Published in Mol Cell Biol on May 10, 2010
The Drosophila IMD pathway in the activation of the humoral immune response. Dev Comp Immunol (2013) 1.21
Drosophila as a model system to unravel the layers of innate immunity to infection. Open Biol (2012) 1.20
Transcriptome analyses of the honeybee response to Nosema ceranae and insecticides. PLoS One (2014) 0.96
Transcriptional control of steroid biosynthesis genes in the Drosophila prothoracic gland by ventral veins lacking and knirps. PLoS Genet (2014) 0.91
The Oct1 homolog Nubbin is a repressor of NF-κB-dependent immune gene expression that increases the tolerance to gut microbiota. BMC Biol (2013) 0.83
Inhibition of the binding of MSG-intermolt-specific complex, MIC, to the sericin-1 gene promoter and sericin-1 gene expression by POU-M1/SGF-3. Dev Genes Evol (2012) 0.82
Genome-wide identification of Grainy head targets in Drosophila reveals regulatory interactions with the POU-domain transcription factor, Vvl. Development (2017) 0.75
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (1993) 58.26
Pathogen recognition and innate immunity. Cell (2006) 44.14
Antimicrobial peptides of multicellular organisms. Nature (2002) 23.50
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science (2006) 18.74
A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature (1986) 14.34
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66
The host defense of Drosophila melanogaster. Annu Rev Immunol (2007) 10.75
Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol (2007) 7.23
Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature (2001) 6.71
Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science (1999) 6.49
The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes Dev (1988) 6.23
The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat Med (2006) 5.20
Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila. Science (2008) 5.14
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature (2003) 5.14
Mammalian defensins in the antimicrobial immune response. Nat Immunol (2005) 4.84
Mode of action of membrane active antimicrobial peptides. Biopolymers (2002) 4.74
Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes. Methods Cell Biol (1994) 4.59
Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science (2002) 4.45
Dif, a dorsal-related gene that mediates an immune response in Drosophila. Cell (1993) 3.68
Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity (2000) 3.37
A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway. EMBO J (1998) 3.13
LL-37, the only human member of the cathelicidin family of antimicrobial peptides. Biochim Biophys Acta (2006) 3.05
The POU domain is a bipartite DNA-binding structure. Nature (1988) 2.92
Genes regulated by mating, sperm, or seminal proteins in mated female Drosophila melanogaster. Curr Biol (2004) 2.84
Anti-microbial peptides: from invertebrates to vertebrates. Immunol Rev (2004) 2.80
Drosophila immunity: paths and patterns. Curr Opin Immunol (2003) 2.68
The evolution and genetics of innate immunity. Nat Rev Genet (2001) 2.60
Expression of the caudal gene in the germ line of Drosophila: formation of an RNA and protein gradient during early embryogenesis. Cell (1987) 2.50
Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage. EMBO Rep (2000) 2.49
POU domain family values: flexibility, partnerships, and developmental codes. Genes Dev (1997) 2.48
Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37. J Immunol (2006) 2.32
kappa B-like motifs regulate the induction of immune genes in Drosophila. J Mol Biol (1993) 2.26
Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defences. Nat Rev Microbiol (2007) 2.15
Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells. J Immunol (2004) 2.05
Real-time quantitative PCR. Methods (2001) 2.00
The immune response in Drosophila: pattern of cecropin expression and biological activity. EMBO J (1990) 1.99
Drosophila sex-peptide stimulates female innate immune system after mating via the Toll and Imd pathways. Curr Biol (2005) 1.81
Dorsoventral pattern formation in Drosophila: signal transduction and nuclear targeting. Trends Genet (1991) 1.75
The role of Toll-like receptors and Nod proteins in bacterial infection. Mol Immunol (2004) 1.61
Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Physiol Genomics (2005) 1.58
Binding of a Drosophila POU-domain protein to a sequence element regulating gene expression in specific dopaminergic neurons. Nature (1990) 1.51
Induction and regulation of antimicrobial peptides in Drosophila. Dev Comp Immunol (1999) 1.48
Serpent regulates Drosophila immunity genes in the larval fat body through an essential GATA motif. EMBO J (1999) 1.44
POU domain factors in the neuroendocrine system: lessons from developmental biology provide insights into human disease. Endocr Rev (2001) 1.43
