab Assembled Microcontroller-Based Sensor Module for Continuous Oxygen Measurement in Portable Hypoxia Chambers. PLoS One (2016) 0.76
The molecular basis for novel therapies. Cancer J (2012) 0.76
Alpha cyano-4-hydroxy-3-methoxycinnamic acid inhibits proliferation and induces apoptosis in human breast cancer cells. PLoS One (2013) 0.76
The Role of Monocarboxylate Transporters and Their Chaperone CD147 in Lactate Efflux Inhibition and the Anticancer Effects of Terminalia chebula in Neuroblastoma Cell Line N2-A. European J Med Plants (2016) 0.75
Clinical association of baseline levels of conjugated dienes in low-density lipoprotein and nitric oxide with aggressive B-cell non-Hodgkin lymphoma and their relationship with immunoglobulins and Th1-to-Th2 ratio. J Blood Med (2016) 0.75
Targeting the Metabolic Reprogramming That Controls Epithelial-to-Mesenchymal Transition in Aggressive Tumors. Front Oncol (2017) 0.75
Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters. Oncotarget (2016) 0.75
Cancer cell behaviors mediated by dysregulated pH dynamics at a glance. J Cell Sci (2017) 0.75
Regulation of glycolysis in head and neck squamous cell carcinoma. Postdoc J (2017) 0.75
The Role of Glucose Modulation and Dietary Supplementation in Patients With Central Nervous System Tumors. Curr Treat Options Oncol (2015) 0.75
The interconnectedness of cancer cell signaling. Neoplasia (2011) 0.75
pH, Lactate, and Hypoxia: Reciprocity in Regulating High-Affinity Monocarboxylate Transporter Expression in Glioblastoma. Neoplasia (2017) 0.75
Optimisation of immunofluorescence methods to determine MCT1 and MCT4 expression in circulating tumour cells. BMC Cancer (2015) 0.75
Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol (1986) 16.65
Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med (1993) 15.51
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell (2007) 9.20
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest (2008) 7.52
A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res (1987) 7.43
Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci U S A (1994) 6.61
Factors involved in production of helper virus-free retrovirus vectors. Somat Cell Mol Genet (1986) 6.48
Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis. Science (2004) 5.74
The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J (1999) 5.51
Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate. Biochem J (1974) 4.00
Metabolic modulation of glioblastoma with dichloroacetate. Sci Transl Med (2010) 3.99
Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res (2006) 3.90
The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch (2003) 3.81
Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res (2009) 3.40
Tumor mitochondria and the bioenergetics of cancer cells. Prog Exp Tumor Res (1978) 3.16
Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion. Int J Biochem Cell Biol (2004) 2.71
Cell migration and invasion assays. Methods (2005) 2.32
Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem (2005) 2.30
The specificity and metabolic implications of the inhibition of pyruvate transport in isolated mitochondria and intact tissue preparations by alpha-Cyano-4-hydroxycinnamate and related compounds. Biochem J (1975) 2.15
Deviant energetic metabolism of glycolytic cancer cells. Biochimie (1992) 1.99
Variables affecting convection-enhanced delivery to the striatum: a systematic examination of rate of infusion, cannula size, infusate concentration, and tissue-cannula sealing time. J Neurosurg (1999) 1.97
L-lactate transport in Ehrlich ascites-tumour cells. Biochem J (1976) 1.94
Lactate: mirror and motor of tumor malignancy. Semin Radiat Oncol (2004) 1.78
Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology. Curr Med Chem (2004) 1.74
The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models. Cancer Res (2003) 1.67
Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS. J Neurol Sci (2010) 1.60
Metabolic changes during carcinogenesis: potential impact on invasiveness. J Theor Biol (2006) 1.59
Regulation of intracellular pH in human melanoma: potential therapeutic implications. Mol Cancer Ther (2002) 1.57
Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain. J Neurosci Res (2004) 1.56
AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem J (2010) 1.54
Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: an in vitro study. Neurosurgery (2004) 1.52
