Published in Cancer Treat Rev on December 01, 2003
Ion channels and cancer. J Membr Biol (2005) 2.56
Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo. Proc Natl Acad Sci U S A (2007) 2.45
Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas. Virchows Arch (2008) 1.71
Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation. Future Oncol (2010) 1.54
The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters. Physiol Rev (2013) 1.50
In vivo chemical exchange saturation transfer imaging allows early detection of a therapeutic response in glioblastoma. Proc Natl Acad Sci U S A (2014) 1.44
Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer. BMC Cancer (2011) 1.39
Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. J Biomed Biotechnol (2010) 1.32
Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets. Neuro Oncol (2012) 1.29
Optical redox ratio differentiates breast cancer cell lines based on estrogen receptor status. Cancer Res (2010) 1.28
Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells. J Biol Chem (2009) 1.28
Anticancer agents that counteract tumor glycolysis. ChemMedChem (2012) 1.17
Proton dynamics in cancer. J Transl Med (2010) 1.14
Multicolored pH-tunable and activatable fluorescence nanoplatform responsive to physiologic pH stimuli. J Am Chem Soc (2012) 1.13
Calcium-dependent regulation of NEMO nuclear export in response to genotoxic stimuli. Mol Cell Biol (2006) 1.12
Acidic tumor microenvironment and pH-sensing G protein-coupled receptors. Front Physiol (2013) 1.10
Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression. Clin Exp Metastasis (2010) 1.09
V-ATPases as drug targets. J Bioenerg Biomembr (2005) 1.07
Vacuolar H(+)-ATPase-an enzyme for all seasons. Pflugers Arch (2008) 1.06
Ultra-pH-sensitive nanoprobe library with broad pH tunability and fluorescence emissions. J Am Chem Soc (2014) 1.04
Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research. J Transl Med (2013) 1.02
Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite? J Pathol (2013) 0.99
Quantum dot-fluorescent protein FRET probes for sensing intracellular pH. ACS Nano (2012) 0.98
Metabolic alterations in cancer cells and therapeutic implications. Chin J Cancer (2011) 0.96
Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question. Oncoscience (2014) 0.96
Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate. J Bioenerg Biomembr (2012) 0.95
Design and investigation of a series of rhodamine-based fluorescent probes for optical measurements of pH. Org Lett (2010) 0.94
Expression of Na+-dependent citrate transport in a strongly metastatic human prostate cancer PC-3M cell line: regulation by voltage-gated Na+ channel activity. J Physiol (2004) 0.93
A ratiometric pH reporter for imaging protein-dye conjugates in living cells. J Am Chem Soc (2009) 0.91
Identifying an uptake mechanism for the antiepileptic and bipolar disorder treatment valproic acid using the simple biomedical model Dictyostelium. J Cell Sci (2011) 0.89
pH-sensitive fluorescent dyes: are they really pH-sensitive in cells? Mol Pharm (2013) 0.89
Cancer cell bioenergetics and pH regulation influence breast cancer cell resistance to paclitaxel and doxorubicin. J Bioenerg Biomembr (2013) 0.85
An acidic environment changes cyclin D1 localization and alters colony forming ability in gliomas. J Neurooncol (2008) 0.85
Prognostic significance of monocarboxylate transporter 4 expression in patients with colorectal cancer. Exp Ther Med (2011) 0.84
Polymorphisms of monocarboxylate transporter genes are associated with clinical outcomes in patients with colorectal cancer. J Cancer Res Clin Oncol (2014) 0.83
Intracellular pH measurements made simple by fluorescent protein probes and the phasor approach to fluorescence lifetime imaging. Chem Commun (Camb) (2012) 0.83
Evidence-based support for the use of proton pump inhibitors in cancer therapy. J Transl Med (2015) 0.83
2-Aminophenoxazine-3-one and 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one cause cellular apoptosis by reducing higher intracellular pH in cancer cells. Proc Jpn Acad Ser B Phys Biol Sci (2011) 0.82
Stereocomplexes Formed From Select Oligomers of Polymer d-lactic Acid (PDLA) and l-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers-Applications of the Warburg Effect. Perspect Medicin Chem (2011) 0.81
Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring. Neuroimage Clin (2016) 0.80
Diverse Applications of Nanomedicine. ACS Nano (2017) 0.80
Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexes. J Biol Inorg Chem (2013) 0.79
Proteomic screening of molecular targets of crocin. Daru (2014) 0.79
The mechanostability of isolated focal adhesions is strongly dependent on pH. Chem Biol (2012) 0.79
Acidosis Sensing Receptor GPR65 Correlates with Anti-Apoptotic Bcl-2 Family Member Expression in CLL Cells: Potential Implications for the CLL Microenvironment. J Leuk (Los Angel) (2014) 0.77
Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas. Oncotarget (2016) 0.77
In Vivo Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors. Neoplasia (2015) 0.77
pHLIP and acidity as a universal biomarker for cancer. Yale J Biol Med (2012) 0.77
Prevention of carcinogenesis and development of gastric and colon cancers by 2-aminophenoxazine-3-one (Phx-3): direct and indirect anti-cancer activity of Phx-3. Int J Mol Sci (2013) 0.77
An integral approach to the etiopathogenesis of human neurodegenerative diseases (HNDDs) and cancer. Possible therapeutic consequences within the frame of the trophic factor withdrawal syndrome (TFWS). Neuropsychiatr Dis Treat (2008) 0.76
Stable DNA Nanomachine Based on Duplex-Triplex Transition for Ratiometric Imaging Instantaneous pH Changes in Living Cells. Anal Chem (2015) 0.76
Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets. Dis Model Mech (2016) 0.75
A vicious cycle between acid sensing and survival signaling in myeloma cells: acid-induced epigenetic alteration. Oncotarget (2016) 0.75
Alterations in Red Blood Cell Functionality Induced by an Indole Scaffold Containing a Y-Iminodiketo Moiety: Potential Antiproliferative Conditions. Oxid Med Cell Longev (2016) 0.75
Substituent Effects on the pH Sensitivity of Acetals and Ketals and Their Correlation with Encapsulation Stability in Polymeric Nanogels. J Am Chem Soc (2017) 0.75
Cancer: fundamentals behind pH targeting and the double-edged approach. Onco Targets Ther (2016) 0.75
Cancer generated lactic acid: Novel therapeutic approach. Int J Appl Basic Med Res (2016) 0.75
MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis. Oncotarget (2016) 0.75
A protein-dye hybrid system as a narrow range tunable intracellular pH sensor. Chem Sci (2016) 0.75
Atrial natriuretic peptide: a magic bullet for cancer therapy targeting Wnt signaling and cellular pH regulators. Curr Med Chem (2014) 0.75
Orexin 2 receptor as a potential target for immunotoxin and antibody-drug conjugate cancer therapy. Oncol Lett (2011) 0.75
Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters. Oncotarget (2016) 0.75
Dorzolamide synergizes the antitumor activity of mitomycin C against Ehrlich's carcinoma grown in mice: role of thioredoxin-interacting protein. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.75
MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling. Cell (2012) 4.01
Effect of vitamin K2 on the recurrence of hepatocellular carcinoma. Hepatology (2011) 3.00
Prevalence and characteristics of foveal retinal detachment without macular hole in high myopia. Am J Ophthalmol (2003) 2.47
Changes of axial length measured by IOL master during 2 years in eyes of adults with pathologic myopia. Graefes Arch Clin Exp Ophthalmol (2012) 2.08
Genotype-phenotype correlations in alternating hemiplegia of childhood. Neurology (2014) 1.82
Tight junction defects in patients with atopic dermatitis. J Allergy Clin Immunol (2010) 1.77
Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort. J Thorac Oncol (2011) 1.71
Increased diffusivity in superior temporal gyrus in patients with schizophrenia: a Diffusion Tensor Imaging study. Schizophr Res (2009) 1.70
Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence. J Hepatol (2011) 1.68
Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription. J Biol Chem (2008) 1.66
Long-term development of significant visual field defects in highly myopic eyes. Am J Ophthalmol (2011) 1.60