Peptidoglycan recognition proteins: on and off switches for innate immunity. Immunol Rev (2004) 1.40
The mode of antifungal action of plant, insect and human defensins. Cell Mol Life Sci (2008) 1.37
The andropin gene and its product, a male-specific antibacterial peptide in Drosophila melanogaster. EMBO J (1991) 1.35
A multilayered defense against infection: combinatorial control of insect immune genes. Trends Genet (2007) 1.31
The human cationic antimicrobial protein (hCAP-18) is expressed in the epithelium of human epididymis, is present in seminal plasma at high concentrations, and is attached to spermatozoa. Infect Immun (2000) 1.30
drifter, a Drosophila POU-domain transcription factor, is required for correct differentiation and migration of tracheal cells and midline glia. Genes Dev (1995) 1.26
A neuron-specific enhancer of the Drosophila dopa decarboxylase gene. Genes Dev (1989) 1.17
The homeobox gene Caudal regulates constitutive local expression of antimicrobial peptide genes in Drosophila epithelia. Mol Cell Biol (2004) 1.15
Adjacent GATA and kappa B-like motifs regulate the expression of a Drosophila immune gene. Nucleic Acids Res (1997) 1.15
An ectopic expression screen reveals the protective and toxic effects of Drosophila seminal fluid proteins. Genetics (2006) 1.11
Functional interactions between Drosophila bHLH/PAS, Sox, and POU transcription factors regulate CNS midline expression of the slit gene. J Neurosci (2000) 1.11
Rapid sequence divergence in mammalian beta-defensins by adaptive evolution. Mol Immunol (2003) 1.08
Specification of Drosophila motoneuron identity by the combinatorial action of POU and LIM-HD factors. Development (2004) 1.07
Interaction between the bHLH-PAS protein Trachealess and the POU-domain protein Drifter, specifies tracheal cell fates. Mech Dev (2000) 1.07
Long-range activation of systemic immunity through peptidoglycan diffusion in Drosophila. PLoS Pathog (2009) 1.06
Cross-regulatory interactions among tracheal genes support a co-operative model for the induction of tracheal fates in the Drosophila embryo. Mech Dev (2000) 1.05
ventral veinless, a POU domain transcription factor, regulates different transduction pathways required for tracheal branching in Drosophila. Development (1997) 1.00
Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6. Development (2001) 1.00
A member of the p38 mitogen-activated protein kinase family is responsible for transcriptional induction of Dopa decarboxylase in the epidermis of Drosophila melanogaster during the innate immune response. Mol Cell Biol (2008) 1.00
Toll-like receptors in skin infections and inflammatory diseases. Infect Disord Drug Targets (2008) 0.99
Host antimicrobial defence peptides in human disease. Curr Top Microbiol Immunol (2006) 0.98
Multiple roles for u-turn/ventral veinless in the development of Drosophila PNS. Development (2003) 0.98
Functional characterization of a novel promoter element required for an innate immune response in Drosophila. Mol Cell Biol (2003) 0.95
Restricted patterning of vestigial expression in Drosophila wing imaginal discs requires synergistic activation by both Mad and the drifter POU domain transcription factor. Development (2000) 0.93
Function of the Drosophila POU domain transcription factor drifter as an upstream regulator of breathless receptor tyrosine kinase expression in developing trachea. Development (1996) 0.93
In vivo regulation of tissue-specific and LPS-inducible expression of the Drosophila Cecropin genes. Insect Mol Biol (1998) 0.93
Ventral veinless, the gene encoding the Cf1a transcription factor, links positional information and cell differentiation during embryonic and imaginal development in Drosophila melanogaster. Development (1995) 0.93
Bioinformatic and expression analysis of novel porcine beta-defensins. Mamm Genome (2006) 0.92
Distinct variant DNA-binding sites determine cell-specific autoregulated expression of the Drosophila POU domain transcription factor drifter in midline glia or trachea. Mol Cell Biol (1996) 0.92
Sick of mating: sexual transmission of a pathogenic bacterium in Drosophila melanogaster. Fly (Austin) (2010) 0.85
Identification, cloning and functional characterization of novel beta-defensins in the rat (Rattus norvegicus). Reprod Biol Endocrinol (2006) 0.84
ventral veins lacking is required for specification of the tritocerebrum in embryonic brain development of Drosophila. Mech Dev (2005) 0.81
Redundant and synergistic effect of Cdx-2 and Brn-4 on regulating proglucagon gene expression. Endocrinology (2005) 0.79
Isolation of regulators of Drosophila immune defense genes by a double interaction screen in yeast. Insect Biochem Mol Biol (2006) 0.79
Disruption of mesectodermal lineages by temporal misexpression of the Drosophila POU-domain transcription factor, drifter. Dev Genet (1996) 0.77
Targeting bacterial virulence: inhibitors of type III secretion in Yersinia. Chem Biol (2003) 2.61