The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma. Mol Pharmacol (2006) 1.49
Neuroscience. Let there be (NADH) light. Science (2004) 1.45
Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited. Exp Cell Res (2002) 1.42
Determination of diffusion and partition coefficients of propofol in rat brain tissue: implications for studies of drug action in vitro. Br J Anaesth (2004) 1.36
Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. J Biomed Biotechnol (2010) 1.32
Safety and efficacy of convection-enhanced delivery of gemcitabine or carboplatin in a malignant glioma model in rats. J Neurosurg (2003) 1.30
Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2. Neuro Oncol (2008) 1.27
Glycolytic metabolism and tumour response to fractionated irradiation. Radiother Oncol (2009) 1.23
Expression of monocarboxylate transporter MCT1 in normal and neoplastic human CNS tissues. Neuroreport (2001) 1.18
A novel model of glioma cell invasion using organotypic brain slice culture. Cancer Res (1998) 1.09
Lactate and malignant tumors: a therapeutic target at the end stage of glycolysis. J Bioenerg Biomembr (2007) 1.08
Identification and characterisation of a new class of highly specific and potent inhibitors of the mitochondrial pyruvate carrier. Biochim Biophys Acta (2004) 1.07
Mouse MCT3 gene is expressed preferentially in retinal pigment and choroid plexus epithelia. Am J Physiol Cell Physiol (2001) 1.06
Intracellular acidification abrogates the heat shock response and compromises survival of human melanoma cells. Mol Cancer Ther (2003) 1.03
Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study. Neurosurgery (2006) 1.03
Validation and implementation of a liquid chromatography/tandem mass spectrometry assay to quantitate aminoflavone (NSC 686288) in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 1.00
Expression of the monocarboxylate transporter MCT1 in the adult human brain cortex. Brain Res (2006) 0.94
Brain tumor invasion model system using organotypic brain-slice culture as an alternative to in vivo model. J Cancer Res Clin Oncol (2002) 0.94
Expression of monocarboxylic acid transporters (MCT) in brain cells. Implication for branched chain alpha-ketoacids transport in neurons. Neurochem Int (2003) 0.94
Metabolic effects of blocking lactate transport in brain cortical tissue slices using an inhibitor specific to MCT1 and MCT2. Neurochem Res (2009) 0.83
A new bioassay using transient transfection for invasion-related gene analysis. Invasion Metastasis (2000) 0.83
Distribution of the monocarboxylate transporter MCT2 in human cerebral cortex: an immunohistochemical study. Brain Res (2008) 0.82
Infusion rates and drug distribution in brain tumor models in rats. J Neurosurg (2005) 0.82
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol (2004) 4.71
EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell (2009) 3.40
Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. Cell (2013) 3.32
Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma. J Neurooncol (2006) 2.33
Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake. Nat Neurosci (2013) 2.30
Patterns of care and outcomes among elderly individuals with primary malignant astrocytoma. J Neurosurg (2008) 2.05
Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell (2011) 2.04
Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. Cell (2011) 1.77
PEP-FOLD: an updated de novo structure prediction server for both linear and disulfide bonded cyclic peptides. Nucleic Acids Res (2012) 1.71
Susceptibility-weighted imaging to visualize blood products and improve tumor contrast in the study of brain masses. J Magn Reson Imaging (2006) 1.70
Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS. J Neurol Sci (2010) 1.60
Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: an in vitro study. Neurosurgery (2004) 1.52
Aerosol delivery in ventilated newborn pigs: an MRI evaluation. Pediatr Res (2008) 1.48
Perioperative complications and neurological outcomes of first and second craniotomies among patients enrolled in the Glioma Outcome Project. J Neurosurg (2003) 1.47
Dendritic cell-based immunotherapy of malignant gliomas. Cancer Invest (2004) 1.40
Trends in central nervous system tumor incidence relative to other common cancers in adults, adolescents, and children in the United States, 2000 to 2010. Cancer (2014) 1.37
A nomogram for individualized estimation of survival among patients with brain metastasis. Neuro Oncol (2012) 1.32
Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration. Cancer Res (2009) 1.30
Relative survival rates and patterns of diagnosis analyzed by time period for individuals with primary malignant brain tumor, 1973-1997. J Neurosurg (2003) 1.29
Regulation of striatal dopamine neurotransmission by nitric oxide: effector pathways and signaling mechanisms. Synapse (2002) 1.27
In vivo uptake and metabolism of alpha-[11C]methyl-L-tryptophan in human brain tumors. J Cereb Blood Flow Metab (2006) 1.26
Heat-shock protein peptide complex-96 vaccination for recurrent glioblastoma: a phase II, single-arm trial. Neuro Oncol (2013) 1.25
Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiol Dis (2007) 1.24
Axonal metabolic recovery and potential neuroprotective effect of glatiramer acetate in relapsing-remitting multiple sclerosis. Mult Scler (2005) 1.21
Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression. J Biol Chem (2003) 1.21
Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia. Neuropsychopharmacology (2009) 1.20
A novel molecular diagnostic of glioblastomas: detection of an extracellular fragment of protein tyrosine phosphatase mu. Neoplasia (2010) 1.16
Characterizing mutational heterogeneity in a glioblastoma patient with double recurrence. PLoS One (2012) 1.16
Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity. Genes Dev (2012) 1.15
Racial/ethnic differences in survival among elderly patients with a primary glioblastoma. J Neurooncol (2007) 1.14
Laminin alpha 2 enables glioblastoma stem cell growth. Ann Neurol (2012) 1.13
PTPmu suppresses glioma cell migration and dispersal. Neuro Oncol (2009) 1.12
Gliosarcoma with multiple extracranial metastases: case report and review of the literature. J Neurooncol (2006) 1.12
Analysis of postnatal eye development in the mouse with high-resolution small animal magnetic resonance imaging. Invest Ophthalmol Vis Sci (2009) 1.11
Topical application of activity-based probes for visualization of brain tumor tissue. PLoS One (2012) 1.10
Lactate and malignant tumors: a therapeutic target at the end stage of glycolysis. J Bioenerg Biomembr (2007) 1.08
Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. Diabetes (2010) 1.08
MRI evaluation of axonal reorganization after bone marrow stromal cell treatment of traumatic brain injury. NMR Biomed (2011) 1.08
The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells. Stem Cells (2014) 1.05
Magnetic resonance spectroscopy: neurochemistry and treatment effects in affective disorders. Psychopharmacol Bull (2002) 1.04
Stereotactic radiosurgery--an organized neurosurgery-sanctioned definition. J Neurosurg (2007) 1.03
Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study. Neurosurgery (2006) 1.03
RNAi based approaches to the treatment of malignant glioma. Technol Cancer Res Treat (2006) 1.02
Long-term treatment of rats with haloperidol: lack of an effect on brain N-acetyl aspartate levels. Neuropsychopharmacology (2006) 0.98
Cadherin-11, a marker of the mesenchymal phenotype, regulates glioblastoma cell migration and survival in vivo. Mol Cancer Res (2012) 0.97
Mouse experimental myopia has features of primate myopia. Invest Ophthalmol Vis Sci (2009) 0.97
Single prolonged stress decreases glutamate, glutamine, and creatine concentrations in the rat medial prefrontal cortex. Neurosci Lett (2010) 0.96
Repeated unpredictable stress and antidepressants differentially regulate expression of the bcl-2 family of apoptotic genes in rat cortical, hippocampal, and limbic brain structures. Neuropsychopharmacology (2007) 0.96
Network signatures of survival in glioblastoma multiforme. PLoS Comput Biol (2013) 0.96
Proton magnetic resonance spectroscopy of brain tumors correlated with pathology. Acad Radiol (2005) 0.95
Blast-induced tinnitus and hearing loss in rats: behavioral and imaging assays. J Neurotrauma (2011) 0.95
Relationship of gliomas to the ventricular walls. J Clin Neurosci (2008) 0.94
Descriptive epidemiology of pituitary tumors in the United States, 2004-2009. J Neurosurg (2014) 0.93
ACR Appropriateness Criteria ® spinal bone metastases. J Palliat Med (2012) 0.92
Neurochemical, hormonal, and behavioral effects of chronic unpredictable stress in the rat. Behav Brain Res (2011) 0.91
Long-term study of brain 1H-MRS study in multiple sclerosis: effect of glatiramer acetate therapy on axonal metabolic function and feasibility of long-Term H-MRS monitoring in multiple sclerosis. J Neuroimaging (2008) 0.90
