Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.

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Published in PLoS One on December 19, 2013

Authors

Hong Wu1, Hong Zeng1, Aiping Dong1, Fengling Li1, Hao He1, Guillermo Senisterra1, Alma Seitova1, Shili Duan2, Peter J Brown1, Masoud Vedadi3, Cheryl H Arrowsmith4, Matthieu Schapira3

Author Affiliations

1: Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
2: Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
3: Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada ; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
4: Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada ; Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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