Axons guided by insulin receptor in Drosophila visual system. Science (2003) 2.10
Cooperative control of Drosophila immune responses by the JNK and NF-kappaB signaling pathways. EMBO J (2006) 1.53
Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalities. Proc Natl Acad Sci U S A (2009) 1.41
A multilayered defense against infection: combinatorial control of insect immune genes. Trends Genet (2007) 1.31
Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds. J Biol Chem (2011) 1.15
Cofactor-interaction motifs and the cooption of a homeotic Hox protein into the segmentation pathway of Drosophila melanogaster. Curr Biol (2005) 1.09
Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations. Hum Mol Genet (2006) 1.07
Regulation of the Drosophila lin-41 homologue dappled by let-7 reveals conservation of a regulatory mechanism within the LIN-41 subclade. Dev Dyn (2008) 1.06
Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling. J Immunol (2010) 1.05
Immune response in the barrier epithelia: lessons from the fruit fly Drosophila melanogaster. J Innate Immun (2012) 1.01
Basic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the Drosophila 26S proteasome. Mol Cell Biol (2010) 0.99
Functional characterization of a novel promoter element required for an innate immune response in Drosophila. Mol Cell Biol (2003) 0.95
Conservation and variation in Hox genes: how insect models pioneered the evo-devo field. Annu Rev Entomol (2013) 0.87
Automated dispensing cabinets. Don't assume they're safe; correct design and use are crucial. Am J Nurs (2007) 0.86
Surprising flexibility in a conserved Hox transcription factor over 550 million years of evolution. Proc Natl Acad Sci U S A (2010) 0.85
Insulin stimulates translocation of human GLUT4 to the membrane in fat bodies of transgenic Drosophila melanogaster. PLoS One (2013) 0.85
Global gene expression analysis in time series following N-acetyl L-cysteine induced epithelial differentiation of human normal and cancer cells in vitro. BMC Cancer (2005) 0.85
Rapid transcriptome sequencing of an invasive pest, the brown marmorated stink bug Halyomorpha halys. BMC Genomics (2014) 0.84
The Oct1 homolog Nubbin is a repressor of NF-κB-dependent immune gene expression that increases the tolerance to gut microbiota. BMC Biol (2013) 0.83
Computational identification of Ftz/Ftz-F1 downstream target genes. Dev Biol (2006) 0.83
Stripy Ftz target genes are coordinately regulated by Ftz-F1. Dev Biol (2009) 0.83
Analysis of signal-dependent changes in the proteome of Drosophila blood cells during an immune response. Mol Cell Proteomics (2004) 0.83
Antagonizing scalloped with a novel vestigial construct reveals an important role for scalloped in Drosophila melanogaster leg, eye and optic lobe development. Genetics (2006) 0.82
Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity. Eur J Med Chem (2011) 0.81
Variation and constraint in Hox gene evolution. Proc Natl Acad Sci U S A (2013) 0.79
Isolation of regulators of Drosophila immune defense genes by a double interaction screen in yeast. Insect Biochem Mol Biol (2006) 0.79
Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity. Org Biomol Chem (2014) 0.78
Wild-type Drosophila melanogaster as a model host to analyze nitrogen source dependent virulence of Candida albicans. PLoS One (2011) 0.78
N-acylated derivatives of sulfamethoxazole and sulfafurazole inhibit intracellular growth of Chlamydia trachomatis. Antimicrob Agents Chemother (2014) 0.78
Design, synthesis and evaluation of triazole functionalized ring-fused 2-pyridones as antibacterial agents. Eur J Med Chem (2012) 0.78
The evolving role of the orphan nuclear receptor ftz-f1, a pair-rule segmentation gene. Evol Dev (2013) 0.78
ftz evolution: findings, hypotheses and speculations (response to DOI 10.1002/bies.201100019). Bioessays (2011) 0.77
Functional studies of the yeast med5, med15 and med16 mediator tail subunits. PLoS One (2013) 0.77
Activation of an innate immune response in large numbers of permeabilized Drosophila embryos. Dev Comp Immunol (2010) 0.76
Functional conservation of Drosophila FTZ-F1 and its mammalian homologs suggests ligand-independent regulation of NR5A family transcriptional activity. Dev Genes Evol (2013) 0.76
Rapid isolation of gene homologs across taxa: Efficient identification and isolation of gene orthologs from non-model organism genomes, a technical report. Evodevo (2011) 0.75
Novel events associated with phenotypic reversion of a P element mutant in Drosophila melanogaster. Genome (2006) 0.75
The POU/Oct Transcription Factor Pdm1/nub Is Necessary for a Beneficial Gut Microbiota and Normal Lifespan of Drosophila. J Innate Immun (2016) 0.75
When sequential-compression devices cause falls. Am J Nurs (2008) 0.75
Expressed breast milk: safety in the hospital. Am J Nurs (2009) 0.75
Preface. Curr Top Dev Biol (2017) 0.75