Recurrence of hepatocellular carcinoma 102 months after successful eradication and removal of membranous obstruction of the inferior vena cava. J Gastroenterol (2004) 1.57
Mechanism of stabilization of a bacterial collagen triple helix in the absence of hydroxyproline. J Biol Chem (2007) 1.56
NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition. Genes Dev (2007) 1.53
Long-term pattern of progression of myopic maculopathy: a natural history study. Ophthalmology (2010) 1.51
Prognostic impact of vitamin B6 metabolism in lung cancer. Cell Rep (2012) 1.45
P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA. Cancer Res (2003) 1.44
Neocortical gray matter volume in first-episode schizophrenia and first-episode affective psychosis: a cross-sectional and longitudinal MRI study. Biol Psychiatry (2007) 1.40
Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification. Cancer Res (2007) 1.40
Regression of cardiac hypertrophy in type 2 diabetes with hypertension by candesartan. Diabetes Res Clin Pract (2006) 1.39
Overexpression of MACC1 mRNA in lung adenocarcinoma is associated with postoperative recurrence. J Thorac Cardiovasc Surg (2010) 1.39
Anatomical features of periprostatic tissue and its surroundings: a histological analysis of 79 radical retropubic prostatectomy specimens. Jpn J Clin Oncol (2004) 1.38
Identification of amino acids in the human tetherin transmembrane domain responsible for HIV-1 Vpu interaction and susceptibility. J Virol (2010) 1.37
Glucocorticoid suppresses the canonical Wnt signal in cultured human osteoblasts. Biochem Biophys Res Commun (2005) 1.37
Characteristics of peripapillary detachment in pathologic myopia. Arch Ophthalmol (2006) 1.34
Endoscopic diagnosis of early squamous neoplasia of the esophagus with iodine staining: high-grade intra-epithelial neoplasia turns pink within a few minutes. J Gastroenterol Hepatol (2007) 1.33
Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung. J Clin Oncol (2008) 1.32
Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. J Biol Chem (2007) 1.32
Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations. Cancer Res (2010) 1.31
Clinical characteristics of posterior staphyloma in eyes with pathologic myopia. Am J Ophthalmol (2008) 1.30
Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis. Cancer Sci (2007) 1.28
Endoscopic submucosal dissection for treatment of early stage hypopharyngeal carcinoma. Gastrointest Endosc (2006) 1.28
Molecular diagnosis of MACC1 status in lung adenocarcinoma by immunohistochemical analysis. Anticancer Res (2011) 1.28
Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. Mol Cell Biol (2008) 1.24
Erlotinib resistance in lung cancer cells mediated by integrin β1/Src/Akt-driven bypass signaling. Cancer Res (2013) 1.23
Acquired resistance to gefitinib: the contribution of mechanisms other than the T790M, MET, and HGF status. Lung Cancer (2009) 1.23
Twist promotes tumor cell growth through YB-1 expression. Cancer Res (2008) 1.22
Identification of c-Src as a potential therapeutic target for gastric cancer and of MET activation as a cause of resistance to c-Src inhibition. Mol Cancer Ther (2010) 1.21
Detection of paravascular lamellar holes and other paravascular abnormalities by optical coherence tomography in eyes with high myopia. Ophthalmology (2007) 1.21
Programmed cell death protein 4 down-regulates Y-box binding protein-1 expression via a direct interaction with Twist1 to suppress cancer cell growth. Cancer Res (2009) 1.20
The basic and clinical implications of ABC transporters, Y-box-binding protein-1 (YB-1) and angiogenesis-related factors in human malignancies. Cancer Sci (2003) 1.20
Successful extirpation of thoracic pleural lipoma by single-port thoracoscopic surgery. Asian J Surg (2011) 1.18
Prospective phase II study of gefitinib in non-small cell lung cancer with epidermal growth factor receptor gene mutations. Lung Cancer (2008) 1.18
The cutaneous innate immune response in patients with atopic dermatitis. J Allergy Clin Immunol (2013) 1.18
Nuclear expression of Y-box-binding protein-1 correlates with P-glycoprotein and topoisomerase II alpha expression, and with poor prognosis in synovial sarcoma. J Pathol (2003) 1.17
Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells. Cancer Sci (2011) 1.16
