Published in Nucleic Acids Res on May 10, 2010
Crystal structure of Cas9 in complex with guide RNA and target DNA. Cell (2014) 5.26
Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems. Biol Direct (2011) 3.92
Structural basis for sequence-specific recognition of DNA by TAL effectors. Science (2012) 3.64
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature (2013) 3.00
Mechanism of foreign DNA selection in a bacterial adaptive immune system. Mol Cell (2012) 2.77
Pore-forming activity and structural autoinhibition of the gasdermin family. Nature (2016) 2.71
Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity (2012) 2.47
Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases. Nat Commun (2013) 2.10
The structural basis for the sensing and binding of cyclic di-GMP by STING. Nat Struct Mol Biol (2012) 2.04
Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions. Acta Crystallogr D Biol Crystallogr (2015) 1.89
CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold. Cell (2012) 1.85
Structural and functional analysis of a plant resistance protein TIR domain reveals interfaces for self-association, signaling, and autoregulation. Cell Host Microbe (2011) 1.83
Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP. Nat Struct Mol Biol (2012) 1.82
Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature (2013) 1.82
MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res (2013) 1.79
Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption. Elife (2016) 1.76
Comparative analysis of two complete Corynebacterium ulcerans genomes and detection of candidate virulence factors. BMC Genomics (2011) 1.75
Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2. Nature (2014) 1.64
Structure of the large ribosomal subunit from human mitochondria. Science (2014) 1.64
Crimean-Congo hemorrhagic fever virus nucleoprotein reveals endonuclease activity in bunyaviruses. Proc Natl Acad Sci U S A (2012) 1.63
CdiA from Enterobacter cloacae delivers a toxic ribosomal RNase into target bacteria. Structure (2014) 1.62
Structure of a mammalian ryanodine receptor. Nature (2014) 1.61
An Interbacterial NAD(P)(+) Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells. Cell (2015) 1.59
The genome of Chenopodium quinoa. Nature (2017) 1.58
Divergence and convergence in enzyme evolution. J Biol Chem (2011) 1.56
An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains. Nat Struct Mol Biol (2011) 1.55
Defense islands in bacterial and archaeal genomes and prediction of novel defense systems. J Bacteriol (2011) 1.53
Multiple origins of viral capsid proteins from cellular ancestors. Proc Natl Acad Sci U S A (2017) 1.53
Structural and evolutionary analyses show unique stabilization strategies in the type IV pili of Clostridium difficile. Structure (2015) 1.49
Structure and function of a spectrin-like regulator of bacterial cytokinesis. Nat Commun (2014) 1.48
Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition. Structure (2014) 1.48
The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains. EMBO J (2011) 1.48
Nonspecific recognition is achieved in Pot1pC through the use of multiple binding modes. Structure (2012) 1.47
Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1. Proc Natl Acad Sci U S A (2013) 1.46
Extrapolation of Inter Domain Communications and Substrate Binding Cavity of Camel HSP70 1A: A Molecular Modeling and Dynamics Simulation Study. PLoS One (2015) 1.46
Crystal structure of the fibre head domain of the Atadenovirus Snake Adenovirus 1. PLoS One (2014) 1.45
Structure of Sputnik, a virophage, at 3.5-Å resolution. Proc Natl Acad Sci U S A (2012) 1.45
Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an Escherichia coli pathovar. PLoS Pathog (2011) 1.44
The carboxy-terminal domain of Erb1 is a seven-bladed ß-propeller that binds RNA. PLoS One (2015) 1.43
Anions mediate ligand binding in Adineta vaga glutamate receptor ion channels. Structure (2013) 1.42
Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA. Cell (2016) 1.41
Crystal structure of calcium binding protein-5 from Entamoeba histolytica and its involvement in initiation of phagocytosis of human erythrocytes. PLoS Pathog (2014) 1.40