Blast-induced neurotrauma leads to neurochemical changes and neuronal degeneration in the rat hippocampus. NMR Biomed (2012) 0.90
Zero-profile hybrid fusion construct versus 2-level plate fixation to treat adjacent-level disease in the cervical spine. J Neurosurg Spine (2014) 0.89
Cancer stem cell-specific scavenger receptor 36 drives glioblastoma progression. Stem Cells (2014) 0.89
Modifications of the transoral approach to the craniovertebral junction: anatomic study and clinical correlations. Neurosurgery (2008) 0.89
Incidence patterns for primary malignant spinal cord gliomas: a Surveillance, Epidemiology, and End Results study. J Neurosurg Spine (2011) 0.88
Endothelial expression of TNF receptor-1 generates a proapoptotic signal inhibited by integrin α6β1 in glioblastoma. Cancer Res (2012) 0.88
Racial differences in survival after diagnosis with primary malignant brain tumor. Cancer (2003) 0.87
Cardiac effects of MDMA on the metabolic profile determined with 1H-magnetic resonance spectroscopy in the rat. NMR Biomed (2009) 0.87
Aptamer identification of brain tumor-initiating cells. Cancer Res (2013) 0.86
Communicating hydrocephalus in adult rats with kaolin obstruction of the basal cisterns or the cortical subarachnoid space. Exp Neurol (2008) 0.85
Somatic alterations in brain tumors. Oncol Rep (2008) 0.85
Vascular complications after radiosurgery for meningiomas. Neurosurg Focus (2007) 0.85
Systematic comparison of dendritic cell-based immunotherapeutic strategies for malignant gliomas: in vitro induction of cytolytic and natural killer-like T cells. Neurosurgery (2004) 0.85
MDMA administration decreases serotonin but not N-acetylaspartate in the rat brain. Neurotoxicology (2010) 0.85
Effects of blast-induced neurotrauma on the nucleus accumbens. J Neurosci Res (2013) 0.85
Dendritic cell-based active specific immunotherapy for malignant glioma. Expert Opin Biol Ther (2007) 0.84
Clinical trial participation among patients enrolled in the Glioma Outcomes Project. Cancer (2002) 0.84
Spinal cord and peripheral nerve injury: current management and investigations. Semin Radiat Oncol (2003) 0.83
Photopic visual input is necessary for emmetropization in mice. Exp Eye Res (2013) 0.83
Single prolonged stress enhances hippocampal glucocorticoid receptor and phosphorylated protein kinase B levels. Neurosci Res (2012) 0.83
Neonatal alcohol-induced region-dependent changes in rat brain neurochemistry measured by high-resolution magnetic resonance spectroscopy. Alcohol Clin Exp Res (2008) 0.83
Symptomatic neurocutaneous melanosis and Dandy-Walker malformation in an adult. J Clin Oncol (2009) 0.82
Protein tyrosine phosphatase mu regulates glioblastoma cell growth and survival in vivo. Neuro Oncol (2012) 0.82
Pediatric brain tumors in non-Hispanics, Hispanics, African Americans and Asians: differences in survival after diagnosis. Cancer Causes Control (2005) 0.81
Neurochemical changes after acute binge toluene inhalation in adolescent and adult rats: a high-resolution magnetic resonance spectroscopy study. Neurotoxicol Teratol (2009) 0.80
Methylation markers of malignant potential in meningiomas. J Neurosurg (2013) 0.80
Low-cost media formulation for culture of brain tumor spheroids (neurospheres). Biotechniques (2013) 0.80
MicroRNA and brain tumors: a cause and a cure? DNA Cell Biol (2007) 0.80
Surgical rehearsal platform: potential uses in microsurgery. Neurosurgery (2013) 0.80
Extended transoral approaches: surgical technique and analysis. Neurosurgery (2010) 0.80
Medial-frontal cortex hypometabolism in chronic phencyclidine exposed rats assessed by high resolution magic angle spin 11.7 T proton magnetic resonance spectroscopy. Neurochem Int (2012) 0.80
Binge toluene exposure alters glutamate, glutamine and GABA in the adolescent rat brain as measured by proton magnetic resonance spectroscopy. Drug Alcohol Depend (2010) 0.79
Effective aerosol delivery during high-frequency ventilation in neonatal pigs. Respirology (2010) 0.79
Significant differences in proton trimethyl ammonium signals between human gastrocnemius and soleus muscle. J Magn Reson Imaging (2004) 0.79
Stereotactic radiosurgery and radiation therapy for spinal tumors. Expert Rev Neurother (2007) 0.79
Effects of variable blast pressures on blood flow and oxygen saturation in rat brain as evidenced using MRI. Magn Reson Imaging (2012) 0.79