Published in Mol Cell Neurosci on May 21, 2010
Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener (2011) 1.58
Physiological functions of APP family proteins. Cold Spring Harb Perspect Med (2012) 1.44
APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. EMBO J (2011) 1.31
Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One (2011) 1.06
Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells. Exp Brain Res (2011) 1.03
STAT3 silencing inhibits glioma single cell infiltration and tumor growth. Neuro Oncol (2013) 1.02
Effects of fatty acid unsaturation numbers on membrane fluidity and α-secretase-dependent amyloid precursor protein processing. Neurochem Int (2010) 0.97
Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. PLoS One (2011) 0.95
Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration. Neurobiol Dis (2012) 0.93
Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging. Exp Brain Res (2011) 0.93
Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway. Cell Death Dis (2014) 0.87
Soluble beta-amyloid precursor protein is related to disease progression in amyotrophic lateral sclerosis. PLoS One (2011) 0.86
The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis. J Comp Neurol (2013) 0.83
GFAP expression and social deficits in transgenic mice overexpressing human sAPPα. Glia (2013) 0.81
Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-α: implications for autism. FASEB J (2011) 0.81
Upregulation of APP, ADAM10 and ADAM17 in the denervated mouse dentate gyrus. PLoS One (2014) 0.80
Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3β signaling pathway. J Neurochem (2015) 0.79
Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems. Alzheimers Res Ther (2012) 0.76
Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease. J Neurosci Res (2016) 0.76
Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences. Front Mol Neurosci (2017) 0.75
Non-amyloidogenic effects of α2 adrenergic agonists: implications for brimonidine-mediated neuroprotection. Cell Death Dis (2016) 0.75
Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα. Front Mol Neurosci (2017) 0.75
Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science (2004) 15.91
Overview of BioCreative II gene mention recognition. Genome Biol (2008) 5.67
The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1. Neuron (2006) 3.17
Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport. Nat Neurosci (2006) 3.05
Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis. Science (2004) 3.01
Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. J Cell Biol (2003) 2.42
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci (2007) 2.25
Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature (2016) 2.24
TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice. Glia (2008) 1.97
Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. Neurobiol Dis (2006) 1.96
Corneal intrastromal tissue modeling with the femtosecond laser. Graefes Arch Clin Exp Ophthalmol (2011) 1.95
Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice. J Neurosci (2005) 1.94
Parkinson patient fibroblasts show increased alpha-synuclein expression. Exp Neurol (2008) 1.79
Neuroanatomical characteristics of the human pre-Bötzinger complex and its involvement in neurodegenerative brainstem diseases. Brain (2010) 1.75
Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation. Neuron (2009) 1.64
AnkyrinG is required to maintain axo-dendritic polarity in vivo. Proc Natl Acad Sci U S A (2009) 1.53
Specific gene delivery to liver sinusoidal and artery endothelial cells. Blood (2013) 1.51
Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors. Nat Methods (2010) 1.48
Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling. Development (2005) 1.44
The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma. Mol Cancer Res (2010) 1.41
Clinical features, neurogenetics and neuropathology of the polyglutamine spinocerebellar ataxias type 1, 2, 3, 6 and 7. Prog Neurobiol (2013) 1.40
IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system. Brain (2011) 1.37
Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation. Mol Cell Neurosci (2003) 1.37
APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. EMBO J (2011) 1.31
Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD). Mol Biol Cell (2006) 1.26
Quantitative mapping of T1 and T2* discloses nigral and brainstem pathology in early Parkinson's disease. Neuroimage (2010) 1.26
Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells. J Neurooncol (2010) 1.22
Vascular endothelial growth factor protects cultured rat hippocampal neurons against hypoxic injury via an antiexcitotoxic, caspase-independent mechanism. J Cereb Blood Flow Metab (2002) 1.20
Natural language processing in aid of FlyBase curators. BMC Bioinformatics (2008) 1.20
Corneal femtosecond laser keratotomy results in isolated stromal injury and favorable wound-healing response. Invest Ophthalmol Vis Sci (2007) 1.20
TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. J Cell Biol (2005) 1.19
Synaptopodin regulates plasticity of dendritic spines in hippocampal neurons. J Neurosci (2009) 1.17
Increased dentate gyrus excitability in neuroligin-2-deficient mice in vivo. Cereb Cortex (2010) 1.13
Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids. Hepatology (2010) 1.13
Outer mitochondrial membrane permeabilization during apoptosis triggers caspase-independent mitochondrial and caspase-dependent plasma membrane potential depolarization: a single-cell analysis. J Cell Sci (2003) 1.13
Repetitive magnetic stimulation induces functional and structural plasticity of excitatory postsynapses in mouse organotypic hippocampal slice cultures. J Neurosci (2012) 1.12
Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons. Mol Cell Neurosci (2006) 1.11
3D-reconstruction and functional properties of GFP-positive and GFP-negative granule cells in the fascia dentata of the Thy1-GFP mouse. Hippocampus (2008) 1.06
Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice. J Comp Neurol (2003) 1.06
New insights into the pathoanatomy of spinocerebellar ataxia type 3 (Machado-Joseph disease). Curr Opin Neurol (2008) 1.06