The Structure of Treponema pallidum Tp0751 (Pallilysin) Reveals a Non-canonical Lipocalin Fold That Mediates Adhesion to Extracellular Matrix Components and Interactions with Host Cells. PLoS Pathog (2016) 1.40
The crystal structure of a self-activating G protein alpha subunit reveals its distinct mechanism of signal initiation. Sci Signal (2011) 1.40
Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A. Genes Dev (2011) 1.40
A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis. Nature (2017) 1.39
A prevalent peptide-binding domain guides ribosomal natural product biosynthesis. Nat Chem Biol (2015) 1.39
A TPR domain-containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B. J Cell Biol (2013) 1.38
Structural basis of outer membrane protein biogenesis in bacteria. J Biol Chem (2011) 1.38
Structure of the phage TP901-1 1.8 MDa baseplate suggests an alternative host adhesion mechanism. Proc Natl Acad Sci U S A (2012) 1.37
Structure and function of the interacting domains of Spire and Fmn-family formins. Proc Natl Acad Sci U S A (2011) 1.36
Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains. PLoS Biol (2013) 1.35
Crystal structure and computational characterization of the lytic polysaccharide monooxygenase GH61D from the Basidiomycota fungus Phanerochaete chrysosporium. J Biol Chem (2013) 1.34
Molecular basis for AUXIN RESPONSE FACTOR protein interaction and the control of auxin response repression. Proc Natl Acad Sci U S A (2014) 1.34
Structures of Phytophthora RXLR effector proteins: a conserved but adaptable fold underpins functional diversity. J Biol Chem (2011) 1.34
Identification of novel positive-strand RNA viruses by metagenomic analysis of archaea-dominated Yellowstone hot springs. J Virol (2012) 1.33
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nat Chem Biol (2011) 1.33
Solution NMR structure of Apo-calmodulin in complex with the IQ motif of human cardiac sodium channel NaV1.5. J Mol Biol (2010) 1.32
Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing. Proc Natl Acad Sci U S A (2012) 1.32
Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer. Open Biol (2012) 1.29
Structure of a peptidoglycan amidase effector targeted to Gram-negative bacteria by the type VI secretion system. Cell Rep (2012) 1.28
Chlorite dismutases, DyPs, and EfeB: 3 microbial heme enzyme families comprise the CDE structural superfamily. J Mol Biol (2011) 1.27
Evolution: On a bender--BARs, ESCRTs, COPs, and finally getting your coat. J Cell Biol (2011) 1.25
Separate inputs modulate phosphorylation-dependent and -independent type VI secretion activation. Mol Microbiol (2011) 1.25
The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB. PLoS Biol (2013) 1.25
Structure of the absent in melanoma 2 (AIM2) pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly. J Biol Chem (2013) 1.24
A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors. Cell (2012) 1.23
Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription. Genes Dev (2012) 1.21
Combining functional and structural genomics to sample the essential Burkholderia structome. PLoS One (2013) 1.21
Divergence of multimodular polyketide synthases revealed by a didomain structure. Nat Chem Biol (2012) 1.20
Structural analysis of Pseudomonas syringae AvrPtoB bound to host BAK1 reveals two similar kinase-interacting domains in a type III Effector. Cell Host Microbe (2011) 1.20
Structural basis for the activation and inhibition of the UCH37 deubiquitylase. Mol Cell (2015) 1.20
A novel mechanism of ligand binding and release in the odorant binding protein 20 from the malaria mosquito Anopheles gambiae. Protein Sci (2012) 1.20
The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold. PLoS Pathog (2012) 1.20
The structures of coiled-coil domains from type III secretion system translocators reveal homology to pore-forming toxins. J Mol Biol (2012) 1.20
Fic domain-catalyzed adenylylation: insight provided by the structural analysis of the type IV secretion system effector BepA. Protein Sci (2011) 1.20
Structure of apo- and monometalated forms of NDM-1--a highly potent carbapenem-hydrolyzing metallo-β-lactamase. PLoS One (2011) 1.19