Milk fermented by Lactobacillus gasseri SBT2055 influences adipocyte size via inhibition of dietary fat absorption in Zucker rats. Br J Nutr (2008) 1.16
Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis. World J Gastroenterol (2010) 1.15
Effects of milk fermented by Lactobacillus gasseri SBT2055 on adipocyte size in rats. Br J Nutr (2007) 1.15
Reduced retinal angiogenesis in MMP-2-deficient mice. Invest Ophthalmol Vis Sci (2003) 1.14
Cisplatin resistance and transcription factors. Curr Med Chem Anticancer Agents (2005) 1.13
Clinicopathological analysis of early-stage gastric cancers detected after successful eradication of Helicobacter pylori. Helicobacter (2011) 1.12
The role of nuclear Y-box binding protein 1 as a global marker in drug resistance. Mol Cancer Ther (2004) 1.12
Hepatic angiomyolipoma: diagnostic findings and management. Int J Hepatol (2012) 1.12
YB-1 is important for an early stage embryonic development: neural tube formation and cell proliferation. J Biol Chem (2006) 1.12
Long-term changes in axial length in adult eyes with pathologic myopia. Am J Ophthalmol (2010) 1.12
Vascular endothelial growth factor upregulates pigment epithelium-derived factor expression via VEGFR-1 in human retinal pigment epithelial cells. Biochem Biophys Res Commun (2003) 1.12
Cisplatin resistance associated with PARP hyperactivation. Cancer Res (2013) 1.11
Human mitochondrial transcription factor A binds preferentially to oxidatively damaged DNA. Biochem Biophys Res Commun (2002) 1.10
Preliminary trial of rebamipide for prevention of low-dose aspirin-induced gastric injury in healthy subjects: a randomized, double-blind, placebo-controlled, cross-over study. J Clin Biochem Nutr (2009) 1.10
Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: Interobserver agreement. Pathol Int (2010) 1.10
Binding capacity of human YB-1 protein for RNA containing 8-oxoguanine. Biochemistry (2002) 1.10
Evolution and expression of chimeric POTE-actin genes in the human genome. Proc Natl Acad Sci U S A (2006) 1.09
p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression. J Biol Chem (2002) 1.09
What is an adequate management strategy for pharyngeal low-grade dysplasia? Gastrointest Endosc (2013) 1.08
Activation of epidermal toll-like receptor 2 enhances tight junction function: implications for atopic dermatitis and skin barrier repair. J Invest Dermatol (2012) 1.08
Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury. Free Radic Biol Med (2011) 1.08
Association of EGFR mutation or ALK rearrangement with expression of DNA repair and synthesis genes in never-smoker women with pulmonary adenocarcinoma. Cancer (2013) 1.08
Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status. J Thorac Oncol (2010) 1.08
Association between lymphangiogenesis-/micrometastasis- and adhesion-related molecules in resected stage I NSCLC. Lung Cancer (2010) 1.08
Comparative study on the effect of human BST-2/Tetherin on HIV-1 release in cells of various species. Retrovirology (2009) 1.08
Fundus characteristics of high myopia in children. Jpn J Ophthalmol (2005) 1.08
Overexpression of peroxiredoxin 4 protects against high-dose streptozotocin-induced diabetes by suppressing oxidative stress and cytokines in transgenic mice. Antioxid Redox Signal (2010) 1.07
Role of Nup98 in nuclear entry of human immunodeficiency virus type 1 cDNA. Microbes Infect (2004) 1.06
Topographic analyses of shape of eyes with pathologic myopia by high-resolution three-dimensional magnetic resonance imaging. Ophthalmology (2011) 1.06
Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis. Biochem Pharmacol (2008) 1.05
Clinical usefulness of mitochondrial transcription factor A expression as a predictive marker in colorectal cancer patients treated with FOLFOX. Cancer Sci (2011) 1.05
Preoperative CYFRA 21-1 and CEA as prognostic factors in patients with stage I non-small cell lung cancer. Lung Cancer (2011) 1.04
Myopic choroidal neovascularization: natural course and treatment. Curr Opin Ophthalmol (2004) 1.04
Characteristics of patients with a favorable natural course of myopic choroidal neovascularization. Graefes Arch Clin Exp Ophthalmol (2004) 1.04
FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins. Blood (2007) 1.03