A role for the spine apparatus in LTP and spatial learning. Behav Brain Res (2008) 1.06
Functions of the APP gene family in the nervous system: insights from mouse models. Exp Brain Res (2011) 1.05
Apoptosis meets autophagy-like cell death in the ischemic penumbra: Two sides of the same coin? Autophagy (2008) 1.05
Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death. J Biol Chem (2001) 1.05
Pharmacological inhibition of Bcl-2 family members reactivates TRAIL-induced apoptosis in malignant glioma. J Neurooncol (2007) 1.04
First appraisal of brain pathology owing to A30P mutant alpha-synuclein. Ann Neurol (2010) 1.03
Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2/STAT3 signaling pathway. Clin Cancer Res (2010) 1.02
Organotypic entorhino-hippocampal slice cultures--a tool to study the molecular and cellular regulation of axonal regeneration and collateral sprouting in vitro. Methods Mol Biol (2007) 1.02
STAT3 silencing inhibits glioma single cell infiltration and tumor growth. Neuro Oncol (2013) 1.02
Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis. FEBS J (2008) 1.01
Knockdown of TFPI-2 promotes migration and invasion of glioma cells. Neurosci Lett (2011) 1.01
Mitochondrial membrane permeabilization and superoxide production during apoptosis. A single-cell analysis. J Biol Chem (2003) 1.01
beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment. J Neurosci Res (2007) 0.98
Laser microdissection of immunolabeled astrocytes allows quantification of astrocytic gene expression. J Neurosci Methods (2004) 0.98
The nontoxic natural compound Curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas. BMC Cancer (2010) 0.98
Comparison of commissural sprouting in the mouse and rat fascia dentata after entorhinal cortex lesion. Hippocampus (2003) 0.97
Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice. J Neurosci (2004) 0.97
Dentate granule cells in reeler mutants and VLDLR and ApoER2 knockout mice. Exp Neurol (2002) 0.97
Intrastromal keratotomy with femtosecond laser avoids profibrotic TGF-beta1 induction. Invest Ophthalmol Vis Sci (2009) 0.96
CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J (2010) 0.96
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I. Proc Natl Acad Sci U S A (2004) 0.95
The spine apparatus, synaptopodin, and dendritic spine plasticity. Neuroscientist (2010) 0.95
Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression. Acta Neuropathol Commun (2014) 0.95
Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity. Acta Neuropathol (2014) 0.94
Vessel ultrastructure in APP23 transgenic mice after passive anti-Abeta immunotherapy and subsequent intracerebral hemorrhage. Neurobiol Aging (2006) 0.94
Lamina-specific distribution of Synaptopodin, an actin-associated molecule essential for the spine apparatus, in identified principal cell dendrites of the mouse hippocampus. J Comp Neurol (2005) 0.93
Homeostatic regulation of gephyrin scaffolds and synaptic strength at mature hippocampal GABAergic postsynapses. Cereb Cortex (2012) 0.93
Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging. Exp Brain Res (2011) 0.93
Regulation of the spatial code for BDNF mRNA isoforms in the rat hippocampus following pilocarpine-treatment: a systematic analysis using laser microdissection and quantitative real-time PCR. Hippocampus (2013) 0.93
Inverse relationship between cerebrovascular lesions and severity of lewy body pathology in patients with lewy body diseases. J Neuropathol Exp Neurol (2010) 0.93
Quantification of layer-specific gene expression in the hippocampus: effective use of laser microdissection in combination with quantitative RT-PCR. J Neurosci Methods (2003) 0.93
Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death. Apoptosis (2013) 0.92
The mammalian molecular clockwork controls rhythmic expression of its own input pathway components. J Neurosci (2009) 0.91
Axonal inclusions in spinocerebellar ataxia type 3. Acta Neuropathol (2010) 0.91
Increased network excitability and impaired induction of long-term potentiation in the dentate gyrus of collybistin-deficient mice in vivo. Mol Cell Neurosci (2009) 0.91
Spinocerebellar ataxia type 3 (SCA3): thalamic neurodegeneration occurs independently from thalamic ataxin-3 immunopositive neuronal intranuclear inclusions. Brain Pathol (2006) 0.91
A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity. Ann Anat (2007) 0.91
Associational sprouting in the mouse fascia dentata after entorhinal lesion in vitro. Brain Res (2003) 0.90
Induction of STAT3 signaling in activated astrocytes and sprouting septal neurons following entorhinal cortex lesion in adult rats. Mol Cell Neurosci (2002) 0.90
A Selective Role for alpha3 Subunit Glycine Receptors in Inflammatory Pain. Front Mol Neurosci (2009) 0.90
Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing. Biochim Biophys Acta (2010) 0.90
Entorhinal denervation induces homeostatic synaptic scaling of excitatory postsynapses of dentate granule cells in mouse organotypic slice cultures. PLoS One (2012) 0.90
Neuronal apoptosis: BH3-only proteins the real killers? J Bioenerg Biomembr (2004) 0.90
VEGFR-1 signaling regulates the homing of bone marrow-derived cells in a mouse stroke model. J Neuropathol Exp Neurol (2010) 0.89
Synaptopodin regulates denervation-induced homeostatic synaptic plasticity. Proc Natl Acad Sci U S A (2013) 0.89
BH3 mimetics reactivate autophagic cell death in anoxia-resistant malignant glioma cells. Neoplasia (2008) 0.89
CNTF and CNTF receptor alpha are constitutively expressed by astrocytes in the mouse brain. Glia (2002) 0.88
Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice. Neurosci Lett (2009) 0.88
Unilateral entorhinal denervation leads to long-lasting dendritic alterations of mouse hippocampal granule cells. Exp Neurol (2011) 0.88
The amyloid precursor protein potentiates CHOP induction and cell death in response to ER Ca2+ depletion. Biochim Biophys Acta (2006) 0.87
Reduced excitability in the dentate gyrus network of betaIV-spectrin mutant mice in vivo. Hippocampus (2009) 0.87