Structure of a pestivirus envelope glycoprotein E2 clarifies its role in cell entry. Cell Rep (2012) 1.18
Structure of the Plasmodium 6-cysteine s48/45 domain. Proc Natl Acad Sci U S A (2012) 1.18
Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors. Proc Natl Acad Sci U S A (2012) 1.17
Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation. Proc Natl Acad Sci U S A (2013) 1.17
Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions. PLoS Pathog (2013) 1.17
Structure of Streptomyces maltosyltransferase GlgE, a homologue of a genetically validated anti-tuberculosis target. J Biol Chem (2011) 1.16
Functional and evolutionary insight from the crystal structure of rubella virus protein E1. Nature (2013) 1.16
Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL. Proc Natl Acad Sci U S A (2013) 1.16
Crystal structure of glycoprotein C from Rift Valley fever virus. Proc Natl Acad Sci U S A (2013) 1.15
A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors. PLoS Pathog (2011) 1.15
Structure of the BamC two-domain protein obtained by Rosetta with a limited NMR data set. J Mol Biol (2011) 1.15
Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival. Mol Cell Biol (2011) 1.14
E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis. EMBO J (2014) 1.14
Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL. Trends Biochem Sci (2012) 1.14
Prp8, the pivotal protein of the spliceosomal catalytic center, evolved from a retroelement-encoded reverse transcriptase. RNA (2011) 1.13
Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations. PLoS One (2013) 1.13
Structural and functional studies on the interaction of GspC and GspD in the type II secretion system. PLoS Pathog (2011) 1.12
Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose deacylase: solution structure and catalytic properties. J Biol Chem (2011) 1.12
Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells. Proc Natl Acad Sci U S A (2013) 1.12
Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Nature (2016) 1.12
Structure of the cytoplasmic region of PelD, a degenerate diguanylate cyclase receptor that regulates exopolysaccharide production in Pseudomonas aeruginosa. J Biol Chem (2012) 1.11
The pseudo GTPase CENP-M drives human kinetochore assembly. Elife (2014) 1.11
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. Acta Crystallogr D Biol Crystallogr (2004) 31.52
Surprising similarities in structure comparison. Curr Opin Struct Biol (1996) 22.27
Dali: a network tool for protein structure comparison. Trends Biochem Sci (1995) 14.13
Mapping the protein universe. Science (1996) 13.72
Data growth and its impact on the SCOP database: new developments. Nucleic Acids Res (2007) 13.44
Searching protein structure databases with DaliLite v.3. Bioinformatics (2008) 12.15
ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures. Nucleic Acids Res (2005) 10.60
ProFunc: a server for predicting protein function from 3D structure. Nucleic Acids Res (2005) 5.79
Advances and pitfalls of protein structural alignment. Curr Opin Struct Biol (2009) 4.17
Evolutionary predictions of binding surfaces and interactions. Curr Opin Struct Biol (2002) 3.43
A common fold mediates vertebrate defense and bacterial attack. Science (2007) 3.43
Identification of related proteins on family, superfamily and fold level. J Mol Biol (2000) 3.24
Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense. Science (2007) 3.13
Protein structure comparison using the markov transition model of evolution. Proteins (2000) 2.94
TOPS++FATCAT: fast flexible structural alignment using constraints derived from TOPS+ Strings Model. BMC Bioinformatics (2008) 2.26
ROC and confusion analysis of structure comparison methods identify the main causes of divergence from manual protein classification. BMC Bioinformatics (2006) 2.18
TOPOFIT-DB, a database of protein structural alignments based on the TOPOFIT method. Nucleic Acids Res (2006) 2.06
Friend or foe: the same fold for attack and defense. Trends Immunol (2008) 1.99
NordicDB: a Nordic pool and portal for genome-wide control data. Eur J Hum Genet (2010) 1.07
Chromosomal aberrations in railroad transit workers: effect of genetic polymorphisms. Environ Mol Mutagen (2009) 0.75